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The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium

 
Anonymous Coward
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02/23/2013 02:20 PM
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The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Some good info about this sensitive subject :



[link to www.benzobuddies.org]


[link to en.wikipedia.org (secure)]


[link to en.wikipedia.org (secure)]


From Wikipedia :


Long-term use of benzodiazepines leads to increasing physical and mental health problems, and as a result, discontinuation is recommended for many long-term users. The withdrawal syndrome from benzodiazepines can range from a mild and short-lasting syndrome to a prolonged and severe syndrome. Withdrawal symptoms leads to continued use of benzodiazepines for many years, long after the original reason for taking benzodiazepines has passed. Many patients know that the benzodiazepines no longer work for them but are unable to discontinue benzodiazepines because of withdrawal symptoms.

Withdrawal symptoms can emerge despite slow reduction but can be reduced by a slower rate of withdrawal. As a result, withdrawal rates have been recommended to be customized to each individual patient. The time needed to withdraw can vary from a couple of months to a year or more and often depends on length of use, dosage taken, lifestyle, health, and social and environmental stress factors.

Diazepam is often recommended due to its long elimination half-life and also because of its availability in low potency doses. The non-benzodiazepine Z drugs such as zolpidem, zaleplon, and zopiclone should not be used as a replacement for benzodiazepines, as they have a similar mechanism of action and can induce a similar dependence. The pharmacological mechanism of benzodiazepine tolerance and dependence is the internalization (removal) of receptor site in the brain and changes in gene transcription codes in the brain.

With long-term use and during withdrawal of benzodiazepines, treatment-emergent depression and emotional blunting may emerge and sometimes also suicidal ideation. There is evidence that the higher the dose used the more likely it is benzodiazepine use will induce these feelings. Reducing the dose or discontinuing benzodiazepines may be indicated in such cases. Withdrawal symptoms can persist for quite some time after discontinuing benzodiazepines. Some common protracted withdrawal symptoms include anxiety, depression, insomnia, and physical symptoms such as gastrointestinal, neurologic, and musculoskeletal effects. The protracted withdrawal state may still occur despite slow titration of dosage. It is believed that the protracted withdrawal effects are due to persisting neuroadapations

Cognitive status

Long-term benzodiazepine use can lead to a generalised impairment of cognition, including sustained attention, verbal learning and memory and psychomotor, visuo-motor and visuo-conceptual abilities. These effects on cognition exist, although their impact on patient's daily functioning is in most but not all cases insignificant. Transient changes in the brain have been found using neuroimaging studies, but no brain abnormalities have been found in patients treated long term with benzodiazepines. When benzodiazepine users cease long-term benzodiazepine therapy, their cognitive function improves in the first six months, although deficits may be permanent or take longer than six months to return to baseline. In the elderly, long-term benzodiazepine therapy is a risk factor for amplifying cognitive decline, although gradual withdrawal is associated with improved cognitive status. A study of alprazolam found that 8 weeks administration of alprazolam resulted in persisting deficits still detectable several weeks later.


Mental and physical health

Long-term benzodiazepine use may lead to the creation or exacerbation of physical and mental health conditions, which improve after 6 or more months of abstinence. After a period of about 3 to 6 months of abstinence after completion of a gradual-reduction regime, marked improvements in mental and physical wellbeing become apparent. For example, one study of hypnotic users gradually withdrawn from their hypnotic medication reported after 6 months of abstinence that they had less severe sleep and anxiety problems, were less distressed, and had a general feeling of improved health. Those having remained on hypnotic medication had no improvements in their insomnia, anxiety, or general health ratings. A study found that individuals having withdrawn from benzodiazepines showed a marked reduction in use of medical and mental health services.

Approximately half of patients attending mental health services for conditions including anxiety disorders such as panic disorder or social phobia may be the result of alcohol or benzodiazepine dependence. Sometimes anxiety disorders pre-existed alcohol or benzodiazepine dependence but the alcohol or benzodiazepine dependence often act to keep the anxiety disorders going and often progressively making them worse. Many people who are addicted to alcohol or prescribed benzodiazepines when it is explained to them they have a choice between ongoing ill mental health or quitting and recovering from their symptoms decide on quitting alcohol and or their benzodiazepines. It was noted that every individual has an individual sensitivity level to alcohol or sedative hypnotic drugs and what one person can tolerate without ill health another will suffer very ill health and that even moderate drinking in sensitive individuals can cause rebound anxiety syndromes and sleep disorders. A person who is suffering the toxic effects of alcohol or benzodiazepines will not benefit from other therapies or medications as they do not address the root cause of the symptoms. Recovery from benzodiazepine dependence tends to take a lot longer than recovery from alcohol but people can regain their previous good health. A review of the literature regarding benzodiazepine hypnotic drugs concluded that these drugs cause an unjustifiable risk to the individual and to public health. The risks include dependence, accidents and other adverse effects. Gradual discontinuation of hypnotics leads to improved health without worsening of sleep.

There is some evidence that long-term use of benzodiazepines is associated with an increased risk of impulsive, aggressive, and violent behaviour. A study showed that 53% of long-term benzodiazepine users showed violent characteristics, whereas only 5.3% of patients receiving psychotherapy developed violent or aggressive behavioural patterns, though controlled studies are needed to confirm this data. Daily users of benzodiazepines are also at a higher risk of experiencing psychotic symptomatology such as delusions and hallucinations. A study found that of 42 patients treated with alprazolam, up to a third of long-term users of the benzodiazepine drug alprazolam (Xanax) develop depression. Studies have shown that long-term use of benzodiazepines and the benzodiazepine receptor agonist nonbenzodiazepine Z drugs are associated with causing depression as well as a markedly raised suicide risk and an overall increased mortality risk.

A study of 50 patients who attended a benzodiazepine withdrawal clinic found that long-term use of benzodiazepines causes a wide range of psychological and physiological disorders. It was found that, after several years of chronic benzodiazepine use, a large portion of patients developed various mental and physical health problems including agoraphobia, irritable bowel syndrome, paraesthesiae, increasing anxiety, and panic attacks, which were not preexisting. The mental health and physical health symptoms induced by long-term benzodiazepine use gradually improved significantly over a period of a year following completion of a slow withdrawal. Three of the 50 patients had wrongly been given a preliminary diagnosis of multiple sclerosis when the symptoms were actually due to chronic benzodiazepine use. Ten of the patients had taken drug overdoses whilst on benzodiazepines, despite the fact that only two of the patients had any prior history of depressive symptomatology. After withdrawal, no patients took any further overdoses after 1 year post-withdrawal. The cause of the deteriorating mental and physical health in a significant proportion of patients was hypothesised to be caused by increasing tolerance where withdrawal type symptoms emerged, despite the administration of stable prescribed doses. Another theory is that chronic benzodiazepine use causes subtle increasing toxicity, which in turn leads to increasing psychopathology in long-term users of benzodiazepines.

Long-term use of benzodiazepines can induce perceptual disturbances and depersonalisation in some people, even in those taking a stable daily dosage, and it can also become a protracted withdrawal feature of the benzodiazepine withdrawal syndrome.

In addition, chronic use of benzodiazepines is a risk factor for blepharospasm. Drug-induced symptoms that resemble withdrawal-like effects can occur on a set dosage as a result of prolonged use, also documented with barbiturate-like substances, as well as alcohol and benzodiazepines. This demonstrates that the effects from chronic use of benzodiazepine drugs is not unique but occurs with other GABAergic sedative hypnotic drugs, i.e., alcohol and barbiturates.

Immune system

Chronic use of benzodiazepines seemed to cause significant immunological disorders in a study of selected outpatients attending a psychopharmacology department. Diazepam and clonazepam have been found to have long-lasting, but not permanent, immunotoxic effects in the fetus of pregnant rats. However, single very high doses of diazepam have been found to cause lifelong immunosuppression in neonatal rats. No studies have been done to assess the immunotoxic effects of diazepam in humans; however, high prescribed doses of diazepam, in humans, has been found to be a major risk of pneumonia, based on a study of people with tetanus. It has been proposed that diazepam may cause long-lasting changes to the GABAA receptors with resultant long-lasting disturbances to behaviour, endocrine function and immune function


Suicide and self-harm

Because benzodiazepines in general may be associated with increased suicide risk, care should be taken when prescribing especially to at risk patients. Depressed adolescents who were taking benzodiazepines were found to have a greatly increased risk of self-harm or suicide, although the sample size was small. The effects of benzodiazepines in individuals under the age of 18 requires further research. Additional caution is required in using benzodiazepines in depressed adolescents. Benzodiazepine dependence often results in an increasingly deteriorating clinical picture, which includes social deterioration leading to comorbid alcoholism and drug abuse. Suicide is a common outcome of chronic benzodiazepine dependence. Benzodiazepine misuse or misuse of other CNS depressants increases the risk of suicide in drug misusers. 11% of males and 23% of females with a sedative hypnotic misuse habit commit suicide.


Carcinogenicity

There has been some controversy around the possible link between benzodiazepine use and development of cancer; early cohort studies in the 1980s suggested a possible link, but follow-up case-control studies have found no link between benzodiazepines and cancer. In the second U.S. national cancer study in 1982, the American Cancer Society conducted a survey of over 1.1 million participants. A marked increased risk of cancer was found in the users of sleeping pills, mainly benzodiazepines. There have been 15 epidemiologic studies that have suggested that benzodiazepine or nonbenzodiazepine hypnotic drug use is associated with increased mortality, mainly due to increased cancer deaths in humans. The cancers included cancer of the brain, lung, bowel, breast, and bladder, and other neoplasms. It has been hypothesised that either depressed immune function or the viral infections themselves were the cause of the increased rates of cancer.

While initially U.S. Food and Drug Administration reviewers expressed concerns about approving the nonbenzodiazepine Z drugs due to concerns of cancer, ultimately they changed their minds and approved the drugs. A recent case-control study, however, found no link between use of benzodiazepines and cancers of the breast, lung, large bowel, lung, uterine lining, ovaries, testes, thyroid, liver, or Hodgkin's Disease, melanoma, or non-Hodgkin's lymphoma. More specific case-control studies since 2000 have shown no link between benzodiazepine use and breast cancer. One study found an association between self-reported benzodiazepine use and development of ovarian cancer.
Anonymous Coward (OP)
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02/23/2013 02:26 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Links between SSRI / Benzodiazepines / Anti Depressants and Violence / Suicide :

[link to ssristories.com]

.
Anonymous Coward (OP)
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02/23/2013 02:29 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Benzodiazepines work as Antidepressant enhancer :

Benzodiazepines induce additive CNS depressant effects when co-administered with other medications which themselves produce CNS depression, such as barbiturates, alcohol, opiates, tricyclic antidepressants, non-selective MAO inhibitors, phenothiazines and other antipsychotics, skeletal muscle relaxants, antihistamines and anaesthetics.
Anonymous Coward (OP)
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02/23/2013 02:33 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Brain Damage from Benzodiazepines: The Troubling Facts, Risks, and History of Minor Tranquilizers

[link to www.psychologytoday.com]

.
CeeLite
>>Haida Gwaii

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02/23/2013 02:47 PM

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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Links between SSRI / Benzodiazepines / Anti Depressants and Violence / Suicide :

[link to ssristories.com]

.
 Quoting: Anonymous Coward 913721


Um, that pages statistics are screwed. Shootings happenen because people are delusional and psychotic. That is a different issue than DEPRESSION. Depression makes people shut down and DO NOTHING...
Pray this thing doesn't hit or sink [link to twitter.com]
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Anonymous Coward (OP)
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02/23/2013 03:30 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Links between SSRI / Benzodiazepines / Anti Depressants and Violence / Suicide :

[link to ssristories.com]

.
 Quoting: Anonymous Coward 913721


Um, that pages statistics are screwed. Shootings happenen because people are delusional and psychotic. That is a different issue than DEPRESSION.
 Quoting: CeeLite


Indeed.

Benzodiazepines are hypnotics that create dulusions and psychosis as soon as you're either dependent or withdraw use.


Wiki about Hypnotics (benzodiazepine is first named hypnotic) :
[link to en.wikipedia.org (secure)]
Anonymous Coward
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02/23/2013 04:02 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Very nasty and dangerous drugs. I have known family and friends whose health has suffered terribly because of being legally prescribed these substances which honestly seem worse than many street drugs.

Thank you OP for trying to raise awareness.
Anonymous Coward (OP)
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02/23/2013 04:16 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Very nasty and dangerous drugs. I have known family and friends whose health has suffered terribly because of being legally prescribed these substances which honestly seem worse than many street drugs.

Thank you OP for trying to raise awareness.
 Quoting: Anonymous Coward 18269231


Thanks for acknowledging this huge social problem.
CeeLite
>>Haida Gwaii

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02/23/2013 04:24 PM

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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Links between SSRI / Benzodiazepines / Anti Depressants and Violence / Suicide :

[link to ssristories.com]

.
 Quoting: Anonymous Coward 913721


Um, that pages statistics are screwed. Shootings happenen because people are delusional and psychotic. That is a different issue than DEPRESSION.
 Quoting: CeeLite


Indeed.

Benzodiazepines are hypnotics that create dulusions and psychosis as soon as you're either dependent or withdraw use.


Wiki about Hypnotics (benzodiazepine is first named hypnotic) :
[link to en.wikipedia.org (secure)]
 Quoting: Anonymous Coward 913721


I've heard withdrawing from benzos and alcohol are the only life threatening withdrawls. Benzos are fucking scary to get off of. But that's second hand info from someone who supposedly was trying to wd. You absolutely DO hallucinate, according to what this person told me. But again, I have no first hand knowledge but they told me what it was like.

Last Edited by CeeLite on 02/23/2013 04:25 PM
Pray this thing doesn't hit or sink [link to twitter.com]
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Anonymous Coward (OP)
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02/23/2013 04:27 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
I've heard withdrawing from benzos and alcohol are the only life threatening withdrawls. Benzos are fucking scary to get off of. But that's second hand info from someone who supposedly was trying to wd. You absolutely DO hallucinate, according to what this person told me. But again, I have no first hand knowledge but they told me what it was like.
 Quoting: CeeLite

You can compare it with withdrawing from heroin... it only takes much longer.

Here in the Netherlands a lot of benzodiazepines are filed under our opium law.
Anonymous Coward
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02/23/2013 04:30 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
This happened to someone I knew. Prescribed for pre-surgery. Took for 1.5 weeks.
Quote:
Increased excitement, irritability, aggression, hostility and impulsivity may occur in some patients who take benzodiazepines.
(Attacked 2 loved ones randomly.)
An association has been noted between benzodiazepine use and depressive symptoms and, in some cases, the emergence of suicidal ideation.
(Next day killed self.)
[link to www.aafp.org]
Anonymous Coward
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02/23/2013 04:34 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
i went to rehab twice for benzo dependence and withdrawal, hospitalized several times too. most dangerous drugs on earth in my opinion. it was about a hundred times more difficult to treat than narcotic abuse.
CeeLite
>>Haida Gwaii

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02/23/2013 04:38 PM

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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
I've heard withdrawing from benzos and alcohol are the only life threatening withdrawls. Benzos are fucking scary to get off of. But that's second hand info from someone who supposedly was trying to wd. You absolutely DO hallucinate, according to what this person told me. But again, I have no first hand knowledge but they told me what it was like.
 Quoting: CeeLite

You can compare it with withdrawing from heroin... it only takes much longer.

Here in the Netherlands a lot of benzodiazepines are filed under our opium law.
 Quoting: Anonymous Coward 913721


Wow!
Pray this thing doesn't hit or sink [link to twitter.com]
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Rebecca
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02/23/2013 04:39 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
I was prescribed xanax during a painful divorce and found it to cause me horrific nightmares. Like it opened a dark door. I threw that shit in the garbage.
Anonymous Coward (OP)
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02/23/2013 04:40 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Here's a nice list with all benzodiazepines, their brand names and half times :


[link to en.wikipedia.org (secure)]

.
Anonymous Coward
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02/23/2013 04:47 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
I use Xanax and Ambien.I take 1mg of xanax daily and a 10mg of xanax at night.Since i started taking them i have terrible nigtmares if i stop taking the ambien.I am on a relatively low dose of both but i am really not able to stop taking these once i started.I am not depressed,suicidal and am usualy the guy who finds the silver lining in everything.These drugs do work,but they also make you dependent.Its a double edged sword.If your going to take them do low doses and never increase your dose.Use them at a maintainence level.
Anonymous Coward (OP)
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02/23/2013 05:12 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
I use Xanax and Ambien.I take 1mg of xanax daily and a 10mg of xanax at night.Since i started taking them i have terrible nigtmares if i stop taking the ambien.I am on a relatively low dose of both but i am really not able to stop taking these once i started.I am not depressed,suicidal and am usualy the guy who finds the silver lining in everything.These drugs do work,but they also make you dependent.Its a double edged sword.If your going to take them do low doses and never increase your dose.Use them at a maintainence level.
 Quoting: Anonymous Coward 33589735


You can safely withdraw with Diazepam, check this forum for good info :

[link to www.benzobuddies.org]


Get yourself some good supplements instead.

Try Glycine, Magnesium, GABA and melatonin
AwakenedDude
"CAN'T" Never Did Anything

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02/23/2013 05:18 PM

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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Thanks for the info OP. People need to know this stuff. I can personally vouch for just about everything you posted.

That shit is pure evil.

Peace.
"The paradigm of science is that creation is all, and the creator is nothing. Religion says the creator is all, and the creation is nothing. These two extremes are the bars of a prison cell. They prevent observation of all phenomenon as an interactive whole." -- Airl
AwakenedDude
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02/23/2013 05:29 PM

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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
I've heard withdrawing from benzos and alcohol are the only life threatening withdrawls. Benzos are fucking scary to get off of. But that's second hand info from someone who supposedly was trying to wd. You absolutely DO hallucinate, according to what this person told me. But again, I have no first hand knowledge but they told me what it was like.
 Quoting: CeeLite

You can compare it with withdrawing from heroin... it only takes much longer.

Here in the Netherlands a lot of benzodiazepines are filed under our opium law.
 Quoting: Anonymous Coward 913721


I can't speak for heroin, but I can vouch for benzo withdrawal as being pure unadulterated hell.

For anyone withdrawing, I recommend you taper your dose down .25% every two weeks. It would be nice if you could wait until you started to level out (feel better) before cutting down the dosage, but that doesn't happen. Hell will start raining down on you. You have to keep plowing through it until you're completely off of it. This can take months.

About 1-2 MONTHS after you are clean, you will BEGIN to feel better.

I don't know how effective other drugs or herbs are in helping to deal with benzo withdrawal, but I personally found they made withdrawal symptoms worse. I had to go cold turkey from just about everything but water.

Peace.
"The paradigm of science is that creation is all, and the creator is nothing. Religion says the creator is all, and the creation is nothing. These two extremes are the bars of a prison cell. They prevent observation of all phenomenon as an interactive whole." -- Airl
Anonymous Coward
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02/23/2013 05:29 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
very good advice from op.

if anyone here is struggling with xanax, ativan, or klonopin, it is a good idea to talk to a doctor about switching to valium. it won't fully satisfy your craving, but it will keep you from losing your mind. tapering is hard, but cold turkey is harder, and dangerous.
Anonymous Coward
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02/24/2013 07:48 AM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Thanks OP, you put some very interesting stuff up here !
Anonymous Coward
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02/24/2013 07:52 AM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Know someone who was recently prescribed benzo's and then hung himself. R.I.P Max.
Anonymous Coward
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02/24/2013 07:58 AM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
I was prescribed xanax during a painful divorce and found it to cause me horrific nightmares. Like it opened a dark door. I threw that shit in the garbage.
 Quoting: Rebecca 32747372


I take them few times a year on average just for those crazy nightmares
Anonymous Coward
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02/24/2013 08:12 AM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Know someone who was recently prescribed benzo's and then hung himself. R.I.P Max.
 Quoting: Anonymous Coward 35067568


Perhaps w/o the benzos they'd hung themselves also. They were prescribed for something the person was going through right? Maybe the situation was the cause.
I was on it
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02/24/2013 08:14 AM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
I was on it for years. Has it affected my cognitive abilities? I hope not but I doubt it. I think a lot of them have an affect while you are on them, and then it mostly fades after you stop.
Anonymous Coward
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02/24/2013 08:21 AM
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Reading the stuff OP posted, it certainly didn't help their situation !
Anonymous Coward
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02/24/2013 08:24 AM
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I was on it for years. Has it affected my cognitive abilities? I hope not but I doubt it. I think a lot of them have an affect while you are on them, and then it mostly fades after you stop.
 Quoting: I was on it 24211503


Did you read anything above ?

You become hooked, dependent within a few weeks and get withdrawal symptoms, the worst ever.

Try that forum OP posted : your word against 10.000's of people having the worst time of their live.
Anonymous Coward (OP)
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03/09/2013 09:12 AM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Did you read anything above ?

You become hooked, dependent within a few weeks and get withdrawal symptoms, the worst ever.

Try that forum OP posted : your word against 10.000's of people having the worst time of their live.
 Quoting: Anonymous Coward 5975214


Thanks for the backup, pal
Anonymous Coward
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03/09/2013 10:14 AM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
My friend gave me a xanax once. i was at the bar having a beer, something bad had happened and she told me it would calm me down. I don't remember how i got home or anything after that beer. Crazy shit and i will never touch it again. honestly, i don't know why i took it. a beer should have been enough to calm me down, i try to work through things on my inner strength and a beer! lol.
Anonymous Coward
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03/09/2013 11:02 AM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
Thanks for the info . i have a older sister that is making us all nuts ,we dont get her, violence and disgust with family, her perpetual remembrance of things that were not good but not terrible for us humans in life , divorce, lost of job..well..we all go trough that ,but her ..always fighting screaming ,in pain and rage. You try to talk to her ..well you wont receive much...I read your info .. saw a bottle of klonopin that she has been using for years... and years. thanks for the info, her Dr.prescribe that for her years ago.
Dapurps

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03/09/2013 12:48 PM
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Re: The truth about benzodiazepine - Xanax Restoril Arivan Klonopin Valium
I've been addicted to literally everything and by far the drug that fucked my life up more then daily alcohol and heroin iv was benzos especially clonazepam.
"What you perceive to be becomes your reality."

:ftwpanda:

dapurps

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