P.S. (for those unfamiliar....)
"The title references an idea first conceived by Drunvalo Melchizedek concerning the possibility of reaching a state of evolution at which the body would have two more than the normal 46 total chromosomes and leave a currently disharmonious state. The premise is that humans would deviate from the current state of human DNA which contains 44 autosomes and 2 sex chromosomes. The next step of evolution would likely result in human DNA being reorganized into 46 and 2 chromosomes, according to Melchizedek.

Furthermore, the song references a wish to experience change through the "shadow"; an idea which represents the parts of one's personality that one hates and fears, which also exists as a recurring theme in the work of Carl Jung."