The bark scorpion is the most venomous scorpion in North America, and its venom can cause severe pain (coupled with numbness and tingling) in adult humans, typically lasting between 24 to 72 hours. Temporary dysfunction in the area stung is common; e.g. a hand or possibly arm can be immobilized or experience convulsions. It also may cause the loss of breath for a short period of time. Due to the extreme pain induced, many victims describe sensations of electrical jolts after envenomation.

Fatalities from scorpion envenomation in the USA are rare and are limited to small animals (including small pets), small children, and adults with compromised immune systems. Extreme reaction to the venom is indicated by numbness, frothing at the mouth, paralysis, and a neuromotor syndrome that may be confused with a seizure and that may make breathing difficult, particularly for small children. Two recorded fatalities have occurred in the state of Arizona since 1968; the number of victims stung each year in Arizona is estimated to be in the thousands. In Mexico, more than 100,000 people are stung annually, and during a peak period in the 1980s, the bark scorpion claimed up to 800 lives there.[2]