bioavailability

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bi·o·a·vail·a·bil·i·ty

(bī′ō-ə-vā′lə-bĭl′ĭ-tē)

The degree to which or rate at which a drug or other substance is absorbed or becomes available at the site of physiological activity after administration.

bi′o·a·vail′a·ble (-lə-bəl) adj.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

bioavailability

(ˌbaɪəʊəˌveɪləˈbɪlɪtɪ)

(Medicine) the extent to which a drug or other substance is taken up by a specific tissue or organ after administration; the proportion of the dose of a drug that reaches the systemic circulation intact after administration by a route other than intravenous. Also called: systemic availability

ˌbioaˈvailable adj

Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

bi•o•a•vail•a•bil•i•ty

(ˌbaɪ oʊ əˌveɪ ləˈbɪl ɪ ti)

n.

the extent to which a substance can be used by the body.

[1965–70]

bi`o•a•vail′a•ble, adj.

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References in periodicals archive ?

NPT520-34 is an orally bioavailable, blood-brain barrier penetrating small molecule.

Neuropore Receives Orphan Drug Designation for NPT520-34 for the Treatment of Amyotrophic Lateral Sclerosis

WP1066 is an orally bioavailable drug currently in Phase I clinical studies in patients with brain tumors.

Moleculin Biotech reports precilinical data in pancreatic cancer candidates

Asceneuron, a company involved in the development of orally bioavailable modulators of tau pathology for the treatment of neurodegenerative diseases, announced yesterday that it has named Peter Van Vlasselaer, PhD as the chairman of the board of directors.

Asceneuron names new chairman

Many people question if HA is bioavailable (digested and effective) when fed.

Oral Hyaluronic Acid for Joints: It may be what you need to add to your program

Memory and brain amyloid and tau effects of a bioavailable form of curcumin in non-demented adults: A double-blind, placebo-controlled 18 month trial.

Effect of curcumin on memory in non-demented older adults

This is a simple calculation of the ratio of total testosterone and sex hormone binding globulin (SHBG) which provides an estimate of the bioavailable testosterone--that is, testosterone that is free (unbound to any protein) plus testosterone that is loosely bound to albumin.

SHBG and FAI are valuable tools in the diagnosis of androgen status

This held over a wide range in measured total N (1-2728 g [ha.sup.-1] [event.sup.-1]), dissolved P (0.03-134 g [ha.sup.-1] [event.sup.-1]), bioavailable P (0.04 - 538 g [ha.sup.-1] [event.sup.-1]), particulate P (0.3-1763 g [ha.sup.-1] [event.sup.-1]), and total P (0.4-1897 g [ha.sup.-1] [event.sup.-1]).

Gully treatment and water quality in the Southern Plains

The question of whether those nutrients are bioavailable is being examined by scientists in the ARS Food Components and Health Laboratory in Beltsville, Maryland.

Going Nuts Over Calories

Even the highest quality kibble or canned pet foods lack raw ingredients and the numerous benefits and bioavailable nutrition they provide.

Steve's Real Food Introduces Two New Ways to Effortlessly Enhance a Kibble Diet Using Freeze Dried Eggs and Goat Milk

(NASDAQ: ARQL) has presented preliminary results from the company's phase 1 dose escalation study for ARQ 531, an orally bioavailable, potent and reversible dual inhibitor of both wild type and C481S-mutant Bruton's tyrosine kinase in patients with relapsed or refractory hematologic malignancies at the 2019 European Hematology Association annual meeting in Amsterdam, the Netherlands, the company said.

ArQule Presents Clinical Proof-of-Concept Data from Ongoing Phase 1 Study of Reversible BTK Inhibitor, ARQ 531, in Patients with Relapsed/Refractory Hematologic Malignancies

ENYO Pharma lead candidate, EYP001, is an orally bioavailable small molecule presently being assessed in phase Ib in patients with chronic hepatitis B.