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<<Advancing Bird Flu-H5N1...Now following MERS and Ebola approaching PANDEMICS>>>

 
arkay (OP)

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02/13/2013 10:05 PM

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Yesterday I reported that there had been another case of H5N1 being reported in Cambodia, and that this patient was responding positivey to treatment.

Regrettably today there is news that this poor child has succumed to this deadly killer.

The bird flu has claimed the life of a Cambodian toddler. The 3-year-old girl has become the sixth fatality of the latest outbreak. The young child reportedly came into contact with poultry in her southern Kampot province village.

There have been recent poultry deaths in the same Cambodian village, US News reports. There have been seven cases of the bird flu in the country so far this year. Only one H5N1 victim survived the infection.


Link here...

[link to www.inquisitr.com]
arkay (OP)

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02/13/2013 10:15 PM

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China is reporting that they have two new confirmed human cases of H5N1 avian influenza.

Regrettably this report also indicates that one of the cases has already been fatal.

Guizhou people infected with the highly pathogenic avian influenza cases there was one death 2013-02-13 14:19 2013-Guiyang, Xinhua, February 13 (LI Jing Asia) Guizhou diagnosed two cases of human infection with highly pathogenic avian influenza, one person died on the 13th, another in critical condition, is still receiving treatment.

Reporters learned from the Guizhou Provincial Health Department, at 9:41 on the 13th, a human bird flu patients due to disease progression, multiple organ failure and died Guizhou Provincial People's Hospital.

The deceased was a female, 21 years old, the onset of February 2 this year, transferred to the Guizhou Provincial People's Hospital for treatment of exacerbations.

On February 10, the detection of their respiratory specimens for review by the Chinese Center for Disease Control, confirmed cases of human avian flu (H5N1).


Link here...

[link to news.xinmin.cn]
arkay (OP)

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02/13/2013 10:25 PM

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While some regions around the globe appear to be well aware of the risks and dangers that H5N1 presents to the world, there are groups here and there that seem to either be unaware or simply dont care about these matters and continue to present an ongoing and unnecessary risk to the world with the practices that they undertake.

This report from Kathmandu seems to indicate those problems.

Farmers' foul play suspected for rise in bird flu cases


Farm owners not following govt directive‚ obstructing response teams

KATHMANDU: The Kathmandu Valley has recorded third confirmed case of bird flu in as many days, taking the number of such incidents to nine in the past 45 days.

The latest confirmed case of bird flu today at a poultry farm owned by Subarna Basnet in Manamaiju, Nepaltar, has prompted experts to claim that poultry farmers have been playing foul. A rapid response team from the Directorate of Animal Health culled 6,060 chicken and destroyed 950 kg of chicken feed at the farm today.

Sources at DoAH said poultry farmers were not following the government directives properly and were indulging in unethical practices like selling poultry products in the market even after knowing that the fowls were infected with virus. “Such cases are on the rise as farm owners are flouting Bird Flu Control Order 2007,” said the sources. The order prohibits import, export or sale of poultry products even if they are suspected of infection.


Link here...

[link to www.thehimalayantimes.com]
Anonymous Coward
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02/14/2013 01:24 PM
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[link to www.bbc.co.uk]
third case of sars mutant h5n1 found in uk fear of human to human transmision
Anonymous Coward
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02/14/2013 04:13 PM
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Re: <<Advancing Bird Flu-H5N1...Now following MERS and Ebola approaching PANDEMICS>>>
[link to rense.com]
please take the time to read this some very eye opening points .....
Anonymous Coward
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02/14/2013 04:17 PM
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[link to www.who.int]
this shows who thought re time period
Anonymous Coward
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02/14/2013 04:31 PM
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[link to www.newscientist.com]
Anonymous Coward
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02/14/2013 04:47 PM
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[link to scrapetv.com]
new sars apparently better at kiling people than the old sars
Anonymous Coward
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02/14/2013 05:54 PM
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[link to occupycorporatism.com]
arkay (OP)

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02/14/2013 06:00 PM

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[link to rense.com]
please take the time to read this some very eye opening points .....
 Quoting: Anonymous Coward 34101971


Thank you UK anon for finding this particularly informative and very important document.

Readers should heed UK anon's suggestion to take the time to carefully read this document.

Essentially what it aludes to is the fact that many human cases of H5N1 avian influenza might have actually been contracted by H2H transmision and to date may have been incorrectly classified, missing this very serious fact.

If this is the case then our currently held belief that H2H transmission is difficult could prove to be a deadly belief and that H5N1 could in fact be relatively easy to contract.

This would also then change what we understand of the remaining mutations for this virus to become a highly contagous virus, with all the dangers that implies for us all.
Anonymous Coward
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02/14/2013 11:09 PM
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[link to wwwnc.cdc.gov]
adding to information above
\
Anonymous Coward
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02/14/2013 11:14 PM
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[link to www.dailymail.co.uk]

this s old but a possible reference point at some point
Anonymous Coward
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02/14/2013 11:18 PM
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[link to www.dailymail.co.uk]

this s old but a possible reference point at some point
 Quoting: Anonymous Coward 34428207


forgive mee this appears to be new having checked the date
Anonymous Coward
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02/14/2013 11:24 PM
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[link to www.dailymail.co.uk]

this s old but a possible reference point at some point
 Quoting: Anonymous Coward 34428207


forgive mee this appears to be new having checked the date
 Quoting: Anonymous Coward 34428207

The WHO, which last month declared Sars a global emergency, has tracked the spread of the disease through air travel.
Beijing is the hardest hit place in China, where Sars is believed to have originated. China has the world's highest death toll from the virus with 106 fatalities.
Authorities there announced the closure of all the capital's schools for two weeks in an attempt to stop Sars from spreading to 1.7 million schoolchildren.
Officials have already said they would quarantine hotels, hospitals or other buildings suspected of infection and would take "compulsory measures" against anyone not co-operating.
Hong Kong, which also reported more deaths and infections, announced a £1bn package to help businesses reeling from the impact of the disease. The city has now had 105 Sars deaths.
Police in Australia have been given new powers to round up and quarantine suspected Sars victims.
In Singapore, where there have been 189 infections and up to 17 deaths, alarm was growing over an outbreak among vendors at its largest vegetable market.


Read more: [link to www.dailymail.co.uk]
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PENG

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02/14/2013 11:36 PM

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BIRD FLU (H5N1) has receded from international headlines for the moment, as few human cases of the deadly virus have been reported this year. But when Dutch researchers recently created an even more deadly strain of the virus in a laboratory for research purposes, they stirred grave concerns about what would happen if it escaped into the outside world


....
Fortunately, during the past 15 years, the virus has claimed only 400 victims worldwide—although the strain can jump species, it hasn’t had the ability to move easily from human to human, a critical limit to its spread.

That’s no longer the case, however. In late 2011, the Dutch researchers announced the creation of an H5N1 virus transmissible through the air between ferrets (the best animal model for studying the impact of disease on humans). The news caused a storm of controversy in the popular press and heated debate among scientists over the ethics of the work. For Lipsitch and many others, the creation of the new strain was cause for alarm. “H5N1 influenza is already one of the most deadly viruses in existence,” he says. “If you make [the virus] transmissible [between humans], you have to be very concerned about what the resulting strain could do.”


Ironically, this is why Ron Fouchier, the Dutch virologist whose lab created the new H5N1 strain, argues that studying it in more depth is crucial. If the virus can be made transmissible in the lab, he reasons, it can also occur in nature—and researchers should have an opportunity to understand as much as possible about the strain before that happens.

Lipsitch, who directs the Center for Communicable Disease Dynamics at HSPH, thinks the risks far outweigh the rewards. Even in labs with the most stringent safety requirements, such as enclosed rubber “space suits” to isolate researchers, accidents do happen. A single unprotected breath could infect a researcher, who might unknowingly spread the virus beyond the confines of the lab.


[link to harvardmagazine.com]

I'm so sick of flus and diseases personally. Besides washing hands and not blowing your nose on people, there isn't much to do but wait and hope it doesn't come to a theater near you.
huffy
"May the road rise up to meet you.... May the wind be always at your back..."
Anonymous Coward
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02/15/2013 05:40 PM
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Re: <<Advancing Bird Flu-H5N1...Now following MERS and Ebola approaching PANDEMICS>>>
[link to www.bbc.co.uk]
third member f same family falls to stars further strengthening human to human transmission claim
Anonymous Coward
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02/15/2013 05:41 PM
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[link to www.bbc.co.uk]
third member f same family falls to stars further strengthening human to human transmission claim
 Quoting: Anonymous Coward 34490161
Anonymous Coward
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02/15/2013 05:42 PM
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[link to www.bbc.co.uk]
third member f same family falls to stars further strengthening human to human transmission claim
 Quoting: Anonymous Coward 34490161

A third member of a family in the UK has been infected with a new respiratory illness similar to the deadly Sars virus, officials say.

It strengthens evidence that the virus can spread between people, however experts say the risk to the general population remains small.
Anonymous Coward
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02/15/2013 05:47 PM
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[link to au.news.yahoo.com]
Anonymous Coward
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02/15/2013 07:12 PM
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H5N1 in Germany.

See Yahoo or Reuters news.
arkay (OP)

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02/16/2013 07:39 PM

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H5N1 in Germany.

See Yahoo or Reuters news.
 Quoting: Anonymous Coward 1839550



Looks like more migratory bird vectoring.

Heres an extract.

Bird flu at German farm, ducks slaughteredAAP
February 17, 2013, 10:08 am tweet0

About 14,000 ducks at a German farm are being slaughtered following a bird flu outbreak.

A federal laboratory confirmed the H5N1 virus was detected at the farm near Seelow, east of Berlin - the first such finding in Germany in more than three years.

On Saturday, officials started slaughtering the farm's ducks. Local council spokesman Tobias Seyfarth told news agency DPA that all poultry within a one kilometre radius of the facility will be kept under observation for the next 21 days, with owners told to keep their birds where they are and report any symptoms.


Link here...

[link to au.news.yahoo.com]
Anonymous Coward
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02/17/2013 01:52 PM
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[link to fluboard.rhizalabs.com]
Anonymous Coward
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02/17/2013 05:12 PM
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[link to crofsblogs.typepad.com]

this is a worrying development
Anonymous Coward
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02/17/2013 05:24 PM
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[link to authorityempire.com]

the suggestion here is this saudi sara is an evolution on the china sara Hcov
is a mutation
Anonymous Coward
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02/17/2013 05:28 PM
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hCoV-EMC .......
Anonymous Coward
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02/17/2013 05:32 PM
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Re: <<Advancing Bird Flu-H5N1...Now following MERS and Ebola approaching PANDEMICS>>>
[link to www.recombinomics.com]


important notes here
Anonymous Coward
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02/17/2013 05:33 PM
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[link to www.recombinomics.com]


important notes here
 Quoting: Anonymous Coward 34632130

Commentary
Novel Coronavirus H1N1pdm09 Dual Infection In UK Case
Recombinomics Commentary 17:00
February 11, 2013

The United Kingdom (UK) has informed WHO of a confirmed case with infection of the novel coronavirus (NCoV). The case is a UK resident who developed symptoms of illness on 26 January 2013. Laboratory investigations on respiratory specimens have revealed both an Influenza A(H1N1)pdm09 infection and a confirmed NCoV infection. He is hospitalized in intensive care unit.

Preliminary investigation reveals that the patient had a history of travel to Pakistan and Saudi Arabia. Further investigation into the case is ongoing.

The above comments from the WHO update indicate the latest novel coronavirus case (UK resident who traveled to the Middle East and Pakistan) was dually infected with H1N1pdm09, which is widespread in the Middle East and eastern Europe.

This development raises serious concerns that the novel coronavirus is widespread, but is being missed because of the detection of H1N1pdm09.

The dual infection would enhance transmission, but significantly decrease detection.
Anonymous Coward
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02/17/2013 05:34 PM
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Novel coronavirus infection – update

11 FEBRUARY 2013 - The United Kingdom (UK) has informed WHO of a confirmed case with infection of the novel coronavirus (NCoV). The case is a UK resident who developed symptoms of illness on 26 January 2013. Laboratory investigations on respiratory specimens have revealed both an Influenza A(H1N1)pdm09 infection and a confirmed NCoV infection. He is hospitalized in intensive care unit.

Preliminary investigation reveals that the patient had a history of travel to Pakistan and Saudi Arabia. Further investigation into the case is ongoing.

The Health Protection Agency (HPA) has instituted stringent infection control measures around the patient and identified contacts who may have been exposed to the patient during his illness.

This is a sporadic case and does not alter the current WHO risk assessment on NCoV but the new case does indicate that the virus is persistent. As of 11 February 2013, a total of 10 confirmed cases of human infection with a novel coronavirus have been notified to WHO.

Based on the current situation and available information, WHO encourages all Member States to continue their surveillance for severe acute respiratory infections (SARI) and to carefully review any unusual patterns. Testing for the new coronavirus of patients with unexplained pneumonias, or patients with severe, progressive or complicated illness not responding to treatment, should be considered especially in persons residing in or returning from the Arabian peninsula and neighboring countries.

Any clusters of SARI or SARI in health care workers should be thoroughly investigated, regardless of where in the world they occur.

New human cases and clusters should be promptly reported both to national health authorities and to WHO.

WHO does not advise special screening at points of entry with regard to this event nor does it recommend that any travel or trade restrictions are applied.
Anonymous Coward
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02/17/2013 05:37 PM
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Commentary
Identical Novel Beta Coronavirus Sequences Signal H2H
Recombinomics Commentary 21:00
November 30, 2012

A paper “Recovery from severe coronavirus infection” published in the Saudi Med J by Dr Ziad Memesh and colleagues describes the third confirmed novel betacornavirus case (45M), which was announced by the Kingdom of Saudi Arabia Ministry of Health on November 4, the date of discharge.

The case is a gym-teacher from Riyadh, Saudi Arabia who developed symptoms on October 9. His conditioned worsened and he visited the emergency room on October 10 and 12. His conditioned continued to worsen and was intubated for mechanical ventilation on October 13 and transferred to the ICU. Kidney failure led to hemodialysis between October 15-23.

The novel betacornavirus was detected in respiratory samples using PCR tests for the upstream region of the E gene as well as ORF1B and N genes. The paper included two sets of sequences for two regions, a 311 Bp fragment of ORF1B (positions 18105-18414) and a 409 BP fragment of E (positions 27278-27868). These sequences were from samples collected from case 1 (60M businessman from Bisha, treated in Jeddah, confirmed at Erasmus Medical Center in the Netherlands) and case 3 described above. The two sets of sequences were identical to the updated public sequence for case 1 (JX869059.2) as well as case 2 (49M businessman from Doha, Qatar and treated in London).

The identity of the two regions in all three cases once again indicates these cases were not infected by an animal source. Media reports continue to cite the relatedness to bat coronaviruses, which were identified under an enhanced surveillance program to identify the natural reservoir for SARS CoV. Bats were found to host a wide variety of coronaviruses including the two members of class 2c found in Guangdong Province, China (HKU4 and HKU5). These cases were identified using the same pan-coronavirus PCR tested used to identify the first two recent human cases. However, for the two regions above the three cases from widely separated areas in two countries (Bisha, Doha, Riyadh) were identical, yet had more than 20% mismatches for the most closely related bat class 2c coronaviruses (HKU4 and HKU5).

Moreover, WHO has now reported two confirmed cases from an ICU outbreak in Zarka, Jordan in April. The novel betacornavirus spread throughout the unit and infected at least seven nurses and a doctor as well as the brother of a fatally infected nurse. The ECDC report cited one fatality, but WHO has already confirmed two fatalities.

Release of sequences from the Jordan outbreak would be useful.
Anonymous Coward
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02/17/2013 05:39 PM
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Beta Coronavirus H2H Transmission In Riyadh Cluster
Recombinomics Commentary 12:30
February 15, 2013

Case No. Date of Onset Age (years) Sex Probable place of infection Date reported Outcome Part of a cluster?
1 April 2012 45 F Jordan 30/11/12 Dead yes - hospital A
2 April 2012 25 M Jordan 30/11/12 Dead yes - hospital A
3 13/06/12 60 M KSA 20/09/12 Dead no
4 03/09/12 49 M Qatar/ KSA 23/09/12 Alive/Hosp no
5 10/10/2012 45 M KSA 04/11/12 Alive no
6 12/10/12 45 M Qatar 23/11/12 Alive no
7 3-5/11/2012 31 M KSA 20/11/12 Alive yes - family A
8 28/10/12 39 M KSA 23/11/12 Dead yes - family A
9 October 2012 not known M KSA 28/11/12 Dead yes - family A
10 24 /1/2013 60 M Pakistan/KSA 8/1/13 Alive/Hosp yes - family B
11 6/2/2013 not known M UK 12/02/13 Alive/Hosp yes - family B

As seen above, the ECDC has updated its table of confirmed beta coronavirus cases, which includes additional information on the ages of the cases as well as disease onset dates, which provide compelling data for the human to human transmission in the Riyadh cluster (cases 7-9 designated as “family A”, but in reverse chronological order).

A cluster of cases linked to a rare disease can be due to human to human (H2H) transmission within the cluster or infection by a common source. When the source is unknown, the best data for distinguishing between the two scenarios is the disease onset dates, which are still lacking for many of the cases, but the dates of death, when coupled with the known disease onset dates can be used to distinguish between a common source and human to human transmission.

The new data for the cluster on Riyadh, when combined with reliable media reports, paint a relatively clear transmission scenario for family A, which included 3 confirmed cases and 1 probable case. Media reports had indicated that the index case (70M) was the father of the second fatal case (39M), which are cases 9 and 8, respectively, in the above list. Although the disease onset date for the father is listed as October, and the son is listed as October 28, media reports indicated that father died 4 days prior to the son, supporting infection of the son by his father.

However, the most compelling data for H2H transmission in family A is the disease onset date for the surviving family member (31M, case 7, and likely another son) which is listed as between November 3-5. The disease onset time gap between the two brothers (39M and 31M) provides strong support for H2H transmission, which is further supported by the earlier date of death for the father. The fourth family member is designated as “probable” by WHO, suggesting a false negative on testing. Similar testing issues surfaced for the father, who was also initially classified as a probable case, but was subsequently confirmed.

Although the updated table includes disease onset dates which strongly support H2H transmission in family A, no disease onset is listed for the two fatal cases in Jordan (other than the month of April). These two cases were part of a larger cluster of a dozen cases linked to an ICU. The size and severity of the cluster created considerable concern. Two health care workers died (nurse, 45F and intern, 25M) while all but one of the reported symptomatic contacts were hospitalized, which included the son of the index case. The cases were described as SARS-like and samples were initially sent to labs in France and Egypt for identification of the etiology agent, signaling significant concerns.

Subsequent re-testing in Egypt (by NAMRU-3), using probes targeting the novel beta 2c coronavirus, confirmed the two fatal cases, Failure to confirm the virus in the other hospitalized cases led to a “probable” designation by WHO. The dates of death for the two confirmed cases were 1 week apart, further supporting H2H transmission within the ICU. WHO has not cited the number of probable cases in Jordan, or given disease onset dates, but like family A in the above list, it is likely that the disease onset dates for the two confirmed cases and the dozen probable cases will have significant time gaps. signaling H2H transmission.

Similarly, the third listed cluster (family B) has significant time gaps in disease onset date, and symptoms developed in two different counties (Saudi Arabia and England) further signaling H2H transmission.

These clusters, with significant gaps in disease onset dates, seriously challenge the ECDC risk assessment analysis, which ignores the probable cases and suggests that the absence of confirmed mild cases supports an animal or environmental origin.

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