BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths | |
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Anonymous Coward User ID: 36021878 United Kingdom 04/26/2013 06:13 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths Tell me about it here in uk virtually nothing in media , [link to www.chp.gov.hk] |
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Anonymous Coward User ID: 36021878 United Kingdom 04/26/2013 06:23 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan (S-YC, P-HL); and Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (J-CT, C-CH, S-CC) 1 Gao R, Cao B, Hu Y, et al. Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med. 2013; published online April 11. DOI:10.1056/NEJMoa1304459. 2 Guan Y, Farooqui A, Zhu H, Dong W, Wang J, Kelvin DJ. H7N9 incident, immune status, the elderly and a warning of an influenza pandemic. J Infect Dev Ctries 2013; 7: 302–07 |
Anonymous Coward User ID: 36021878 United Kingdom 04/26/2013 06:25 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths [link to shanghaiist.com] Quoting: Vic-chick13 Not really any new info here, but the last sentence made me laugh my ass off. WTF was that? LOL. There's no need for panic unless there are human-to-human transmissions," said Hui. Presumably, Hui's statement followed with, "in that case, by all means, freak the fuck out," but he probably had already passed his word count. thought you would find that funny |
Anonymous Coward User ID: 36021878 United Kingdom 04/26/2013 06:28 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths Quoting: prodlikegod I couldn't get the rest of the article- it went to an ad, anyway, I don't know where they got 300%, but I think they are playing w/numbers. BioCryst Heats Up: H7N9 Virus Hits Taiwan, Fatalities Up Nearly 300% BioCryst really needed the good news after the withdrawal of the IND application for BCX5191, and a failed attempt at a merger with Presidio Pharmaceuticals which raised major concerns about the company’s prospects going forward. By Bio-Wire Apr 25, 2013 2:05:34 PM PDT | 27 View(s) | No Comment(s) - Post a Comment Rating inShare Print Email BIO-WIRE Home Analysis (0) Articles (117) Blogs (0) Files (0) Picks (0) SEND MESSAGE ADD TO CONTACTS FOLLOW We’ve been seeing a lot of new activity in BioCryst Pharmaceuticals (NASDAQ: BCRX), which we last covered on April 7th following a 42% run in the stock chasing the good news that the company received from the FDA about its antiviral agent peramivir. The program, which was presumed to be dead after suspension of its phase III trial in November 2012 due to futility, received a second life when the FDA decided to arrange a meeting with the company to discuss a possible path towards an NDA submission. It seems that the FDA agrees with the notion that the phase III trial was set up to be a failure due to its design, and that peramivir has demonstrated its worth as an antiviral agent in previous situations. While many drugs development programs never survive a Phase III failure, peramivir seems to be a very special case. BioCryst really needed the good news after the withdrawal of the IND application for BCX5191, and a failed attempt at a merger with Presidio Pharmaceuticals which raised major concerns about the company’s prospects going forward. Now that confidence has been restored in the neuramindase inhibitor peramivir, investors are trying to gauge how much the drug could be worth based on the market success of Tamiflu (oseltamivir) and Relenza (zanamivir). While the method of peramivir’s delivery is different (it is an IV formulation), some evidence suggests that it may be particularly efficacious against strains of bird flu despite a similar mechanism of action. This was why the drug was temporarily approved and utilized in the bird flu outbreak of 2009 in Asia. Looking back, we can see that the hype over peramivir caused an enormous rally in shares of BioCryst, sending the company well above $10/share as investors attempted to chase what seemed to be a best-in-class antiviral agent. Although it wasn’t proven in clinical trials, some still believe that peramivir could be the best neuramindase inhibitor out there. H7N9, which is the most recent strain of bird flu, has caused a lot of recent interest in BCRX as investors remember how high the stock went in 2009. As described in an update on April 8th, 2013, the H7N9 virus infected at least 26 people at that point and killed at least 6. Between then and now, infections have risen to at least 108 and the death toll has risen to 22. Even more terrifying to Asian governments is the confirmation that the virus has spread to Taiwan, and commentary given by the World Health Organization. Not only are they struggling to determine the source of the infection, but they have confirmed that it is an “unusually dangerous virus for humans” and that “more easily transmitted from poultry to humans than H5N1”. H5N1 was the strain of bird flu that claimed 332 lives between 2004 and 2007. While BioCryst is unlikely to see financial benefit in the event that China, Taiwan, and other nations stockpile peramivir in reaction to the H7N9 outbreak, it’s possible that investors may bid up BCRX (again) in anticipation of a repeat of the run-up we saw in 2009. This may also put pressure on the FDA to approve peramivir through some alternative route, although we will see the details on this matter after BioCryst holds and reports the results of their pre-NDA meeting. The Takeaway Investors should realize that BCRX is a very news-driven speculative stock right now that will remain volatile and quite unpredictable as more news trickles in from Asia about the spread of H7N9 and the infection rates, as well as the death toll. If these rise, expect more bullish speculation on this particular ticker. Also note that Peramivir’s US development program was “brought back from the dead” with the FDA’s pre-NDA meeting which will (hopefully) provide a path towards FDA approval for BioCryst. Depending on the results of this meeting, BCRX should either move up (or down) quite violently, as this is the company’s “flagship” development program. |
prodlikegod User ID: 5301647 United Kingdom 04/26/2013 06:29 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths Quoting: Anonymous Coward 36021878 Horrible Did not bother reading the next one this is bad enough The Frightening Story Of A Man Who Bought A Chicken And Then Died Of Bird Flu Read more: [link to www.businessinsider.com] |
CrazyMama73 User ID: 36333347 Canada 04/26/2013 06:37 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths I wonder if anyone has tried any natural remedies that may help beat this damn flu? I remember when SARS hit Toronto a while back. That was creepy. I had a few friends whose whole family were quarantined. People were wearing masks everywhere. You seen people walking up and down stairs or going on escalators but not holding the rails in fear of getting germs on their hands. Scary times are a head of us! |
prodlikegod User ID: 5301647 United Kingdom 04/26/2013 06:49 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths Quoting: prodlikegod I couldn't get the rest of the article- it went to an ad, anyway, I don't know where they got 300%, but I think they are playing w/numbers. BioCryst Heats Up: H7N9 Virus Hits Taiwan, Fatalities Up Nearly 300% BioCryst really needed the good news after the withdrawal of the IND application for BCX5191, and a failed attempt at a merger with Presidio Pharmaceuticals which raised major concerns about the company’s prospects going forward. By Bio-Wire Apr 25, 2013 2:05:34 PM PDT | 27 View(s) | No Comment(s) - Post a Comment Rating inShare Print Email BIO-WIRE Home Analysis (0) Articles (117) Blogs (0) Files (0) Picks (0) SEND MESSAGE ADD TO CONTACTS FOLLOW We’ve been seeing a lot of new activity in BioCryst Pharmaceuticals (NASDAQ: BCRX), which we last covered on April 7th following a 42% run in the stock chasing the good news that the company received from the FDA about its antiviral agent peramivir. The program, which was presumed to be dead after suspension of its phase III trial in November 2012 due to futility, received a second life when the FDA decided to arrange a meeting with the company to discuss a possible path towards an NDA submission. It seems that the FDA agrees with the notion that the phase III trial was set up to be a failure due to its design, and that peramivir has demonstrated its worth as an antiviral agent in previous situations. While many drugs development programs never survive a Phase III failure, peramivir seems to be a very special case. BioCryst really needed the good news after the withdrawal of the IND application for BCX5191, and a failed attempt at a merger with Presidio Pharmaceuticals which raised major concerns about the company’s prospects going forward. Now that confidence has been restored in the neuramindase inhibitor peramivir, investors are trying to gauge how much the drug could be worth based on the market success of Tamiflu (oseltamivir) and Relenza (zanamivir). While the method of peramivir’s delivery is different (it is an IV formulation), some evidence suggests that it may be particularly efficacious against strains of bird flu despite a similar mechanism of action. This was why the drug was temporarily approved and utilized in the bird flu outbreak of 2009 in Asia. Looking back, we can see that the hype over peramivir caused an enormous rally in shares of BioCryst, sending the company well above $10/share as investors attempted to chase what seemed to be a best-in-class antiviral agent. Although it wasn’t proven in clinical trials, some still believe that peramivir could be the best neuramindase inhibitor out there. H7N9, which is the most recent strain of bird flu, has caused a lot of recent interest in BCRX as investors remember how high the stock went in 2009. As described in an update on April 8th, 2013, the H7N9 virus infected at least 26 people at that point and killed at least 6. Between then and now, infections have risen to at least 108 and the death toll has risen to 22. Even more terrifying to Asian governments is the confirmation that the virus has spread to Taiwan, and commentary given by the World Health Organization. Not only are they struggling to determine the source of the infection, but they have confirmed that it is an “unusually dangerous virus for humans” and that “more easily transmitted from poultry to humans than H5N1”. H5N1 was the strain of bird flu that claimed 332 lives between 2004 and 2007. While BioCryst is unlikely to see financial benefit in the event that China, Taiwan, and other nations stockpile peramivir in reaction to the H7N9 outbreak, it’s possible that investors may bid up BCRX (again) in anticipation of a repeat of the run-up we saw in 2009. This may also put pressure on the FDA to approve peramivir through some alternative route, although we will see the details on this matter after BioCryst holds and reports the results of their pre-NDA meeting. The Takeaway Investors should realize that BCRX is a very news-driven speculative stock right now that will remain volatile and quite unpredictable as more news trickles in from Asia about the spread of H7N9 and the infection rates, as well as the death toll. If these rise, expect more bullish speculation on this particular ticker. Also note that Peramivir’s US development program was “brought back from the dead” with the FDA’s pre-NDA meeting which will (hopefully) provide a path towards FDA approval for BioCryst. Depending on the results of this meeting, BCRX should either move up (or down) quite violently, as this is the company’s “flagship” development program. Shorting Birdflu Via BioCryst Pharma (NASDAQ:BCRX) by Steve Kanaval - on Apr 8th 2013 - Naples Fla 4/8/2013 (BasicsMedia) – I saw another Birdflu volley today as the scare resurfaces, it is as common to resurface as the human flu. (NASDAQ:BCRX) was trading $4.10 p/s , and don’t forget March 2012 when it was a lofty $5.50 p/s when Wall Street was convinced we would all contract some deadly disease if we walked under a flying bird. [link to basicsmedia.com] Last Edited by prodlikegod on 04/26/2013 06:51 PM |
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Ollo User ID: 38471863 United States 04/26/2013 07:21 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths April 26, 2013 BEIJING — As of Thursday 109 people have been confirmed to be dead from the H7N9 virus which emerged rather quickly this April after the typical flu season. Human-to-human transmission has not yet been documented. However, reports from the World Health Organization state that 40% of the victims did not have contact with any type of poultry raising concern amongst the medical community. Even more alarming is the fact that the virus has over a 20% mortality rate right out of the gate. If this proves to continue, we could possibly be looking at one of the most deadly viral outbreaks of all time. This is backed up by others such as journalist, Patrick Di Justo, who wrote, “As of today, dividing the number of confirmed cases by the number of deaths makes it look as though H7N9 is an especially bad flu, with a twenty-per-cent mortality rate. If true, this would be terrifying: the 1918 Spanish Flu, which has been called one of the deadliest plagues in human history, also had a mortality rate of around two percent.” Is that a typo??? |
Anonymous Coward User ID: 1540313 United States 04/26/2013 08:04 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths April 26, 2013 BEIJING — As of Thursday 109 people have been confirmed to be dead from the H7N9 virus which emerged rather quickly this April after the typical flu season. Human-to-human transmission has not yet been documented. However, reports from the World Health Organization state that 40% of the victims did not have contact with any type of poultry raising concern amongst the medical community. Even more alarming is the fact that the virus has over a 20% mortality rate right out of the gate. If this proves to continue, we could possibly be looking at one of the most deadly viral outbreaks of all time. This is backed up by others such as journalist, Patrick Di Justo, who wrote, “As of today, dividing the number of confirmed cases by the number of deaths makes it look as though H7N9 is an especially bad flu, with a twenty-per-cent mortality rate. If true, this would be terrifying: the 1918 Spanish Flu, which has been called one of the deadliest plagues in human history, also had a mortality rate of around two percent.” Is that a typo??? Yes I think so, 23 dead so far known positive flu. |
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Anonymous Coward User ID: 1540313 United States 04/26/2013 08:11 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths The first case of H7N9 Quoting: Anonymous Coward 36021878 influenza in Taiwan We report here the first case of H7N9 infection outside mainland China. A 53-year-old male patient was admitted because of fever for 3 days after returning from Suchow, Jiangsu Province, China on April 9, 2013. He had been otherwise well except for a history of hypertension and chronic hepatitis B virus infection. The patient did not report a history of contact with sick persons or animals during the travel. He began to get fever and general malaise on April 12. He had no respiratory symptoms, gastrointestinal symptoms, or myalgias. The patient sought medical attention on April 16 when fevers continued. Two throatswab specimens tested negative for H7N9 with real-time PCR on April 17 and April 20, respectively. The first chest radiograph was normal. Treatment with oseltamivir was started at a dose of 75 mg twice daily. A follow-up chest radiograph on April 18 revealed interstitial pneumonia at the right lower lung, for which moxifloxacin was added. Progressive dyspnoea developed on April 19. Follow-up chest radiographs showed progressive bilateral lower-lung consolidation. He was transferred to National Taiwan University Hospital on April 20. The dose of oseltamivir was increased to 150 mg twice daily. Endotracheal intubation and mechanical ventilator support was given on arrival because of respiratory failure. Ceftazidime and levofloxacin were started, although microbiological investigations were negative. Desaturation worsened despite use of supplemental O₂ at O₂ fraction of 100%. Inhalational NO was added on April 21 without benefit. Chest radiography and sonography did not reveal pneumothorax. He was put on extracorporeal membrane oxygenation on April 22. This patient’s sputum specimen was subtyped as H7N9 with the protocol provided by WHO Collaborating Centre in Beijing. Very high H7N9 viral loads (4·5-51·4x107 copies per mL) were found in the two sputum specimens and one throat-swab specimen (collected on April 20 and April 22, respectively) while the viral load was undetectable in the blood specimens collected daily between 20 and 23 April. H7N9 might spread to other areas beyond Shanghai, China. Due to the rapidly progressing lower respiratory tract infections in infected individuals,1,2 extensive preventive efforts are needed to prevent further spreading of H7N9. We declare that we have no conflicts of interest. Sui-Yuan Chang, Pi-Han Lin, Jen-Chih Tsai, Chien-Ching Hung, *Shan-Chwen Chang [email protected] Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan (S-YC, P-HL); and Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (J-CT, C-CH, S-CC) 1 Gao R, Cao B, Hu Y, et al. Human infection with a novel avian-origin influenza A (H7N9) virus. N Engl J Med. 2013; published online April 11. DOI:10.1056/NEJMoa1304459. 2 Guan Y, Farooqui A, Zhu H, Dong W, Wang J, Kelvin DJ. H7N9 incident, immune status, the elderly and a warning of an influenza pandemic. J Infect Dev Ctries 2013; 7: 302–07 Thanks for this post!!! Holy shit, this is bad, doesn't show up in bloodwork, just in sputum from lungs/and lower resp. tract, holy shit, this thing is a nightmare come true. Oh and, VERY HIGH VIRAL LOADS. OMG. |
Ollo User ID: 38471863 United States 04/26/2013 08:22 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths April 26, 2013 BEIJING — As of Thursday 109 people have been confirmed to be dead from the H7N9 virus which emerged rather quickly this April after the typical flu season. Human-to-human transmission has not yet been documented. However, reports from the World Health Organization state that 40% of the victims did not have contact with any type of poultry raising concern amongst the medical community. Even more alarming is the fact that the virus has over a 20% mortality rate right out of the gate. If this proves to continue, we could possibly be looking at one of the most deadly viral outbreaks of all time. This is backed up by others such as journalist, Patrick Di Justo, who wrote, “As of today, dividing the number of confirmed cases by the number of deaths makes it look as though H7N9 is an especially bad flu, with a twenty-per-cent mortality rate. If true, this would be terrifying: the 1918 Spanish Flu, which has been called one of the deadliest plagues in human history, also had a mortality rate of around two percent.” Is that a typo??? Yes I think so, 23 dead so far known positive flu. OK, that's what I thought...saw that and thought we were really screwed! |
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Anonymous Coward User ID: 2890226 Canada 04/26/2013 09:19 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths The scientists also tracked 385 family members, co-workers and health care staff who had unprotected contact with the patients. None of them showed any symptoms of H7N9 infection over 14 days of follow-up, which suggests that the virus currently cannot be spread among people. Quoting: prodlikegod [link to m.news24.com] Depends how close of contact they're in doesnt it? I'll do the honorable thing. I'll infect myself with H7N9, go to taiwan and do the following: talk to one girl kiss one girl get a beej from another shag another and while I'm at it, arrange a 3some or even a 4gasm Then I'll check the transmission progress of each. Someone has to do it (lol). |
Anonymous Coward User ID: 2890226 Canada 04/26/2013 09:21 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths [link to news.xinhuanet.com] Quoting: Vic-chick13 First H7N9 bird flu case confirmed in Fujian Luo tested positive for the H7N9 virus at 11 a.m. on Friday by the Chinese Center for Disease Control and Prevention. An examination of the patient at a clinical laboratory in Fujian Province also confirmed Luo's infection with the H7N9 bird flu, the statement said. A little more info here. [link to au.news.yahoo.com] Just out of curiosity - Is there a site that overlays the cities with a confirmed case over a map? I've only been to China once and havent played Dynasty Warriors in soooo long. |
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Anonymous Coward User ID: 38938952 United Kingdom 04/26/2013 09:26 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths Holy shit, this is bad, doesn't show up in bloodwork, just in sputum from lungs/and lower resp. tract, holy shit, this thing is a nightmare come true. Oh and, VERY HIGH VIRAL LOADS. OMG. spider this is much more widely spread than we are being given the numbers for my guess is close to 200 dead not the 28 figure being given |
Anonymous Coward User ID: 2890226 Canada 04/26/2013 09:29 PM Report Abusive Post Report Copyright Violation | Re: BREAKING UPDATE August 11, 2015 / 591 cases / 300 deaths from H7N9 . MERS CoV 1352 Cases, 479 deaths Just from my general speculation, I'd believe that if you had more cells of any strain of viri then you're immune system would be more inclined to be at either the advantage of knowing how to handle new intruders or possibly running the risk of new strains binding to pre existing receptors or mutating with other similar cells. |
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