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Women left at the mercy of untested prescription drugs as most drugs are only tested on men

 
Anonymous Coward
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India
11/12/2012 08:51 AM
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Women left at the mercy of untested prescription drugs as most drugs are only tested on men
Many pills most commonly used daily by women — such as painkillers and heart drugs — were never tested on females, pregnant or otherwise, before being put on the market, researchers have revealed.

This may explain who women are likelier to suffer side-effects from prescribed drugs than men, suggests some researchers.

“Women are about twice as likely to suffer side-effects from prescribed drugs as men,” the Daily Mail quoted Dr Anita Holdcroft, a consultant anaesthetist at Imperial College London as saying.

Dr Holdcroft arrived at his figure by studying the latest official figures on reported side-effects, released earlier this year by the official drugs watchdog, the Medicines and Healthcare Products Regulatory Agency (MHRA).

Harmful side-effects are reported to the agency by doctors and patients.
Of course, men also react badly to drugs. But the fact that they report only half as many bad side-effects indicates women’s problems differ widely in their scale and nature.

It may also be that women perceive side-effects differently than men — they may be more alert to their bodies’ responses — but again, this has not been investigated properly.

Even with the most common drugs, such as non-steroidal anti-inflammatory painkillers, “we do not know how they affect women differently, even though these drugs are potentially dangerous,” said Dr Holdcroft, who is a member of the Medical Women’s Foundation, the largest organisation of women doctors in the UK.

There are no legal barriers to women participating in clinical trials, but practices in the pharmaceutical industry means they are often excluded.
This is particularly true when drugs are safety-tested in humans for the first time, with dosages gradually increased.

“Women are more variable as research subjects. They have hormonal cycles and child-bearing, and their responses to drugs may change again after the menopause,” said Dr Holdcroft.

Drug researchers often avoid testing such variations because they complicate results, which is not what drug companies want.

As the first stage of clinical trials are aimed mainly at persuading regulators that a medicine is safe and effective enough to be licensed for profitable commercial use, drug company researchers focus on the more physically stable male sex.

Independent pharmaceutical consultant Dr Peter Dewland, who has been involved in running more than 100 human drug trials, said nearly all these studies have been on men — at the drug companies’ request.


[link to www.dailymail.co.uk]

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