Hi All, What a truly amazing place this is (especially this thread) and what an awesome bunch of humans you people are .

For my first post I would really like to start discussion on something that I feel is of high importance.

I kinda get the code that’s goin on and how you don talk too much at once and all that when posting but here are some thoughts and concerns….

So your thoughts too please.

As posted: They seek blood type rf- etc etc 13 Oct ect +11

The is this of concern…

The Rh blood group is one of the most complex blood groups known in humans. From its discovery 60 years ago where it was named (in error) after the Rhesus monkey, it has become second in importance only to the ABO blood group in the field of transfusion medicine. It has remained of primary importance in obstetrics, being the main cause of hemolytic disease of the newborn (HDN).

The complexity of the Rh blood group antigens begins with the highly polymorphic genes that encode them. There are two genes, RHD and RHCE, that are closely linked. Numerous genetic rearrangements between them has produced hybrid Rh genes that encode a myriad of distinct Rh antigens. To date, 49 Rh antigens are known.

The significance of the Rh blood group is related to the fact that the Rh antigens are highly immunogenic. In the case of the D antigen, individuals who do not produce the D antigen will produce anti-D if they encounter the D antigen on transfused RBCs (causing a hemolytic transfusion reaction, HTR) or on fetal RBCs (causing HDN).

For this reason, the Rh status is routinely determined in blood donors, transfusion recipients, and in mothers-to-be.
Despite the importance of the Rh antigens in blood transfusion and HDN, we can only speculate about the physiological function of the proteins, which may involve transporting ammonium across the RBC membrane and maintaining the integrity of the RBC membrane.

Antigen-carrying molecules

Proteins with unknown function The RhD and RhCE proteins are both transmembrane, multipass proteins that are integral to the RBC membrane. The RhCE protein encodes the C/c antigen (in the 2nd extracellular loop) and the E/e antigen (in the 4th extracellular loop), plus many other Rh antigens e.g., Cw, Cx. Unlike most cell surface molecules, the Rh proteins are not glycosylated (they do not contain oligosaccharides) but they are closely associated with a RBC membrane glycoprotein called RhAG. The function of the Rh-RhAG complex might involve transporting ammonium or carbon dioxide. The RhD protein encodes the D antigen.

Frequency of Rh antigens

D: 85% Caucasians, 92% Blacks, 99% Asians C: 68% Caucasians, 27% Blacks, 93% Asians E: 29% Caucasians, 22% Blacks, 39% Asians c: 80% Caucasians, 96% Blacks, 47% Asians e: 98% Caucasians, 98% Blacks, 96% Asians (1)

Frequency of Rh phenotypes

Rh haplotype DCe: most common in Caucasians (42%), Native Americans (44%), and Asians (70%) Rh haplotype Dce: most common in Blacks (44%) Rh D-negative phenotype: most common in Caucasians (15%), less common in Blacks (8%), and rare in Asians (1%) (1)

Antibodies produced against Rh antigens
Antibody type

Mainly IgG, some IgM The majority of Rh antibodies are of the IgG type.

Antibody reactivity

Capable of hemolysis Rh antibodies rarely activate complement. They bind to RBCs and mark them up for destruction in the spleen (extravascular hemolysis).