A Brief History of Human
Diploid Cell Strains

Human diploid cell strains (HDCSs) are batches of cells that are currently used
for different purposes, including culturing viruses for the manufacturing of vaccines.
HDCS-derived human vaccines have been licensed worldwide for polio IVP and
OVP, rabies, rubella, measles, varicella-zoster, mumps, and hepatitis A. Current vac-
cines contain extremely small traces of the original fetal DNA, while the cell strains
contain the complete fetal chromosomal set. The choice of
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