I'm sort of split on two ideas.

1) The physical temple will be rebuilt on the mount. But that seems unlikely any time soon as the Dome on the Rock is in place.

2) God gave the temple to Israel as a symbol for what He was going to do in the Person of Christ and the Body of Christ, that is His Holy Spirit would dwell first in Christ and then the Body of Christ following Pentecost. If you follow that line of reasoning then the temple does not need to be rebuilt for the Body of Christ is the temple. Then the anti-christ would just represent the head of the false church which in appearance represents the Body of Christ but is not.

Of course something else really strange could happen, maybe fragments of Jesus' DNA could be found, maybe on the Shroud of Turin, and a clone of Jesus made. That would be the abomination of desolation, the vessel in which the spirit of anti-christ abides.