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Home < [link to www.curcuminhealth.info] > | Thursday 18th August 2005
´Curcumin Can Work On At Least
One Dozen Cancers´
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Dear Friend of Truth in Health,
My name is Robert Redfern, and I make it my job to publicize studies
that prove poisonous drugs are not the best way to health, and there are
many natural health remedies that can resolve the problem, without any
side effects. One such remedy is Curcumin. This is the first of a series
of newsletters that will explore the many uses of this amazing solution
to a wide range of health problems.
Today´s News Story:
´Curcumin Can Work On At Least One Dozen Cancers´
Says Dr. Bharat Aggarwal.
Dr. Bharat Aggarwal, who headed the 12-member team of
researchers at University of Texas (U.T.) M.D. Anderson Cancer Center,
said earlier this week that his clinical research has made available not
only "the master switch to turn off cancer, but also a cure for it."
"It was already known that Curcumin can prevent cancer,"
Aggarwal said. "Now it can also be used to cure cancer." And, he added:
"We are providing evidence that Curcumin can work on at least one dozen
cancers."
"In fact, let´s put it this way: we have not found a single
cancer on which Curcumin doesn´t work," Aggarwal asserted.
Turmeric, whose vernacular name is haldi, is a rhizome of the
plant Curcuma longa. The medicinal use of this plant has been documented
in Ayurveda, a 5,000-year-old system of medicine that has its origins in
India.
Turmeric has long been used as a food preservative, a coloring
agent, a spice to flavor food, and as a folk medicine to cleanse the
body.
"Because of turmeric´s extensive use in foods in India and
Pakistan, the incidence of cancer, especially breast, colon, prostate
and lung, is a lot less in those countries", Aggarwal said. "And because
South Indians use turmeric more widely than North Indians, the
prevalence of cancer is less among them than among North Indians," he
said.
"The spice has been shown to relieve arthritis as well", he
added. The U.T. team´s research focused on how Curcumin stops laboratory
strains of melanoma from proliferating, and pushes the cancer cells to
commit suicide.
The team homed in on a molecule called NF-kappa B, a powerful
protein known to promote an abnormal inflammatory response that leads to
cancer in some people, arthritis in others, and a wide range of other
diseases in other people.
Aggarwal said, "Nearly 98 percent of all diseases are controlled
by this molecule. The humble yellow dye can subdue this potent molecule.
"
Two to five percent of turmeric is Curcumin and researchers have
now found that Curcumin at 95% concentration is far more potent than
plain old Turmeric. When combined with Piperine (a black pepper extract)
supplements become up to 20 times more potent, a fact that has resulted
in the manufacture in the U.S. of a formulation containing 200 capsules
each containing 500mg of 95% Curcumin and 3mg of Piperine and sold as a
dietary supplement.
Aggarwal said that Indians have known all along about the
anti-inflammatory benefits of turmeric, but "there was no documented
proof" up until now.
Dozens of clinical trials have already begun in the U.S., India,
Israel and the U.K., to see if Curcumin also has the same effect on
people as it has in the laboratory experiences.
The UT findings will be published in the Aug. 15 issue of the
journal, Cancer.
What is Curcumin?
Curcumin is a standardized extract of Curcuma Longa root. The
active ingredients in Curcuma Longa are a group of plant substances
called curcuminoids. Known collectively as "Curcumin," curcuminoids have
demonstrated potent antioxidant properties in scientific studies. In the
better formulas, there are 200 capsules of 500 mg Curcumin + 3mg
Piperine in each bottle.
Curcuminoids are responsible for turmeric´s distinctive yellow
color, but there can be less than 4% content in turmeric. Advanced
Curcumin complexes usually supply 95% total curcuminoids, and Piperine
is added as a natural bio-enhancer, to promote absorption of the
Curcumin.
Where does it come from? Turmeric Plant
Native to Southeast Asia, Curcuma longa is a tall tropical
shrub. The genus "Curcuma" belongs to the Zingiberaceae family, which
includes ginger. The plant possesses a large root structure with fleshy,
bulbous underground parts called "rhizomes." These rhizomes, known as
turmeric root, are harvested at maturity, dried and cured for commercial
use.
Turmeric is named in ancient Ayurvedic and Chinese herbal texts
as a traditional folk remedy. Historically, turmeric was used externally
for wounds, and sprains, and internally for digestive complaints,
rheumatism, liver disorders, coughs and colds.
Nature´s Absorption Enhancer Boosts Curcumin Power
Traditional Ayurvedic herbal formulas often include black pepper
and long pepper as synergistic herbs. The active ingredient in both
black pepper and long pepper is the alkaloid Piperine. Experiments
carried out to evaluate the scientific basis for the use of peppers have
shown that Piperine significantly enhances bio-availability when
consumed with other substances. Several, double blind, clinical studies,
have confirmed that Piperine increases absorption of nutrients.
All Around Herb for General Wellbeing.
Curcumin is the main biologically active part of Turmeric. Over
500 references to articles on Turmeric and Curcumin have been published
in peer reviewed professional journals.
It has been identified in pharmacology as:
v Anti-bacterial v Anti-inflammatory
v Anti-viral v Anti-oxidant
v Anti-fungal v Anti-spasmodic
v Anti-yeast v Carminative
v Anti-allergenic v Diuretic and anti-tumour
Turmeric and Curcumin have traditionally also been used to
support those suffering from pain and inflammatory conditions:
v Acne, allergies v Chicken pox
v Ascites v Diabetes
v Auto- immune disorders v Digestive disorders
v Burns v Gallbladder problems
v Liver damage v Liver disorders
v Skin rashes v Ulcers
v Tumours v Eye problems such as cataracts
If that is not enough, Turmeric has been used for thousands of
years by Indian women to make their skin beautiful and blemish free.
There are plenty of New Studies that show potential benefits
with:
v Alzheimer´s v Kidney-Disease
v Liver Disease v Anti-Arthritic
v Anti-Coagulant v Anti-Carcinogenic and Anti-Cancer
v Lowering-LDL v Raising HDL-Cholesterols
The Science
The numerous beneficial effects attributed to Turmeric are
probably due to the antioxidant properties of Curcumin.
Antioxidants neutralize free radicals, which are highly unstable
molecules that can damage cellular structures through abnormal oxidative
reactions. Curcumin is a potent "scavenger" of the superoxide radical, a
free radical that initiates potentially harmful oxidative processes,
such as lipid peroxidation. Through this activity, Curcumin has been
shown to protect skin cells from the injurious effect of nitro blue
tetrazolium, a toxin that generates superoxide radicals.
Curcumin also increases survival of cells exposed in vitro to
the enzyme hypoxanthine/xanthine oxidase, which stimulates superoxide
and hydrogen peroxide production, possibly by stimulating the enzyme
catalyse.
Curcumin itself is not toxic to cells, even at high
concentrations. Because free radicals are involved in aging and exert
harmful effects on skin, these results suggest Curcumin may help to slow
skin aging.
Curcumin demonstrates several other in vitro effects linked to free
radical scavenging.
Curcumin scavenges nitric oxide, a compound that when in excess
is associated with the body´s inflammatory response.
Pure curcumin and turmeric extracts protect red blood cells from
lipid peroxidation induced by hydrogen peroxide.
Curcumin has been shown to protect DNA from oxidative damage,
inhibit binding of toxic metabolites to DNA, and reduce DNA mutations in
the Ames test.
Curcumin also demonstrates in vitro inhibition of COX-I and
COX-II enzymes, which are involved in the inflammatory reaction.
Together, these results strongly suggest that curcumin has a
potent bio-protective effect, with a potentially wide range of
therapeutic applications.
Curcumin is poorly absorbed in the intestinal tract, limiting its
therapeutic effectiveness. Oral doses are largely excreted in faeces,
and only trace amounts appear in the blood. Administration of 3 mg of
Piperine with 500mg of Curcumin (1 capsule) can, in exceptional
circumstances increase the bio availability of curcumin by 2000%.
We state 100% increase from 500mg to the equivalent to 1000mg is about
right. Be aware that the bioavailability of all other nutrients taken
around the same time (and DRUGS) may also be increased by the same
proportion.
Side Effects
No side effects have been found when taking high doses of
Curcumin. Rare cases of stomach upset or diarrhoea may be resolved by
temporarily reducing the dosage and taking with food.
With kindest and healthiest regards
Robert Redfern
[email protected]
www.curcuminhealth.info < [link to www.curcuminhealth.info] >
< [link to www.eyesight.nu] >
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Subject: Curcumin E-Alert - Issue 01
Date: Thu, 18 Aug 2005 20:36:40 -0400
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Issue 01 | Register for E-Alerts Home | Thursday 18th August 2005
´Curcumin Can Work On At Least
One Dozen Cancers´
Dear Friend of Truth in Health,
My name is Robert Redfern, and I make it my job to publicize studies that prove poisonous drugs are not the best way to health, and there are many natural health remedies that can resolve the problem, without any side effects. One such remedy is Curcumin. This is the first of a series of newsletters that will explore the many uses of this amazing solution to a wide range of health problems.
Today´s News Story:
´Curcumin Can Work On At Least One Dozen Cancers´
Says Dr. Bharat Aggarwal.
Dr. Bharat Aggarwal, who headed the 12-member team of researchers at University of Texas (U.T.) M.D. Anderson Cancer Center, said earlier this week that his clinical research has made available not only "the master switch to turn off cancer, but also a cure for it."
"It was already known that Curcumin can prevent cancer," Aggarwal said. "Now it can also be used to cure cancer." And, he added: "We are providing evidence that Curcumin can work on at least one dozen cancers."
"In fact, let´s put it this way: we have not found a single cancer on which Curcumin doesn´t work," Aggarwal asserted.
Turmeric, whose vernacular name is haldi, is a rhizome of the plant Curcuma longa. The medicinal use of this plant has been documented in Ayurveda, a 5,000-year-old system of medicine that has its origins in India.
Turmeric has long been used as a food preservative, a coloring agent, a spice to flavor food, and as a folk medicine to cleanse the body.
"Because of turmeric´s extensive use in foods in India and Pakistan, the incidence of cancer, especially breast, colon, prostate and lung, is a lot less in those countries", Aggarwal said. "And because South Indians use turmeric more widely than North Indians, the prevalence of cancer is less among them than among North Indians," he said.
"The spice has been shown to relieve arthritis as well", he added. The U.T. team´s research focused on how Curcumin stops laboratory strains of melanoma from proliferating, and pushes the cancer cells to commit suicide.
The team homed in on a molecule called NF-kappa B, a powerful protein known to promote an abnormal inflammatory response that leads to cancer in some people, arthritis in others, and a wide range of other diseases in other people.
Aggarwal said, "Nearly 98 percent of all diseases are controlled by this molecule. The humble yellow dye can subdue this potent molecule. "
Two to five percent of turmeric is Curcumin and researchers have now found that Curcumin at 95% concentration is far more potent than plain old Turmeric. When combined with Piperine (a black pepper extract) supplements become up to 20 times more potent, a fact that has resulted in the manufacture in the U.S. of a formulation containing 200 capsules each containing 500mg of 95% Curcumin and 3mg of Piperine and sold as a dietary supplement.
Aggarwal said that Indians have known all along about the anti-inflammatory benefits of turmeric, but "there was no documented proof" up until now.
Dozens of clinical trials have already begun in the U.S., India, Israel and the U.K., to see if Curcumin also has the same effect on people as it has in the laboratory experiences.
The UT findings will be published in the Aug. 15 issue of the journal, Cancer.
What is Curcumin?
Curcumin is a standardized extract of Curcuma Longa root. The active ingredients in Curcuma Longa are a group of plant substances called curcuminoids. Known collectively as "Curcumin," curcuminoids have demonstrated potent antioxidant properties in scientific studies. In the better formulas, there are 200 capsules of 500 mg Curcumin + 3mg Piperine in each bottle.
Curcuminoids are responsible for turmeric´s distinctive yellow color, but there can be less than 4% content in turmeric. Advanced Curcumin complexes usually supply 95% total curcuminoids, and Piperine is added as a natural bio-enhancer, to promote absorption of the Curcumin.
Where does it come from?
Native to Southeast Asia, Curcuma longa is a tall tropical shrub. The genus "Curcuma" belongs to the Zingiberaceae family, which includes ginger. The plant possesses a large root structure with fleshy, bulbous underground parts called "rhizomes." These rhizomes, known as turmeric root, are harvested at maturity, dried and cured for commercial use.
Turmeric is named in ancient Ayurvedic and Chinese herbal texts as a traditional folk remedy. Historically, turmeric was used externally for wounds, and sprains, and internally for digestive complaints, rheumatism, liver disorders, coughs and colds.
Nature´s Absorption Enhancer Boosts Curcumin Power
Traditional Ayurvedic herbal formulas often include black pepper and long pepper as synergistic herbs. The active ingredient in both black pepper and long pepper is the alkaloid Piperine. Experiments carried out to evaluate the scientific basis for the use of peppers have shown that Piperine significantly enhances bio-availability when consumed with other substances. Several, double blind, clinical studies, have confirmed that Piperine increases absorption of nutrients.
All Around Herb for General Wellbeing.
Curcumin is the main biologically active part of Turmeric. Over 500 references to articles on Turmeric and Curcumin have been published in peer reviewed professional journals.
It has been identified in pharmacology as:
v Anti-bacterial v Anti-inflammatory
v Anti-viral v Anti-oxidant
v Anti-fungal v Anti-spasmodic
v Anti-yeast v Carminative
v Anti-allergenic v Diuretic and anti-tumour
Turmeric and Curcumin have traditionally also been used to support those suffering from pain and inflammatory conditions:
v Acne, allergies v Chicken pox
v Ascites v Diabetes
v Auto- immune disorders v Digestive disorders
v Burns v Gallbladder problems
v Liver damage v Liver disorders
v Skin rashes v Ulcers
v Tumours v Eye problems such as cataracts
If that is not enough, Turmeric has been used for thousands of years by Indian women to make their skin beautiful and blemish free.
There are plenty of New Studies that show potential benefits with:
v Alzheimer´s v Kidney-Disease
v Liver Disease v Anti-Arthritic
v Anti-Coagulant v Anti-Carcinogenic and Anti-Cancer
v Lowering-LDL v Raising HDL-Cholesterols
The Science
The numerous beneficial effects attributed to Turmeric are probably due to the antioxidant properties of Curcumin.
Antioxidants neutralize free radicals, which are highly unstable molecules that can damage cellular structures through abnormal oxidative reactions. Curcumin is a potent "scavenger" of the superoxide radical, a free radical that initiates potentially harmful oxidative processes, such as lipid peroxidation. Through this activity, Curcumin has been shown to protect skin cells from the injurious effect of nitro blue tetrazolium, a toxin that generates superoxide radicals.
Curcumin also increases survival of cells exposed in vitro to the enzyme hypoxanthine/xanthine oxidase, which stimulates superoxide and hydrogen peroxide production, possibly by stimulating the enzyme catalyse.
Curcumin itself is not toxic to cells, even at high concentrations. Because free radicals are involved in aging and exert harmful effects on skin, these results suggest Curcumin may help to slow skin aging.
Curcumin demonstrates several other in vitro effects linked to free radical scavenging.
Curcumin scavenges nitric oxide, a compound that when in excess is associated with the body´s inflammatory response.
Pure curcumin and turmeric extracts protect red blood cells from lipid peroxidation induced by hydrogen peroxide.
Curcumin has been shown to protect DNA from oxidative damage, inhibit binding of toxic metabolites to DNA, and reduce DNA mutations in the Ames test.
Curcumin also demonstrates in vitro inhibition of COX-I and COX-II enzymes, which are involved in the inflammatory reaction.
Together, these results strongly suggest that curcumin has a potent bio-protective effect, with a potentially wide range of therapeutic applications.
Curcumin is poorly absorbed in the intestinal tract, limiting its therapeutic effectiveness. Oral doses are largely excreted in faeces, and only trace amounts appear in the blood. Administration of 3 mg of Piperine with 500mg of Curcumin (1 capsule) can, in exceptional circumstances increase the bio availability of curcumin by 2000%.
We state 100% increase from 500mg to the equivalent to 1000mg is about right. Be aware that the bioavailability of all other nutrients taken around the same time (and DRUGS) may also be increased by the same proportion.
Side Effects
No side effects have been found when taking high doses of Curcumin. Rare cases of stomach upset or diarrhoea may be resolved by temporarily reducing the dosage and taking with food.
With kindest and healthiest regards
Robert Redfern
[email protected]
www.curcuminhealth.info
|
