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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1968 1
1969 2
1970 1
1971 1
1972 5
1973 3
1974 9
1975 2
1976 3
1977 3
1978 5
1979 7
1980 4
1981 6
1982 7
1983 12
1984 6
1985 2
1986 7
1987 3
1988 5
1989 7
1990 8
1991 11
1992 6
1993 17
1994 17
1995 13
1996 22
1997 16
1998 18
1999 32
2000 20
2001 21
2002 31
2003 20
2004 27
2005 34
2006 24
2007 17
2008 20
2009 20
2010 23
2011 27
2012 21
2013 27
2014 19
2015 30
2016 14
2017 21
2018 16
2019 18
2020 16
2021 19
2022 14
2023 9
2024 3

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726 results

Results by year

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Page 1
Genome-scale CRISPR-Cas9 knockout screening in human cells.
Shalem O, Sanjana NE, Hartenian E, Shi X, Scott DA, Mikkelson T, Heckl D, Ebert BL, Root DE, Doench JG, Zhang F. Shalem O, et al. Science. 2014 Jan 3;343(6166):84-87. doi: 10.1126/science.1247005. Epub 2013 Dec 12. Science. 2014. PMID: 24336571 Free PMC article.
First, we used the GeCKO library to identify genes essential for cell viability in cancer and pluripotent stem cells. Next, in a melanoma model, we screened for genes whose loss is involved in resistance to vemurafenib, a therapeutic RAF inhibitor. ...
First, we used the GeCKO library to identify genes essential for cell viability in cancer and pluripotent stem cells. Next, in a melanoma …
Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.
Chiappinelli KB, Strissel PL, Desrichard A, Li H, Henke C, Akman B, Hein A, Rote NS, Cope LM, Snyder A, Makarov V, Budhu S, Slamon DJ, Wolchok JD, Pardoll DM, Beckmann MW, Zahnow CA, Merghoub T, Chan TA, Baylin SB, Strick R. Chiappinelli KB, et al. Cell. 2015 Aug 27;162(5):974-86. doi: 10.1016/j.cell.2015.07.011. Cell. 2015. PMID: 26317466 Free PMC article.
Knocking down dsRNA sensors TLR3 and MAVS reduces this response 2-fold and blocking interferon beta or its receptor abrogates it. Upregulation of hypermethylated endogenous retrovirus (ERV) genes accompanies the response and ERV overexpression activates the response. Basal …
Knocking down dsRNA sensors TLR3 and MAVS reduces this response 2-fold and blocking interferon beta or its receptor abrogates it. Upregulati …
Retrovirus packaging cells.
Miller AD. Miller AD. Hum Gene Ther. 1990 Spring;1(1):5-14. doi: 10.1089/hum.1990.1.1-5. Hum Gene Ther. 1990. PMID: 2081186 Review.
An important contribution to their utility was the development of retrovirus packaging cells, which allow the production of retroviral vectors in the absence of replication-competent virus. ...Indeed, a retroviral vector recently has been used to mark tumor infiltrating ly …
An important contribution to their utility was the development of retrovirus packaging cells, which allow the production of retrovira …
Cancer regression in patients after transfer of genetically engineered lymphocytes.
Morgan RA, Dudley ME, Wunderlich JR, Hughes MS, Yang JC, Sherry RM, Royal RE, Topalian SL, Kammula US, Restifo NP, Zheng Z, Nahvi A, de Vries CR, Rogers-Freezer LJ, Mavroukakis SA, Rosenberg SA. Morgan RA, et al. Science. 2006 Oct 6;314(5796):126-9. doi: 10.1126/science.1129003. Epub 2006 Aug 31. Science. 2006. PMID: 16946036 Free PMC article. Clinical Trial.
Through the adoptive transfer of lymphocytes after host immunodepletion, it is possible to mediate objective cancer regression in human patients with metastatic melanoma. However, the generation of tumor-specific T cells in this mode of immunotherapy is often limiting. ... …
Through the adoptive transfer of lymphocytes after host immunodepletion, it is possible to mediate objective cancer regression in human pati …
SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy.
Pan D, Bao X, Hu M, Jiao M, Li F, Li CY. Pan D, et al. Cancer Res. 2022 Aug 3;82(15):2748-2760. doi: 10.1158/0008-5472.CAN-21-3523. Cancer Res. 2022. PMID: 35648422 Free PMC article.
Here we show that the histone methyltransferase SETDB1 is a potent suppressor of radiation-induced endogenous retrovirus expression. SETDB1 inhibition significantly enhanced the efficacy of radiotherapy by promoting radiation-induced viral mimicry to upregulate type I inte …
Here we show that the histone methyltransferase SETDB1 is a potent suppressor of radiation-induced endogenous retrovirus expression. …
PRMT7 ablation stimulates anti-tumor immunity and sensitizes melanoma to immune checkpoint blockade.
Srour N, Villarreal OD, Hardikar S, Yu Z, Preston S, Miller WH Jr, Szewczyk MM, Barsyte-Lovejoy D, Xu H, Chen T, Del Rincón SV, Richard S. Srour N, et al. Cell Rep. 2022 Mar 29;38(13):110582. doi: 10.1016/j.celrep.2022.110582. Cell Rep. 2022. PMID: 35354055 Free PMC article.
Herein, we report that combining PRMT7 inhibition with ICI therapy induces a strong anti-tumor T cell immunity and restrains tumor growth in vivo by increasing immune cell infiltration. PRMT7-deficient B16.F10 melanoma exhibits increased expression of genes in the interfer …
Herein, we report that combining PRMT7 inhibition with ICI therapy induces a strong anti-tumor T cell immunity and restrains tumor growth in …
Inhibition of melanoma-associated antigen expression and ecotropic retrovirus production in B16BL6 melanoma cells transfected with major histocompatibility complex class I genes.
Li M, Muller J, Xu F, Hearing VJ, Gorelik E. Li M, et al. Cancer Res. 1996 Oct 1;56(19):4464-74. Cancer Res. 1996. PMID: 8813142
In contrast, expression of the endogenous H-2Db gene or transfection with the H-2Dd or H-2Ld gene had no effect on MAA expression or retrovirus production. Northern blot analysis showed equivalent retroviral messages in retrovirus-producing and -nonproducing BL6 …
In contrast, expression of the endogenous H-2Db gene or transfection with the H-2Dd or H-2Ld gene had no effect on MAA expression or retr …
Ultraviolet light-induced collagen degradation inhibits melanoma invasion.
Budden T, Gaudy-Marqueste C, Porter A, Kay E, Gurung S, Earnshaw CH, Roeck K, Craig S, Traves V, Krutmann J, Muller P, Motta L, Zanivan S, Malliri A, Furney SJ, Nagore E, Virós A. Budden T, et al. Nat Commun. 2021 May 12;12(1):2742. doi: 10.1038/s41467-021-22953-z. Nat Commun. 2021. PMID: 33980846 Free PMC article.
Primary cutaneous melanomas of aged humans show more cancer cells invade as single cells at the invasive front of melanomas expressing and depositing more collagen, and collagen and single melanoma cell invasion are robust predictors of poor melanoma-s …
Primary cutaneous melanomas of aged humans show more cancer cells invade as single cells at the invasive front of melanomas ex …
Sequence and insertion sites of murine melanoma-associated retrovirus.
Li M, Huang X, Zhu Z, Gorelik E. Li M, et al. J Virol. 1999 Nov;73(11):9178-86. doi: 10.1128/JVI.73.11.9178-9186.1999. J Virol. 1999. PMID: 10516025 Free PMC article.
We previously showed that B16 melanoma cells produce ecotropic melanoma-associated retrovirus (MelARV) which encodes a melanoma-associated antigen recognized by MM2-9B6 monoclonal antibody. ...Some observed differences in the gag and pol regions of Mel …
We previously showed that B16 melanoma cells produce ecotropic melanoma-associated retrovirus (MelARV) which encodes a …
Transcriptional profiling of human endogenous retrovirus group HERV-K(HML-2) loci in melanoma.
Schmitt K, Reichrath J, Roesch A, Meese E, Mayer J. Schmitt K, et al. Genome Biol Evol. 2013;5(2):307-28. doi: 10.1093/gbe/evt010. Genome Biol Evol. 2013. PMID: 23338945 Free PMC article.
Recent studies suggested a role for the human endogenous retrovirus (HERV) group HERV-K(HML-2) in melanoma because of upregulated transcription and expression of HERV-K(HML-2)-encoded proteins. ...Transcription profiles of loci differed significantly between samples …
Recent studies suggested a role for the human endogenous retrovirus (HERV) group HERV-K(HML-2) in melanoma because of upregula …
726 results