They're two of America's most high profile talk show hosts.

But there's clearly no love lost between Piers Morgan and Chelsea Handler as they bickered their way through a strained interview on Wednesday night, to mark the British star's second anniversary of his show on CNN.

Appearing as a guest on Chelsea Lately, Piers spent his entire slot poking fun at the rival host, who ended up losing her cool and telling him: 'You can suck my a**.'

The 47-year-old former newspaper editor had barely sat down in his chair before the insults started flying, proving just how much rivalry there is between two hosts.

As soon as he took his seat, the acerbic blonde presenter asked him: 'What are you looking at?'
Piers replied with a rather back-handed compliment: 'Either you've had plastic surgery or a makeover as you look really hot today.'

Clearly not impressed with his cheeky comment, the 37-year-old replied: 'You are so annoying, you are so obnoxious and you wonder why everyone hates you.'

I specifically covered up so you couldn't look at me and undress me with your molester eyes,' she added, contributing to the escalating banter between the pair(...)