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Anonymous Coward User ID: 24092166 United States 09/30/2012 09:52 AM Report Abusive Post Report Copyright Violation | |
Fred User ID: 24397363 United States 09/30/2012 09:53 AM Report Abusive Post Report Copyright Violation | WTF did they quit making leg openers, i mean qualudes, they were the best party drug? Quoting: thetrickybigguy Way before my time! But my understanding was that the FDA pulled the drug from the market because it became recreational and was being used "off lable". SSRI's are the new gold standard. Aside from meth, I personally no of no other drug that has done so much damage. Worse they are highly addictive, but without patients being informed. When rapid withdrawal fails they are told they must take them for life. I know people personally who consider Effexor withdrawal to be far worse than the hardest opiates. |
Anonymous Coward (OP) User ID: 16088471 United States 09/30/2012 09:55 AM Report Abusive Post Report Copyright Violation | Guys, please let not ask this guy questions he can't answer like about Satan and the antichrist. We finally got a real insider to answer our questions and curiosities! Quoting: Anonymous Coward 24681494 So, how are psychiatric drugs exactly manufactured when they don't know what chemical imbalances are exactly causing the dysfunction? And why do so many of these drugs use fluoride as a component, like Prozac? Is it true that they have an effect on some glands of the body, like the pineal gland, hampering the natural production of melatonin and the like? Also, are there instances were big pharma knows of cheap cures for certain diseases, but chooses to ignore them and sell the more expensive ones? For example, is niacin really helpful in stopping addiction to substances, as some claim? thanks in advance. pyschiatric drugs is NOT an exact science. May times we simply do not know why a drug works only that that it has a desirable effect on obsevable behaviors. Fluoride is used as an ingredient because it assists as a part of a drug delivery system in getting the active ingredient of a SSRI through the BBB (blood brain barrier). |
Anonymous Coward (OP) User ID: 16088471 United States 09/30/2012 09:57 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward (OP) User ID: 16088471 United States 09/30/2012 09:59 AM Report Abusive Post Report Copyright Violation | WTF did they quit making leg openers, i mean qualudes, they were the best party drug? Quoting: thetrickybigguy Way before my time! But my understanding was that the FDA pulled the drug from the market because it became recreational and was being used "off lable". SSRI's are the new gold standard. Aside from meth, I personally no of no other drug that has done so much damage. Worse they are highly addictive, but without patients being informed. When rapid withdrawal fails they are told they must take them for life. I know people personally who consider Effexor withdrawal to be far worse than the hardest opiates. The Effexor side effect profile is harsh. Many suicides when patients DC'ed this drug. |
Anonymous Coward (OP) User ID: 16088471 United States 09/30/2012 10:06 AM Report Abusive Post Report Copyright Violation | Guys, please let not ask this guy questions he can't answer like about Satan and the antichrist. We finally got a real insider to answer our questions and curiosities! Quoting: Anonymous Coward 24681494 So, how are psychiatric drugs exactly manufactured when they don't know what chemical imbalances are exactly causing the dysfunction? And why do so many of these drugs use fluoride as a component, like Prozac? Is it true that they have an effect on some glands of the body, like the pineal gland, hampering the natural production of melatonin and the like? Also, are there instances were big pharma knows of cheap cures for certain diseases, but chooses to ignore them and sell the more expensive ones? For example, is niacin really helpful in stopping addiction to substances, as some claim? thanks in advance. Sorry I missed the last part of your question. Yes, there is in fact a cure for type 1 Diabetes but we will NEVER see it. B3 is always good to take! |
Anonymous Coward User ID: 24637436 United States 09/30/2012 10:16 AM Report Abusive Post Report Copyright Violation | Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA. Diabetes Center and the Department of Medicine, University of California, San Francisco, CA 94143, USA. Abstract The recent development of small-molecule tyrosine kinase (TK) inhibitors offers increasing opportunities for the treatment of autoimmune diseases. In this study, we investigated the potential of this new class of drugs to treat and cure type 1 diabetes (T1D) in the NOD mouse. Treatment of prediabetic and new onset diabetic mice with imatinib (Gleevec) prevented and reversed type 1 diabetes. Similar results were observed with sunitinib (Sutent), an additional approved multikinase inhibitor, suggesting that the primary target of imatinib, c-Abl, was not essential in blocking disease in this model. Additional studies with another TK inhibitor, PLX647 (targeting c-Kit and c-Fms) or an anti-c-Kit mAb showed only marginal efficacy whereas a soluble form of platelet-derived growth factor receptor (PDGFR), PDGFRbetaIg, rapidly reversed diabetes. These findings strongly suggest that inhibition of PDGFR is critical to reverse diabetes and highlight a crucial role of inflammation in the development of T1D. These conclusions were supported by the finding that the adaptive immune system was not significantly affected by imatinib treatment. Finally, and most significantly, imatinib treatment led to durable remission after discontinuation of therapy at 10 weeks in a majority of mice. Thus, long-term efficacy and tolerance is likely to depend on inhibiting a combination of tyrosine kinases supporting the use of selective kinase inhibitors as a new, potentially very attractive approach for the treatment of T1D. |
Anonymous Coward User ID: 19726321 United States 09/30/2012 10:21 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward (OP) User ID: 16088471 United States 09/30/2012 10:24 AM Report Abusive Post Report Copyright Violation | Tyrosine kinase inhibitors reverse type 1 diabetes in nonobese diabetic mice. Quoting: Anonymous Coward 24637436 Louvet C, Szot GL, Lang J, Lee MR, Martinier N, Bollag G, Zhu S, Weiss A, Bluestone JA. Diabetes Center and the Department of Medicine, University of California, San Francisco, CA 94143, USA. Abstract The recent development of small-molecule tyrosine kinase (TK) inhibitors offers increasing opportunities for the treatment of autoimmune diseases. In this study, we investigated the potential of this new class of drugs to treat and cure type 1 diabetes (T1D) in the NOD mouse. Treatment of prediabetic and new onset diabetic mice with imatinib (Gleevec) prevented and reversed type 1 diabetes. Similar results were observed with sunitinib (Sutent), an additional approved multikinase inhibitor, suggesting that the primary target of imatinib, c-Abl, was not essential in blocking disease in this model. Additional studies with another TK inhibitor, PLX647 (targeting c-Kit and c-Fms) or an anti-c-Kit mAb showed only marginal efficacy whereas a soluble form of platelet-derived growth factor receptor (PDGFR), PDGFRbetaIg, rapidly reversed diabetes. These findings strongly suggest that inhibition of PDGFR is critical to reverse diabetes and highlight a crucial role of inflammation in the development of T1D. These conclusions were supported by the finding that the adaptive immune system was not significantly affected by imatinib treatment. Finally, and most significantly, imatinib treatment led to durable remission after discontinuation of therapy at 10 weeks in a majority of mice. Thus, long-term efficacy and tolerance is likely to depend on inhibiting a combination of tyrosine kinases supporting the use of selective kinase inhibitors as a new, potentially very attractive approach for the treatment of T1D. They only cite the in vtro here (lab rats). While in fact in vivo (human trials) have already been conducted outside the US. |
Anonymous Coward (OP) User ID: 16088471 United States 09/30/2012 10:27 AM Report Abusive Post Report Copyright Violation | how is it that all kinds of information can correlate vaccines to autism, yet there is no proof of any link between autism and vaccinations??? Quoting: Anonymous Coward 19726321 Great question! My personal bias is that eventually there WILL BE and observable causitive correlation between the two. But for now the science continues, inexact and slow as it sometimes is. |
Anonymous Coward (OP) User ID: 16088471 United States 09/30/2012 10:31 AM Report Abusive Post Report Copyright Violation | |
Flew User ID: 19547842 United States 09/30/2012 11:05 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward (OP) User ID: 16088471 United States 09/30/2012 11:41 AM Report Abusive Post Report Copyright Violation | *Actual* shelf life of Synthroid? And any good alternatives in case of shortages or disaster scenarios? Quoting: Flew 19547842 Synthroid (solid form) is actually one of the exceptions. Generally speaking it is relativly unstable (loses potency) as it nears its expiration date. I would not recomend taking it after it has expired. Unforunately there are no highly effective FDA approved substitutes OTC. |
Anonymous Coward User ID: 24681494 United Kingdom 09/30/2012 04:36 PM Report Abusive Post Report Copyright Violation | Guys, please let not ask this guy questions he can't answer like about Satan and the antichrist. We finally got a real insider to answer our questions and curiosities! Quoting: Anonymous Coward 24681494 So, how are psychiatric drugs exactly manufactured when they don't know what chemical imbalances are exactly causing the dysfunction? And why do so many of these drugs use fluoride as a component, like Prozac? Is it true that they have an effect on some glands of the body, like the pineal gland, hampering the natural production of melatonin and the like? Also, are there instances were big pharma knows of cheap cures for certain diseases, but chooses to ignore them and sell the more expensive ones? For example, is niacin really helpful in stopping addiction to substances, as some claim? thanks in advance. Sorry I missed the last part of your question. Yes, there is in fact a cure for type 1 Diabetes but we will NEVER see it. B3 is always good to take! Thank you for your answers A cure for type 1 Diabetes?? That's insane!! My cousin has that! What's the cure and story behind it, and why will we never see it? Is it because it makes more profit to sell insulin shots for life??? |
Anonymous Coward User ID: 1112115 United States 10/03/2012 10:08 AM Report Abusive Post Report Copyright Violation | |