Do pitchers in baseball feel like hell after a game?

I rarely watch baseball. Saw a little bit today and tim lincecum, is not very big. He seems very skinny and slightly above average height. But man this guy threw like 150 pitches, most of which were going 95 miles per hour. Watching his throwing style, he uses his entire body to throw a pitch. I mean I am impressed with this ability, I certainly can't do it. But anyway after a game is this man in agony? Is he on some heavy meds? How does he cope with the strain on his body?