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BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths

 
Wash (OP)

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04/26/2013 03:00 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
Via Xinhua, a report posted just before midnight, April 26: Six more H7N9 bird flu cases reported in China.

Six more cases of H7N9 bird flu were reported on Friday in the Chinese provinces of Fujian, Jiangsu, Jiangxi and Zhejiang.
[link to crofsblogs.typepad.com]
Roll Tide Roll.
Anonymous Coward
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04/26/2013 03:08 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
Is it spreading as fast as other years Wash?
prodlikegod

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04/26/2013 03:15 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
...


We are very fortunate that none of us are 'required' to take a flu shot for work. My daughter is exempt from any vaccines due to a family history (me) of severe allergies.
 Quoting: Vic-chick13

So you have the same set up in Canada, and by giving everyone the h1n1 vaccine they set the host up for a more serious infection when exposed at a later date to a similar virus.Nice
 Quoting: prodlikegod


Oh shit! That is just greatgaahgaahgaah
 Quoting: SpiderJones


Hi folks.
 Quoting: Wash


Hi Wash I'm addicted to this thread some good info coming in
Wash (OP)

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04/26/2013 03:16 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
Is it spreading as fast as other years Wash?
 Quoting: Kerensa


This is the first time H7N9 has been in the human population so thats hard to say. They still have not determined how it is spreading.

we do know:
1. it is very deadly.
2. it is spreading (somehow)
3. This is not the typical time of year for am influenza out break.
4. the WHO is taking this very seriously.
Roll Tide Roll.
Wash (OP)

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04/26/2013 03:17 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
...

So you have the same set up in Canada, and by giving everyone the h1n1 vaccine they set the host up for a more serious infection when exposed at a later date to a similar virus.Nice
 Quoting: prodlikegod


Oh shit! That is just greatgaahgaahgaah
 Quoting: SpiderJones


Hi folks.
 Quoting: Wash


Hi Wash I'm addicted to this thread some good info coming in
 Quoting: prodlikegod


I love the new info coming in evreyday. I'm glad the thread caught on.
Roll Tide Roll.
Luisport

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04/26/2013 03:20 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
Updated: Friday, 26 April, 2013 at 04:37 UTC
Description
The H7N9 strain responsible for the bird flu outbreak in China is unlike any that has previously been seen in this type of virus. So far, 110 cases have been reported, including one in Taiwan, and 23 people have died. Here are some things to know about this virus: No evidence of human-to-human transmission to date. So far, authorities said, there is no evidence that this virus can pass from person to person. That doesn't mean it can't happen later. "If limited person-to-person transmission is demonstrated in the future, this really will not be surprising," Keiji Fukuda, the World Health Organization's assistant director-general for health, security and the environment, told a news conference Wednesday in Beijing. The virus appears to be transmitted more easily from poultry to humans than H5N1, Fukuda said, referring to the strain responsible for the outbreak between 2004 and 2007, which claimed 332 lives. "This is definitely one of the most lethal influenza viruses that we have seen so far," he said. The H7N9 strain was never known to infect people until March. Before then, it was only found in birds. If the virus does start to spread easily between people, it could trigger a pandemic. "This is a serious public health situation and it's possible that a pandemic could start if this virus were to change to spread easily between people," the U.S. Centers for Disease Control and Prevention said on its website. "CDC is preparing for that possibility."
[link to hisz.rsoe.hu]
Wash (OP)

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04/26/2013 03:22 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
Updated: Friday, 26 April, 2013 at 04:37 UTC
Description
The H7N9 strain responsible for the bird flu outbreak in China is unlike any that has previously been seen in this type of virus. So far, 110 cases have been reported, including one in Taiwan, and 23 people have died. Here are some things to know about this virus: No evidence of human-to-human transmission to date. So far, authorities said, there is no evidence that this virus can pass from person to person. That doesn't mean it can't happen later. "If limited person-to-person transmission is demonstrated in the future, this really will not be surprising," Keiji Fukuda, the World Health Organization's assistant director-general for health, security and the environment, told a news conference Wednesday in Beijing. The virus appears to be transmitted more easily from poultry to humans than H5N1, Fukuda said, referring to the strain responsible for the outbreak between 2004 and 2007, which claimed 332 lives. "This is definitely one of the most lethal influenza viruses that we have seen so far," he said. The H7N9 strain was never known to infect people until March. Before then, it was only found in birds. If the virus does start to spread easily between people, it could trigger a pandemic. "This is a serious public health situation and it's possible that a pandemic could start if this virus were to change to spread easily between people," the U.S. Centers for Disease Control and Prevention said on its website. "CDC is preparing for that possibility."
[link to hisz.rsoe.hu]
 Quoting: Luisport



"This is definitely one of the most lethal influenza viruses that we have seen so far," he said. The H7N9 strain was never known to infect people until March. Before then, it was only found in birds. If the virus does start to spread easily between people, it could trigger a pandemic. "This is a serious public health situation and it's possible that a pandemic could start if this virus were to change to spread easily between people,"

This part could potentially make the summer a scary time.
Thanks Luisport.
Roll Tide Roll.
prodlikegod

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04/26/2013 03:57 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
Taiwan has stopped talking about the three health workers who became ill after taking care of their case #1- hear anything about that?
 Quoting: SpiderJones


I think its a waiting game, by the look of things people have to come in physical contact with fluids that people excrete from having a cold. This a problem in places like China because they are buggers for spitting etc.

So to me this will be highly contagious in these parts of the world, and is a real danger
 Quoting: prodlikegod

bump
Mukk1234

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04/26/2013 04:32 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
Taiwan has stopped talking about the three health workers who became ill after taking care of their case #1- hear anything about that?
 Quoting: SpiderJones


I think its a waiting game, by the look of things people have to come in physical contact with fluids that people excrete from having a cold. This a problem in places like China because they are buggers for spitting etc.

So to me this will be highly contagious in these parts of the world, and is a real danger
 Quoting: prodlikegod

bump
 Quoting: prodlikegod


Very true, they fucking spit everywhere.....disgusting....lived it for many years.....Just recently they have found over 18k dead pigs floating down the Shanghai river....um...then we hear about this flu...
Fuck it, lets party!!!!
prodlikegod

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04/26/2013 05:12 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
Taiwan has stopped talking about the three health workers who became ill after taking care of their case #1- hear anything about that?
 Quoting: SpiderJones


I think its a waiting game, by the look of things people have to come in physical contact with fluids that people excrete from having a cold. This a problem in places like China because they are buggers for spitting etc.

So to me this will be highly contagious in these parts of the world, and is a real danger
 Quoting: prodlikegod

bump
 Quoting: prodlikegod


Very true, they fucking spit everywhere.....disgusting....lived it for many years.....Just recently they have found over 18k dead pigs floating down the Shanghai river....um...then we hear about this flu...
 Quoting: Mukk1234

Bet thats not the only thing floating in that river.
Anonymous Coward
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04/26/2013 05:41 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
The first case of H7N9
influenza in Taiwan
We report here the first case of H7N9
infection outside mainland China.
A 53-year-old male patient was
admitted because of fever for 3 days
after returning from Suchow, Jiangsu
Province, China on April 9, 2013. He
had been otherwise well except for a
history of hypertension and chronic
hepatitis B virus infection. The patient
did not report a history of contact
with sick persons or animals during
the travel. He began to get fever and
general malaise on April 12. He had no
respiratory symptoms, gastrointestinal
symptoms, or myalgias. The patient
sought medical attention on April 16
when fevers continued. Two throatswab specimens tested negative for
H7N9 with real-time PCR on April
17 and April 20, respectively. The
first chest radiograph was normal.
Treatment with oseltamivir was
started at a dose of 75 mg twice daily.
A follow-up chest radiograph on April
18 revealed interstitial pneumonia
at the right lower lung, for which
moxifloxacin was added. Progressive
dyspnoea developed on April 19.
Follow-up chest radiographs showed
progressive bilateral lower-lung
consolidation. He was transferred to
National Taiwan University Hospital
on April 20. The dose of oseltamivir
was increased to 150 mg twice
daily. Endotracheal intubation and
mechanical ventilator support was
given on arrival because of respiratory
failure. Ceftazidime and levofloxacin
were started, although microbiological
investigations were negative. Desaturation worsened despite use of
supplemental O₂ at O₂ fraction of
100%. Inhalational NO was added
on April 21 without benefit. Chest
radiography and sonography did not
reveal pneumothorax. He was put on
extracorporeal membrane oxygenation
on April 22. This patient’s sputum
specimen was subtyped as H7N9
with the protocol provided by WHO
Collaborating Centre in Beijing. Very
high H7N9 viral loads (4·5-51·4x107
copies per mL) were found in the
two sputum specimens and one
throat-swab specimen (collected on
April 20 and April 22, respectively)
while the viral load was undetectable
in the blood specimens collected daily
between 20 and 23 April.
H7N9 might spread to other
areas beyond Shanghai, China. Due
to the rapidly progressing lower
respiratory tract infections in infected
individuals,1,2 extensive preventive
efforts are needed to prevent further
spreading of H7N9.
We declare that we have no conflicts of interest.
Sui-Yuan Chang, Pi-Han Lin,
Jen-Chih Tsai, Chien-Ching Hung,
*Shan-Chwen Chang
changsc@ntu.edu.tw
Department of Clinical Laboratory Sciences and
Medical Biotechnology, National Taiwan University
College of Medicine, Taipei, Taiwan (S-YC, P-HL);
and Internal Medicine, National Taiwan University
Hospital and National Taiwan University College of
Medicine, Taipei, Taiwan (J-CT, C-CH, S-CC)
1 Gao R, Cao B, Hu Y, et al. Human infection with
a novel avian-origin influenza A (H7N9) virus.
N Engl J Med. 2013; published online April 11.
DOI:10.1056/NEJMoa1304459.
2 Guan Y, Farooqui A, Zhu H, Dong W, Wang J,
Kelvin DJ. H7N9 incident, immune status, the
elderly and a warning of an influenza
pandemic. J Infect Dev Ctries 2013; 7: 302–07
Anonymous Coward
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04/26/2013 05:42 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
[link to fluboard.rhizalabs.com]
Anonymous Coward
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04/26/2013 05:44 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
[link to maps.google.com (secure)]
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04/26/2013 05:47 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
[link to www.shtfplan.com]
Anonymous Coward
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04/26/2013 05:50 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
[link to focustaiwan.tw]
Anonymous Coward
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04/26/2013 05:52 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
[link to intellihub.com]
Anonymous Coward
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04/26/2013 05:53 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
 Quoting: Anonymous Coward 36021878

April 26, 2013

BEIJING — As of Thursday 109 people have been confirmed to be dead from the H7N9 virus which emerged rather quickly this April after the typical flu season.

Human-to-human transmission has not yet been documented. However, reports from the World Health Organization state that 40% of the victims did not have contact with any type of poultry raising concern amongst the medical community.

Even more alarming is the fact that the virus has over a 20% mortality rate right out of the gate. If this proves to continue, we could possibly be looking at one of the most deadly viral outbreaks of all time. This is backed up by others such as journalist, Patrick Di Justo, who wrote, “As of today, dividing the number of confirmed cases by the number of deaths makes it look as though H7N9 is an especially bad flu, with a twenty-per-cent mortality rate. If true, this would be terrifying: the 1918 Spanish Flu, which has been called one of the deadliest plagues in human history, also had a mortality rate of around two percent.”
prodlikegod

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04/26/2013 05:54 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
 Quoting: Anonymous Coward 36021878

Good mapping loads of good info
Anonymous Coward
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04/26/2013 05:59 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
[link to crofsblogs.typepad.com]
Anonymous Coward
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04/26/2013 06:01 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
 Quoting: Anonymous Coward 36021878

Good mapping loads of good info
 Quoting: prodlikegod


your putting up some great leads as well important to stay informedhf
Anonymous Coward
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04/26/2013 06:06 PM
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[link to www.businessinsider.com]
Vic-chick13

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04/26/2013 06:10 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
 Quoting: Anonymous Coward 36021878


Wow. Has a bit of an ominous ring to it.
Anonymous Coward
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04/26/2013 06:13 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
 Quoting: Anonymous Coward 36021878


Wow. Has a bit of an ominous ring to it.
 Quoting: Vic-chick13


Tell me about it here in uk virtually nothing in media ,
[link to www.chp.gov.hk]
Vic-chick13

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04/26/2013 06:14 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
 Quoting: Anonymous Coward 36021878


Jesus wept! That one doesn't pull any punches!
Anonymous Coward
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04/26/2013 06:16 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
 Quoting: Anonymous Coward 36021878

Here's What Happens When You Get Bird Flu
Anonymous Coward
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04/26/2013 06:19 PM
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[link to www.chp.gov.hk]
Anonymous Coward
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04/26/2013 06:21 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
Jesus wept! That one doesn't pull any punches!


horrible death ........Ireally feel for there families
Anonymous Coward
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04/26/2013 06:23 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
 Quoting: Anonymous Coward 36021878

Department of Clinical Laboratory Sciences and
Medical Biotechnology, National Taiwan University
College of Medicine, Taipei, Taiwan (S-YC, P-HL);
and Internal Medicine, National Taiwan University
Hospital and National Taiwan University College of
Medicine, Taipei, Taiwan (J-CT, C-CH, S-CC)
1 Gao R, Cao B, Hu Y, et al. Human infection with
a novel avian-origin influenza A (H7N9) virus.
N Engl J Med. 2013; published online April 11.
DOI:10.1056/NEJMoa1304459.
2 Guan Y, Farooqui A, Zhu H, Dong W, Wang J,
Kelvin DJ. H7N9 incident, immune status, the
elderly and a warning of an influenza
pandemic. J Infect Dev Ctries 2013; 7: 302–07
Anonymous Coward
User ID: 36021878
United Kingdom
04/26/2013 06:25 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
[link to shanghaiist.com]

Not really any new info here, but the last sentence made me laugh my ass off.
 Quoting: Vic-chick13


WTF was that? LOL.
 Quoting: SpiderJones

There's no need for panic unless there are human-to-human transmissions," said Hui.
Presumably, Hui's statement followed with, "in that case, by all means, freak the fuck out," but he probably had already passed his word count.


thought you would find that funny
hf
Anonymous Coward
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04/26/2013 06:28 PM
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[link to seekingalpha.com]


taiwan fatalities up nearly 300%
 Quoting: Anonymous Coward 36021878


Can't read the full article are the fatalities really up 300%
 Quoting: prodlikegod


I couldn't get the rest of the article- it went to an ad, anyway, I don't know where they got 300%, but I think they are playing w/numbers.
 Quoting: SpiderJones



BioCryst Heats Up: H7N9 Virus Hits Taiwan, Fatalities Up Nearly 300%
BioCryst really needed the good news after the withdrawal of the IND application for BCX5191, and a failed attempt at a merger with Presidio Pharmaceuticals which raised major concerns about the company’s prospects going forward.
By Bio-Wire
Apr 25, 2013 2:05:34 PM PDT | 27 View(s) | No Comment(s) - Post a Comment Rating

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We’ve been seeing a lot of new activity in BioCryst Pharmaceuticals (NASDAQ: BCRX), which we last covered on April 7th following a 42% run in the stock chasing the good news that the company received from the FDA about its antiviral agent peramivir. The program, which was presumed to be dead after suspension of its phase III trial in November 2012 due to futility, received a second life when the FDA decided to arrange a meeting with the company to discuss a possible path towards an NDA submission.

It seems that the FDA agrees with the notion that the phase III trial was set up to be a failure due to its design, and that peramivir has demonstrated its worth as an antiviral agent in previous situations. While many drugs development programs never survive a Phase III failure, peramivir seems to be a very special case.

BioCryst really needed the good news after the withdrawal of the IND application for BCX5191, and a failed attempt at a merger with Presidio Pharmaceuticals which raised major concerns about the company’s prospects going forward.

Now that confidence has been restored in the neuramindase inhibitor peramivir, investors are trying to gauge how much the drug could be worth based on the market success of Tamiflu (oseltamivir) and Relenza (zanamivir). While the method of peramivir’s delivery is different (it is an IV formulation), some evidence suggests that it may be particularly efficacious against strains of bird flu despite a similar mechanism of action.

This was why the drug was temporarily approved and utilized in the bird flu outbreak of 2009 in Asia. Looking back, we can see that the hype over peramivir caused an enormous rally in shares of BioCryst, sending the company well above $10/share as investors attempted to chase what seemed to be a best-in-class antiviral agent. Although it wasn’t proven in clinical trials, some still believe that peramivir could be the best neuramindase inhibitor out there.

H7N9, which is the most recent strain of bird flu, has caused a lot of recent interest in BCRX as investors remember how high the stock went in 2009. As described in an update on April 8th, 2013, the H7N9 virus infected at least 26 people at that point and killed at least 6. Between then and now, infections have risen to at least 108 and the death toll has risen to 22. Even more terrifying to Asian governments is the confirmation that the virus has spread to Taiwan, and commentary given by the World Health Organization.

Not only are they struggling to determine the source of the infection, but they have confirmed that it is an “unusually dangerous virus for humans” and that “more easily transmitted from poultry to humans than H5N1”. H5N1 was the strain of bird flu that claimed 332 lives between 2004 and 2007.

While BioCryst is unlikely to see financial benefit in the event that China, Taiwan, and other nations stockpile peramivir in reaction to the H7N9 outbreak, it’s possible that investors may bid up BCRX (again) in anticipation of a repeat of the run-up we saw in 2009. This may also put pressure on the FDA to approve peramivir through some alternative route, although we will see the details on this matter after BioCryst holds and reports the results of their pre-NDA meeting.

The Takeaway

Investors should realize that BCRX is a very news-driven speculative stock right now that will remain volatile and quite unpredictable as more news trickles in from Asia about the spread of H7N9 and the infection rates, as well as the death toll. If these rise, expect more bullish speculation on this particular ticker. Also note that Peramivir’s US development program was “brought back from the dead” with the FDA’s pre-NDA meeting which will (hopefully) provide a path towards FDA approval for BioCryst. Depending on the results of this meeting, BCRX should either move up (or down) quite violently, as this is the company’s “flagship” development program.

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