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Cheap, safe drug kills most cancers!!!

 
Anonymous Coward
User ID: 174788
United States
01/31/2007 01:40 AM
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Cheap, safe drug kills most cancers!!!
[link to www.newscientist.com]
Amagine that!

New Scientist has received an unprecedented amount of interest in this story from readers. If you would like up-to-date information on any plans for clinical trials of DCA in patients with cancer, or would like to donate towards a fund for such trials, please visit the site set up by the University of Alberta and the Alberta Cancer Board. We will also follow events closely and will report any progress as it happens.

IT SOUNDS almost too good to be true: a cheap and simple drug that kills almost all cancers by switching off their "immortality". The drug, dichloroacetate (DCA), has already been used for years to treat rare metabolic disorders and so is known to be relatively safe. It also has no patent, meaning it could be manufactured for a fraction of the cost of newly developed drugs.

Evangelos Michelakis of the University of Alberta in Edmonton, Canada, and his colleagues tested DCA on human cells cultured outside the body and found that it killed lung, breast and brain cancer cells, but not healthy cells. Tumours in rats deliberately infected with human cancer also shrank drastically when they were fed DCA-laced water for several weeks.

DCA attacks a unique feature of cancer cells: the fact that they make their energy throughout the main body of the cell, rather than in distinct organelles called mitochondria. This process, called glycolysis, is inefficient and uses up vast amounts of sugar. Until now it had been assumed that cancer cells used glycolysis because their mitochondria were irreparably damaged. However, Michelakis's experiments prove this is not the case, because DCA reawakened the mitochondria in cancer cells. The cells then withered and died (Cancer Cell, DOI: 10.1016/j.ccr.2006.10.020).

Michelakis suggests that the switch to glycolysis as an energy source occurs when cells in the middle of an abnormal but benign lump don't get enough oxygen for their mitochondria to work properly (see Diagram). In order to survive, they switch off their mitochondria and start producing energy through glycolysis.

more at above link

Last Edited by SPUD on 06/17/2013 12:54 PM
Anonymous Coward
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01/31/2007 04:03 AM
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Re: Cheap, safe drug kills most cancers!!!
I just glanced over your post. My initial reaction is that, even if is all you say about curing cancer is true, it still sounds dangerous if reactions with tranquilizers are known to cause death. Looks like you have to be very careful what you might take it with. So it doesn't sound safe for it to be released for unsupervised use by the general public.

There are some things available for general use that are safe AFAIK and often effective in cancer cases
IP6 and Inositol
Brocolli sprouts

Regarding the question of whether metabolism or mutations spark off cancers, I think the issue is really if the immune system is able to defend the body. When the immune system is weak or overwhelmed, then cancerous cells can multiply. If you have something in the body that is screwing up the metabolism, say a toxin secreted by a virus, fungus, or bacteria or some micro-organism, or some chemical that came in from the external environment (pollution or pesticide, etc), then this will make mutations more likely to occur - if the metabolism is thrown off then mutations are more likely... Likewise, if mutations happen, even by random chance or cosmic ray etc, then that may affect the metabolism. So the subjects of mutations and metabolisms are interwoven together, you can not separate them apart from each other very well.



"The drug's discoverer, Dr. Joseph Gold, had found that HS reacted badly if patients were taking other drugs, especially tranquilizers. Several warnings were given to NCI before it began its test. The warnings were explicit. Patients could DIE if they were taking tranquilizers."

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