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Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine

 
Krispy71

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04/25/2013 07:17 AM

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
[[snipped post]]

PS - hey Tutes, did you see the 'ERK' article on the previous page? Was a little surprised no-one has twigged to it's relevance. Kinda erking me... LOL!
 Quoting: BadHairDay


To be honestly, I read that post of you but no bells or bubbles happened in my head :(
I am sorry ... would have liked the magic to happen.

But I do appreciated that post thumbs


xxxMzK
 Quoting: Krispy71


Well, interesting that ERK is now mentioned in an MSM article to do with Human DNA, and changes in how interactions occur using modern techniques.

Techniques that have only been around and in research since 2010. Interesting timing.

The definition that HouseDad came up with for bezERK never sat right with me, as there never was any proof of its meaning, despite many requests to ellaborate.

I dont know if HD still posts on TCP, and he has never answered any mails from me, so I gave up. Acolyte also never gave up any more that congratulating HD, and that was that. Nuf said, and it never went further than that.

Now here is an article from conventional medicine using ERK as a concept.

That BEZERK has and always will be in capitals at the top of every post we make and that we never really got any further than HD's possible meaning suggests to me that the HUNT for the meaning was shut down, like so many other paths we have gone down.

Another bezerker has suggested the BEZ is the experiment we are all a part of, and this is intriguing, and something I am going to follow up on.

Certainly, I am still pushing forward with new concepts, and what and where this thread is ultimately going, but I cant help but look back where this all started, and try to open up some answers to the basic core word of the story.
 Quoting: BadHairDay



THANX Monkey-daddy !!!!
Your words and your energy made it so much more clear and perfectly understandable for me hf

Indeed interesting timing ...

I remember the BEZ-post, and remember liking it :)

I am looking forward to your follow-ups on it :D


xxxMzk
Krispy71

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04/25/2013 08:32 AM

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
-[snipped other quotes]-

I have, if oranges and lemons consist of dangerous particles.

For some reason, beginning last fall after the citrus crop came on the market, I became violently ill eating oranges, which I've eaten all my life. A few weeks ago, having forgotten about my newly acquired allergy, I ate a lemon and became violently ill. What's up with that? I won't be eating oranges or lemons again.

For some reason, there is no negative effect from eating grapefruit.
 Quoting: Anonymous Coward 38838812


Have you looked where the oranges and lemon were grown ?
And where the grapefruit came from ?

Grapefruit is not cultivated in such big quantities as the other 2.
It could make a difference from which country they came from and which pesticides were used during cultivation or for transport.
I would not want to eat anything native American with all that corexit & oil in the water and atmosphere ...



xxxMzK
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04/25/2013 08:40 AM
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
@ BHD

I think we [BEZERKERS] all pictured Augie as a blob, but I'm starting to change my mind on that.

Personally I had thought the BEZ ERK warning was about Synthia, and a synthetic, uncontrollable outbreak of life occuring in the GoM. But now I think it is about the activation by Mother Earth of various substances to force change and rectify issues holding Her/us back.

If as Aco's last post states, that water is also becomming intelligent then anything can be Augie.

That's the elephant in the room statement.

It always has been intelligent. It just has not needed to be 'active' as it, and other substances of Mother Earth are now becomming active in defence of ttwb holding back a natural progression of us, planet, solar system, galaxy.

If we stay 'stuck' here, we may end up in a whole different reality/dimension to what we are used to, but with all the same BS we are currently experiencing.


If though, we progress, as an entire planet, sharing the experience, we will come to understand that much of what we 'believe' today is obsolete and we will throw away childish things, and concentrate on a whole new experience centering on love and respect for all things - including new friends that will be introduced as a result of ascention/progression.


Well Done!!!!!!!!!!!

This all ties in to many other things which have NOT been mentioned here or other places, partly I think because people wanted to stay alive.

When "The Nameless One" returns home, and the PTB loose their hold over the black powers.. Then the homes of the Crystal Skulls will be revealed, so when the knowledge comes together, so we will be able to see who we are once more.

Love and Light

yoda
 Quoting: Eagle'sWings

Well done !!!!
hf
You might be very very right ...

(sorry for the long absence, but I had and have other things to do. Other causes to defend.
Other things are showing up in my life now, and exposing their needs and or magic.

The most remarkable thing I have experienced lately is the changes in TIME-experience. Things that happened last week seem WEEKS ago, and I find myself a lot in dimensionbubbels where time is both expanding, accellerating and contracting, slowing down. Time seems/feels not linear anymore. There is more energy and more time or should I say "space" to fill up with things to do, yet time seems to pass so quicly ... Very strange.

I wish you all well, I stay lurking and popping in from time to time to read and or post quick.

Big huggers, Krispy xx
 Quoting: Krispy71

Hello Again.

In the light of the latest: BEZ ERK SCHISM, Maybe a good moment for us BEZERKERS, to remote view this very original exchange of info, between Krispers and BHD?

In the light of Housedad's original view on ERK?

Here it is: <Quote>

Nature. 2010 Dec 16;468(7326):968-72. doi: 10.1038/nature09627. Epub 2010 Nov 24.

COT drives resistance to RAF inhibition through MAP kinase pathway reactivation.

Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA.

Source

Broad Institute of Harvard and Massachusetts Institute of Technology, 7 Cambridge Center, Cambridge, Massachusetts 02142, USA.

Abstract

Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50-70% of malignant melanomas. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma-an observation that has been validated by the success of RAF and MEK inhibitors in clinical trials.

However, clinical responses to targeted anticancer therapeutics are frequently confounded by de novo or acquired resistance.

Identification of resistance mechanisms in a manner that elucidates alternative 'druggable' targets may inform effective long-term treatment strategies.

Here we expressed &#8764;600 kinase and kinase-related open reading frames (ORFs) in parallel to interrogate resistance to a selective RAF kinase inhibitor. We identified MAP3K8 (the gene encoding COT/Tpl2) as a MAPK pathway agonist that drives resistance to RAF inhibition in B-RAF(V600E) cell lines. COT activates ERK primarily through MEK-dependent mechanisms that do not require RAF signalling. Moreover, COT expression is associated with de novo resistance in B-RAF(V600E) cultured cell lines and acquired resistance in melanoma cells and tissue obtained from relapsing patients following treatment with MEK or RAF inhibitors.

We further identify combinatorial MAPK pathway inhibition or targeting of COT kinase activity as possible therapeutic strategies for reducing MAPK pathway activation in this setting.

ogether, these results provide new insights into resistance mechanisms involving the MAPK pathway and articulate an integrative approach through which high-throughput functional screens may inform the development of novel therapeutic strategies.

Comment in Drug discovery: How melanomas bypass new therapy. [Nature. 2010]

Therapy: Multiple bypass problem for BRAF inhibition. [Nat Rev Cancer. 2011]

PMID: 21107320 [PubMed - indexed for MEDLINE] PMCID: PMC3058384 Free PMC Article.

Stick to your guns, BHD, here comes THE MAGIC?

FOCUS on the TARGET and then, take AIM ~ gently, SQUEEZING The TRIGGER?

banana
Krispy71

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04/25/2013 09:00 AM

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Whhooaa! this vid from Lex on one of the explosion threads...


It's the High Flyer...

 Quoting: Lex 36773218




Had no idea the Texas thing had happened before, almost in identical fashion.

Wonder if the ships exploding has similar history and connection?
Are the Carnival cruise ships bringing something back from the GoM in to these water ways?

The latest ship was reportedly degaussed with a massive chain being dragged around and across its body, suggesting it was magnetised, and why no electric motors (bow and stern thrusters, pumps for toilets etc) would work.

That Cruise ships have constantly been associate with this thread is no coincicdence I think, nor is the coincidence of a Carnival cruise ship being so close to the explosion today.
 Quoting: BadHairDay


Yes you might have a point there ...

the magnetised field of the ship could have ignited or influenced things in the harbour to go vavoem.
Maybe there already was a small tiny leakage somewhere ...
maybe the FREQUENCY of THAT MAGNETISATION was so specific that it not only affected the ship's engine, but also the engines of the gas-facility nearby [close to or under the water] which made the pressure build-up a reaction....

Put with that the report of chemicals and fluids in garages gone hay-wire, so will the fluids that make a ship work ...

Just like the supposedly airplane-fuel BUG,
me thinks it was not a BUG at all but the first signs of Transmutation and reactions to the Galactic-Alignment (pre)Effects ... becoz of planes are high in the atmosPHere they are the first to be affected.
Maybe thats why also space-programs were scrapt-off coz they are even more susceptible to harmonic-alterations high in our atmosPHere and outside in Space !!! Maybe that is one of the reasons why the Grunt-PHobos mission failed !!! The fuel adapted to quick and made it more difficult for the sensitive technology to process. ... You think NASA or the Chin/Ruskies would ever admit that they had FUEL-MUTATIONS? ---> Nope.

So the GA [Galactic Alignment] has influence on our vibe, harmonics, electro magnetism, gravity and the PH of Earth and us Lifeforms ...
The Elites tried many things to diffuse and to de-resonate the effects of the GA.
They spilled oil injected with artificial organisms [Venter's], mixed corexit added with IRON in the waters ... chemicals and iron change the PH drastically !!!! Add algae and other bacteria which eat from the marine-life die-off, less marine life = also changing the PH.
Jelly's react to changes in PH and electrical environment of oceanwaters by multiplying ...
Use lasers and other tech to deliberately melt off glaciers and Ant-/Arctic Ice and blame it on Greenhouse-gasses !
Fresh and Salt water reacts > changing PH
Cold and warm waters react > changing PH and electric signature ...
etc etc ...
Venter's bacteria cause problems or effects the normal uninformed working people cant handle > disasters occur

It is man-made and Natural effects doing a dance-battle ... but Dan Karaty nor Michael Jackson wasnt the choreograph ...lol...



Is that helping you BHD and other bezerkers ?
Does that make sense ?


xxxMzK
Krispy71

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04/25/2013 09:08 AM

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Integrator please adjust your post.

It was not between BHD and ME,
but a reply from Eagle's Wings to BHD, and a response to Eagle's Wings from me.

BHD is not in the quote you picked out !

Please make sure you quote and name the right persons !!!!

XXXBossyBeetroot




(edited becoz I forgot BOSSY ..lol...)

Last Edited by Krispy71 on 04/25/2013 09:09 AM
Krispy71

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04/25/2013 09:24 AM

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Maybe totally not relevant,
but I would like to share this info so that people could prepare ...

“Nuke Event In LA April 28th”
[link to www.latenightinthemidlands.com]

followed up by a FEMA publication :


Zombie UFO Crash Disaster Full-Scale Exercise
Saturday April 27th 2013 9:00am to 5:00pm

[link to web.archive.org]


Maybe it will blow away like many others did, without VISIBLE effects ...
Krispy71

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04/25/2013 10:05 AM

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Monsanto is 1 of the leading companies to MASK any re-setting of genes or harmonic-mutation {restoring the old or keeping the old}

I realised this when I read an article in Dutch about that now also
Europe plant control on small scale cultivation of fruits and vegetables

Remember my post a few pages back of the Swiss man working for the pharmaceutical giant Ciba (now Novartis) who was able to restore the ancient gene-data of plants, in which a normal fern would grow out as a now extinct prehistoric version ?
And Corn that did not had 1 or 2 corns at his knob, but 5 at the same time !! Like in ancient days !!!

THIS was not the result of radio-active gene-destruction,
but of ANCIENT GENE RESTORATION !!!
By having the seeds in a special Electrical-field ...
The Ciba-Geigy effect or The "Primeval Code"
[link to www.bibliotecapleyades.net]
[link to www.urzeit-code.com]

Guido Ebner and Heinz Schürch appear to have discovered a biological method of effectively creating antecedents from progeny – without using genetic engineering. Or as both researchers put it: "Our experiments do not involve a mutation of the organism in question, which in the case of genetic engineering involves channelling an additional gene into the organism. No entirely new organism is created. In the electrostatic field, only the gene expression is altered – the retrieval of the existing gene. That is something different."

In addition to corn and trout experiments, the results of experiments with wheat were also amazing: thus the cereal exposed to the electrostatic field developed new proteins, which people looked for in the original wheat to no avail. Furthermore, it surprisingly produced much larger roots than the control group. This had the advantage of allowing the crops to grow far more rapidly. And occasionally in these experiments, a variant emerged which resembled the genetic antecedents of the wheat.

"In the case of our 'manipulated' wheat, growth was so rapid that it was ripe in four weeks instead of the usual seven months", Heinz Schürch recalled. "However one has to say that although the ears and stalks were somewhat smaller, there were more ears per plant. The actual benefit is that we could cultivate this wheat in regions where spring and summer are short – where conventional wheat cannot be grown at all." In this case, one can also cheerfully refrain from using pesticides and herbicides: "The pests that have adapted to the growth process of normal wheat have not yet developed when we harvest our wheat as early as four to eight weeks after planting."

For "primeval cereals" from an electric field yield more than modern genetically engineered varieties and do not require fertilisers. Furthermore, it is completely natural and thus healthier. It can be grown by anybody at minimal cost.
 Quoting: snip


Lots of Radiation poison makes plants and lifeforms produce deficient off-spring ...
But like I questioned before in an other post : ARE ALL the " mutations" we see the result of radio-active contamination ? Are they all the result of chemical GM-fertilisers ?
Yes some are ...
But others are adapting again to the changed electrical charges in the atmosPHere, and awaken to their ancestral gene-coding ...

Again The Elites and Monsanto & Venter do not wish the mass to know, so they lead them blind-deaf-and-crippel that it comes from gamma-rays and CME's and stuff we use and indeed radiation-effects like from Chernobyl & Fukushima !!!
How would they have to explain all the lies and bullshit they forced through our throats ? With acknowledging the CIBA-GEIGY EFFECT they loose EVERY control on control !!!!
Coz these plants and lifeforms dont need fertilizers or meds !!!

In essence what Monsanto does is making seeds infertile ... they wont reproduce from the off-spring, so new seeds have to be purchased ... Monsanto in control.

Now after the big GA, and all the results with it
lifeforms are going to harmonise to this new PH of the earth,
in which AUtomatically ancient gene-data will be activated [your JUNK-DNA will restore in response to the Earth and Galaxy !!!]

Can you see and understand why Monsanto & Elites want to have this monopoly position on seeds ?
If this proceeds there will come a time that the government will claim your highly evolved children [with for example 3 DNA-chains or even 6 or 12 Chains, or other fringe attributes as a result of Natural Universal Fractal Harmonisation ...] and claim Monsanto has a pattent-right on them coz they ALLEGEDLY consumed his GM-seeds, GM-veggies and GM-meat !!!!
Nothing of this would be the real reason, coz these children would be fringe species and test-subjects for the Elites to perfect their control even more ...

I can see the day coming that humans have to pay for egg-cells and sperm ... coz Monsanto made almost all of us infertile with his foods and products. The ultimate population control !!!!


But Nature is stronger then any GM-product or sceme !!!




Do you understand what I mean ?


xxxMzK

Last Edited by Krispy71 on 04/25/2013 10:09 AM
U3

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04/25/2013 10:30 AM
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
That frequency shapes all feels so comfortable, dont you think? I've been chatting with some bezerk types about that phenominon where by folks can hear colour, and see sound, or taste colour etc. I forget it's name. But with that 'gift' the world would make a lot mor sense I think, being able to see these sound and wave patterns creating shapes, and guiding outcomes.


PS - [snipped]
 Quoting: BadHairDay


Comfortable because it's what is. Frequency provides the template for physicality. Energy is stepped down in harmonic resonance and woven into 3D around that geometric template created by frequency. Remember, frequency has all those sensual expressions - not only sacred geometry, but sound, color, etc.
Synesthesia is the word for which you were groping.
That "gift" may be experienced with an ayahuasca cocktail, preferably in ceremony, under the supervision of a shaman....very expensive and hard to find. Never tried it myself.

Erk, eh? [snipped]
 Quoting: TutuWuwu 6581438



Love that part !!!!
Beautifully said !
hf
 Quoting: Krispy71





Hi Bezerk'ers hi

I always get a smile when I drop by! I love to see your topic of discussion.

Anyway, thought you might find this video interesting:

Russians sent plasma with suspended dust particles in it, into space. It created a black hole. The non-material shapes the material.



I got the video from this thread: Thread: Russian Plasma Experiment in Space Redefines 'Reality' - Down the Rabbit Hole...oops, that's not a 'hole'
Happy Holidays! xmas
U3

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04/25/2013 10:42 AM
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
When the explosions first happened in Mobile, someone (an "official", don't remember who) said it was a static electricity charge. It will be interesting to see what they finally conclude.

What I am noticing is explosions occur as the dying throes of old, archaic energy are released as an asbtract world emerges.

(That's my 2 cents!) afro
Happy Holidays! xmas
U3

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04/25/2013 11:18 AM
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
That frequency shapes all feels so comfortable, dont you think? I've been chatting with some bezerk types about that phenominon where by folks can hear colour, and see sound, or taste colour etc. I forget it's name. But with that 'gift' the world would make a lot mor sense I think, being able to see these sound and wave patterns creating shapes, and guiding outcomes.


PS - [snipped]
 Quoting: BadHairDay


Comfortable because it's what is. Frequency provides the template for physicality. Energy is stepped down in harmonic resonance and woven into 3D around that geometric template created by frequency. Remember, frequency has all those sensual expressions - not only sacred geometry, but sound, color, etc.
Synesthesia is the word for which you were groping.
That "gift" may be experienced with an ayahuasca cocktail, preferably in ceremony, under the supervision of a shaman....very expensive and hard to find. Never tried it myself.

Erk, eh? [snipped]
 Quoting: TutuWuwu 6581438



Love that part !!!!
Beautifully said !
hf
 Quoting: Krispy71




Instead of editing posts, I'll just re-use this one. (It's so full of good stuff, lol)

Synesthesia:

1) Daniel Tammet, autistic savant, sees colors, emotions & shapes, in numbers and learned Icelandic in one week.



2) Neil Harbisson, born color blind. He hears color and is the first "official" cyborg.




Humanity is leaping into a new species...biology intermingled with technology is one earmark of it, imo.

XOXOXOXOXOXOXOXO

Last Edited by ERE3 on 04/25/2013 11:24 AM
Happy Holidays! xmas
SouthernLight

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04/25/2013 12:17 PM

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Yes you might have a point there ...

the magnetised field of the ship could have ignited or influenced things in the harbour to go vavoem.
<snipped>

xxxMzK
 Quoting: Krispy71


Something else I have been seeing here... LOTS of STRONG static electricity!

It has been so bad that touching the car door as I am getting out can actually Hurt! Last night I got too near the door with the keys and a bright arc nailed me despite my care not to touch it. grr lol

Many have been complaining about it and the phones are having issues too... no reception or spotty with both cells and land lines. Add in dying batteries and all sorts of mechanical failures(alternators, starters, generators, etc.)...
More and more things that make you go hmmmmm.

hi

Didn't see this before posting!
Sure doesn't surprise me.

When the explosions first happened in Mobile, someone (an "official", don't remember who) said it was a static electricity charge. It will be interesting to see what they finally conclude.

What I am noticing is explosions occur as the dying throes of old, archaic energy are released as an asbtract world emerges.

(That's my 2 cents!) afro
 Quoting: U3


Last Edited by SouthernLight on 04/25/2013 12:20 PM
“You can't wake a person who is pretending to be asleep”
Navajo proverb
Krispy71

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04/25/2013 12:37 PM

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Yes you might have a point there ...

the magnetised field of the ship could have ignited or influenced things in the harbour to go vavoem.
<snipped>

xxxMzK
 Quoting: Krispy71


Something else I have been seeing here... LOTS of STRONG static electricity!

It has been so bad that touching the car door as I am getting out can actually Hurt! Last night I got too near the door with the keys and a bright arc nailed me despite my care not to touch it. grr lol

Many have been complaining about it and the phones are having issues too... no reception or spotty with both cells and land lines. Add in dying batteries and all sorts of mechanical failures(alternators, starters, generators, etc.)...
More and more things that make you go hmmmmm.

hi

Didn't see this before posting!
Sure doesn't surprise me.

When the explosions first happened in Mobile, someone (an "official", don't remember who) said it was a static electricity charge. It will be interesting to see what they finally conclude.

What I am noticing is explosions occur as the dying throes of old, archaic energy are released as an asbtract world emerges.

(That's my 2 cents!) afro
 Quoting: U3

 Quoting: SouthernLight


I have exactly the same !!!
Static when I want to grab the handle of my livingroom-door (which is metalic) and other doors !!!
I am glad you mention it SL hf

Also my phone is living 6min ahead of time now !!!!
While it should synchronise with global internet time.




@ U3
Yes that is what I meant.

The NEW has a different CHARGE as the OLD and thus a dis-charge is needed, happening ... or in other cases the OLD energy seems to be sucked up dry, leaving ships and tech out-of-order ;)

This is so freaking interesting !!!!
5a


xxxMzK
U3

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Yes you might have a point there ...

the magnetised field of the ship could have ignited or influenced things in the harbour to go vavoem.
<snipped>

xxxMzK
 Quoting: Krispy71


Something else I have been seeing here... LOTS of STRONG static electricity!

It has been so bad that touching the car door as I am getting out can actually Hurt! Last night I got too near the door with the keys and a bright arc nailed me despite my care not to touch it. grr lol

Many have been complaining about it and the phones are having issues too... no reception or spotty with both cells and land lines. Add in dying batteries and all sorts of mechanical failures(alternators, starters, generators, etc.)...
More and more things that make you go hmmmmm.

hi

Didn't see this before posting!
Sure doesn't surprise me.

When the explosions first happened in Mobile, someone (an "official", don't remember who) said it was a static electricity charge. It will be interesting to see what they finally conclude.

What I am noticing is explosions occur as the dying throes of old, archaic energy are released as an asbtract world emerges.

(That's my 2 cents!) afro
 Quoting: U3

 Quoting: SouthernLight


I have exactly the same !!!
Static when I want to grab the handle of my livingroom-door (which is metalic) and other doors !!!
I am glad you mention it SL hf

Also my phone is living 6min ahead of time now !!!!
While it should synchronise with global internet time.




@ U3
Yes that is what I meant.

The NEW has a different CHARGE as the OLD and thus a dis-charge is needed, happening ... or in other cases the OLD energy seems to be sucked up dry, leaving ships and tech out-of-order ;)

This is so freaking interesting !!!!
5a


xxxMzK
 Quoting: Krispy71




Amen to that!!!

I have been getting a static charge from water, of all things! I turn on the tap, start to touch my hand to it and get a charge the instant my hand feels water!!!!! So, now to think of it, no surprise about the explosions in the marina!

I'm hoping as the old energies clear away, it takes it's toxins with it!!!!!
Happy Holidays! xmas
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
[[snipped post]]

PS - hey Tutes, did you see the 'ERK' article on the previous page? Was a little surprised no-one has twigged to it's relevance. Kinda erking me... LOL!
 Quoting: BadHairDay


To be honestly, I read that post of you but no bells or bubbles happened in my head :(
I am sorry ... would have liked the magic to happen.

But I do appreciated that post thumbs


xxxMzK
 Quoting: Krispy71


Well, interesting that ERK is now mentioned in an MSM article to do with Human DNA, and changes in how interactions occur using modern techniques.

Techniques that have only been around and in research since 2010. Interesting timing.

The definition that HouseDad came up with for bezERK never sat right with me, as there never was any proof of its meaning, despite many requests to ellaborate.

I dont know if HD still posts on TCP, and he has never answered any mails from me, so I gave up. Acolyte also never gave up any more that congratulating HD, and that was that. Nuf said, and it never went further than that.

Now here is an article from conventional medicine using ERK as a concept.

That BEZERK has and always will be in capitals at the top of every post we make and that we never really got any further than HD's possible meaning suggests to me that the HUNT for the meaning was shut down, like so many other paths we have gone down.

Another bezerker has suggested the BEZ is the experiment we are all a part of, and this is intriguing, and something I am going to follow up on.

Certainly, I am still pushing forward with new concepts, and what and where this thread is ultimately going, but I cant help but look back where this all started, and try to open up some answers to the basic core word of the story.
 Quoting: BadHairDay


BHD ~ can you please repost the srticles about ERK you are referring to and enlighten BEZERKERS a little, here?

I checked back on early HD's posts and reposted one of them on this page thinking it was the one you meant but, apparently got the ref to you wrong so, immediately got some "stick"(!), from our dearest b/beetroot (lol) where she can be seen, cracking her whip!!, ~ which rather took the spotlight off the subtle points being made, about a the Harvard thesis!

Looks as though this could be quite important so would you please clarify your views, for us BEZERKERS, thanks.

bdance
Krispy71

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Lol Integrator .. you just bring out that leathered whipping part in me ...
cant help myself ... you brought the B-Beetroot up ...lol...

thumbsup




xxxLWBB

Last Edited by Krispy71 on 04/25/2013 03:07 PM
Krispy71

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Posts of Housedad and his ERK's
I still have the feeling that more should be found about it, but I couldnt find it ...

Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Housedad's post..
here may be a answer to this thread and how DNA could be altered.


The following has taken me many many hours of research and thought. Please consider it VERY CAREFULLY. I have really tried to figure this out.




The entire thing may be activated by something Called ERK's. ERk's are chemicals called Externally Regulated Kinases.

Now that is a mouthful, I know. But just imagine them as the carekeepers of the DNA.

And, they can be hindered or helped and told what to do in their job by chemical signals from outside the DNA, not just DNA coding.



There is another set of chemicals (sort of like a string or cap) attached at the end of Your DNA Called Tolemerase.

Much of the function of Tolemerase has been hidden from us in the past. But Tolemerase does regulate the Pottassium and other pathways that regulate and communicate with the ERK's.

Imagine what would happen to us if the Tolemerase was vibrated at a quantum level by a Russian Haarp signal. It could very well set off a string of signals to the ERK enzymes and activate or deactiate a particular
DNA strand, depending on what freuency was used. Done by affecting the pathway that potassium, melamin and other chemicals get to the ERK's.

So, quantum Vibration of the tolemerase effects a repair/housekeeping enzyme to do something to the DNA chain.

Quantum Tolemerase Enzyme Enhancement. OR: Quantum T.E.E.


Biologically or Broadcast
Ecrypted or Enabled
Zero
Energy or Evidence
Reprogramming
(OF)
Kinases

SOMETHING went BEZERK in the Gulf of Mexico.

Something IS going on.
 Quoting: RenegadeSon




Re: Chinese briefcases were opened today - what will you be told?
Oncogenic mutations in the serine/threonine kinase B-RAF (also known as BRAF) are found in 50–70% of malignant melanomas1. Pre-clinical studies have demonstrated that the B-RAF(V600E) mutation predicts a dependency on the mitogen-activated protein kinase (MAPK) signalling cascade in melanoma2, 3, 4, 5, 6—an observation that has been validated by the success of RAF and MEK inhibitors in clinical trials7, 8, 9. However, clinical responses to targeted anticancer therapeutics are frequently confounded by de novo or acquired resistance10, 11, 12. Identification of resistance mechanisms in a manner that elucidates alternative ‘druggable’ targets may inform effective long-term treatment strategies13. Here we expressed ~600 kinase and kinase-related open reading frames (ORFs) in parallel to interrogate resistance to a selective RAF kinase inhibitor. We identified MAP3K8 (the gene encoding COT/Tpl2) as a MAPK pathway agonist that drives resistance to RAF inhibition in B-RAF(V600E) cell lines. COT activates ERK primarily through MEK-dependent mechanisms that do not require RAF signalling. Moreover, COT expression is associated with de novo resistance in B-RAF(V600E) cultured cell lines and acquired resistance in melanoma cells and tissue obtained from relapsing patients following treatment with MEK or RAF inhibitors. We further identify combinatorial MAPK pathway inhibition or targeting of COT kinase activity as possible therapeutic strategies for reducing MAPK pathway activation in this setting. Together, these results provide new insights into resistance mechanisms involving the MAPK pathway and articulate an integrative approach through which high-throughput functional screens may inform the development of novel therapeutic strategies.
 Quoting: acolyte



BEZ235

some examples:


[link to www.axonmedchem.com]

[link to activebiochem.com]

Benzoic acid molecule:


[link to pubchem.ncbi.nlm.nih.gov]


Externally Regulated Kinase

Is this BEZERK? I wonder...


[link to www.ncbi.nlm.nih.gov]
 Quoting: Housedad




Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Mechanism of rewriting DNA in a living cell by a simple process that could be used by selective nanobot tech.




ERK



[link to en.wikipedia.org]


[link to en.wikipedia.org]


And: take your choice:

(melatonin pathway)

[link to www.google.com]


(Melamin pathway)

[link to www.google.com]


The ability to alter Extracellular Receptor Kinase directly would give the nano the ability to alter any dna and reprogram it. No matter what the organsim.

I feel that is the most likely pathway for the Nano enhanced organism to do it's dirty work.
 Quoting: Housedad


WOW Housedad,

Great post.

I think you just came very close in explaining the "ERK" in "BEZERK"
 Quoting: acolyte



Very close ... but not exact ...


Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
I should also point otu that the chemical Benzoic acid, also known as BEZ, is a mutagen and carcinogen. It also afects the ERK pathways.


mitogen-activated protein kinase pathway
 Quoting: Housedad



Benzoic acid is used in cosmetics, food (as preservative), etc. It is also found naturally in many plants, etc...
----------------------------
Benzoic acid
From Wikipedia, the free encyclopediaJump to: navigation, search
Benzoic acid

<<snipped whole text, very longggg>>

 Quoting: fairflight




Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Wild colleen.

misspelled or misinterpreted.

Wild choline

Wake Induced Lucid Dream Choline

ERK activator.
 Quoting: Housedad

250mg Choline + 250 mg Inositol daily will ward off gray hair.
edit: and activate your ERK too, amirite, HD?
 Quoting: TutuWuwu



Re: UVB-76 - Important message in 16 days.
From the Bezerk thread:

---snip---
OP:
Good day. I'm preparing updates and will post them. As time is Of the Essence at this juncture, I want to thank Housedad for one of his posts and point others in that direction.

This is for Housedad and may help your analyses further:
"The specific TEE activator is most prevalent in the gene sequence of the Chinese Race and descendents"

QED
---

HD:
The entire thing may be activated by something Called ERK's. ERk's are chemicals called Externally Regulated Kinases.

Now that is a mouthful, I know. But just imagine them as the carekeepers of the DNA.

And, they can be hindered or helped and told what to do in their job by chemical signals from outside the DNA, not just DNA coding.



There is another set of chemicals (sort of like a string or cap) attached at the end of Your DNA Called Tolemerase.

Much of the function of Tolemerase has been hidden from us in the past. But Tolemerase does regulate the Pottassium and other pathways that regulate and communicate with the ERK's.

Imagine what would happen to us if the Tolemerase was vibrated at a quantum level by a Russian Haarp signal. It could very well set off a string of signals to the ERK enzymes and activate or deactiate a particular
DNA strand, depending on what freuency was used. Done by affecting the pathway that potassium, melamin and other chemicals get to the ERK's.

So, quantum Vibration of the tolemerase effects a repair/housekeeping enzyme to do something to the DNA chain.

Quantum Tolemerase Enzyme Enhancement. OR: Quantum T.E.E.
---snip---
 Quoting: Anonymous Coward 1131987




Re: Chinese briefcases were opened today - what will you be told?
Update:
<<snipped>>

Housedad on the Bezerk thread was highlighted in a recent post, as follows:
=-----------------------------------------------------------

Housedad's post..
Quote:
here may be a answer to this thread and how DNA could be altered. The following has taken me many many hours of research and thought. Please consider it VERY CAREFULLY. I have really tried to figure this out.
The entire thing may be activated by something Called ERK's. ERk's are chemicals called Externally Regulated Kinases.
Now that is a mouthful, I know. But just imagine them as the carekeepers of the DNA.
And, they can be hindered or helped and told what to do in their job by chemical signals from outside the DNA, not just DNA coding.
There is another set of chemicals (sort of like a string or cap) attached at the end of Your DNA Called Tolemerase.
Much of the function of Tolemerase has been hidden from us in the past. But Tolemerase does regulate the Pottassium and other pathways that regulate and communicate with the ERK's.
Imagine what would happen to us if the Tolemerase was vibrated at a quantum level by a Russian Haarp signal. It could very well set off a string of signals to the ERK enzymes and activate or deactiate a particular
DNA strand, depending on what freuency was used. Done by affecting the pathway that potassium, melamin and other chemicals get to the ERK's.
So, quantum Vibration of the tolemerase effects a repair/housekeeping enzyme to do something to the DNA chain.
Quantum Tolemerase Enzyme Enhancement. OR: Quantum T.E.E.

Biologically or Broadcast
Ecrypted or Enabled
Zero
Energy or Evidence
Reprogramming
(OF)
Kinases

SOMETHING went BEZERK in the Gulf of Mexico.
Something IS going on.

ref: Thread: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine (Page 831)
EndQuote:

=----------------------------------------------------------
OP's response was:
Quote:
Good day. I'm preparing updates and will post them. As time is Of the Essence at this juncture, I want to thank Housedad for one of his posts and point others in that direction.
This is for Housedad and may help your analyses further:
"The specific TEE activator is most prevalent in the gene sequence of the Chinese Race and descendents"
QED
EndQuote:
-------------------------------

I'm sure Bao will be grinning from ear to ear over that one! That's all I got for this morning - more if or when I get something of relevance. Thanks for all the kind comments from readers past and present. I'd love to acknowledge each and every one of you as the special infomaniacs, or info-warriors that you are - but it would make this thread into yet another social forum.
peace
 Quoting: nexuseditor







Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Quote from housedad on : ERK/DNA/Potassium

"Much of the function of Tolemerase has been hidden from us in the past. But Tolemerase does regulate the Pottassium and other pathways that regulate and communicate with the ERK's.

Imagine what would happen to us if the Tolemerase was vibrated at a quantum level by a Russian Haarp signal. It could very well set off a string of signals to the ERK enzymes and activate or deactiate a particular
DNA strand, depending on what freuency was used. Done by affecting the pathway that potassium, melamin and other chemicals get to the ERK's.

So, quantum Vibration of the tolemerase effects a repair/housekeeping enzyme to do something to the DNA chain."


BEZERK pg806
 Quoting: Housedad


Requoting my reply on that:
I like to repeat a line : quantum Vibration of the tolemerase effects a repair/housekeeping enzyme to do something to the DNA chain.
This ties in with the thoughts of me , BHD and others that AUgie is a REPAIR ORGANISM.



























Just found a post that I felt was good to repost, concerning the HARMLESS PARTICLES part ;)


[link to www.huffingtonpost.com]


I think this says enough to tie things together
 Quoting: Housedad


yes it does :D


Snips from article :

"But doomsday sayers should be careful about speculation on this one. If the star does go super-nova, Earth will be showered with harmless particles, according to Carter. "They will flood through the Earth and bizarrely enough, even though the supernova we see visually will light up the night sky, 99 per cent of the energy in the supernova is released in these particles that will come through our bodies and through the Earth with absolutely no harm whatsoever," he told news.com.au."


>>> I love that ! ...harmless !


"In fact, a neutrino shower could be beneficial to Earth. According to Carter this "star stuff" makes up the universe. "It literally makes things like gold, silver - all the heavy elements - even things like uranium....a star like Betelgeuse is instantly forming for us all sorts of heavy elements and atoms that our own Earth and our own bodies have from long past supernovi," said Carter."

"Far from being a sign of the apocalypse, according to Dr Carter the supernova will provide Earth with elements necessary for survival and continuity."



>>> Basically : neutrino's are a big part in the activation of gold (forming) !
No/not AUGIE instructed by bad aliens, but neutrinos from the sun (betlegeuse and also our own sun which sends more neutrino waves lately for some time.

A lot of the neutrinos go though us and the earth without ever touching our atoms, but when they collide they produce the Cherenkov-radiation.
I suspect that those spots are called splashzones. So when Bettleguese blows here neutrino's, presumably at the end of 2012, then earth will be 1 big splashzone ... and a lot of Cherenkov radiation will spark the changes needed in the transformation and the shift.
See, all cosmic events add up to support the allignment with the galactic center in 2012. Fantasssstic !!!!
More gold and other elements will be created/formed.




Great find HD hf
 Quoting: Krispy71





xxxMzK

Last Edited by Krispy71 on 04/25/2013 03:54 PM
TutuWuwu
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
I got a call from 1221 last night to tell me about the explosions in Mobile. My brother - a captain of river tugboats is currently working in Mobile, so I called him today to get the straight skinny. Seems like one of the tugs he sometimes skippers was tied up to one of the barges. His friend, also a skipper, was down in the engine room of the tug when the barge blew. It caused a tertiary explosion aboard the tug, and his friend was burned over 1/3 of his body. I'll hear from him later tonight for more details.
stoner
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
I miss House Dad sumthin' fierce.

rimshot

@MzK smile_kiss
BadHairDay

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
He was a little too good at digging methinks, and dug up something he didnt like the taste of.

Hope your bro' and his friends are OK Tutes.

hf
It's all about the 'vibe'
SouthernLight

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04/25/2013 09:55 PM

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Quite an article, which came out in Newsweek, evidently.
It's long, but well worth the read!

What BP Doesn’t Want You to Know About the 2010 Gulf Spill

[link to www.thedailybeast.com]

"Not only did BP fail to inform workers of the potential hazards of Corexit and to provide them with safety training and protective gear, according to interviews with dozens of cleanup workers, the company also allegedly threatened to fire workers who complained about the lack of respirators and protective clothing.

“I worked with probably a couple hundred different fishermen on the [cleanup],” Acy Cooper, Guidry’s second in command, tells me in Venice, the coastal town from which many VoO vessels departed. “Not one of them got any safety information or training concerning the toxic materials they encountered.” Cooper says that BP did provide workers with body suits and gloves designed for handling hazardous materials. “But when I’d talk with [the BP representative] about getting my guys respirators and air monitors, I’d never get any response.”

Roughly 58 percent of the 1.84 million gallons of Corexit used in the cleanup was sprayed onto the gulf from C-130 airplanes. The spray sometimes ended up hitting cleanup workers in the face.

“Our boat was sprayed four times,” says Jorey Danos, a 32-year-old father of three who suffered racking coughing fits, severe fatigue, and memory loss after working on the BP cleanup. “I could see the stuff coming out of the plane—like a shower of mist, a smoky color. I could see [it] coming at me, but there was nothing I could do.”

“The next day,” Danos continues, “when the BP rep came around on his speed boat, I asked, ‘Hey, what’s the deal with that stuff that was coming out of those planes yesterday?’ He told me, ‘Don’t worry about it.’ I said, ‘Man, that s--t was burning my face—it ain’t right.’ He said, ‘Don’t worry about it.’ I said, ‘Well, could we get some respirators or something, because that s--t is bad.’ He said, ‘No, that wouldn’t look good to the media. You got two choices: you can either be relieved of your duties or you can deal with it.’”"

Far Less than 50%
“You can't wake a person who is pretending to be asleep”
Navajo proverb
Anonymous Coward
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04/25/2013 10:13 PM
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Got a phone call today from a bytch acquaintance who, among other things, was complaining that her BP royalty checks have been down about 80% from what they were a few years ago.

I am amazed that BP can send any checks at all.
Anonymous Coward
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04/25/2013 10:21 PM
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
May I ask a favour?

When posting quotes, and using multiple quotes, can you be very carefull with 'snips' and deleting parts, as the consequences can oftem mean that someone is incorrectly quoted or attributed to a post.

Down the track it can cause .. issues.
 Quoting: BadHairDay


Toooooooootally agree with that !!!!

:thumbsup:



Thats why I always put my name/signature under important postings,
if the copying failed then its always proof of being written by me, unless they snip my name too ...lol...


xxxMzK
 Quoting: Krispy71


Issues .... too, when authors amend their posts without noting the terms of the amendment. Often makes subsequent posters appear to be off-track.
Anonymous Coward
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Whhooaa! this vid from Lex on one of the explosion threads...


It's the High Flyer...

 Quoting: Lex 36773218




Had no idea the Texas thing had happened before, almost in identical fashion.

Wonder if the ships exploding has similar history and connection?
Are the Carnival cruise ships bringing something back from the GoM in to these water ways?

The latest ship was reportedly degaussed with a massive chain being dragged around and across its body, suggesting it was magnetised, and why no electric motors (bow and stern thrusters, pumps for toilets etc) would work.

That Cruise ships have constantly been associate with this thread is no coincicdence I think, nor is the coincidence of a Carnival cruise ship being so close to the explosion today.
 Quoting: BadHairDay


The Texas thing looks like an even-Steven event, in spite of the Matrix kitty slipped into the video.

Monsanto's then, Monsanto's rival now. (was suing Monsanto)
Anonymous Coward
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04/25/2013 10:30 PM
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
the average age of a car in America is 11 years, so yes, you are going to have to replace alternators, etc.
You're overdoing it a little don't you think?


Yes you might have a point there ...

the magnetised field of the ship could have ignited or influenced things in the harbour to go vavoem.
<snipped>

xxxMzK
 Quoting: Krispy71


Something else I have been seeing here... LOTS of STRONG static electricity!

It has been so bad that touching the car door as I am getting out can actually Hurt! Last night I got too near the door with the keys and a bright arc nailed me despite my care not to touch it. grr lol

Many have been complaining about it and the phones are having issues too... no reception or spotty with both cells and land lines. Add in dying batteries and all sorts of mechanical failures(alternators, starters, generators, etc.)...
More and more things that make you go hmmmmm.

hi

Didn't see this before posting!
Sure doesn't surprise me.

When the explosions first happened in Mobile, someone (an "official", don't remember who) said it was a static electricity charge. It will be interesting to see what they finally conclude.

What I am noticing is explosions occur as the dying throes of old, archaic energy are released as an asbtract world emerges.

(That's my 2 cents!) afro
 Quoting: U3

 Quoting: SouthernLight
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
-[snipped other quotes]-

I have, if oranges and lemons consist of dangerous particles.

For some reason, beginning last fall after the citrus crop came on the market, I became violently ill eating oranges, which I've eaten all my life. A few weeks ago, having forgotten about my newly acquired allergy, I ate a lemon and became violently ill. What's up with that? I won't be eating oranges or lemons again.

For some reason, there is no negative effect from eating grapefruit.
 Quoting: Anonymous Coward 38838812


Have you looked where the oranges and lemon were grown ?
And where the grapefruit came from ?

Grapefruit is not cultivated in such big quantities as the other 2.
It could make a difference from which country they came from and which pesticides were used during cultivation or for transport.
I would not want to eat anything native American with all that corexit & oil in the water and atmosphere ...



xxxMzK
 Quoting: Krispy71


Florida citrus and well-washed before eating. Could be the Corexit, et al. Dunno. Doc said I appeared to have acquired an "allergy." Certainly can't eat fruit and veggies from Cali, too much Fuku on the produce.

We get Valencias from Spain. Excepting that, usually no citrus from other countries in our local grocery stores. Prolly won't try attempt to eat any next season.

"Indian River" citrus from Florida has, in the past, been wonderful tasting fruit.
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
May I ask a favour?

When posting quotes, and using multiple quotes, can you be very carefull with 'snips' and deleting parts, as the consequences can oftem mean that someone is incorrectly quoted or attributed to a post.

Down the track it can cause .. issues.
 Quoting: BadHairDay


Toooooooootally agree with that !!!!

thumbsup



Thats why I always put my name/signature under important postings,
if the copying failed then its always proof of being written by me, unless they snip my name too ...lol...


xxxMzK
 Quoting: Krispy71


Issues .... too, when authors amend their posts without noting the terms of the amendment. Often makes subsequent posters appear to be off-track.
 Quoting: Anonymous Coward 38887887


Yeah, best to say something up front, so it is there for all to see.

Mind you... I'm guilty of throwing up for days when I find an anomaly I dont like.

Last Edited by BadHairDay on 04/26/2013 03:19 AM
It's all about the 'vibe'
Isis7
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
GOM update from Gabe's thread:

HuffPost: Countless Gulf residents with symptoms as if from sci-fi horror film — Bleeding from ears, anus, breasts
Title: Corexit, Oil Dispersant Used By BP, Is Destroying Gulf Marine Life, Scientists Say
Source: Huffington Post
Author: TakePart’s David Kirby
Date: April 25, 2013 at 5:02p ET

[...] In April 2012, Louisiana State University’s Department of Oceanography and Coastal Sciences was finding lesions and grotesque deformities in sea life—including millions of shrimp with no eyes and crabs without eyes or claws—possibly linked to oil and dispersants. [...]

EcoRigs divers took water and marine life samples at several locations in the months following the blowout. Now, they and countless other Gulf residents are sick, with symptoms resembling something from a sci-fi horror film, including bleeding from the nose, ears, breasts, and even anus. Others complain of cognitive damage, including what one man calls getting “stuck stupid,” when he temporarily cannot move or speak, but can still hear. [...]

[EcoRigs founder Steve Kolian'a] team has done studies of their own to alarming results. “We recently submitted a paper showing levels of hydrocarbons in seafood were up to 3,000 times higher than safety thresholds for human consumption,” he said. [...]
[link to enenews.com]

Prayers for you EC hf
 Quoting: AKObserver
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine

[[snipped post]]

PS - hey Tutes, did you see the 'ERK' article on the previous page? Was a little surprised no-one has twigged to it's relevance. Kinda erking me... LOL!
 Quoting: BadHairDay

Hay, BHD

Can you kindly post the ERK article you referred as it would be interesting and useful if BEZERKERS
could see what relevance actually erked you!

Thanks,

Integrator

flip
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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
Integrator, whats with that middle-finger icon ????
Never ever use that on me or you will get to know my super mega Bossy-Beetroot ;)

xxxMzBB
Krispy71

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Re: Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine
@ Integrator
Why you ask for the link to the article when its in BHD's post ?



Same protein that fires up cancer-promoting Erk also blocks its activation

A protein which is intimately involved in cancer-promoting cell signaling also keeps a key component of the signaling pathway tied down and inactive, a team led by scientists from The University of Texas MD Anderson Cancer Center reports this week in Nature Structural Molecular Biology.

Shc, pronounced "schick," plays a key role in activating signals which lead to cell proliferation (and cancer) when cells are stimulated, however it unexpectedly turns out to be a tumor-suppressor, keeping Erk under wraps when a cell is less active, said senior author John Ladbury, Ph.D., professor in MD Anderson's Department of Biochemistry and Molecular Biology.

"Shc is a checkpoint to prevent out of control cell growth, binding to Erk when a cell is not being stimulated by growth factors," Ladbury said. "Otherwise, the lower-level background signaling that's always present in a cell would be uncontrolled."

Keeping Erk in check while the cell idles

Overexpression of Erk occurs in many types of cancer, including ovarian and prostate cancer and Hodgkin lymphoma, so cellular control of its activity is important.

In the absence of external stimulation by growth factors, cells remain active but lower levels of cell signaling occur, which Ladbury compares to a car idling, ready to roll. Under these conditions control mechanisms are in place to prevent the cell kicking into gear. Shc turns out to be one of these controllers.

"We're essentially looking at the cell in a resting, but ready, state," Ladbury said. "I would argue that's probably more like a cell behaves in tissue, it's not normally getting a slug of growth factors as is often the way when we investigate signaling in experiments in the lab. There's still a lot going on in the cell, basically background activity."

These findings point to a number of therapeutic possibilities, including the measurement of Shc concentration levels as a diagnostic tool and of finding small molecule drugs that block growth-factor signaling to Shc, keeping it bound to Erk, Ladbury noted.

Growth factors provide double boost for Erk

When the appropriate growth factor receptor is stimulated Erk is activated in the MAP Kinase pathway. It dives into the cell nucleus and turns on a variety of genes, actions that contribute to cancer proliferation, blood vessel production and metastasis when signaling is out of control.

When receptor tyrosine kinases on the cell surface connect with growth factors, they normally send a signal via Shc that sets off a chain of actions leading to Erk activation. Ladbury and colleagues looked at Shc's connections to epidermal growth factor receptor (EGFR) signaling.

The team found in mammalian cell lines that:

•Under non-stimulated conditions Shc binds to Erk in the cell cytoplasm at binding sites that are unique on both proteins.
•Stimulation via EGFR reduces this connection, but not by competing with Shc at the Shc-Erk binding site.
•Instead, on stimulation from outside the cells, EGFR adds phosphate groups to itself at specific sites. One of these forms a binding for Shc, which distorts the protein's shape, making it impossible for Erk to bind.
•Overexpression of Shc decreases the amount of activated Erk, because Shc mops up free Erk molecules.
•Depleting Shc expression with short hairpin RNA resulted in higher levels of activated Erk.
•When separated from Shc, Erk moves into the nucleus and activates genes even when the cell is not receiving a stimulus. Thus without the controlling influence of Shc, Erk can run riot in the cell giving rise to unrestrained cell reproduction.
Shc-Erk connection confirmed

Ladbury and colleagues then tested their results in the C.Elegans, a worm model frequently employed in biological research. Both Shc and Erk are greatly similar between humans and the worms.

Experiments showed that Shc blocks Erk function by sequestering it away from the Ras-Raf-Mek MAPK pathway in the worms. Without the Shc-Erk connection, the MAPK pathway is activated, causing excessive Erk activation.

EGFR stimulation not only sets off the normal activation of Erk via Shc and the MAPK pathway, Ladbury said, but also frees Erk for greater availability for activation by breaking the tie to Shc.

[link to phys.org]

There's the last half.

[HD, where for art thou HD?]
 Quoting: BadHairDay



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Last Edited by Krispy71 on 04/26/2013 07:47 AM

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