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BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths

 
prodlikegod

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04/26/2013 06:29 PM

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 Quoting: Anonymous Coward 36021878

Here's What Happens When You Get Bird Flu
 Quoting: Anonymous Coward 36021878

Horrible Did not bother reading the next one
this is bad enough
The Frightening Story Of A Man Who Bought A Chicken And Then Died Of Bird Flu

Read more: [link to www.businessinsider.com]
CrazyMama73

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04/26/2013 06:37 PM

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I wonder if anyone has tried any natural remedies that may help beat this damn flu?

I remember when SARS hit Toronto a while back. That was creepy. I had a few friends whose whole family were quarantined. People were wearing masks everywhere. You seen people walking up and down stairs or going on escalators but not holding the rails in fear of getting germs on their hands.

Scary times are a head of us!
CrazyMama73
prodlikegod

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04/26/2013 06:49 PM

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[link to seekingalpha.com]


taiwan fatalities up nearly 300%
 Quoting: Anonymous Coward 36021878


Can't read the full article are the fatalities really up 300%
 Quoting: prodlikegod


I couldn't get the rest of the article- it went to an ad, anyway, I don't know where they got 300%, but I think they are playing w/numbers.
 Quoting: SpiderJones



BioCryst Heats Up: H7N9 Virus Hits Taiwan, Fatalities Up Nearly 300%
BioCryst really needed the good news after the withdrawal of the IND application for BCX5191, and a failed attempt at a merger with Presidio Pharmaceuticals which raised major concerns about the company’s prospects going forward.
By Bio-Wire
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We’ve been seeing a lot of new activity in BioCryst Pharmaceuticals (NASDAQ: BCRX), which we last covered on April 7th following a 42% run in the stock chasing the good news that the company received from the FDA about its antiviral agent peramivir. The program, which was presumed to be dead after suspension of its phase III trial in November 2012 due to futility, received a second life when the FDA decided to arrange a meeting with the company to discuss a possible path towards an NDA submission.

It seems that the FDA agrees with the notion that the phase III trial was set up to be a failure due to its design, and that peramivir has demonstrated its worth as an antiviral agent in previous situations. While many drugs development programs never survive a Phase III failure, peramivir seems to be a very special case.

BioCryst really needed the good news after the withdrawal of the IND application for BCX5191, and a failed attempt at a merger with Presidio Pharmaceuticals which raised major concerns about the company’s prospects going forward.

Now that confidence has been restored in the neuramindase inhibitor peramivir, investors are trying to gauge how much the drug could be worth based on the market success of Tamiflu (oseltamivir) and Relenza (zanamivir). While the method of peramivir’s delivery is different (it is an IV formulation), some evidence suggests that it may be particularly efficacious against strains of bird flu despite a similar mechanism of action.

This was why the drug was temporarily approved and utilized in the bird flu outbreak of 2009 in Asia. Looking back, we can see that the hype over peramivir caused an enormous rally in shares of BioCryst, sending the company well above $10/share as investors attempted to chase what seemed to be a best-in-class antiviral agent. Although it wasn’t proven in clinical trials, some still believe that peramivir could be the best neuramindase inhibitor out there.

H7N9, which is the most recent strain of bird flu, has caused a lot of recent interest in BCRX as investors remember how high the stock went in 2009. As described in an update on April 8th, 2013, the H7N9 virus infected at least 26 people at that point and killed at least 6. Between then and now, infections have risen to at least 108 and the death toll has risen to 22. Even more terrifying to Asian governments is the confirmation that the virus has spread to Taiwan, and commentary given by the World Health Organization.

Not only are they struggling to determine the source of the infection, but they have confirmed that it is an “unusually dangerous virus for humans” and that “more easily transmitted from poultry to humans than H5N1”. H5N1 was the strain of bird flu that claimed 332 lives between 2004 and 2007.

While BioCryst is unlikely to see financial benefit in the event that China, Taiwan, and other nations stockpile peramivir in reaction to the H7N9 outbreak, it’s possible that investors may bid up BCRX (again) in anticipation of a repeat of the run-up we saw in 2009. This may also put pressure on the FDA to approve peramivir through some alternative route, although we will see the details on this matter after BioCryst holds and reports the results of their pre-NDA meeting.

The Takeaway

Investors should realize that BCRX is a very news-driven speculative stock right now that will remain volatile and quite unpredictable as more news trickles in from Asia about the spread of H7N9 and the infection rates, as well as the death toll. If these rise, expect more bullish speculation on this particular ticker. Also note that Peramivir’s US development program was “brought back from the dead” with the FDA’s pre-NDA meeting which will (hopefully) provide a path towards FDA approval for BioCryst. Depending on the results of this meeting, BCRX should either move up (or down) quite violently, as this is the company’s “flagship” development program.
 Quoting: Anonymous Coward 36021878

Shorting Birdflu Via BioCryst Pharma (NASDAQ:BCRX)
by Steve Kanaval - on Apr 8th 2013 -
Naples Fla 4/8/2013 (BasicsMedia) – I saw another Birdflu volley today as the scare resurfaces, it is as common to resurface as the human flu. (NASDAQ:BCRX) was trading $4.10 p/s , and don’t forget March 2012 when it was a lofty $5.50 p/s when Wall Street was convinced we would all contract some deadly disease if we walked under a flying bird.
[link to basicsmedia.com]

Last Edited by prodlikegod on 04/26/2013 06:51 PM
Anonymous Coward
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04/26/2013 06:51 PM
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[link to www.cidrap.umn.edu]
Anonymous Coward
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04/26/2013 06:56 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
[link to www.ecdc.europa.eu]

cpr approx 60,5 would you say looking at the graphs ???
Ollo

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04/26/2013 07:21 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
 Quoting: Anonymous Coward 36021878

April 26, 2013

BEIJING — As of Thursday 109 people have been confirmed to be dead from the H7N9 virus which emerged rather quickly this April after the typical flu season.

Human-to-human transmission has not yet been documented. However, reports from the World Health Organization state that 40% of the victims did not have contact with any type of poultry raising concern amongst the medical community.

Even more alarming is the fact that the virus has over a 20% mortality rate right out of the gate. If this proves to continue, we could possibly be looking at one of the most deadly viral outbreaks of all time. This is backed up by others such as journalist, Patrick Di Justo, who wrote, “As of today, dividing the number of confirmed cases by the number of deaths makes it look as though H7N9 is an especially bad flu, with a twenty-per-cent mortality rate. If true, this would be terrifying: the 1918 Spanish Flu, which has been called one of the deadliest plagues in human history, also had a mortality rate of around two percent.”
 Quoting: Anonymous Coward 36021878


Is that a typo???
Anonymous Coward
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04/26/2013 08:04 PM
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 Quoting: Anonymous Coward 36021878

April 26, 2013

BEIJING — As of Thursday 109 people have been confirmed to be dead from the H7N9 virus which emerged rather quickly this April after the typical flu season.

Human-to-human transmission has not yet been documented. However, reports from the World Health Organization state that 40% of the victims did not have contact with any type of poultry raising concern amongst the medical community.

Even more alarming is the fact that the virus has over a 20% mortality rate right out of the gate. If this proves to continue, we could possibly be looking at one of the most deadly viral outbreaks of all time. This is backed up by others such as journalist, Patrick Di Justo, who wrote, “As of today, dividing the number of confirmed cases by the number of deaths makes it look as though H7N9 is an especially bad flu, with a twenty-per-cent mortality rate. If true, this would be terrifying: the 1918 Spanish Flu, which has been called one of the deadliest plagues in human history, also had a mortality rate of around two percent.”
 Quoting: Anonymous Coward 36021878


Is that a typo???
 Quoting: Ollo


Yes I think so, 23 dead so far known positive flu.
Anonymous Coward
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04/26/2013 08:05 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
 Quoting: Anonymous Coward 36021878


Jesus wept! That one doesn't pull any punches!
 Quoting: Vic-chick13


This is why I have been so worried about this flu- it is an ugly way to die.verysad
Anonymous Coward
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04/26/2013 08:11 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
The first case of H7N9
influenza in Taiwan
We report here the first case of H7N9
infection outside mainland China.
A 53-year-old male patient was
admitted because of fever for 3 days
after returning from Suchow, Jiangsu
Province, China on April 9, 2013. He
had been otherwise well except for a
history of hypertension and chronic
hepatitis B virus infection. The patient
did not report a history of contact
with sick persons or animals during
the travel. He began to get fever and
general malaise on April 12. He had no
respiratory symptoms, gastrointestinal
symptoms, or myalgias. The patient
sought medical attention on April 16
when fevers continued. Two throatswab specimens tested negative for
H7N9 with real-time PCR on April
17 and April 20, respectively. The
first chest radiograph was normal.
Treatment with oseltamivir was
started at a dose of 75 mg twice daily.
A follow-up chest radiograph on April
18 revealed interstitial pneumonia
at the right lower lung, for which
moxifloxacin was added. Progressive
dyspnoea developed on April 19.
Follow-up chest radiographs showed
progressive bilateral lower-lung
consolidation. He was transferred to
National Taiwan University Hospital
on April 20. The dose of oseltamivir
was increased to 150 mg twice
daily. Endotracheal intubation and
mechanical ventilator support was
given on arrival because of respiratory
failure. Ceftazidime and levofloxacin
were started, although microbiological
investigations were negative. Desaturation worsened despite use of
supplemental O₂ at O₂ fraction of
100%. Inhalational NO was added
on April 21 without benefit. Chest
radiography and sonography did not
reveal pneumothorax. He was put on
extracorporeal membrane oxygenation
on April 22. This patient’s sputum
specimen was subtyped as H7N9
with the protocol provided by WHO
Collaborating Centre in Beijing. Very
high H7N9 viral loads (4·5-51·4x107
copies per mL) were found in the
two sputum specimens and one
throat-swab specimen (collected on
April 20 and April 22, respectively)
while the viral load was undetectable
in the blood specimens collected daily
between 20 and 23 April.
H7N9 might spread to other
areas beyond Shanghai, China. Due
to the rapidly progressing lower
respiratory tract infections in infected
individuals,1,2 extensive preventive
efforts are needed to prevent further
spreading of H7N9.
We declare that we have no conflicts of interest.
Sui-Yuan Chang, Pi-Han Lin,
Jen-Chih Tsai, Chien-Ching Hung,
*Shan-Chwen Chang
changsc@ntu.edu.tw
Department of Clinical Laboratory Sciences and
Medical Biotechnology, National Taiwan University
College of Medicine, Taipei, Taiwan (S-YC, P-HL);
and Internal Medicine, National Taiwan University
Hospital and National Taiwan University College of
Medicine, Taipei, Taiwan (J-CT, C-CH, S-CC)
1 Gao R, Cao B, Hu Y, et al. Human infection with
a novel avian-origin influenza A (H7N9) virus.
N Engl J Med. 2013; published online April 11.
DOI:10.1056/NEJMoa1304459.
2 Guan Y, Farooqui A, Zhu H, Dong W, Wang J,
Kelvin DJ. H7N9 incident, immune status, the
elderly and a warning of an influenza
pandemic. J Infect Dev Ctries 2013; 7: 302–07
 Quoting: Anonymous Coward 36021878

Thanks for this post!!!
Holy shit, this is bad, doesn't show up in bloodwork, just in sputum from lungs/and lower resp. tract, holy shit, this thing is a nightmare come true. Oh and, VERY HIGH VIRAL LOADS. OMG.
Ollo

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04/26/2013 08:22 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
 Quoting: Anonymous Coward 36021878

April 26, 2013

BEIJING — As of Thursday 109 people have been confirmed to be dead from the H7N9 virus which emerged rather quickly this April after the typical flu season.

Human-to-human transmission has not yet been documented. However, reports from the World Health Organization state that 40% of the victims did not have contact with any type of poultry raising concern amongst the medical community.

Even more alarming is the fact that the virus has over a 20% mortality rate right out of the gate. If this proves to continue, we could possibly be looking at one of the most deadly viral outbreaks of all time. This is backed up by others such as journalist, Patrick Di Justo, who wrote, “As of today, dividing the number of confirmed cases by the number of deaths makes it look as though H7N9 is an especially bad flu, with a twenty-per-cent mortality rate. If true, this would be terrifying: the 1918 Spanish Flu, which has been called one of the deadliest plagues in human history, also had a mortality rate of around two percent.”
 Quoting: Anonymous Coward 36021878


Is that a typo???
 Quoting: Ollo


Yes I think so, 23 dead so far known positive flu.
 Quoting: SpiderJones


OK, that's what I thought...saw that and thought we were really screwed!
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04/26/2013 09:12 PM
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[link to www.whatsonxiamen.com]
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04/26/2013 09:19 PM
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[link to translate.google.com]
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04/26/2013 09:19 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
The scientists also tracked 385 family members, co-workers and health care staff who had unprotected contact with the patients. None of them showed any symptoms of H7N9 infection over 14 days of follow-up, which suggests that the virus currently cannot be spread among people.

[link to m.news24.com]
 Quoting: prodlikegod


Depends how close of contact they're in doesnt it?

I'll do the honorable thing. I'll infect myself with H7N9, go to taiwan and do the following:

talk to one girl
kiss one girl
get a beej from another
shag another
and while I'm at it, arrange a 3some or even a 4gasm

Then I'll check the transmission progress of each.

Someone has to do it (lol).
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04/26/2013 09:21 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
[link to news.xinhuanet.com]

First H7N9 bird flu case confirmed in Fujian


Luo tested positive for the H7N9 virus at 11 a.m. on Friday by the Chinese Center for Disease Control and Prevention. An examination of the patient at a clinical laboratory in Fujian Province also confirmed Luo's infection with the H7N9 bird flu, the statement said.

A little more info here.

[link to au.news.yahoo.com]
 Quoting: Vic-chick13


Just out of curiosity - Is there a site that overlays the cities with a confirmed case over a map? I've only been to China once and havent played Dynasty Warriors in soooo long.
Anonymous Coward
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04/26/2013 09:23 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
[link to www.cidrap.umn.edu]


does this mean if you had h1n1 your more likely to contract h7n9 ?
Anonymous Coward
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04/26/2013 09:26 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
Thanks for this post!!!
Holy shit, this is bad, doesn't show up in bloodwork, just in sputum from lungs/and lower resp. tract, holy shit, this thing is a nightmare come true. Oh and, VERY HIGH VIRAL LOADS. OMG.



spider this is much more widely spread than we are being given the numbers for my guess is close to 200 dead not the 28 figure being given
Anonymous Coward
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04/26/2013 09:29 PM
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[link to www.cidrap.umn.edu]


does this mean if you had h1n1 your more likely to contract h7n9 ?
 Quoting: Anonymous Coward 38938952


Just from my general speculation, I'd believe that if you had more cells of any strain of viri then you're immune system would be more inclined to be at either the advantage of knowing how to handle new intruders or possibly running the risk of new strains binding to pre existing receptors or mutating with other similar cells.
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04/26/2013 09:31 PM
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Thanks for this post!!!
Holy shit, this is bad, doesn't show up in bloodwork, just in sputum from lungs/and lower resp. tract, holy shit, this thing is a nightmare come true. Oh and, VERY HIGH VIRAL LOADS. OMG.
 Quoting: Anonymous Coward 38938952


So how long does a test swab take to hit the market?
Anonymous Coward
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04/26/2013 09:32 PM
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
[link to www.biosciencetrends.com]

x rays of h7n9 chest cavity
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04/26/2013 09:37 PM
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 Quoting: Anonymous Coward 38938952


Guangdong province is the next one south of this one- that is a bad place for the flu to show up.
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04/26/2013 09:39 PM
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[link to news.xinhuanet.com]
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04/26/2013 09:40 PM
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 Quoting: Anonymous Coward 38938952


Guangdong province is the next one south of this one- that is a bad place for the flu to show up.
 Quoting: SpiderJones


Quick google search, population of Guandong:

104.4 Million.
Anonymous Coward
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04/26/2013 09:41 PM
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 Quoting: Anonymous Coward 38938952


Guangdong province is the next one south of this one- that is a bad place for the flu to show up.
 Quoting: SpiderJones


Quick google search, population of Guandong:

104.4 Million.
 Quoting: Anonymous Coward 2890226


And I just noticed, that was in 2010.
Anonymous Coward
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04/26/2013 09:44 PM
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important routes for bird migrations, Guizhou, QingHai lake..
Anonymous Coward
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04/26/2013 09:45 PM
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[link to www.biosciencetrends.com]

x rays of h7n9 chest cavity
 Quoting: Anonymous Coward 38938952


nice find.
CrazyMama73

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04/26/2013 09:46 PM

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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
I couldn't imagine dying that way. I know when I have had asthma attacks, it is a frightening feeling of drowning and gasping for air... this would be ten fold, to say it lightly.

Is it too early to start ordering new face masks? As well as a slew load of other shit? Better to do now, then wait until everything is unavailable?
CrazyMama73
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 Quoting: Anonymous Coward 38938952


Guangdong province is the next one south of this one- that is a bad place for the flu to show up.
 Quoting: SpiderJones


Quick google search, population of Guandong:

104.4 Million.
 Quoting: Anonymous Coward 2890226


And I just noticed, that was in 2010.
 Quoting: Anonymous Coward 2890226


that's what I'm talkin about, bad place for it to turn up. Let's hope it doesn't!
Too many people, nature finds a way to get rid of some, the hard way, truely awful.
In reality, we are just meat puppets for viruses- we do our thing until we become useful to them. Horror, isn't it?
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[link to www.flutrackers.com]
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04/26/2013 09:50 PM
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...


Guangdong province is the next one south of this one- that is a bad place for the flu to show up.
 Quoting: SpiderJones


Quick google search, population of Guandong:

104.4 Million.
 Quoting: Anonymous Coward 2890226


And I just noticed, that was in 2010.
 Quoting: Anonymous Coward 2890226


that's what I'm talkin about, bad place for it to turn up. Let's hope it doesn't!
 Quoting: SpiderJones


And currently 20C and probably humid as fuuuuuck.

On a completely different note, I realize they're probably used to the humidity but how can they not sweat in China while wearing long sleeves and pants.. wtf to that.
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Re: BREAKING UPDATE April 21st, 2014 / 421st case / 145 deaths from H7N9 . MERS CoV 228 Cases, 92 deaths
I couldn't imagine dying that way. I know when I have had asthma attacks, it is a frightening feeling of drowning and gasping for air... this would be ten fold, to say it lightly.

Is it too early to start ordering new face masks? As well as a slew load of other shit? Better to do now, then wait until everything is unavailable?
 Quoting: CrazyMama73


get prepared as much as you can , try to avoid public transport , stock up on food , try looking at a site millennium ark for food water storage ideas good luck

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