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In our view, it can be assumed that the primary function of the autoimmune T cells in patients with schizophrenia is to rectify the imbalance causing chemical abnormalities in the CNS. It is likely, however, that the spontaneous response of these T cells is not strong enough, or not of the required phenotype, or not of suitable antigenic specificity to do the job. In our mouse model, vaccination with a self-like antigen might be a way to boost T cells that can crossreact with brain-specific antigens, thus inducing the anti-psychotic effect.