Chromosome 6: CNR1 & HLA-B27(AS) Connection?

..Cannabinoid 1 Receptor (CNR1) and HLA-B27 (common in those with AS[Ankylosing Spondylitis]), both located on Chromosome 6..

I noticed this 'connection' in passing, while researching my condition..

Can anyone offer insight about what this might mean?

From what I've found, the HLA-B27 'marker' is not very common. But what is interesting to me is the CNR1 aspect.. while cannabis does provide relief, I would testify that cannabis (The Mother Plant) not only helps me physically, but other ways, as well.

On a side note; I always thought, even as a social user, that cannabis didn't get me 'high'. It's always made me feel level or 'normal'. How I *should feel all the time, without it. It felt like it had been missing the whole time..

AS
[link to ghr.nlm.nih.gov]

CNR1
[link to www.ncbi.nlm.nih.gov]

Chromosome 6
[link to ghr.nlm.nih.gov]

Look into Vitamin D.

In its powerful hormone form called Calcitriol basically acts as DNA repair and maintenance hormone.

[link to www.vitamindcouncil.org]

Chronic vitamin D deficiency in early life made have caused AS. While Vitamin D is not a cure, it's supposed to be effective treatment at the right dosage to prevent lesions.

Last Edited by AlcoholicRunner on 11/27/2012 11:29 AM

Thanks for that AR!

I found out some interesting things about vit. D, in my searches about Rh- blood types. Which run heavy in my fam.. but for about five years, I was going thru 2 gallons of 2% every week. I don't do that anymore, in fact, I don't drink it much at all, now. I did feel like it helped. I actually seemed to 'crave' it, and it seemed to be much better than other things, as far as fluids. *After I had cut back on my own, I found out that too much vit. D is not good (of course, too much of anything..)

Vit. D supplements would be worth looking into?

hmm, I though there were many 'medical industry' type here at GLP..

Nobody else wants to touch on this?

Possibly for good reason?

..surely I, being a lowly commoner, could not be the only person who sees a connection here.. or maybe this is rare area. maybe I'm on to something..

Just bumping this for you, Op. I don't have any information on your question.

Just did a search on +"ankylosing spondylitis" +"Vitamin D", and it might be worth looking at for relief.

Good Luck!

I am HLA B27+ also with AS, I use both. RH neg runs in family too. I am looking for all info on the subject. Thank you for the post and thread and the honesty.

Thank You for your responses!

This isn't something I just 'put together'
It has piqued my curiosity for over a year. No mention of it anywhere, but it seems plain to me that this might be something worth looking at more closely. With my limited knowledge of genetics, I am grasping at the idea of a CNR1 'defect' or inefficiency, being a reason I experience relief from cannabis use.

I realize it sounds absurd, and I might be putting too much value on a loose coincidence..

I will use cannabis no matter what because it helps, hugely. But the truth is, it's hard to find 'the good stuff', and I couldn't afford it regularly, anyway.

I try to stay in good spirits regardless, but it's hard to convey how frustrating it is to have something work (without ANY negative side-effects), and to have that something be 'neatly' out of reach, unless within certain borders..

..but let me not skew to the tangent, this really is not meant to be about me. I just hope for some forward progression for all who suffer from this little-known-of devil, and in fact other problems which may be remedied by cannabis and its variations. We won't know until there is more research, or the *true* research is brought to light.

Thanks again!

It makes other people sleepy and groggy, it makes me energetic, helping the pain makes me more active but it does effect me different than others. It seems to dull others brains but makes mine more active. It just lifts the brain fog and the pain, but I can not do it often, I cough for at least a day after one or two puffs, I worked too many years contruction, fried my lungs. Eating it does not work for me. I sure would like to try the pot beer but could I aford it and harder to get than good bud LOL
I have not noticed any differance with the vit D but I take it every day anyway.

I have noticed almonds make it worse and drinking too much.
Do you have problems with your eyes, blurry vision? A lot of AS do. Mine swell up for a day or two often and hurt.
I have what they call reactive AS it effects my internal organs with a lot of nausia. Thats how I found pot helps, It stops the nausia instantly.

I spend most of time the pain is realy bad in a hot hot hot bath. I choose that over the harsh pain meds on my bleeding stomach.

The smoke seems to be my only option, I have considered learning to shoot up or shoot myself if it gets that bad, I have not had the courage to resort to that, but I would not hold it against others. The advanced stages of AS is a living hell. Medical help is crap at best.

Thanks for the bump and response!

No problems with eyes/vision to report. I am thankful. I think they call that aspect of the disease, Iritis(?). I have heard and read about it.

I'm not ashamed to admit that I am 'well-versed' to the drug culture, and have found that various 'street' and 'legit' drugs relive the pain and emotional grief that accompanies it. But the fact is, the only one that doesn't concern me as far as long term/daily use is The Mary..

I saw a thread earlier somewhat on-topic, and it was discussing antibiotic treatment. Some fellow made a comment alluding to the dangers of antibiotics (best I could tell, due to their tendency to make bugs resistant) and what type of future overuse of antibiotics could usher.. A reply said something along the lines of "You mean to say you are more worried about the antibiotic aspect, than the fact that a frightening number of people who die from connective tissue disorders, such as these, are by suicide?"

I'm not gonna take sides too much there, but suicidal? Let me tell you what.. I don't sit around with a gun in my mouth, and it's not all "poor me. my life is terrible. nothing goes right. what's the point!?!" But that gun has looked mighty tasty, on occasion. And truth be told, there are plenty of times that if I had had a handful of opiates, I would not be here right now.

It's not about being a coward! Anyone who struggles with this (and other chronic illnesses) knows it takes tons of courage to look towards another day with pain. The human body is resilient in many ways, but when you get to the point where you *know that every new day will bring pain, pain that affects every part of your being.. well, I don't feel I need to elaborate; but it would be about being in control, if even for an instant, and being rid of the torture. I have lost my 20's and I'm on track to losing my 30's..

I am very thankful though, for the AS community. We understand each other when others don't! : )

You might find this website interesting [link to www.RhNegativeRegistry.com] - Research on Rh-Negative Blood, AS and HLA-B27 connections :) Good Luck!

I'm a regular (lurker) at the RHReg. But it's good to know what others know! Thank You!! : )

B27 is NOT that uncommon. Certainly it is more common than say, B13 and B39 (both of which I have).

Are you Rh negative, OP?

Never mind; I scrolled down and see that you are.

What about gut disorders -- ulcerative colitis, IBS?

..excuse my choice of wording : P

what I meant was, not so much a common thing (HLA-B27), of course not to say 'rare', necessarily.. po-tay-to/po-tah-to, I suppose..

And yes, pappy had/has ulcerative colitis. Supposedly onset from him 'swallowing of tooth infection'..

And yes, I am aware of UC/AS connection. Thanks!

**disclaimer**

I have done my homework to the fullest! ; )

..thread title is what I B most concerned about. because the *only* place (I have found) that put what I'm inquiring about on the same page, is ironically, Wikipedia..

I understand it is terrible form to do this, but..


[link to en.wikipedia.org]

OK.

But why the concern? You have already stated that cannibis helps you and you will continue to use it no matter what. So who cares? Is this just an intellectual inquiry?

Well to be honest, it's about answers. As I stated, this is bigger than just me.. Im curious about what I don't understand, especially if there seems to be 'relation'

If you can't see what I'm saying/asking, then I don't think you can help. But Thank You! : )

..Lowered Expecta-ations..

I think what OP may be trying to understand is, if there is a cure potential, not just a treatment here.

^^+1 !!Thank You!! +1^^

Cheers! : )

Quote; I am very thankful though, for the AS community. We understand each other when others don't! : )

Where did you find an AS community? I am on my own here. Can not even find a doctor to deal with it.

Hello!

I am so sorry to hear you are dealing with this alone.. Many who have this condition will tell you that sometimes even getting diagnosed can be a pain (no pun intended).

First, if you haven't already, you should check into a specialist of Rheumatology. Fam docs or general docs will likely be of little help. I realize that depending on area, finding a Rheumatologist may not be easy either. But that is your starting point *if you haven't started there..

As far as community, I may have overstated that a bit. As you know by now, this condition is not well known of. But there are a few places you can go to for info and ideas/guidance. And these people understand, because they are going thru it too!

[link to www.kickas.org]

this is a good place for info and people, they also have a facebook page

RH registry is another site with info/people. Supposedly there is some connection between RH- blood type and HLA-B27.. someone posted the link to that site, above

Also, crazy as it might sound, Youtube.. Type ankylosing spondylitis into the search field.. there are some people there that make videos. Be sure to read comments as well!

I am determined to not let this thread die. It may slow down from time to time, but I think there might be something here.. I will continue to add to this periodically, in hopes that someone will see it and maybe can help clear up the grey areas. It may end up being a fruitless effort, but I will feel better at least in letting people know that they ARE NOT ALONE in this, and that there are people out there that DO know how you/we feel!

Thank You!

..I am suddenly reminded while texting with a friend in Colo., that there is actually a strain of cannabis grown in a place called Cripple Creek, Colorado. The strain is named Cripple Creek, and is said to treat, you guessed it; Ankylosing Spondylitis. I am truly thinking possible cure over treatment. Natural treatment is definitely a start. I will see if I can find a link..

[link to modernagemedicine.com]