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I worked in the pharmaceutical industry for 20 years. Ask me a question

 
Anonymous Coward
User ID: 24092166
United States
09/30/2012 09:52 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
how is old stock disposed of?
Fred
User ID: 24397363
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09/30/2012 09:53 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
WTF did they quit making leg openers, i mean qualudes, they were the best party drug?
 Quoting: thetrickybigguy


Way before my time! But my understanding was that the FDA pulled the drug from the market because it became recreational and was being used "off lable". SSRI's are the new gold standard.
 Quoting: Anonymous Coward 16088471


Aside from meth, I personally no of no other drug that has done so much damage. Worse they are highly addictive, but without patients being informed. When rapid withdrawal fails they are told they must take them for life.

I know people personally who consider Effexor withdrawal to be far worse than the hardest opiates.
Anonymous Coward (OP)
User ID: 16088471
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09/30/2012 09:55 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
Guys, please let not ask this guy questions he can't answer like about Satan and the antichrist. We finally got a real insider to answer our questions and curiosities!

So, how are psychiatric drugs exactly manufactured when they don't know what chemical imbalances are exactly causing the dysfunction? And why do so many of these drugs use fluoride as a component, like Prozac? Is it true that they have an effect on some glands of the body, like the pineal gland, hampering the natural production of melatonin and the like?

Also, are there instances were big pharma knows of cheap cures for certain diseases, but chooses to ignore them and sell the more expensive ones? For example, is niacin really helpful in stopping addiction to substances, as some claim?

thanks in advance.
 Quoting: Anonymous Coward 24681494


pyschiatric drugs is NOT an exact science. May times we simply do not know why a drug works only that that it has a desirable effect on obsevable behaviors.

Fluoride is used as an ingredient because it assists as a part of a drug delivery system in getting the active ingredient of a SSRI through the BBB (blood brain barrier).
Anonymous Coward (OP)
User ID: 16088471
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09/30/2012 09:57 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
how is old stock disposed of?
 Quoting: Anonymous Coward 24092166


Two ways. 1. incinerated. 2. shipped over seas if it is less than 18 months expired.
Anonymous Coward (OP)
User ID: 16088471
United States
09/30/2012 09:59 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
WTF did they quit making leg openers, i mean qualudes, they were the best party drug?
 Quoting: thetrickybigguy


Way before my time! But my understanding was that the FDA pulled the drug from the market because it became recreational and was being used "off lable". SSRI's are the new gold standard.
 Quoting: Anonymous Coward 16088471


Aside from meth, I personally no of no other drug that has done so much damage. Worse they are highly addictive, but without patients being informed. When rapid withdrawal fails they are told they must take them for life.

I know people personally who consider Effexor withdrawal to be far worse than the hardest opiates.
 Quoting: Fred 24397363


The Effexor side effect profile is harsh. Many suicides when patients DC'ed this drug.
Anonymous Coward (OP)
User ID: 16088471
United States
09/30/2012 10:06 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
Guys, please let not ask this guy questions he can't answer like about Satan and the antichrist. We finally got a real insider to answer our questions and curiosities!

So, how are psychiatric drugs exactly manufactured when they don't know what chemical imbalances are exactly causing the dysfunction? And why do so many of these drugs use fluoride as a component, like Prozac? Is it true that they have an effect on some glands of the body, like the pineal gland, hampering the natural production of melatonin and the like?

Also, are there instances were big pharma knows of cheap cures for certain diseases, but chooses to ignore them and sell the more expensive ones? For example, is niacin really helpful in stopping addiction to substances, as some claim?

thanks in advance.
 Quoting: Anonymous Coward 24681494


Sorry I missed the last part of your question.

Yes, there is in fact a cure for type 1 Diabetes but we will NEVER see it.

B3 is always good to take!
Anonymous Coward
User ID: 24637436
United States
09/30/2012 10:16 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.

Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA.

Diabetes Center and the Department of Medicine, University of California, San Francisco, CA 94143, USA.

Abstract
The recent development of small-molecule tyrosine kinase (TK) inhibitors offers increasing opportunities for the treatment of autoimmune diseases. In this study, we investigated the potential of this new class of drugs to treat and cure type 1 diabetes (T1D) in the NOD mouse. Treatment of prediabetic and new onset diabetic mice with imatinib (Gleevec) prevented and reversed type 1 diabetes. Similar results were observed with sunitinib (Sutent), an additional approved multikinase inhibitor, suggesting that the primary target of imatinib, c-Abl, was not essential in blocking disease in this model. Additional studies with another TK inhibitor, PLX647 (targeting c-Kit and c-Fms) or an anti-c-Kit mAb showed only marginal efficacy whereas a soluble form of platelet-derived growth factor receptor (PDGFR), PDGFRbetaIg, rapidly reversed diabetes. These findings strongly suggest that inhibition of PDGFR is critical to reverse diabetes and highlight a crucial role of inflammation in the development of T1D. These conclusions were supported by the finding that the adaptive immune system was not significantly affected by imatinib treatment. Finally, and most significantly, imatinib treatment led to durable remission after discontinuation of therapy at 10 weeks in a majority of mice. Thus, long-term efficacy and tolerance is likely to depend on inhibiting a combination of tyrosine kinases supporting the use of selective kinase inhibitors as a new, potentially very attractive approach for the treatment of T1D.
Anonymous Coward
User ID: 19726321
United States
09/30/2012 10:21 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
how is it that all kinds of information can correlate vaccines to autism, yet there is no proof of any link between autism and vaccinations???
Anonymous Coward (OP)
User ID: 16088471
United States
09/30/2012 10:24 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice.

Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA.

Diabetes Center and the Department of Medicine, University of California, San Francisco, CA 94143, USA.

Abstract
The recent development of small-molecule tyrosine kinase (TK) inhibitors offers increasing opportunities for the treatment of autoimmune diseases. In this study, we investigated the potential of this new class of drugs to treat and cure type 1 diabetes (T1D) in the NOD mouse. Treatment of prediabetic and new onset diabetic mice with imatinib (Gleevec) prevented and reversed type 1 diabetes. Similar results were observed with sunitinib (Sutent), an additional approved multikinase inhibitor, suggesting that the primary target of imatinib, c-Abl, was not essential in blocking disease in this model. Additional studies with another TK inhibitor, PLX647 (targeting c-Kit and c-Fms) or an anti-c-Kit mAb showed only marginal efficacy whereas a soluble form of platelet-derived growth factor receptor (PDGFR), PDGFRbetaIg, rapidly reversed diabetes. These findings strongly suggest that inhibition of PDGFR is critical to reverse diabetes and highlight a crucial role of inflammation in the development of T1D. These conclusions were supported by the finding that the adaptive immune system was not significantly affected by imatinib treatment. Finally, and most significantly, imatinib treatment led to durable remission after discontinuation of therapy at 10 weeks in a majority of mice. Thus, long-term efficacy and tolerance is likely to depend on inhibiting a combination of tyrosine kinases supporting the use of selective kinase inhibitors as a new, potentially very attractive approach for the treatment of T1D.
 Quoting: Anonymous Coward 24637436


They only cite the in vtro here (lab rats). While in fact in vivo (human trials) have already been conducted outside the US.
Anonymous Coward (OP)
User ID: 16088471
United States
09/30/2012 10:27 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
how is it that all kinds of information can correlate vaccines to autism, yet there is no proof of any link between autism and vaccinations???
 Quoting: Anonymous Coward 19726321


Great question! My personal bias is that eventually there WILL BE and observable causitive correlation between the two. But for now the science continues, inexact and slow as it sometimes is.
Anonymous Coward (OP)
User ID: 16088471
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09/30/2012 10:31 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
Here'a a little known fact. On average, about 12% of a PHARMA salesforce file for a divorce after a national sales meeting.
Flew
User ID: 19547842
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09/30/2012 11:05 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
*Actual* shelf life of Synthroid? And any good alternatives in case of shortages or disaster scenarios?
Anonymous Coward (OP)
User ID: 16088471
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09/30/2012 11:41 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
*Actual* shelf life of Synthroid? And any good alternatives in case of shortages or disaster scenarios?
 Quoting: Flew 19547842


Synthroid (solid form) is actually one of the exceptions. Generally speaking it is relativly unstable (loses potency) as it nears its expiration date. I would not recomend taking it after it has expired. Unforunately there are no highly effective FDA approved substitutes OTC.
Anonymous Coward
User ID: 24681494
United Kingdom
09/30/2012 04:36 PM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
Guys, please let not ask this guy questions he can't answer like about Satan and the antichrist. We finally got a real insider to answer our questions and curiosities!

So, how are psychiatric drugs exactly manufactured when they don't know what chemical imbalances are exactly causing the dysfunction? And why do so many of these drugs use fluoride as a component, like Prozac? Is it true that they have an effect on some glands of the body, like the pineal gland, hampering the natural production of melatonin and the like?

Also, are there instances were big pharma knows of cheap cures for certain diseases, but chooses to ignore them and sell the more expensive ones? For example, is niacin really helpful in stopping addiction to substances, as some claim?

thanks in advance.
 Quoting: Anonymous Coward 24681494


Sorry I missed the last part of your question.

Yes, there is in fact a cure for type 1 Diabetes but we will NEVER see it.

B3 is always good to take!
 Quoting: Anonymous Coward 16088471



Thank you for your answers

A cure for type 1 Diabetes?? That's insane!! My cousin has that! What's the cure and story behind it, and why will we never see it? Is it because it makes more profit to sell insulin shots for life???
Anonymous Coward
User ID: 1112115
United States
10/03/2012 10:08 AM
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Re: I worked in the pharmaceutical industry for 20 years. Ask me a question
Do you know anything about MMS?

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