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New, approved flu vaccine represents landmark in flu vaccine technology...
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In accordance with industry accepted best practices we ask that users limit their copy / paste of copyrighted material to the relevant portions of the article you wish to discuss and no more than 50% of the source material, provide a link back to the original article and provide your original comments / criticism in your post with the article.
[quote:Anonymous Coward 24641849:MV8yMTE0MTQxXzM1NjU0OTI3X0YzRTQwMkY0] [quote:Anonymous Coward 25898128:MV8yMTE0MTQxXzM1NjU0NzA2X0JDNEI3REVB] maybe the modified baculovirus will recombine my DNA and turn me into spiderman! YEAH! :spiderman: [/quote] whats funny is that they say it cannot infect human cells... meanwhile i found a scientific journal stating otherwise. Here you go.... http://www.ncbi.nlm.nih.gov/pubmed/11134309 J Virol. 2001 Jan;75(2):961-70. Baculovirus infection of nondividing mammalian cells: mechanisms of entry and nuclear transport of capsids. van Loo ND, Fortunati E, Ehlert E, Rabelink M, Grosveld F, Scholte BJ. Source Department of Cell Biology, Erasmus University, 3000 DR Rotterdam, The Netherlands. Abstract We have studied the infection pathway of Autographa californica multinuclear polyhedrosis virus (baculovirus) in mammalian cells. By titration with a baculovirus containing a green fluorescent protein cassette, we found that several, but not all, mammalian cell types can be infected efficiently. In contrast to previous suggestions, our data show that the asialoglycoprotein receptor is not required for efficient infection. We demonstrate for the first time that this baculovirus can infect nondividing mammalian cells, which implies that the baculovirus is able to transport its genome across the nuclear membrane of mammalian cells. Our data further show that the virus enters via endocytosis, followed by an acid-induced fusion event, which releases the nucleocapsid into the cytoplasm. Cytochalasin D strongly reduces the infection efficiency but not the delivery of nucleocapsids to the cytoplasm, suggesting involvement of actin filaments in cytoplasmic transport of the capsids. Electron microscopic analysis shows the cigar-shaped nucleocapsids located at nuclear pores of nondividing cells. Under these conditions, we observed the viral genome, major capsid protein, and electron-dense capsids inside the nucleus. This suggests that the nucleocapsid is transported through the nuclear pore. This mode of transport seems different from viruses with large spherical capsids, such as herpes simplex virus and adenovirus, which are disassembled before nuclear transport of the genome. The implications for the application of baculovirus or its capsid proteins in gene therapy are discussed. [/quote]
Original Message
Our nation has reached a landmark in influenza vaccine history with the U.S. Food and Drug Administration’s approval of a new seasonal flu vaccine, called Flublok, made with novel technology.
This method uses recombinant DNA and a modified baculovirus (a virus that infects insects) to produce a safe and effective human flu vaccine.
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