Quelling the Abstinential Forces of Devourance (Tripping into Thyrule)

Information itself is one thing. Expressing and cohering that information as to unravel the rooted revelation from coils of convolution... is a boisterous blessing.

Yes, the risk of hyperprolactinaemia and increase of phospho-CREB would allude to its efficacy.

Okay, I see. Standard/high doses inhibit D2/D3 receptors; low doses facilitate dopamine release. If I were to get my hands on it, I'd take standard doses at night (as I'm doing with corydalis).

As for rhodiola, of the neurotransmitters deaminated by MAO-A, the only one I'd care to spare would be dopamine. Not sure about its other effects; seems useful as an adaptogen. Then again, I've come to rely more on diet for hormonal modulation.



Forskolin, famous cAMP-booster, had drastically exacerbated my anhedonia.

Inhibition of cAMP response element-binding protein or dynorphin in the nucleus accumbens produces an antidepressant-like effect.
[link to www.ncbi.nlm.nih.gov]

Reports of Forskholin and liver issues anecdotally or second hand as an FYI.

Vita C and Selenium with the Iodine to help reverse hypothyroid according to some.

To depend only on diet seems most wise


It's the craving for salt I can't seem to lick

Thanks for sharing.

Appears it's some other not yet elucidated constituent of Coleus forskohlii that's responsible. [link to www.ncbi.nlm.nih.gov]

But yeah, avoid forskolin anyway.

Easy on the iodine, though. I've mega-dosed, and, let's just say, diet trumps all for me.

Effects of increased iodine intake on thyroid disorders.
[link to www.ncbi.nlm.nih.gov]

Iodine excess as an environmental risk factor for autoimmune thyroid disease.
[link to www.ncbi.nlm.nih.gov]

.... an ecdytic pulse as an empathic expression, to me belies the notion of the existence of a cold-blooded heart.

Thank you. Yeah I need to retest levels and stop the high oral levels. Got some nascent and will use Lugol's on the skin is the plan now to get and stay where I need to be. Don't know if it was all because of mercury toxicity from my tooth filling breaking and swallowing it or just deficient but I've always had the neck bump since growing up. Could be both. It definitely helps me to feel better and think better to an extent. Better, more consistent energy to an extent as well. I was so deficient for so long it seems. It appears many people are and don't know it. I tended to always stay away from salt and thus iodine when young. Was always colder physically it seemed and had other symptoms as well.

Indeed. The slightest spark still surrenders to the crux-clutching generative will of fluxive flame, sworn to stave snuff.

Hmmmm but of course noradrenaline is a strut before a booster rocket

Yet oh-so-rarely do I awaken to the world, terrified at my own power.

Anti-inflammatory Activity of a Honey Flavonoid Extract on Lipopolysaccharide-Activated N13 Microglial Cells

Neuroinflammation is an important contributor to pathogenesis of age-related neurodegenerative disorders such as Alzheimer’s or Parkinson’s disease. Accumulating evidence indicates that inhibition of microglia-mediated neuroinflammation may become a reliable protective strategy for neurodegenerative processes. Flavonoids, widely distributed in the vegetable kingdom and in foods such as honey, have been suggested as novel therapeutic agents for the reduction of the deleterious effects of neuroinflammation. The present study investigated the potential protective effect of a honey flavonoid extract (HFE) on the production of pro-inflammatory mediators by lipopolysaccharide-stimulated N13 microglia. The results show that HFE significantly inhibited the release of pro-inflammatory cytokines such as TNF-a and IL-1B. The expressions of iNOS and the production of reactive oxygen intermediates (ROS) were also significantly inhibited. Accordingly, the present study demonstrates that HFE is a potent inhibitor of microglial activation and thus a potential preventive–therapeutic agent for neurodegenerative diseases involving neuroinflammation.
[link to pubs.acs.org]

Diagram - [link to pubs.acs.org]

[link to www.greenmedinfo.com]

Honey even helps sebh. dermatitis on the head it appears. Helping people with dandruff and on the face from one study. Hopefully that link worked from greenmedinfo dot com. In ancient Egypt honey was the most mentioned substance according to this article.

Although the molecular mechanism of vulnerability of dopaminergic neurons in the substantia nigra pars compacta is not known, it is suggested that monoamine oxidase-mediated abnormal dopamine metabolism, hydrogen peroxide generation, abnormal mitochondrial and proteasomal dysfunctions along with microglial cell activation may be closely associated with neurodegenerative process [5].

...

Activation of nitric oxide synthase (NOS) generates nitric oxide (NO), which reacts with superoxide to form peroxynitrite. This molecule oxidatively modifies nucleic acid, lipid, sugar, and protein, leading to nuclear damage, mitochondrial damage, proteasome inhibition, and endoplasmic reticulum (ER) stress [16]. NO and peroxynitrite not only decrease glutathione but also S-nitrosylate many proteins. Excessive nitrosative stress contributes to the hyperactivation of the N-methyl-D-aspartate (NMDA)-type glutamate receptor, mitochondrial dysfunction, and cellular aging.

...

In addition, NO-mediated effects on dopaminergic neurons may also include the inhibition of cytochrome oxidase, ribonucleotide reductase, mitochondrial complexes I, II, and IV in the respiratory chain, superoxide dismutase, glyceraldehyde-3-phosphate dehydrogenase, activation or initiation of DNA strand breakage, poly (ADP-ribose) synthase, lipid peroxidation, protein oxidation, release of iron, and increased generation of toxic radicals such as hydroxyl radicals and peroxynitrite [19].

...

Accumulating evidence suggests that in PD degeneration of dopaminergic neurons in substantia nigra is accompanied not only by the progressive loss of NM [neuromelanin] but also by the induction of microgliosis [59]. Although NM particles are phagocytized and degraded by microglial cells within minutes, but extracellular NM particle-mediated microglial activation results in the generation of superoxide, nitric oxide, hydrogen peroxide, and other proinflammatory factors including cytokines and chemokines, which support oxidative stress and inflammation in the brain [36, 37, 59].

Conclusions
PD is a common neurodegenerative movement disorder, which affects increasing number of elderly population. The disorder is caused by a selective degeneration of dopaminergic neurons in the substantia nigra pars compacta. Although the molecular mechanism associated with neurodegeneration in PD is not known, it is becoming increasingly evident that neurodegeneration in PD is a multifactorial process that may involve monoamine oxidase-mediated abnormal dopamine metabolism, increase in iron levels, hydrogen peroxide generation, abnormal mitochondrial and proteasomal function along with microgliosis may be closely associated with the pathogenesis of PD. Microglial cells play a critical role in forming a self-propelling cycle leading to sustained chronic neuroinflammation and driving the progressive neurodegeneration in PD. The above-mentioned processes have been shown to contribute to the oxidative stress, accumulation of a-synuclein, and neuroinflammation not only in cell culture and animal models of PD, but also in brains of PD patients.

Hmmmm no wait.... we can begin by saying that salient perceptions arise from serotonin as the 'final root source', OR, we can begin by saying that norepinephrine will be the bottleneck on perceptual reception/synthesis

With the latter, serotonin becomes invisible to the neurologician.... I could go so far as to call a Will-o-the-Wisp a serotonergic dimensional range limiter type thing but why not just say they'd be, rathermore, DMT?

To be whisked away by feckless flickerings, or to renounce into myopic misery.

I seem to experience a hypodopaminergic elongation of the latent period. Often picking out only the most relevant information. In that sense, I am close-minded.