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Researchers Grow Brain Cells on a Chip

 
Face Palmer
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05/19/2017 05:11 AM
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Researchers Grow Brain Cells on a Chip
Every human thought starts with a signal traveling from one neuron to another in the brain. Yet we know relatively little about how these connections form. In an effort to watch that process unfold, Australian researchers engineered a nanowire scaffold on a semiconductor chip that enables brain cells to grow and form circuits. The scientists described their device recently in the journal Nano Letters.

The neural scaffold falls far short of any brain-on-a-chip that futurists might imagine. But it does provide a way for scientists to guide the growth of neurons and study their connectivity, says Vini Gautam, a biomaterials engineer at Australian National University who led the study.

That has been a challenge for scientists trying to recreate neural circuitry in the lab. Neurons in the brain connect and communicate in a highly ordered way. But in the lab, the cells tend to reconstruct randomly and suffer from experimental limitations that render the circuitry nothing like the real thing in the brain.

“Understanding how neural circuits form in the brain is one of the fundamental questions in neuroscience,” Gautam says. Those connections form the basis for how we process information, and understanding them is key to developing treatments for mental disorders, she says.

[link to spectrum.ieee.org]

Oh well...
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Face Palmer (OP)

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05/19/2017 05:13 AM
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Re: Researchers Grow Brain Cells on a Chip
Instant pin lol. Thanks hf
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Anonymous Coward
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05/19/2017 05:19 AM
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Re: Researchers Grow Brain Cells on a Chip
We all knew he dint have any.
Anonymous Coward
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05/19/2017 05:30 AM
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Re: Researchers Grow Brain Cells on a Chip
glpaward
NowIhavetothinkofanam​e

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05/19/2017 05:38 AM
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Re: Researchers Grow Brain Cells on a Chip
Instant pin lol. Thanks hf
 Quoting: Face Palmer


It deserves it dood. This thread is the best on GLP today. I don't have much karma but this is definitely pin worthy.
NowIhavetothinkofanameohnoithurts
It's all bull!
Nevertheless, the ruler is not truly wise who cannot discern evils before they develop themselves, and this is a faculty given to few. Niccolo Machiavelli
Karma is funny, people who kick dogs usually get bitten.
If someone doesn't add value to your life, then that someone shouldn't be a part of it.
You can always trust people to do whatever is in their own interests.
Anonymous Coward
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05/19/2017 05:52 AM
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Re: Researchers Grow Brain Cells on a Chip
Yeah but it all starts on the head of a penis needle
Anonymous Coward
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05/19/2017 06:04 AM
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Re: Researchers Grow Brain Cells on a Chip
Unethical.
a Dude, not THE Dude
No one of consequence

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05/19/2017 06:06 AM

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Re: Researchers Grow Brain Cells on a Chip
This is cool and scary at the same time. The potential to use it to develop real treatments that work...great!

The potential to use it to interface humans and machines...could go really bad.
Sydney Pollack
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05/19/2017 06:10 AM
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Re: Researchers Grow Brain Cells on a Chip
after all...it's a good news for some folkslol

pennbrains
BRIEF
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05/19/2017 06:12 AM

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Re: Researchers Grow Brain Cells on a Chip
After the first 5 brain cells were formed it was already smarter than a Nagger...
With freedom comes responsibility.

Science: The subtle worship of God through the study of His creation.

There is no God for the atheist.

Briefcut4892
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05/19/2017 06:15 AM
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Re: Researchers Grow Brain Cells on a Chip
ah Clinton clones cant wait
Anonymous Coward
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05/19/2017 06:16 AM
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Re: Researchers Grow Brain Cells on a Chip
old
Face Palmer (OP)

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05/19/2017 06:19 AM
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Re: Researchers Grow Brain Cells on a Chip
bwainz
"The world will soon wake up to the reality that everyone is broke and can collect nothing from the bankrupt, who are owed unlimited amounts by the insolvent, who are attempting to make late payments on a bank holiday in the wrong country, with an unacceptable currency, against defaulted collateral, of which nobody is sure who holds title."

Never attribute to malice that which is adequately explained by stupidity.

The woman who is not pursued sets up the doctrine that pursuit is offensive to her sex, and wants to make it a felony. No genuinely attractive woman has any such desire. - H.L. Mencken, In Defense Of Women
Anonymous Coward
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05/19/2017 06:20 AM
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Re: Researchers Grow Brain Cells on a Chip
good ol face palma science threads
Anonymous Coward
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05/19/2017 06:24 AM
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Re: Researchers Grow Brain Cells on a Chip
This is cool and scary at the same time. The potential to use it to develop real treatments that work...great!

The potential to use it to interface humans and machines...could go really bad.
 Quoting: a Dude, not THE Dude


maybe we are already an example of a variant of just that...
Judethz
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05/19/2017 06:27 AM

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Re: Researchers Grow Brain Cells on a Chip
shivacern The fact is that a great many scientists, chemists and others are quite knowingly doing the devils work. There will be many of them heading for hell.

Dan 2:43 And whereas thou sawest iron mixed with miry clay, they shall mingle themselves with the seed of men: but they shall not cleave one to another, even as iron is not mixed with clay.
Anonymous Coward
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05/19/2017 06:30 AM
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Re: Researchers Grow Brain Cells on a Chip
Good. I need an extra brain.
Anonymous Coward
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05/19/2017 06:32 AM
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Re: Researchers Grow Brain Cells on a Chip
This is cool and scary at the same time. The potential to use it to develop real treatments that work...great!

The potential to use it to interface humans and machines...could go really bad.
 Quoting: a Dude, not THE Dude


How's that. Ever since I was a kid, I've wanted a neural computer interface.
Anomalous Coward
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05/19/2017 06:36 AM
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Re: Researchers Grow Brain Cells on a Chip
Thanks for the interesting post OP. hf

I'm rather interested in the subject, for I will be practicing in neuroregenerative cell research group this autumn, I've read the group utilizes 2- or 3D biomaterials but haven't actually read they could be grown over chips too. The group which I work with focuses on applications in e.g. in vitro modeling of biological processes and neurological diseases, graft development, and neurotoxicity screening platforms. Pretty excited working in there.

I find it rather fashinating that the processes and active potentials happening in our brains can actually be simulated and stimulated. But is it really "thought"? Doesn't simulating real brain processes need a "processor" or processer, "You"? Without the processor, the cell growth is similiar to transformated cells, also known as cancer cells, growing endlessly without purpose. It is merely random bits of ones and zeroes if "you" don't know to read it. But this is still merely a conjecture.

You can practically grow limitless amount of nerve cells from pluripotent stem cells in liquid suspension. It's really new and complicated stuff, but who knows if something great could arise from that area, something similiar to invention of penicillin. Could come from anywhere really.

Cheers.
BRIEF
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05/19/2017 06:37 AM

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Re: Researchers Grow Brain Cells on a Chip
This is cool and scary at the same time. The potential to use it to develop real treatments that work...great!

The potential to use it to interface humans and machines...could go really bad.
 Quoting: a Dude, not THE Dude


How's that. Ever since I was a kid, I've wanted a neural computer interface.
 Quoting: Anonymous Coward 70261815


Yup, ET's use the technology to control their ships with telepathy.
With freedom comes responsibility.

Science: The subtle worship of God through the study of His creation.

There is no God for the atheist.

Briefcut4892
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05/19/2017 06:51 AM
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Re: Researchers Grow Brain Cells on a Chip
:shivacern: The fact is that a great many scientists, chemists and others are quite knowingly doing the devils work. There will be many of them heading for hell.

Dan 2:43 And whereas thou sawest iron mixed with miry clay, they shall mingle themselves with the seed of men: but they shall not cleave one to another, even as iron is not mixed with clay.

 Quoting: Judethz


It is mindsetting like that that has hindered human development for hundreds and thousands of years. I'm sure you also think that millions of people having different mental problems have caused their problems themselves, if you can even see so far behind that false and self-righteous zealousness of yours. It is the frightened ones who are the worst fearmongers.

Go back live in a cave where you belong, or for the love of Life try to better yourself.

CERN is entirely different thing anyways.
Anonymous Coward
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05/19/2017 06:55 AM
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Re: Researchers Grow Brain Cells on a Chip
Thanks for the interesting post OP. hf

I'm rather interested in the subject, for I will be practicing in neuroregenerative cell research group this autumn, I've read the group utilizes 2- or 3D biomaterials but haven't actually read they could be grown over chips too. The group which I work with focuses on applications in e.g. in vitro modeling of biological processes and neurological diseases, graft development, and neurotoxicity screening platforms. Pretty excited working in there.

I find it rather fashinating that the processes and active potentials happening in our brains can actually be simulated and stimulated. But is it really "thought"? Doesn't simulating real brain processes need a "processor" or processer, "You"? Without the processor, the cell growth is similiar to transformated cells, also known as cancer cells, growing endlessly without purpose. It is merely random bits of ones and zeroes if "you" don't know to read it. But this is still merely a conjecture.

You can practically grow limitless amount of nerve cells from pluripotent stem cells in liquid suspension. It's really new and complicated stuff, but who knows if something great could arise from that area, something similiar to invention of penicillin. Could come from anywhere really.

Cheers.
 Quoting: Anomalous Coward 74921226


Not a science person, but for what it's worth I'd say yes, there would have to be a subject or consciousness to spark any neural process into action. Without such a central command or processor any connections sparked would probably be random and meaningless. Or so it seems to me. I actually doubt they will ever come close to simulating human brain function in any meaningful way.
Anonymous Coward
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05/19/2017 06:58 AM
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Re: Researchers Grow Brain Cells on a Chip
Thanks for the interesting post OP. hf

I'm rather interested in the subject, for I will be practicing in neuroregenerative cell research group this autumn, I've read the group utilizes 2- or 3D biomaterials but haven't actually read they could be grown over chips too. The group which I work with focuses on applications in e.g. in vitro modeling of biological processes and neurological diseases, graft development, and neurotoxicity screening platforms. Pretty excited working in there.

I find it rather fashinating that the processes and active potentials happening in our brains can actually be simulated and stimulated. But is it really "thought"? Doesn't simulating real brain processes need a "processor" or processer, "You"? Without the processor, the cell growth is similiar to transformated cells, also known as cancer cells, growing endlessly without purpose. It is merely random bits of ones and zeroes if "you" don't know to read it. But this is still merely a conjecture.

You can practically grow limitless amount of nerve cells from pluripotent stem cells in liquid suspension. It's really new and complicated stuff, but who knows if something great could arise from that area, something similiar to invention of penicillin. Could come from anywhere really.

Cheers.
 Quoting: Anomalous Coward 74921226


Not a science person, but for what it's worth I'd say yes, there would have to be a subject or consciousness to spark any neural process into action. Without such a central command or processor any connections sparked would probably be random and meaningless. Or so it seems to me. I actually doubt they will ever come close to simulating human brain function in any meaningful way.
 Quoting: Anonymous Coward 43725420


That sentence should have read:

Without such a central command or processor any connections sparked BY ARTIFICIAL MEANS would probably be random and meaningless.
Anomalous Coward
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05/19/2017 07:21 AM
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Re: Researchers Grow Brain Cells on a Chip
Not a science person, but for what it's worth I'd say yes, there would have to be a subject or consciousness to spark any neural process into action. Without such a central command or processor any connections sparked by artificial means would probably be random and meaningless. Or so it seems to me. I actually doubt they will ever come close to simulating human brain function in any meaningful way.
 Quoting: Anonymous Coward 43725420


I agree, I think we are still very far from actually growing a brain as an organ, like scientists can already grow other organ and tissue transplants. I think there needs to be some kind of artifical stimulation of different genes that manifest different parts of the desired organ (i.e brain), but how that all can be done in proprly "organized" sequence is another matter entirely. I too think it's rather far out, but who knows. Technological and ethical issues have to be taken into account also.

I think simulating real brain activity isn't what medical research aims for, but instead simply trying to find better ways to help with different physical and neurological problems and disorders, for example more efficient ways to help people recover from brain infarct or cerebral hemorrhage. If we had more knowledge how nerve cells regenerate and how we could help them regenerate, we could help many many people. Maybe I'll get to do research like that someday, maybe it's already being done, don't really know for sure. The future is coming on is coming on is coming on...
Anonymous Coward
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05/19/2017 07:21 AM
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Re: Researchers Grow Brain Cells on a Chip
Resistance is futile. You will be assimilated.
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05/19/2017 07:32 AM
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Re: Researchers Grow Brain Cells on a Chip
Every human thought starts with a signal traveling from one neuron to another in the brain. Yet we know relatively little about how these connections form. In an effort to watch that process unfold, Australian researchers engineered a nanowire scaffold on a semiconductor chip that enables brain cells to grow and form circuits. The scientists described their device recently in the journal Nano Letters.

The neural scaffold falls far short of any brain-on-a-chip that futurists might imagine. But it does provide a way for scientists to guide the growth of neurons and study their connectivity, says Vini Gautam, a biomaterials engineer at Australian National University who led the study.

That has been a challenge for scientists trying to recreate neural circuitry in the lab. Neurons in the brain connect and communicate in a highly ordered way. But in the lab, the cells tend to reconstruct randomly and suffer from experimental limitations that render the circuitry nothing like the real thing in the brain.

“Understanding how neural circuits form in the brain is one of the fundamental questions in neuroscience,” Gautam says. Those connections form the basis for how we process information, and understanding them is key to developing treatments for mental disorders, she says.

[link to spectrum.ieee.org]

Oh well...
 Quoting: Face Palmer


Still not even close to even replicating Gods most highly advanced machine, the human body. Let alone creating something entirely unique. Everything man does is simply a manipulation or a copy of what already is and most times cant even get close to replicating what already is. All of our "intelligence" and not even close, not even a hairs breadth to creating something even remotely close to as advanced as the human body/brain. Yet we think an entirely random unintelligent process created all of it. The stupidity and arrogance of man.
Servant

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05/19/2017 07:39 AM
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Re: Researchers Grow Brain Cells on a Chip
It brings a whole new meaning to the saying - CHIP off the old block!
Anonymous Coward
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05/19/2017 07:43 AM
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Re: Researchers Grow Brain Cells on a Chip
They did this way back in 99 or 2000. I specifically remember reading an article on this right around the same time they grew a human ear on a rat's back. I will look for a link.
Anonymous Coward
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05/19/2017 07:48 AM
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Re: Researchers Grow Brain Cells on a Chip
They did this way back in 99 or 2000. I specifically remember reading an article on this right around the same time they grew a human ear on a rat's back. I will look for a link.
 Quoting: Anonymous Coward 65741633


Earliest I could find: March 1, 2004

[link to www.cbc.ca]

March 27, 2006:

[link to www.livescience.com]
Anonymous Coward
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05/19/2017 07:48 AM
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Re: Researchers Grow Brain Cells on a Chip
Brain in a box.
Aladdin Spain

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05/19/2017 07:51 AM
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Re: Researchers Grow Brain Cells on a Chip
A french fry?



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