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FoxM1B - Eternal life within.

 
DailyEntertainment
User ID: 8379586
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04/12/2013 11:11 PM
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FoxM1B - Eternal life within.
My Daily Entertainment.

[link to www.scienceagogo.com]

"The body's inability to grow new tissue as it ages might be overcome by increasing the activity of a gene known as FoxM1B, according to a study published in the Sept. 25 issue of the Proceedings of the National Academy of Science. By increasing the activity, or expression, of this gene in aged experimental mice, Robert Costa, professor of molecular genetics at the University of Illinois at Chicago College of Medicine, and his colleagues were able to restore the regeneration of liver cells to rates of growth typical of young mice.

Because in humans the FoxM1B gene exists not only in the liver but also throughout the body, the researchers believe their discovery might one day be used in gene therapy in the elderly to restore their ability to replace old cells with new ones and rejuvenate worn-out organs. Cells divide normally when stimulated by FoxM1B, making it an ideal candidate for use in therapeutic intervention, according to Costa."
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[link to en.wikipedia.org]

"Issues with this gene are "FOXM1 gene is now known as a human proto-oncogene.[10] Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide."

What stimulates this gene behavior to produce cancer? Anti aging ointments? Hand Cream? Sun Block? 5a Do these thing's also make us age faster? Or just give us cancer?

I don't have the answer to my own questions. Maybe everyone can help me with the research of the youth gene and it's link to cancer?

I find it fascinating that the same gene in which controls aging, also controls cancer.

Any thoughts?
DailyEntertainment (OP)

User ID: 8379586
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04/12/2013 11:19 PM

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Re: FoxM1B - Eternal life within.
"FoxM1B regulates NEDD4-1 expression, leading to cellular transformation and full malignant phenotype in immortalized human astrocytes."


[link to en.wikipedia.org]


"Astrocytes, also known collectively as astroglia, are characteristic star-shaped glial cells in the brain and spinal cord. They are the most abundant cell of the human brain."
-Benjamin Franklin-

“Believe none of what you hear, and only half of what you see.”
DailyEntertainment (OP)

User ID: 8379586
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04/12/2013 11:22 PM

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Re: FoxM1B - Eternal life within.
"Our recent studies have shown that the FoxM1B transcription factor is overexpressed in human glioma tissues and that the level of its expression correlates directly with glioma grade. However, whether FoxM1B plays a role in the early development of glioma (i.e., in transformation)"cancer" is unknown."

[link to www.google.com]

Last Edited by DailyEntertainment on 04/12/2013 11:22 PM
-Benjamin Franklin-

“Believe none of what you hear, and only half of what you see.”
N3m3s1s

User ID: 37917461
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04/12/2013 11:23 PM

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Re: FoxM1B - Eternal life within.
Interesting Bump for later
DailyEntertainment (OP)

User ID: 8379586
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04/12/2013 11:26 PM

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Re: FoxM1B - Eternal life within.
[link to www.researchgrantdatabase.com]

"An underlying mechanism of the aging process involves reduced cellular proliferation and repair in response to tissue injury. This involves both diminished DNA replication (S-Phase) and progression into mitosis (G2/M block), resulting in accumulation of polyploid cells with 4N DNA content and ultimately causing chromosome instability and mutations leading to a variety of diseases found in the elderly.

The mechanisms involved in the progressive decline in cellular proliferation with aging remain uncharacterized. Recent studies have shown that diminished expression of the proliferation-specific Forkhead Box M1B (FoxM1B) transcription factor is associated with reduction in both cellular proliferation and expression of cell cycle progression genes during aging.

We recently performed liver regeneration studies to demonstrate that maintaining hepatocyte expression of FoxM1B in 12-month old (old-aged) transgenic (TG) mice increased hepatocyte proliferation to levels similar to those observed in young regenerating mouse liver.

Maintaining FoxM1B levels in old-aged proliferating cells is associated with increased expression of numerous genes required for progression into S-phase and mitosis. Collectively, these results suggest that FoxM1B controls the transcriptional network of genes essential for cellular proliferation and that its reduced expression contributes to the decline in cellular proliferation during aging.


Our long-term goal is to determine whether maintaining FoxM1B expression will prevent age-related proliferation defects and result in life span extension. We plan to do so with the following Specific Aims

1) We will conditionally delete the FoxM1B gene in young adult mice to test the hypothesis that extinguished FoxM1B expression in proliferating cells will lead to defective S-phase and M-phase progression observed in premature aging. 2) We have created TG mice that use the Rosa-26 promoter region to drive FoxM1B expression in all cell types. We will use these mice to examine the hypothesis that maintaining FoxM1B levels in all cell types will stimulate cellular proliferation during aging and lead to life span extension.

3) We find that the tumor suppressor protein, p19ARF (p19), inhibits FoxM1B transcriptional activity. Because the FoxM1B controls expression of cell cycle progression genes, these results suggest that the p19 protein also mediates growth arrest by inhibition of FoxM1B transcriptional activity.

We will further characterize the FoxM1B and p19 protein interaction and use mouse embryo fibroblasts (MEFs) from Rosa26-FoxM1B TG mice to test the hypothesis that increased FoxM1 B levels will delay p19 mediated replicative senescence (G1 arrest)."

Last Edited by DailyEntertainment on 04/12/2013 11:28 PM
-Benjamin Franklin-

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DailyEntertainment (OP)

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04/12/2013 11:31 PM

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Re: FoxM1B - Eternal life within.
Keep in mind all this has been found out by using mice.

fact remains, regardless of mice, monkey or fish. The FoxM1B gene is incharge of aging and the production of cancer! The real question is; What triggers this gene to produce cancer instead of allowing the healthy cell splitting of used/toxic blood cells?

Last Edited by DailyEntertainment on 04/12/2013 11:33 PM
-Benjamin Franklin-

“Believe none of what you hear, and only half of what you see.”

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