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Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
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[quote:INTEGRATOR 38275237:MV8xMTEzNTg2XzM3NjA0ODQzXzQzMTU5NTZF] So sorry, [b]KRISPY, [/b] [b][color=red][LoL][/color][/b] hope I've got it right this time! [b]KRISPY QUOTE:[/b] [b][color=darkblue]I like to repeat a line : quantum Vibration of the tolemerase effects a repair/housekeeping enzyme to do something to the DNA chain. This ties in with the thoughts of me, BHD and others that AUgie is a REPAIR ORGANISM.[/color][/b] And indeed, this was [b]BHD's QUOTE: [/b] [quote:BadHairDay:MV8xMTEzNTg2XzM3NDUxNTEwXzFENDU3RDhC] [b]Same protein that fires up cancer-promoting [color=red]Erk[/color] also blocks its activation[/b] A protein which is intimately involved in cancer-promoting cell signaling also keeps a key component of the signaling pathway tied down and inactive, a team led by scientists from The University of Texas MD Anderson Cancer Center reports this week in Nature Structural Molecular Biology. Shc, pronounced "schick," plays a key role in activating signals which lead to cell proliferation (and cancer) when cells are stimulated, however it unexpectedly turns out to be a tumor-suppressor, keeping [b]Erk[/b] under wraps when a cell is less active, said senior author John Ladbury, Ph.D., professor in MD Anderson's Department of Biochemistry and Molecular Biology. "Shc is a checkpoint to prevent out of control cell growth, binding to [b]Erk[/b] when a cell is not being stimulated by growth factors," Ladbury said. "Otherwise, the lower-level background signaling that's always present in a cell would be uncontrolled." Keeping [b]Erk[/b] in check while the cell idles <SNIP> These findings point to a number of [b][color=blue]therapeutic possibilities[/color][/b], including the measurement of Shc concentration levels as a diagnostic tool and of finding small molecule drugs that block growth-factor signaling to Shc, keeping it bound to [b]Erk[/b], Ladbury noted. Growth factors provide double boost for [b]Erk[/b] When the appropriate growth factor receptor is stimulated Erk is activated in the MAP Kinase pathway. It dives into the cell nucleus and turns on a variety of genes, actions that contribute to cancer proliferation, blood vessel production and metastasis when signaling is out of control. When receptor tyrosine kinases on the cell surface connect with growth factors, they normally send a signal via Shc that sets off a chain of actions leading to Erk activation. Ladbury and colleagues looked at Shc's connections to epidermal growth factor receptor (EGFR) signaling. <SNIP> [b][color=darkblue]•When separated from Shc, [b]Erk[/b] moves into the nucleus and activates genes even when the cell is not receiving a stimulus. [i]Thus without the controlling influence of Shc, [b]Erk[/b] can run riot in the cell giving rise to unrestrained cell reproduction.[/i] [/color][/b] [color=red]Shc[/color]-[b]Erk[/b] connection confirmed. Ladbury and colleagues then tested their results in the C.Elegans, a worm model frequently employed in biological research. Both Shc and [b]Erk[/b] are greatly similar between humans and the worms. <SNIP> EGFR stimulation not only sets off the normal activation of [b]Erk[/b] via Shc and the MAPK pathway, Ladbury said, but also frees [b]Erk[/b] for greater availability for activation by breaking the tie to Shc. http://phys.org/news/2013-04-protein-cancer-promoting-erk-blocks.html There's the last half. [HD,[b][color=red] where for art thou HD?][/color][/b] [/quote] [b]Hope this sorts it out and gets us [b]BEZERKERS[/b], right back on [b][color=red]TARGET[/color][/b][/b] = [b][color=darkblue]Quantum Vibration of the Tolemerase effects (see HD)?[/color][/b] :banana: [/quote]
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My girl friend has a D.E.D link on her laptop from the French Embassy. (She works at the embassy)
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