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<<Advancing Bird Flu-H5N1...now its Vietnam and spreading?

 
arkay (OP)

User ID: 944501
Australia
09/06/2012 08:41 PM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
The FDA in America has released the contents list for next years flu vaccine and also the list of laborities lisenced to manufacture this vaccine.

While this recepie list doesent specifically make mention as to exactly which H3N2 virus strain it is including, previous mention that the current vaccine does NOT give cover to the new H3N2V variant strain which contains the H1N1 M gene, what this release does say is that it will give protection to two newer strains so from that, one would be lead to believe that this new variant strain is in fact a part of this new vaccine.

Better clarification is naturally be highly sought after on this very important aspect.

FDA NEWS RELEASE
For Immediate Release: Aug. 13, 2012
Media Inquiries: Heidi Rebello, 301-796-4566, heidi.rebello@fda.hhs.gov
Consumer Inquiries: 888-INFO-FDA, OCOD@fda.hhs.gov

FDA approves vaccines for the 2012-2013 influenza season

The U.S. Food and Drug Administration announced today that it has approved the 2012-2013 influenza (flu) vaccine formulation for all six manufacturers licensed to produce and distribute the vaccines in the United States.

Each year experts from the FDA, the World Health Organization, the Centers for Disease Control and Prevention (CDC), and other public health experts study influenza virus samples and global disease patterns to identify virus strains likely to cause the most illness during the upcoming flu season.

Based on that information and the recommendations of the FDA’s Vaccines and Related Biological Products Advisory Committee, the strains selected for inclusion in the 2012-2013 flu vaccines are:
A/California/7/2009 (H1N1)-like virus
A/Victoria/361/2011 (H3N2)-like virus
B/Wisconsin/1/2010-like virus.

While the H1N1 virus is the same as what was included in the 2011-2012 influenza vaccines, this year’s influenza H3N2 and B viruses differ from those in the 2011-2012 influenza vaccines.
Vaccination remains the cornerstone of preventing influenza, a contagious respiratory disease caused by different influenza viruses infecting the nose, throat and lungs. This year’s seasonal vaccines will provide protection against the three influenza virus strains that global surveillance indicates are likely to be the most common strains circulating during the upcoming season.

There is always a possibility of a less than optimal match between the virus strains predicted to circulate and the virus strains that end up causing the most illness. However, even if the vaccine and the circulating strains are not an exact match, the vaccine may reduce the severity of the illness or may help prevent influenza-related complications.

“The best way to prevent influenza is by getting vaccinated each year,” said Karen Midthun, M.D., director of the FDA’s Center for Biologics Evaluation and Research. “It is especially important to get vaccinated this year because two of the three virus strains used in this season’s influenza vaccines differ from the strains included in last year’s vaccines.”

According to the CDC, between 5 percent and 20 percent of the U.S. population develops influenza each year. This leads to more than 200,000 hospitalizations from related complications. Influenza seasons are unpredictable and can be severe, with annual influenza-related deaths ranging from a low of about 3,000 to a high of 49,000 people in the U.S. The CDC’s Advisory Committee on Immunization Practices, recommends that everyone six months of age and older receive an annual influenza vaccine.

Health care providers play an important role in advising their patients to get vaccinated each year and should also protect themselves, their patients, their family, and the community from influenza by getting vaccinated.

The manufacturers licensed to produce the nation’s 2012-2013 flu vaccines and the brand names of the vaccines for the upcoming flu season are:
Afluria, manufactured by CSL Limited;
Fluarix, manufactured by GlaxoSmithKline Biologicals;
FluLaval, manufactured by ID Biomedical Corporation;
FluMist, manufactured by MedImmune Vaccines Inc.;
Fluvirin, manufactured by Novartis Vaccines and Diagnostics Limited; and
Fluzone, Fluzone High-Dose and Fluzone Intradermal, manufactured by Sanofi Pasteur.


Link here...

[link to www.fda.gov]
arkay (OP)

User ID: 944501
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09/06/2012 08:46 PM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
In a very brief news article there has been a report of another positive test for H1N1 in India bringing the total to that region to 5.

Indore, Sep 5 (PTI) A man today tested positive for swine flu infection, taking the number of people affected by the H1N1 virus in western Mahdya Pradesh to five, authorities said. Integrated Disease Surveillance Project (IDSP) in-charge Dr G L Sodhi told reporters that a 52-year-old man tested positive for H1N1 virus, and was undergoing treatment at a private hospital here

Link here...

[link to ibnlive.in.com]
arkay (OP)

User ID: 944501
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09/06/2012 08:53 PM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
Report Number 76 from Vietnam which is some 53 pages long indicates the state of new outbreaks of H5N1 being reported to date.

Follow-up report No.76
Report reference: 1828/TY-DT, Reference OIE : 12264, Report Date : 06/09/2012, Country : Vietnam
Report Summary
Name of sender of the report Dr Nam Hoang Van Telephone (84-43) 868 59 91
Position Director General Fax (84-43) 869 13 11
Address N° 15/78 Giai Phong Road, Dong Da
Hanoi Hanoi
Email hvnamdah@gmail.com
Date submitted to OIE 06/09/2012
Animal type Terrestrial Date of report 06/09/2012
Disease Highly pathogenic avian influenza Date of start of the event 06/12/2006
Causal Agent Highly pathogenic avian influenza virus Date of pre-confirmation of the
event
19/12/2006
Serotype(s) H5N1 Date of last occurrence 10/08/2006
Reason Reoccurrence of a listed disease Diagnosis Clinical, Laboratory (basic), Laboratory (advanced)
Country or zone a zone or compartment Clinical signs yes
Number of reported outbreaks Submitted= 358, draft= 0


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[link to www.oie.int]
arkay (OP)

User ID: 944501
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09/06/2012 08:58 PM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
In another report we get a clearer view of what is currently happening in Vietnam and the news is not good.

Not only are we witnessing a growth of H5N1, mixed in with this is a newer strain that has in all likelyhood has been smuggled in from China and this strain of H5N1 is far more virulent in poultry and also spreading very quickly.

Its impact on humans so far is unknown, another great concern.

Vietnam: avian influenza cases on the rise
6 September, 2012

Avian influenza H5N1 have increased significantly in several cities and provinces over the past three weeks, according to a report on the diseases released by the Ministry of Agriculture and Rural Development's Department of Animal Health.

H5N1 avian influenza had broken out in 11 hamlets in Cho Don District, with about 380 birds infected and 2,370 birds having to be destroyed.


Link here...

[link to www.poultrymed.com]
Anonymous Coward
User ID: 23257613
United States
09/06/2012 09:07 PM
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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
Hi Arkay......hope that you are doing well. Thanks for the posts.


To my knowledge, most people who die from the flu.....actually die from pneumonia.....or cytokine storm.....fluid in the lungs......or perhaps a secondary bacterial infection. Is that your understanding as well?


It does not seem to me to be in the virus best interest to kill off it's host right away. Of course, bio-weapons would be an exception to this general rule.
arkay (OP)

User ID: 944501
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09/06/2012 09:09 PM

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This next article has nothing to do with the threads topic, its included here out of sheer disgust of how some of my country persons can act so dishonestly and Im posting it here in the hope that it serves to spread the news far and wide as an example of how these type of disshonest trade needs to be named and shamed as far as possible.

Hopefully this sort of reporting will stress these business operators out of the market where they can then be replaced by more honest and deserving operators.

As consumers we deserve and demand better.

Am I ruthles in matters like this, you bet.

Do I apolagise for my strong stance, never.

arkay.

Australia: Egg supplier fined for selling cage eggs advertised as free-range
6 September, 2012
The Federal Court has fined an egg supplier, Rosemary Bruhn, $50,000 for selling caged eggs labelled as free-range.


Link here...

[link to www.poultrymed.com]
arkay (OP)

User ID: 944501
Australia
09/06/2012 09:12 PM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
More news on the H5N1 outbreaks in Vietnam, this time indicating the provinces of activity.

Increase in Viet Nam H5N1 Outbreaks
06 September 2012
VIET NAM - Three further outbreaks of avian influenza virus H5N1 have been reported to the OIE.

The new outbreaks were reported by Dr Nam Hoang Van, Director General, Department of Animal Health, Ministry of Agriculture and Rural Development, Hanoi, Vietnam.

The outbreaks occurred in the following regions:

•Lien Loc, Hau Loc, THANH HOA
•Hoa Loc, Hau Loc, THANH HOA
•Hanh Thuan, Nghia Hanh, QUANG NGAI
In total, 153 birds showed symptoms and 53 died of a total of 2,205 susceptible birds, all described as 'village' poultry; 2,152 birds were destroyed
.



Link here...

[link to www.thepoultrysite.com]
arkay (OP)

User ID: 944501
Australia
09/06/2012 09:23 PM

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We have from time to time been following various articles bought to us from Jane Bergermeister, the lady who is persuing the case involving Baxter Pharmacuticles and their attenpt to release Live H5N1 viruses in vaccines they manufactured some years ago.

This next article from Jane with the following heading is unfortunately her last, according to her final words of this article and posted here for our readers.

Let me wish Jane all the best with her departure from her homeland of Austria, and also please allow me to offer her all our best wishes for success in her future, she has been and Im sure will remain a huge benefit and representative of all of what is decent in humans and we need more people with her passion and committment to society.

I hope that wherever she goes that she will find peace and happiness in whatever she decides to persue in her life.

Hopefully we will see more of her in the future.

Good luck from us all here Jane.

cheers

arkay.

The Death of a Father: an old photo brings back Austria’s traumatic history
September 5, 2012

(break to end of article.)

"This is my last post Austria, onto a new city, a new life and hopefully a new website."
arkay (OP)

User ID: 944501
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09/07/2012 09:19 PM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
News of the new strain of avian influenza H5N1 in Vietnam has finally hit main stream media, all be it several days after it was reported here.

This new strain is really going to cause serious grief, as it is being reported as far more highly virulent, though not yet H2H transmissible.

However, should this strain make the mutations to become H2H contagous then we might be looking at an even deadlier enemy than we have been concerning ourselves with so far to date, and that would be a senario so horrifying to contemplate.

The current 60% mortality rate associated with the "known" virus would wipe out billions of people, but a virus more virulent could send the world back into the dark ages if it managed to go pandemic.

HANOI (AFP) - A new highly-toxic strain of the potentially deadly bird flu virus has appeared in Vietnam and is spreading fast, according to state media reports.

The strain appeared to be a mutation of the H5N1 virus which swept through the country's poultry flocks last year, forcing mass culls of birds in affected areas, according to agriculture officials.


Link here...

[link to au.news.yahoo.com]
arkay (OP)

User ID: 944501
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09/07/2012 10:08 PM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
We have been following the unusual case of H3N2v that has emerged under suspicous circumstances in the US and has been conveniently associated with a number of county fairs where swine were on display, but now we are hearing reports of yet another influenza strain designated H1N2v, the "v" because of human infection and now is also being associated with county fairs.

So far this "new" strain has only been detected in three people with a fourth awaiting test results, but what is of real note here is that this "new" strain has also been identified as carrying the H1N1 "M" gene.

With this fresh outbreak, in all probability it has originated from swine that have also been affected by the H3N2v strain and there has been a reassortment that they may well be transmitting back to humans.

This would be a logical senario resultant to the original artificial innoculation of patient zero with the H3N2v strain that carried the H1N1 "M" gene.

Now in the "wild" it has found new ways to naturally reassort itself with other flu strains and is now doing the rounds and infecting humans.

It is now time to shut down all public contact with swine and attempt to stop this new H1N2v strain in its tracks BEFORE it gets a solid foothold and become next years seasonal influenza, failure now will be disasterous for us all next year.

It should be noted that just yesterday we posted here the "recepie" for next years flu vaccines.

These had just been released by the USDA, and notably (and conveniently) this new strain H1N2v of influenza is NOT a part of that vaccine, so while the authorities may have included protection to H3N2V influenza, ( the one apparently spread out of those county fairs) this new emerging strain ( H1N2V) is one step ahead again and could well be the seasonal influenza next year that will cause havoc worldwide as there wont be any vaccines to offer protectetion against it.

All just a lot too smelly from this persons point of view.

Ive consistently asserted that this really does appear to have a deliberate, intended and artificial influence behind it, designed to give nature a helping hand with reassortments and other mutation opportunities, and also keep in mind the immediate problems that are surfacing in Vietnam with their new and highly virulent H5N1 avian influenza strain.

Is this (H5N1) strain from Vietnam, more predisposed to reassortment towards Human to Human transmission when and if it comes into contact with this new H1N2v strain, which carries the Pandemic "M" gene, and which we will have no defense against in the upcoming influenza year, due to the lack of vaccines against it for next years Influenza season?

I know that all this is becoming a bit difficult to follow with each step making following it a little more confusing unless youve been at the coal face from the beginning, but we have!

And as such we will continue to watch very carefully how these new developments work and possibly conspire to bring about an eventual deadly pandemic.

All the hallmarks are there.

Flu parallels: Swine-origin H1N2 has gene from 2009 H1N1
Robert Roos News Editor


Sep 7, 2012 (CIDRAP News) – The swine-origin H1N2 virus found in three Minnesotans last week carries the matrix gene from the 2009 H1N1 pandemic virus, marking the first time such a virus has been found in humans, according to state and federal health officials.

The variant H1N2, or H1N2v, virus is different from the swine-origin H3N2v strain that has cropped up in nearly 300 people within the past year. But the two are alike in that both picked up the pandemic virus's matrix gene.

The number of H3N2v cases has risen to 297, an increase of 7 since a week ago, according to the Centers for Disease Control and Prevention's (CDC's) new count, posted today. Nearly all the cases have been in people who were exposed to pigs, most of them at agricultural fairs this summer. Only one death, that of an Ohio woman who had other medical conditions, has been linked to the virus, but there have been 16 hospitalizations.

No ongoing human-to-human transmission of either H3N2v or H1N2v viruses has been reported, but the CDC has said that the H1N1 matrix gene might increase the transmissibility of H3N2v and that a few instances of likely human-to-human spread of that virus have been found.

In reporting the H1N2v cases in a statement today, the CDC said the population probably has some immunity to it because of past exposure to seasonal H1N1 flu viruses.

"Genetic analysis shows that the hemagglutinin (H) of this virus is similar to human seasonal influenza viruses that circulated in people as recently as 2009, so there would likely be protective immunity against this particular virus in the human population," the agency said.

The three confirmed H1N2v cases reported in Minnesota last week were all in people who were exposed to pigs at the State Fair. The Minnesota Department of Health (MDH) said today that a fourth case has since been reported and is awaiting confirmation by the CDC.


Flu parallels: Swine-origin H1N2 has gene from 2009 H1N1
Robert Roos News Editor


Sep 7, 2012 (CIDRAP News) – The swine-origin H1N2 virus found in three Minnesotans last week carries the matrix gene from the 2009 H1N1 pandemic virus, marking the first time such a virus has been found in humans, according to state and federal health officials.

The variant H1N2, or H1N2v, virus is different from the swine-origin H3N2v strain that has cropped up in nearly 300 people within the past year. But the two are alike in that both picked up the pandemic virus's matrix gene.

The number of H3N2v cases has risen to 297, an increase of 7 since a week ago, according to the Centers for Disease Control and Prevention's (CDC's) new count, posted today. Nearly all the cases have been in people who were exposed to pigs, most of them at agricultural fairs this summer. Only one death, that of an Ohio woman who had other medical conditions, has been linked to the virus, but there have been 16 hospitalizations.

No ongoing human-to-human transmission of either H3N2v or H1N2v viruses has been reported, but the CDC has said that the H1N1 matrix gene might increase the transmissibility of H3N2v and that a few instances of likely human-to-human spread of that virus have been found.

In reporting the H1N2v cases in a statement today, the CDC said the population probably has some immunity to it because of past exposure to seasonal H1N1 flu viruses.

"Genetic analysis shows that the hemagglutinin (H) of this virus is similar to human seasonal influenza viruses that circulated in people as recently as 2009, so there would likely be protective immunity against this particular virus in the human population," the agency said.

The three confirmed H1N2v cases reported in Minnesota last week were all in people who were exposed to pigs at the State Fair. The Minnesota Department of Health (MDH) said today that a fourth case has since been reported and is awaiting confirmation by the CDC.


Link here...

[link to www.cidrap.umn.edu]
arkay (OP)

User ID: 944501
Australia
09/07/2012 10:26 PM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
This next article is perhaps one of the most unique studies conducted on several aspects of H1N1 pandemic virus as it has been done in an area where the swine herds have been insulated from the rest of the world, giving researchers a unique opportunity to study that strain after it showed up in these "virgin" herds.

These researchers have also been able to follow the progress and evolution of this isolated virus over time and their reasearch has been helpful in providing a unique understanding of this virus.

The article is a little technical, but most readers should be able gain an understanding without the need for specialist training to comprehend its overall thrust.

A very worthwhile document to read, with some interesting outcomes made available that could have future impact for us all with this H1N1 virus, as well as other pandemic potential viruses.

Influenza A(H1N1)pdm09 Virus in Pigs, Réunion Island

Abstract
During 2009, pandemic influenza A(H1N1)pdm09 virus affected humans on Réunion Island. Since then, the virus has sustained circulation among local swine herds, raising concerns about the potential for genetic evolution of the virus and possible retransmission back to humans of variants with increased virulence. Continuous surveillance of A(H1N1)pdm09 infection in pigs is recommended.


Link here...

[link to wwwnc.cdc.gov]
arkay (OP)

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Australia
09/07/2012 10:34 PM

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A new iniative that combines multi-disciplinary fields is being formed in a new and fresh approach to combine this collective knowledge to better assist with more rapid and better preparedness to these threats to our health.

This is good evolution of sciences, bringing as much knowledge as possible in the same place and at the same time to build a far stronger line of understanding and ongoing activities to benefit us all.

Increasing incidences of emerging and re-emerging diseases that are mostly zoonotic (e.g. severe acute respiratory syndrome, avian influenza H5N1, pandemic influenza) has led to the need for a multidisciplinary approach to tackling these threats to public and animal health. Accordingly, a global movement of ‘One-Health/One-Medicine’ has been launched to foster collaborative efforts amongst animal and human health officials and researchers to address these problems. Historical evidence points to the fact that pandemics caused by influenza A viruses remain a major zoonotic threat to mankind.

Link here...

[link to onlinelibrary.wiley.com]
arkay (OP)

User ID: 944501
Australia
09/07/2012 10:38 PM

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Here is another excellent example of the diverse manner that needs to be applied to understanding the various ways that viruses like H5N1 can vector in less than immediately obvious ways.

Contaminated Soil and Transmission of Influenza Virus (H5N1).
Gutiérrez RA, Buchy P.
Abstract
TO THE EDITOR: Highly pathogenic avian influenza (HPAI) virus (H5N1) has been responsible for 603 confirmed human cases worldwide, including 356 that resulted in death, and for >7,000 epizootic outbreaks (1,2). Direct contact between hosts is the main mechanism of transmission for avian influenza viruses, but the possible role of the environment as a source of HPAI virus (H5N1) infection has been rarely studied, particularly in the context of countries where the virus is enzootic or epizootic (3-7). To determine if contaminated soil contributes to the transmission cycle of HPAI virus (H5N1), we used experimental and simulated field conditions to assess possible transmission in chickens.


Link here...

[link to www.ncbi.nlm.nih.gov]
arkay (OP)

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Australia
09/07/2012 10:46 PM

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It would appear that the CDC continues to follow the path of missinformation with their assertions regarding the current outbreak of Influenzas in the US, as they continue to dissmiss the errors that are obviously present.

PCR pdmInfA Negative = No H3N2v Community Transmission?
Recombinomics Commentary 15:30
September 7, 2012

Specimens from humans infected with A(H3N2)v will be positive for InfA, H3, and pdmInfA markers and negative for H1 and pdmH1 markers.

The above comment is from the August 6, 2012 CDC document entitled “Data Interpretation Update to the CDC Flu rRT-PCR Dx Panel” which describes the marker pattern for H3N2v positives and allows states to classify samples with this pattern as an H3N2v “presumptive positive”. This update was due to the explosion of H3N2v cases and potential delays due to a CDC backlog in sequence verification. Indeed the CDC has released full or partial sequences on 43 H3N2v cases (as well as one H1N2v) from samples collected in July and August.

However, the pattern for seasonal H3N2 differs from H3N2v in the pdmInfA (NP) marker, which is negative for seasonal H3N2, but also gives a false negative in samples with low RNA levels, leading to a misdiagnosis.


Break to last para...

Thus, the CDC claim of no reported community transmission of H3N2v is largely based on a negative result for pdmInfA, which has been a false negative for prior H3N2v cases, such as A/Maine/06/2011, A/Maine/07/2011 and A/West Virginia/07/2011.

Release of sequences from the 233 “seasonal” H3 cases reported for weeks 30-33 would be useful.


Link here...

[link to www.recombinomics.com]
arkay (OP)

User ID: 944501
Australia
09/07/2012 11:01 PM

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Back here in Australia, news is surfacing that there has been an outbreak of an unnamed Influenza A that has killed 40 pigs on a property near Kingaroy.

Further in the article, mention is made that the herd was 400 strong indicating that 10% of the heard has succumed to this virus, which is significant.

Kingaroy is well inland, which might suggest that this, as yet to be advised strain, may have come from a human vector, but this is my supposition, we shall endevour to find better information.

Piggery lockdown
Jordan Philp | 7th September 2012 1:25 PM

TROUBLES: A spate of deaths has a Kingaroy piggery in lockdown. Photo: Martina Berg

Martina BergAdvertisementA PIGGERY at Kingaroy is in lockdown.

The piggery was placed under a full quarantine after a foreign virus was detected in its pigs two weeks ago.

The outbreak is the first confirmed report of Influenza A in pigs in the South Burnett.

And about 40 animals have died as a result.


Link here...

[link to www.southburnetttimes.com.au]
arkay (OP)

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09/07/2012 11:18 PM

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Further to the above post we have discovered another article with some more specific detail.

Mention is made of H1N2 as the strain and that the suspected vector is indeed human, but now we have a serious dilema, where have these "workers" been to contract H1N2, as it is NOT a circulating virus here in Australia.

And further still, keep in mind the fresh reports of H1N2v that are just being identified in the US and guess where, county fairs where swine are on display.

So now we appear to be seeing a deadly outbreak of this strain on two seperate continents appearing more or less spontaneously.

Oh, the plot thickens, is the saying that comes immediately to mind.

It would be extremely helpful to have this strain fully sequenced to see if there is any relationship with the American strains, and this protocol should be high on the adgenda right now, as serious questions are desperately in need of answers.

The best answer would be that some worker has recently attended one of those American county fairs and has inadvertantly returned back to Australia and unwittingly vectored the disease from America, but this seems highly unlikely as we arent hearing that the American strain is killing swine as is being reported here.

This is definately a case where there are far more questions than answers currently available and serious alarm bells need to be ringing loud and long, there is no place for complacency here.

No Need To Fear Pork
7 September 2012 Filed under Latest News, Rural Posted by admin September 7, 2012

Influenza in pigs is like influenza in humans … it’s a regular occurrence, and although it needs to be managed, there’s no need to fear pork or pork products.

That’s the message this afternoon from John Coward, a pork industry veteran and current president of industry group Queensland Pork Inc.

A Biosecurity Queensland spokesman confirmed today that a commercial piggery near Kingaroy had been quarantined as a precaution after a higher number of deaths than usual occurred in a group of pigs.

These deaths have been linked to Influenza A and bacterial infections.

The piggery is a “farrow to finish” breeding property with about 400 animals.


Break to further into the article...

He said the pigs possibly caught the flu, which had been identified as the H1N2 variety, from a worker.

Link here...

[link to southburnett.com.au]
arkay (OP)

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09/07/2012 11:29 PM

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In more local news there has been the report of another tragic death in Queensland from Influenza, bringing this years total number to three fatalities.

...Breaking National News

Flu epidemic not over yet: Qld Health From: AAP August 27, 2012 6:26PM

WHILE the number of medical notifications is falling, Queensland Health (QH) says it's too early to say the flu epidemic sweeping the state is over.
QH says it can't confirm three people have died from flu complications in the past three weeks - including a 38-year-old woman who died on Monday.

The Courier Mail reports the mother of four had been in the Prince Charles Hospital's intensive care unit for more than a month before she died.


Link here...

[link to www.couriermail.com.au]
arkay (OP)

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09/07/2012 11:40 PM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
More information here on the newly reported cases of H1N2v influenzas being detected in the US.

This article is excellent and has several links to other associated information that is highly recommended reading to gain a better overall understanding of several flu issues.

Avian Flu Diary constantly provides excellent content that is easy reading for lay people and Id highly recommend keeping this site in your "favorites" as an excellent and up to date source of information on a broader range of health isssues than we tend to cover here.

A week ago we learned of three human infections with the H1N2v virus in Minnesota, which - while of swine origin – is a different strain than the one behind the cluster of nearly 300 H3N2v infections we’ve been watching over the summer (see Minnesota Reports Swine H1N2v Flu).



H1N2 is one of three swine influenza viruses that are commonly found in pigs, the others are H1N1 and H3N2. Until last week, since 2005, only 2 cases of human infection with trH1N2 (now called H1N2v) had been detected in humans.



The three cases reported last week are similar to the 2 previous cases, with the exception that the H1N2v virus – like H3N2v – has picked up the M gene segment from the 2009 H1N1 pandemic virus.


Link here...

[link to afludiary.blogspot.it]
Anonymous Coward
User ID: 7024207
United States
09/08/2012 12:05 AM
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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
For your info.


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arkay (OP)

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09/08/2012 11:33 AM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
Hi Arkay......hope that you are doing well. Thanks for the posts.


To my knowledge, most people who die from the flu.....actually die from pneumonia.....or cytokine storm.....fluid in the lungs......or perhaps a secondary bacterial infection. Is that your understanding as well?


It does not seem to me to be in the virus best interest to kill off it's host right away. Of course, bio-weapons would be an exception to this general rule.
 Quoting: Anonymous Coward 23257613


Hi AC, I am so sorry that I missed this post of yours and your very important questions.

Please accept my deepest apolagies for my oversight.

Hopefully I can provide you with something of assistance now.

To the best of my knowledge your assertions are right on the mark.

What is known about the Spanish flu from early last century is that it killed the healthier of the community.

That implies that those people actually had healthy immune systems and it was their own immune systems that did all the dmage, usually to delicate lung tissues.

I will attach a link at the end of this post that will explain the cytokine storm effect which is this particular matter of concern.

Basically when a healthy bodies immune system "sees" a presence such as a virus that is so alien to its experience, it goes into overdrive to produce massive quantities of antibodies to fight off that alien invasion.

Unfortunately this storm of antibodies can be harmful to the delicate tissues of our lungs and that actual cause of death is typically one where the patient actually drowns in their own body fluids through their lungs being damaged by the victims own antibodies.

But, that is only part of the answer to your question.

As to why a parasite, like a virus would actually kill its host, all that is necessary to understand that the virus wishes to survive, reproduce and distribute itself, as do all living creatures, so, once it has gained entry into our cells it multiplies and then the cell dies and releases an army of new viruses that have multiplied in just that one cell, they then go on to infect ever greater numbers of cells till they may aventually kill its host.

So it is in fact contributing to its natural reproduction and distribution cycle, some viruses do this very fast as was the case with the Spanish flu, where it was said that if you got it today you either woke up tomorrow or you would not, such was its speed of action, but it never the less was able to very successfully transmit itself sufficiently to kill over an estimated 50 million people at the time.

Did you know that when the Spanish flu burnt itself out after its relatively short life as a pandemic, all traces of it virtually completely vanished off the face of the planet, it was finally discovered in the body of an Inuitt that had been buried in the perma frost in alaska where researchers finally found a sample of this virus, which incidentally has since returned at intervals as the Russian flu and later known as H1N1 Swine flu that again went pandemic in 2009.

Assumedly, it continued to exist in swine as its primary resevoir, and from time to time it undergoes slight changes then re-emerges as a H2H virus again.

Now I am only a casual observer, essentially untrained so I may have some of my history incorrect with what I have just described, I think that Ive got it pretty right from what Ive learnt over time, but if wrong please feel free to clarify any innacuracies I may have made above.

With H5N1 avian influenza which at this stage has a 60% mortality rate as opposed to the 16% estimated for Spanish flu, the thing about H5N1 that is understood so far is that a person could be shedding viruses for anything up to ten days before they become symptomatic, and once actually displaying symptoms and becoming ill, a patient may hang on for anything up to another ten days before they finally succumb to the virus, if untreated.

This gives this virus a huge advantage to propogate itself and so make it a very dangerous virus should it ever acquire the necessary mutations that it needs to become a human to human transmitted virus and at which time it would also become a deadly pandemic virus.

Unfortunately these viruses are constantly finding ways to vary themselves ever so slightly, which is a fluid and constant process, most changes contribute little to nothing in terms of advancing the virus to H2H transmission, but eventually some of those slight changes bring it that tiny bit closer and as an evolutionary action, sooner or later this virus will find a successful neiche and be just that bit closer to that H2H transmission outcome.

At this point in time it is widely accepted that H5N1 only has 3 mutations to make to achieve pandemic status.

And on a note of major caution here, just this least week we have been witnessing major outbreaks of a new and far more virulent strain of H5N1 emerge in Vietnam, where it has always been a very stubborn and difficult problem to deal effectively with.

This could be a very serious change in how this bug behaves and it is essential that all efforts are made to assist Vietnam to stamp this strain out ,but unfortunately that is not very likely to be the case, so we have to wait and watch.

Finally, as a bio weapon one must look at who and why it might be used.

It would be completely useless for anyone to attempt to use this virus as a form of weaponry for one country or state against another, as it simply doesent discriminate and doesent respect nominally drawn borders.

So in that manner, it is useles as it will kill the instigators equally as the people that they would intend to harm, but...

If there were some reason, like reduction of global population, in a general sense, then you really are looking at a very useful tool to carry out that type of armageddon aganst humanity, and unfortunately we have been hearing some rumblings from certain circles suggesting that this might actually be a desired thing.

Certainly we have witnessed one pretty clear case a few years ago where Baxter Pharmacuticals distributed some 72 Kilograms of vaccines to 18 countries that contained live H5N1 viruses and had it not been for the dilligence of a sub-contractor in the Chech Repiblic who discovered this contamination , then Baxter would have been directly responsible for triggering a spontaneous world wide pandemic that would have killed billions of people.

You have to understand that in this case, Baxter operates a level 3 bio-hazard facility and this could never have been any type of mistake or accident for all that vaccine to be contaminated and distributed.

The number of safety systems and protocols that had to be crossed here in that matter would have had to have involved several people for all those checks and balances to have been breached.

Incidentally, Baxter has never been bought and held to account for this action and they continue to operate today as if nothing had ever happened.

Personally I believe that all their products should be black banned by the peoples of the world so that they would eventually be starved out of existance, but also unfortunately the people who orchestrated this action would only slip through the cracks a eventually resurface again somewhere else.

Perhaps a good old fashioned witch hunt for the top executives would be more appropriate in dealing with this matter as the authorities worldlide have to be sharing some complicity in that incident, otherwise we would have seen more affirmative actions to bring those responsible to justice sooner than now, and there is NO talk of any of that happening any time soon.

I hope that I have been able to answer your request adequately, if not and you or anyone elso would like to know more Im sure the either I or someone else more skilled will be only too willing to assist greater, so please do not hesitate to put your questions forward, that is why we are here doing all this on this thread.

cheers

arkay

Here is that cytokine storm link.

Hope it is useful.

[link to www.cytokinestorm.com]
Anonymous Coward
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09/08/2012 12:32 PM
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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
Thanks arkay for the detailed response. Very nice.


In my opinion, like in the Ukraine, an area could be sprayed and there would be some rapid deaths from the unusual virus.

However in Ukraine, it could not really spread too much because they closed down travel from one area to another and people began to wear masks, etc. The sickness therefore burnt out rather quickly.

However, it could have been greatly extended had to govt. imposed mandatory vaccines......with the killer bug included in the vaccine.


This would be controlled death in a way......just as the Nazis injected people with poison.


Those elites who wanted protection naturally would have an anti-dote vaccine prepared in advance just for themselves........prior to releasing the weapon upon the masses.
arkay (OP)

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09/08/2012 10:04 PM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
You are quite correct with your observations.

However with H5N1 and the matter of vaccines, it is true that a vaccine could be developed to combat and provide (some) protection in advance.

However, this is at best risky, due to a couple of conditions.

The first is that it usually takes about 6 months to produce a vaccine and to test it for its effectiveness, but far more relevant here is the fact that even those that receive vaccination for the annual influenza, still manage to contract it.

We have observed this even on this thread here, on a couple of occasions where say the national figures for Australia might show up with people testing positive for seasonal flu being reported as say 3.4% of the population that have been vaccinated and the comparison would be something like 3.9% of the population being those who had NOT been previously vaccinated.

Its not a very big gap!

This, while just imaginary figures does represent the typical story, so it does imply that vaccination wont necessarily outright prevent illness, but it probably deminishes the severity of the illness.

With all that in mind, I think that youd have to be pretty brave or pretty desperate to travel down that road with so much uncertainty.

However, again, there has been ample talk of massive undergorund bunkers being in existance in numerous places that have been strategically placed, and of course, as you point out it could be possible to totally isolate a place like, well ideally, Australia from all travel and let a bug loose to impact the rest of the world.

Of course there are a couple of things that would be rather obvious, and many questions would be asked.

Also, from an elitists point of view, you would not be selectively removing any desired section of the community and you still wouldnt gain certainty from exposure as one of the issues with H5N1 or any number of other influenzas is the fact that they are actually vectored naturally by migrating birds.

In these modern times we humans would be the most efficient vector with our worldwide rapid and highly diverse travel habits, but that could still be replaced with a slightly slower natural vectoring, and in fact Australia has been identified as the first of the Western nations to be expected to be impacted this way through migrating birds flying from Vietnam, Thailand and Southern Asian regions, where they already do have significant problems controlling the natural influenza outbreaks in their particular regions.

This is why we acquired massive stockpiles of Tamiflu before most other nations go it when it was first released on to the market around 2006-7 and supplies were rare.

The problem we had back then and our government was (rightfully) criticized for was the fact that, that stockpile was being reserved as an allocation of up to ten packets of Tamiflu each, for only essential and government workers, NOT the general population.

Two things from that, the first indicationg the absolute bloody mindedness of our then ruling political party and its totally unappolagetic ellitist leanings.

And the next, the total lack of understanding that those same politicians possesed in relation to the effective use of Tamiflu, and, in spite of being fully informed anyway.

A final sour taste that we also had to contend with was the fact that we, the ordinary people of Australia actuually footed the bill for essentially what may have been our own death sentences as well.

That little senario should be a very careful warning of the absolute bastardry that some people in power will lower themselves to in the face of adversity.

Just jump ship and let the rest swim and flounder for themselves.

To this day this remains THE most cowardly political decision making and planning I have ever become aware of in modern times and it comes from my own country.

In this regard I feel shame on a level that is otherwise unknown and I will go to my grave wishing for those responsible for that decision making process to be bought to account for themselves.

They are MURDERERS, its just that luckily for them nobody died.

It however does NOT change the fact that they put a MURDEROUS protocol into play back then, so the sin still and will always lay with them.

They will one day be judged for their complicity there and they will receive not a single thought of sympathy for their evil, inhumane, animal, and totally cowerdly actions from me nor any other decent human on this planet.

They will always remain the worst scum that humanity has ever spawned, and I cant direct sufficient vitriol to project my utter disgust towards them.

Let them all go to hell.

arkay

Last Edited by arkay on 09/08/2012 10:41 PM
Anonymous Coward
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09/09/2012 01:31 PM
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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
arkay your doing brilliant things with this thread keep up the good work
If I can Ill try to contribute more just up to my neck right now
take care hfhfhf
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09/09/2012 04:58 PM
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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
A ProMED-mail post
[link to www.promedmail.org]
ProMED-mail is a program of the
International Society for Infectious Diseases
[link to www.isid.org]

Date: Fri 7 Sep 2012

Source: CDC Seasonal Influenza

[link to www.cdc.gov]





H1N2 Variant Virus Detected in Minnesota


-----------------------------------


The Minnesota Department of Health has reported detection of 3 infections with an influenza an A(H1N2) variant ("H1N2v") virus with the pandemic M gene from the 2009 H1N1 virus. These cases were reportedly associated with prolonged contact with pigs at a fair. H1N2 viruses normally circulate in pigs, not people, but rare human infections with this virus have been detected in the past. This virus is different from the H3N2v virus that, as of today, is reported to have caused 296 human infections across 10 U.S. states since July 2012. These additional human infections underscore the fact that swine influenza viruses can spread to people after close contact with infected pigs, and support the importance of ongoing surveillance for both human and swine influenza viruses.



According to the state of Minnesota, each of the 3 people infected with the H1N2v virus had exhibited pig(s) or spent prolonged time with pig(s) at the Minnesota State Fair. Two of the 3 people had underlying health conditions that placed them at high risk of serious flu complications; one of the 2 people with high risk factors was hospitalized, highlighting again the importance of the CDC recommendation that people with high risk factors avoid close contact with pigs and pig arenas at fairs this season. All 3 people have recovered from their illnesses.



People who are at high risk of serious flu complications include children younger than 5 years, people 65 years and older, pregnant women, and people with certain long-term health conditions (like asthma and other lung disease, diabetes, heart disease, weakened immune systems, and neurological or neurodevelopmental conditions). A full list of high risk factors is available on the CDC seasonal flu site.



In addition to avoiding pigs and pig arenas at fairs this year, as always, people with high risk conditions who develop flu-like symptoms should seek prompt medical attention. The H1N2v virus should be susceptible to both currently recommended influenza antiviral drugs [oseltamivir (Tamiflu) and zanamivir (Relenza)].



CDC has confirmed the Minnesota samples as H1N2v viruses. Sequencing of the viruses indicates these H1N2 variant viruses are very similar to those found in humans previously; with the exception of the addition of the pandemic M gene. This is the 1st time this virus has included the M gene from the 2009 H1N1 pandemic virus when isolated from a person. Genetic analysis shows that the hemagglutinin (H) of this virus is similar to human seasonal influenza viruses that circulated in people as recently as 2007, so there would likely be protective immunity against this particular virus in the human population.



The University of Minnesota Veterinary Diagnostic Lab also isolated an H1N2 virus from swine sampled at the Minnesota State Fair. Sequencing at National Veterinary Services Laboratories in Ames, Iowa, confirmed that it matches the human isolates



--

Communicated by:

ProMED-mail

<promed@promedmail.org>


the use of this material is for educational purposes only no copyright infringement is meant
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09/09/2012 05:01 PM
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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
[link to www.thelocal.de]
germany expecting heavy flu season after australia reported twice as many cases this year as in 2011
arkay (OP)

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09/09/2012 11:44 PM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
[link to www.thelocal.de]
germany expecting heavy flu season after australia reported twice as many cases this year as in 2011
 Quoting: Anonymous Coward 23465979


If you look closely at this link you will also notice a heading that refers to another H1N1 vaccine article, extract below.

I am reminded of my last post yesterday where I made mention of the "special" treatment that the Australian government treated itself to a while ago in relation to stock piling Tamiflu.

This sounds just so similar, but there is one very vexing aspect to this news and that is that the different vaccine that the German Government is treating itself and its protectors with is manufactured by none other than our "good friends", Baxter Pharmacuticles.

By "good friends" I am being highly sarcastic here as we all know of Baxters history.

What worries me is that this could be interpreted as the population being given some sort of less than acceptable vaccine while the elite get the better vaccine or in other words, an antidote!

What exactly is going on this year in Germany, first they warn everyone to "expect" a massive flu season, then the select few receive a different vacine made by a highly discredited Pharmacutical company.

This is really disturbing news.

Germany editionChange edition:France |Norway |Sweden |SwitzerlandThe Local: Germany's news in English

Government to get special swine flu vaccine
Published: 18 Oct 09 12:00 CET
Online: [link to www.thelocal.de]

Just a week after it emerged that the German armed forces was getting a different kind of A/H1N1 vaccine to the general population, Der Spiegel magazine reports that the government will also get special treatment.


•Health authorities warn of severe flu season (9 Sep 12)
•Merkel calls for a 'Greece solution' (9 Sep 12)
•ECB bond-buying under fire in Germany (8 Sep 12)
The general population will be offered the GlaxoSmithKline vaccine, called Pandemrix, which contains a new booster element, or adjuvant, as well as a preservative containing mercury.

Controversy has grown around the rapid licensing of the GSK vaccine – and a similar one being made by Novartis. Critics said not enough testing had been conducted before European licensing authorities rushed an approval.

Chancellor Angela Merkel, her cabinet members and ministry civil servants as well as those working for other agencies will get Celvapan, produced by US firm Baxter, which does not have the adjuvant or the preservative, according to Der Spiegel.

It is thought the adjuvant may lead to a stronger reaction in the patient – which to a certain degree is the point, meaning the vaccine can contain less of the virus yet still provoke the crucial immune system reaction.

But this is also what some say is the additional risk – and has led to stocks of the traditional kind of vaccine being bought in for pregnant women and young children.

Celvapan does not contain the adjuvant or the preservative. Rather, it contains entire dead viruses rather than the pieces which are in the traditional vaccine. The Baxter version is the one being given to the armed forces, as well as being made available for pregnant women and children.


Link here...

[link to www.thelocal.de]

Last Edited by arkay on 09/09/2012 11:48 PM
arkay (OP)

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09/10/2012 12:14 AM

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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
arkay your doing brilliant things with this thread keep up the good work
If I can Ill try to contribute more just up to my neck right now
take care hfhfhf
 Quoting: Anonymous Coward 23465979


Thank you UK anon.

Wishing you all the best and always appreciating everything that you bring here to us, not to mention the personal thoughts that you know are with me for you always as well.

Rest as and when you can, and when you are able we will be here waithing for you.

As always, all the very best for you.

cheers

arkay.

hf

smile_hear

hugs

Last Edited by arkay on 09/10/2012 12:15 AM
taniatarn

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New Zealand
09/10/2012 02:41 AM
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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
[link to www.thelocal.de]
germany expecting heavy flu season after australia reported twice as many cases this year as in 2011
 Quoting: Anonymous Coward 23465979


If you look closely at this link you will also notice a heading that refers to another H1N1 vaccine article, extract below.

I am reminded of my last post yesterday where I made mention of the "special" treatment that the Australian government treated itself to a while ago in relation to stock piling Tamiflu.

This sounds just so similar, but there is one very vexing aspect to this news and that is that the different vaccine that the German Government is treating itself and its protectors with is manufactured by none other than our "good friends", Baxter Pharmacuticles.

By "good friends" I am being highly sarcastic here as we all know of Baxters history.

What worries me is that this could be interpreted as the population being given some sort of less than acceptable vaccine while the elite get the better vaccine or in other words, an antidote!

What exactly is going on this year in Germany, first they warn everyone to "expect" a massive flu season, then the select few receive a different vacine made by a highly discredited Pharmacutical company.

This is really disturbing news.

Germany editionChange edition:France |Norway |Sweden |SwitzerlandThe Local: Germany's news in English

Government to get special swine flu vaccine
Published: 18 Oct 09 12:00 CET
Online: [link to www.thelocal.de]

Just a week after it emerged that the German armed forces was getting a different kind of A/H1N1 vaccine to the general population, Der Spiegel magazine reports that the government will also get special treatment.


•Health authorities warn of severe flu season (9 Sep 12)
•Merkel calls for a 'Greece solution' (9 Sep 12)
•ECB bond-buying under fire in Germany (8 Sep 12)
The general population will be offered the GlaxoSmithKline vaccine, called Pandemrix, which contains a new booster element, or adjuvant, as well as a preservative containing mercury.

Controversy has grown around the rapid licensing of the GSK vaccine – and a similar one being made by Novartis. Critics said not enough testing had been conducted before European licensing authorities rushed an approval.

Chancellor Angela Merkel, her cabinet members and ministry civil servants as well as those working for other agencies will get Celvapan, produced by US firm Baxter, which does not have the adjuvant or the preservative, according to Der Spiegel.

It is thought the adjuvant may lead to a stronger reaction in the patient – which to a certain degree is the point, meaning the vaccine can contain less of the virus yet still provoke the crucial immune system reaction.

But this is also what some say is the additional risk – and has led to stocks of the traditional kind of vaccine being bought in for pregnant women and young children.

Celvapan does not contain the adjuvant or the preservative. Rather, it contains entire dead viruses rather than the pieces which are in the traditional vaccine. The Baxter version is the one being given to the armed forces, as well as being made available for pregnant women and children.


Link here...

[link to www.thelocal.de]
 Quoting: arkay


Some great information in your post and a real eye opener. Its not a matter of if but when by the looks....

And sad to say that mankind is are more than capable of commiting some horrific acts towards each other.

Great thread thanks!

hf
Interested observer of all things interesting!

Please note : Where appropriate for posted images/ graphs I acknowledge the New Zealand GeoNet project and its sponsors EQC, GNS Science and LINZ, for providing data/images used in my study and analyses of Volcanic and Earthquake information in New Zealand.
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09/10/2012 07:24 PM
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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
[link to www.edmontonjournal.com]
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09/10/2012 07:28 PM
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Re: <<Advancing Bird Flu-H5N1...now its Vietnam and spreading?
[link to medicalxpress.com]

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