Another recent post highlighted the observation that H5N1 avian influenza in the Egyptian region might be mutating to a closer H2H transmissibility.
This next article by the worlds top H5N1 authority also looks at this possible mutation from a technical perspective.
The article is a little technical, but not so much as to be beyond the range of general comprehension for we lay people.Egyptian H5N1 Influenza Viruses—Cause for Concern?
Gabriele Neumann1, Catherine A. Macken2, Alexander I. Karasin1, Ron A. M. Fouchier3, Yoshihiro Kawaoka1,4,5,6,7*
1 Department of Pathobiological Sciences, University of Wisconsin-Madison, Madison, Wisconsin, United States of America, 2 Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America, 3 Department of Virology, Erasmus Medical Center, Rotterdam, The Netherlands, 4 ERATO Infection-Induced Host Responses Project, Saitama, Japan, 5 Department of Special Pathogens, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan, 6 Department of Microbiology and Infectious Diseases, Kobe University, Hyogo, Japan, 7 Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Citation: Neumann G, Macken CA, Karasin AI, Fouchier RAM, Kawaoka Y (2012) Egyptian H5N1 Influenza Viruses—Cause for Concern? PLoS Pathog 8(11): e1002932. doi:10.1371/journal.ppat.1002932
Editor: Glenn F. Rall, The Fox Chase Cancer Center, United States of America
Published: November 15, 2012
Copyright: © 2012 Neumann et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Funding: Funding came from a grant from the Bill & Melinda Gates foundation (#OPPGH5383) (G.N., Y.K., C.M.) and from NIAID-NIH contract HHSN266200700010C (R.F., G.N., Y.K). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: I have read the journal's policy and have the following conflicts: G.N. was a consultant for Theraclone and is a Co-Founder of FluGen. Y.K. has received speaker's honoraria from Chugai Pharmaceuticals, Novartis, Daiichi-Sankyo, Toyama Chemical, Wyeth, and GlaxoSmithKline; grant support from Chugai Pharmaceuticals, Daiichi Sankyo Pharmaceutical, Toyama Chemical, Otsuka Pharmaceutical Co., Ltd.; is a consultant for Theraclone and Crucell, and is a Co-Founder of FluGen. This does not alter our adherence to all the PLOS Pathogens policies on sharing data and materials. The other authors declare that they have no competing interests.
* E-mail: Kawaokay@svm.vetmed.wisc.edu
Highly pathogenic avian H5N1 influenza viruses are now enzootic in parts of Southeast Asia and the Middle East. Occasionally, these viruses transmit to humans and cause severe respiratory disease and fatalities. Currently, these viruses are not efficiently transmitted from person to person, although limited human-to-human transmission may have occurred –.
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