Something Just Went BEZERK in the Gulf of Mexico. The US Navy just sunk a French Submarine | |
Krispy71 User ID: 34333335 Netherlands 04/25/2013 10:05 AM Report Abusive Post Report Copyright Violation | I realised this when I read an article in Dutch about that now also Europe plant control on small scale cultivation of fruits and vegetables Remember my post a few pages back of the Swiss man working for the pharmaceutical giant Ciba (now Novartis) who was able to restore the ancient gene-data of plants, in which a normal fern would grow out as a now extinct prehistoric version ? And Corn that did not had 1 or 2 corns at his knob, but 5 at the same time !! Like in ancient days !!! THIS was not the result of radio-active gene-destruction, but of ANCIENT GENE RESTORATION !!! By having the seeds in a special Electrical-field ... The Ciba-Geigy effect or The "Primeval Code" [link to www.bibliotecapleyades.net] [link to www.urzeit-code.com] Guido Ebner and Heinz Schürch appear to have discovered a biological method of effectively creating antecedents from progeny – without using genetic engineering. Or as both researchers put it: "Our experiments do not involve a mutation of the organism in question, which in the case of genetic engineering involves channelling an additional gene into the organism. No entirely new organism is created. In the electrostatic field, only the gene expression is altered – the retrieval of the existing gene. That is something different." Quoting: snipIn addition to corn and trout experiments, the results of experiments with wheat were also amazing: thus the cereal exposed to the electrostatic field developed new proteins, which people looked for in the original wheat to no avail. Furthermore, it surprisingly produced much larger roots than the control group. This had the advantage of allowing the crops to grow far more rapidly. And occasionally in these experiments, a variant emerged which resembled the genetic antecedents of the wheat. "In the case of our 'manipulated' wheat, growth was so rapid that it was ripe in four weeks instead of the usual seven months", Heinz Schürch recalled. "However one has to say that although the ears and stalks were somewhat smaller, there were more ears per plant. The actual benefit is that we could cultivate this wheat in regions where spring and summer are short – where conventional wheat cannot be grown at all." In this case, one can also cheerfully refrain from using pesticides and herbicides: "The pests that have adapted to the growth process of normal wheat have not yet developed when we harvest our wheat as early as four to eight weeks after planting." For "primeval cereals" from an electric field yield more than modern genetically engineered varieties and do not require fertilisers. Furthermore, it is completely natural and thus healthier. It can be grown by anybody at minimal cost. Lots of Radiation poison makes plants and lifeforms produce deficient off-spring ... But like I questioned before in an other post : ARE ALL the " mutations" we see the result of radio-active contamination ? Are they all the result of chemical GM-fertilisers ? Yes some are ... But others are adapting again to the changed electrical charges in the atmosPHere, and awaken to their ancestral gene-coding ... Again The Elites and Monsanto & Venter do not wish the mass to know, so they lead them blind-deaf-and-crippel that it comes from gamma-rays and CME's and stuff we use and indeed radiation-effects like from Chernobyl & Fukushima !!! How would they have to explain all the lies and bullshit they forced through our throats ? With acknowledging the CIBA-GEIGY EFFECT they loose EVERY control on control !!!! Coz these plants and lifeforms dont need fertilizers or meds !!! In essence what Monsanto does is making seeds infertile ... they wont reproduce from the off-spring, so new seeds have to be purchased ... Monsanto in control. Now after the big GA, and all the results with it lifeforms are going to harmonise to this new PH of the earth, in which AUtomatically ancient gene-data will be activated [your JUNK-DNA will restore in response to the Earth and Galaxy !!!] Can you see and understand why Monsanto & Elites want to have this monopoly position on seeds ? If this proceeds there will come a time that the government will claim your highly evolved children [with for example 3 DNA-chains or even 6 or 12 Chains, or other fringe attributes as a result of Natural Universal Fractal Harmonisation ...] and claim Monsanto has a pattent-right on them coz they ALLEGEDLY consumed his GM-seeds, GM-veggies and GM-meat !!!! Nothing of this would be the real reason, coz these children would be fringe species and test-subjects for the Elites to perfect their control even more ... I can see the day coming that humans have to pay for egg-cells and sperm ... coz Monsanto made almost all of us infertile with his foods and products. The ultimate population control !!!! But Nature is stronger then any GM-product or sceme !!! Do you understand what I mean ? xxxMzK Last Edited by Krispy71 on 04/25/2013 10:09 AM |
U3 User ID: 9834739 United States 04/25/2013 10:30 AM Report Abusive Post Report Copyright Violation | That frequency shapes all feels so comfortable, dont you think? I've been chatting with some bezerk types about that phenominon where by folks can hear colour, and see sound, or taste colour etc. I forget it's name. But with that 'gift' the world would make a lot mor sense I think, being able to see these sound and wave patterns creating shapes, and guiding outcomes. Quoting: BadHairDay PS - [snipped] Comfortable because it's what is. Frequency provides the template for physicality. Energy is stepped down in harmonic resonance and woven into 3D around that geometric template created by frequency. Remember, frequency has all those sensual expressions - not only sacred geometry, but sound, color, etc. Synesthesia is the word for which you were groping. That "gift" may be experienced with an ayahuasca cocktail, preferably in ceremony, under the supervision of a shaman....very expensive and hard to find. Never tried it myself. Erk, eh? [snipped] Love that part !!!! Beautifully said ! Hi Bezerk'ers I always get a smile when I drop by! I love to see your topic of discussion. Anyway, thought you might find this video interesting: Russians sent plasma with suspended dust particles in it, into space. It created a black hole. The non-material shapes the material. I got the video from this thread: Thread: Russian Plasma Experiment in Space Redefines 'Reality' - Down the Rabbit Hole...oops, that's not a 'hole' "We are the music makers. And we are the dreamers of dreams." Willy Wonka |
U3 User ID: 9834739 United States 04/25/2013 10:42 AM Report Abusive Post Report Copyright Violation | When the explosions first happened in Mobile, someone (an "official", don't remember who) said it was a static electricity charge. It will be interesting to see what they finally conclude. What I am noticing is explosions occur as the dying throes of old, archaic energy are released as an asbtract world emerges. (That's my 2 cents!) "We are the music makers. And we are the dreamers of dreams." Willy Wonka |
U3 User ID: 9834739 United States 04/25/2013 11:18 AM Report Abusive Post Report Copyright Violation | That frequency shapes all feels so comfortable, dont you think? I've been chatting with some bezerk types about that phenominon where by folks can hear colour, and see sound, or taste colour etc. I forget it's name. But with that 'gift' the world would make a lot mor sense I think, being able to see these sound and wave patterns creating shapes, and guiding outcomes. Quoting: BadHairDay PS - [snipped] Comfortable because it's what is. Frequency provides the template for physicality. Energy is stepped down in harmonic resonance and woven into 3D around that geometric template created by frequency. Remember, frequency has all those sensual expressions - not only sacred geometry, but sound, color, etc. Synesthesia is the word for which you were groping. That "gift" may be experienced with an ayahuasca cocktail, preferably in ceremony, under the supervision of a shaman....very expensive and hard to find. Never tried it myself. Erk, eh? [snipped] Love that part !!!! Beautifully said ! Instead of editing posts, I'll just re-use this one. (It's so full of good stuff, lol) Synesthesia: 1) Daniel Tammet, autistic savant, sees colors, emotions & shapes, in numbers and learned Icelandic in one week. 2) Neil Harbisson, born color blind. He hears color and is the first "official" cyborg. Humanity is leaping into a new species...biology intermingled with technology is one earmark of it, imo. XOXOXOXOXOXOXOXO Last Edited by ERE3 on 04/25/2013 11:24 AM "We are the music makers. And we are the dreamers of dreams." Willy Wonka |
SouthernLight User ID: 2920692 United States 04/25/2013 12:17 PM Report Abusive Post Report Copyright Violation | Yes you might have a point there ... Quoting: Krispy71 the magnetised field of the ship could have ignited or influenced things in the harbour to go vavoem. <snipped> xxxMzK Something else I have been seeing here... LOTS of STRONG static electricity! It has been so bad that touching the car door as I am getting out can actually Hurt! Last night I got too near the door with the keys and a bright arc nailed me despite my care not to touch it. grr lol Many have been complaining about it and the phones are having issues too... no reception or spotty with both cells and land lines. Add in dying batteries and all sorts of mechanical failures(alternators, starters, generators, etc.)... More and more things that make you go hmmmmm. Didn't see this before posting! Sure doesn't surprise me. When the explosions first happened in Mobile, someone (an "official", don't remember who) said it was a static electricity charge. It will be interesting to see what they finally conclude. Quoting: U3 What I am noticing is explosions occur as the dying throes of old, archaic energy are released as an asbtract world emerges. (That's my 2 cents!) Last Edited by SouthernLight on 04/25/2013 12:20 PM We know more than we know and understand less than we think. |
Krispy71 User ID: 34333335 Netherlands 04/25/2013 12:37 PM Report Abusive Post Report Copyright Violation | Yes you might have a point there ... Quoting: Krispy71 the magnetised field of the ship could have ignited or influenced things in the harbour to go vavoem. <snipped> xxxMzK Something else I have been seeing here... LOTS of STRONG static electricity! It has been so bad that touching the car door as I am getting out can actually Hurt! Last night I got too near the door with the keys and a bright arc nailed me despite my care not to touch it. grr lol Many have been complaining about it and the phones are having issues too... no reception or spotty with both cells and land lines. Add in dying batteries and all sorts of mechanical failures(alternators, starters, generators, etc.)... More and more things that make you go hmmmmm. Didn't see this before posting! Sure doesn't surprise me. When the explosions first happened in Mobile, someone (an "official", don't remember who) said it was a static electricity charge. It will be interesting to see what they finally conclude. Quoting: U3 What I am noticing is explosions occur as the dying throes of old, archaic energy are released as an asbtract world emerges. (That's my 2 cents!) I have exactly the same !!! Static when I want to grab the handle of my livingroom-door (which is metalic) and other doors !!! I am glad you mention it SL Also my phone is living 6min ahead of time now !!!! While it should synchronise with global internet time. @ U3 Yes that is what I meant. The NEW has a different CHARGE as the OLD and thus a dis-charge is needed, happening ... or in other cases the OLD energy seems to be sucked up dry, leaving ships and tech out-of-order ;) This is so freaking interesting !!!! xxxMzK |
U3 User ID: 9834739 United States 04/25/2013 02:00 PM Report Abusive Post Report Copyright Violation | Yes you might have a point there ... Quoting: Krispy71 the magnetised field of the ship could have ignited or influenced things in the harbour to go vavoem. <snipped> xxxMzK Something else I have been seeing here... LOTS of STRONG static electricity! It has been so bad that touching the car door as I am getting out can actually Hurt! Last night I got too near the door with the keys and a bright arc nailed me despite my care not to touch it. grr lol Many have been complaining about it and the phones are having issues too... no reception or spotty with both cells and land lines. Add in dying batteries and all sorts of mechanical failures(alternators, starters, generators, etc.)... More and more things that make you go hmmmmm. Didn't see this before posting! Sure doesn't surprise me. When the explosions first happened in Mobile, someone (an "official", don't remember who) said it was a static electricity charge. It will be interesting to see what they finally conclude. Quoting: U3 What I am noticing is explosions occur as the dying throes of old, archaic energy are released as an asbtract world emerges. (That's my 2 cents!) I have exactly the same !!! Static when I want to grab the handle of my livingroom-door (which is metalic) and other doors !!! I am glad you mention it SL Also my phone is living 6min ahead of time now !!!! While it should synchronise with global internet time. @ U3 Yes that is what I meant. The NEW has a different CHARGE as the OLD and thus a dis-charge is needed, happening ... or in other cases the OLD energy seems to be sucked up dry, leaving ships and tech out-of-order ;) This is so freaking interesting !!!! xxxMzK Amen to that!!! I have been getting a static charge from water, of all things! I turn on the tap, start to touch my hand to it and get a charge the instant my hand feels water!!!!! So, now to think of it, no surprise about the explosions in the marina! I'm hoping as the old energies clear away, it takes it's toxins with it!!!!! "We are the music makers. And we are the dreamers of dreams." Willy Wonka |
INTEGRATOR User ID: 38275237 United Kingdom 04/25/2013 02:15 PM Report Abusive Post Report Copyright Violation | [[snipped post]] Quoting: BadHairDay PS - hey Tutes, did you see the 'ERK' article on the previous page? Was a little surprised no-one has twigged to it's relevance. Kinda erking me... LOL! To be honestly, I read that post of you but no bells or bubbles happened in my head :( I am sorry ... would have liked the magic to happen. But I do appreciated that post xxxMzK Well, interesting that ERK is now mentioned in an MSM article to do with Human DNA, and changes in how interactions occur using modern techniques. Techniques that have only been around and in research since 2010. Interesting timing. The definition that HouseDad came up with for bezERK never sat right with me, as there never was any proof of its meaning, despite many requests to ellaborate. I dont know if HD still posts on TCP, and he has never answered any mails from me, so I gave up. Acolyte also never gave up any more that congratulating HD, and that was that. Nuf said, and it never went further than that. Now here is an article from conventional medicine using ERK as a concept. That BEZERK has and always will be in capitals at the top of every post we make and that we never really got any further than HD's possible meaning suggests to me that the HUNT for the meaning was shut down, like so many other paths we have gone down. Another bezerker has suggested the BEZ is the experiment we are all a part of, and this is intriguing, and something I am going to follow up on. Certainly, I am still pushing forward with new concepts, and what and where this thread is ultimately going, but I cant help but look back where this all started, and try to open up some answers to the basic core word of the story. BHD ~ can you please repost the srticles about ERK you are referring to and enlighten BEZERKERS a little, here? I checked back on early HD's posts and reposted one of them on this page thinking it was the one you meant but, apparently got the ref to you wrong so, immediately got some "stick"(!), from our dearest b/beetroot (lol) where she can be seen, cracking her whip!!, ~ which rather took the spotlight off the subtle points being made, about a the Harvard thesis! Looks as though this could be quite important so would you please clarify your views, for us BEZERKERS, thanks. |
Krispy71 User ID: 34333335 Netherlands 04/25/2013 02:39 PM Report Abusive Post Report Copyright Violation | Lol Integrator .. you just bring out that leathered whipping part in me ... cant help myself ... you brought the B-Beetroot up ...lol... xxxLWBB Last Edited by Krispy71 on 04/25/2013 03:07 PM |
TutuWuwu User ID: 6581438 United States 04/25/2013 07:40 PM Report Abusive Post Report Copyright Violation | I got a call from 1221 last night to tell me about the explosions in Mobile. My brother - a captain of river tugboats is currently working in Mobile, so I called him today to get the straight skinny. Seems like one of the tugs he sometimes skippers was tied up to one of the barges. His friend, also a skipper, was down in the engine room of the tug when the barge blew. It caused a tertiary explosion aboard the tug, and his friend was burned over 1/3 of his body. I'll hear from him later tonight for more details. |
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SouthernLight User ID: 2920692 United States 04/25/2013 09:55 PM Report Abusive Post Report Copyright Violation | Quite an article, which came out in Newsweek, evidently. It's long, but well worth the read! What BP Doesn’t Want You to Know About the 2010 Gulf Spill [link to www.thedailybeast.com] "Not only did BP fail to inform workers of the potential hazards of Corexit and to provide them with safety training and protective gear, according to interviews with dozens of cleanup workers, the company also allegedly threatened to fire workers who complained about the lack of respirators and protective clothing. “I worked with probably a couple hundred different fishermen on the [cleanup],” Acy Cooper, Guidry’s second in command, tells me in Venice, the coastal town from which many VoO vessels departed. “Not one of them got any safety information or training concerning the toxic materials they encountered.” Cooper says that BP did provide workers with body suits and gloves designed for handling hazardous materials. “But when I’d talk with [the BP representative] about getting my guys respirators and air monitors, I’d never get any response.” Roughly 58 percent of the 1.84 million gallons of Corexit used in the cleanup was sprayed onto the gulf from C-130 airplanes. The spray sometimes ended up hitting cleanup workers in the face. “Our boat was sprayed four times,” says Jorey Danos, a 32-year-old father of three who suffered racking coughing fits, severe fatigue, and memory loss after working on the BP cleanup. “I could see the stuff coming out of the plane—like a shower of mist, a smoky color. I could see [it] coming at me, but there was nothing I could do.” “The next day,” Danos continues, “when the BP rep came around on his speed boat, I asked, ‘Hey, what’s the deal with that stuff that was coming out of those planes yesterday?’ He told me, ‘Don’t worry about it.’ I said, ‘Man, that s--t was burning my face—it ain’t right.’ He said, ‘Don’t worry about it.’ I said, ‘Well, could we get some respirators or something, because that s--t is bad.’ He said, ‘No, that wouldn’t look good to the media. You got two choices: you can either be relieved of your duties or you can deal with it.’”" Far Less than 50% We know more than we know and understand less than we think. |
Anonymous Coward User ID: 38887887 Netherlands 04/25/2013 10:13 PM Report Abusive Post Report Copyright Violation | Got a phone call today from a bytch acquaintance who, among other things, was complaining that her BP royalty checks have been down about 80% from what they were a few years ago. I am amazed that BP can send any checks at all. |
Anonymous Coward User ID: 38887887 Netherlands 04/25/2013 10:21 PM Report Abusive Post Report Copyright Violation | May I ask a favour? Quoting: BadHairDay When posting quotes, and using multiple quotes, can you be very carefull with 'snips' and deleting parts, as the consequences can oftem mean that someone is incorrectly quoted or attributed to a post. Down the track it can cause .. issues. Toooooooootally agree with that !!!! :thumbsup: Thats why I always put my name/signature under important postings, if the copying failed then its always proof of being written by me, unless they snip my name too ...lol... xxxMzK Issues .... too, when authors amend their posts without noting the terms of the amendment. Often makes subsequent posters appear to be off-track. |
Anonymous Coward User ID: 38887887 Netherlands 04/25/2013 10:24 PM Report Abusive Post Report Copyright Violation | Whhooaa! this vid from Lex on one of the explosion threads... Quoting: BadHairDay Had no idea the Texas thing had happened before, almost in identical fashion. Wonder if the ships exploding has similar history and connection? Are the Carnival cruise ships bringing something back from the GoM in to these water ways? The latest ship was reportedly degaussed with a massive chain being dragged around and across its body, suggesting it was magnetised, and why no electric motors (bow and stern thrusters, pumps for toilets etc) would work. That Cruise ships have constantly been associate with this thread is no coincicdence I think, nor is the coincidence of a Carnival cruise ship being so close to the explosion today. The Texas thing looks like an even-Steven event, in spite of the Matrix kitty slipped into the video. Monsanto's then, Monsanto's rival now. (was suing Monsanto) |
Anonymous Coward User ID: 6676701 United States 04/25/2013 10:30 PM Report Abusive Post Report Copyright Violation | the average age of a car in America is 11 years, so yes, you are going to have to replace alternators, etc. You're overdoing it a little don't you think? Yes you might have a point there ... Quoting: Krispy71 the magnetised field of the ship could have ignited or influenced things in the harbour to go vavoem. <snipped> xxxMzK Something else I have been seeing here... LOTS of STRONG static electricity! It has been so bad that touching the car door as I am getting out can actually Hurt! Last night I got too near the door with the keys and a bright arc nailed me despite my care not to touch it. grr lol Many have been complaining about it and the phones are having issues too... no reception or spotty with both cells and land lines. Add in dying batteries and all sorts of mechanical failures(alternators, starters, generators, etc.)... More and more things that make you go hmmmmm. Didn't see this before posting! Sure doesn't surprise me. When the explosions first happened in Mobile, someone (an "official", don't remember who) said it was a static electricity charge. It will be interesting to see what they finally conclude. Quoting: U3 What I am noticing is explosions occur as the dying throes of old, archaic energy are released as an asbtract world emerges. (That's my 2 cents!) |
Anonymous Coward User ID: 38887887 Netherlands 04/25/2013 10:36 PM Report Abusive Post Report Copyright Violation | -[snipped other quotes]- Quoting: Anonymous Coward 38838812 I have, if oranges and lemons consist of dangerous particles. For some reason, beginning last fall after the citrus crop came on the market, I became violently ill eating oranges, which I've eaten all my life. A few weeks ago, having forgotten about my newly acquired allergy, I ate a lemon and became violently ill. What's up with that? I won't be eating oranges or lemons again. For some reason, there is no negative effect from eating grapefruit. Have you looked where the oranges and lemon were grown ? And where the grapefruit came from ? Grapefruit is not cultivated in such big quantities as the other 2. It could make a difference from which country they came from and which pesticides were used during cultivation or for transport. I would not want to eat anything native American with all that corexit & oil in the water and atmosphere ... xxxMzK Florida citrus and well-washed before eating. Could be the Corexit, et al. Dunno. Doc said I appeared to have acquired an "allergy." Certainly can't eat fruit and veggies from Cali, too much Fuku on the produce. We get Valencias from Spain. Excepting that, usually no citrus from other countries in our local grocery stores. Prolly won't try attempt to eat any next season. "Indian River" citrus from Florida has, in the past, been wonderful tasting fruit. |
Anonymous Coward User ID: 30857551 Australia 04/26/2013 03:04 AM Report Abusive Post Report Copyright Violation | May I ask a favour? Quoting: BadHairDay When posting quotes, and using multiple quotes, can you be very carefull with 'snips' and deleting parts, as the consequences can oftem mean that someone is incorrectly quoted or attributed to a post. Down the track it can cause .. issues. Toooooooootally agree with that !!!! :thumbsup: Thats why I always put my name/signature under important postings, if the copying failed then its always proof of being written by me, unless they snip my name too ...lol... xxxMzK Issues .... too, when authors amend their posts without noting the terms of the amendment. Often makes subsequent posters appear to be off-track. Yeah, best to say something up front, so it is there for all to see. Mind you... I'm guilty of throwing up for days when I find an anomaly I dont like. |
Isis7 User ID: 25804806 United States 04/26/2013 03:10 AM Report Abusive Post Report Copyright Violation | GOM update from Gabe's thread: HuffPost: Countless Gulf residents with symptoms as if from sci-fi horror film — Bleeding from ears, anus, breasts Quoting: AKObserver Title: Corexit, Oil Dispersant Used By BP, Is Destroying Gulf Marine Life, Scientists Say Source: Huffington Post Author: TakePart’s David Kirby Date: April 25, 2013 at 5:02p ET [...] In April 2012, Louisiana State University’s Department of Oceanography and Coastal Sciences was finding lesions and grotesque deformities in sea life—including millions of shrimp with no eyes and crabs without eyes or claws—possibly linked to oil and dispersants. [...] EcoRigs divers took water and marine life samples at several locations in the months following the blowout. Now, they and countless other Gulf residents are sick, with symptoms resembling something from a sci-fi horror film, including bleeding from the nose, ears, breasts, and even anus. Others complain of cognitive damage, including what one man calls getting “stuck stupid,” when he temporarily cannot move or speak, but can still hear. [...] [EcoRigs founder Steve Kolian'a] team has done studies of their own to alarming results. “We recently submitted a paper showing levels of hydrocarbons in seafood were up to 3,000 times higher than safety thresholds for human consumption,” he said. [...] [link to enenews.com] Prayers for you EC |
Anonymous Coward User ID: 38275237 United Kingdom 04/26/2013 06:28 AM Report Abusive Post Report Copyright Violation | [[snipped post]] Quoting: BadHairDay PS - hey Tutes, did you see the 'ERK' article on the previous page? Was a little surprised no-one has twigged to it's relevance. Kinda erking me... LOL! Hay, BHD Can you kindly post the ERK article you referred as it would be interesting and useful if BEZERKERS could see what relevance actually erked you! Thanks, Integrator |
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Krispy71 User ID: 34333335 Netherlands 04/26/2013 07:45 AM Report Abusive Post Report Copyright Violation | @ Integrator Why you ask for the link to the article when its in BHD's post ? Same protein that fires up cancer-promoting Erk also blocks its activation Quoting: BadHairDay A protein which is intimately involved in cancer-promoting cell signaling also keeps a key component of the signaling pathway tied down and inactive, a team led by scientists from The University of Texas MD Anderson Cancer Center reports this week in Nature Structural Molecular Biology. Shc, pronounced "schick," plays a key role in activating signals which lead to cell proliferation (and cancer) when cells are stimulated, however it unexpectedly turns out to be a tumor-suppressor, keeping Erk under wraps when a cell is less active, said senior author John Ladbury, Ph.D., professor in MD Anderson's Department of Biochemistry and Molecular Biology. "Shc is a checkpoint to prevent out of control cell growth, binding to Erk when a cell is not being stimulated by growth factors," Ladbury said. "Otherwise, the lower-level background signaling that's always present in a cell would be uncontrolled." Keeping Erk in check while the cell idles Overexpression of Erk occurs in many types of cancer, including ovarian and prostate cancer and Hodgkin lymphoma, so cellular control of its activity is important. In the absence of external stimulation by growth factors, cells remain active but lower levels of cell signaling occur, which Ladbury compares to a car idling, ready to roll. Under these conditions control mechanisms are in place to prevent the cell kicking into gear. Shc turns out to be one of these controllers. "We're essentially looking at the cell in a resting, but ready, state," Ladbury said. "I would argue that's probably more like a cell behaves in tissue, it's not normally getting a slug of growth factors as is often the way when we investigate signaling in experiments in the lab. There's still a lot going on in the cell, basically background activity." These findings point to a number of therapeutic possibilities, including the measurement of Shc concentration levels as a diagnostic tool and of finding small molecule drugs that block growth-factor signaling to Shc, keeping it bound to Erk, Ladbury noted. Growth factors provide double boost for Erk When the appropriate growth factor receptor is stimulated Erk is activated in the MAP Kinase pathway. It dives into the cell nucleus and turns on a variety of genes, actions that contribute to cancer proliferation, blood vessel production and metastasis when signaling is out of control. When receptor tyrosine kinases on the cell surface connect with growth factors, they normally send a signal via Shc that sets off a chain of actions leading to Erk activation. Ladbury and colleagues looked at Shc's connections to epidermal growth factor receptor (EGFR) signaling. The team found in mammalian cell lines that: •Under non-stimulated conditions Shc binds to Erk in the cell cytoplasm at binding sites that are unique on both proteins. •Stimulation via EGFR reduces this connection, but not by competing with Shc at the Shc-Erk binding site. •Instead, on stimulation from outside the cells, EGFR adds phosphate groups to itself at specific sites. One of these forms a binding for Shc, which distorts the protein's shape, making it impossible for Erk to bind. •Overexpression of Shc decreases the amount of activated Erk, because Shc mops up free Erk molecules. •Depleting Shc expression with short hairpin RNA resulted in higher levels of activated Erk. •When separated from Shc, Erk moves into the nucleus and activates genes even when the cell is not receiving a stimulus. Thus without the controlling influence of Shc, Erk can run riot in the cell giving rise to unrestrained cell reproduction. Shc-Erk connection confirmed Ladbury and colleagues then tested their results in the C.Elegans, a worm model frequently employed in biological research. Both Shc and Erk are greatly similar between humans and the worms. Experiments showed that Shc blocks Erk function by sequestering it away from the Ras-Raf-Mek MAPK pathway in the worms. Without the Shc-Erk connection, the MAPK pathway is activated, causing excessive Erk activation. EGFR stimulation not only sets off the normal activation of Erk via Shc and the MAPK pathway, Ladbury said, but also frees Erk for greater availability for activation by breaking the tie to Shc. [link to phys.org] There's the last half. [HD, where for art thou HD?] xxxMzK Last Edited by Krispy71 on 04/26/2013 07:47 AM |
fs/rsts User ID: 38640547 Australia 04/26/2013 07:51 AM Report Abusive Post Report Copyright Violation | me?a shit stirrer? sheesh... I'm hurt... now c'mon...who told ya about recombinante gene splicin'huh? sheesh... who toldya about polypeptides n stuff, aggregation n stuff.. huh? talk about you havin a fuckin "bad hair day"...try th elittle fuckers growin in ya! not funny hatall... anyway... the'turgidity of mater' is all Im gonna say since ya wont come and have a beer! |
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Anonymous Coward User ID: 30857551 Australia 04/26/2013 08:34 PM Report Abusive Post Report Copyright Violation | Do you guys remember the astronauts training in caves? Also remember the astronauts training underwater off Florida? I've been looking for historical sinkholes around the GoM, especially in Florida, that might link the odd astronaut stories, as I think there may be a connection. I also think there is a connection to this closer to Mexico, with all the caves and sinkholes and caverns there. I found a 1981 article on a Lake that lost water inexplicably, and it mentions many other lakes that have drained, plus caves and caverns beneath Florida. [link to news.google.com] Might be nothing, might be a window in to why/where this is leading. Using astronauts, who have rather specific training to go diving and caving... suggests there are things going on beneath the ground of an unEarthly nature, maybe even of a temporal nature. Hmmm, BlueETs work springs to mind. |