Godlike Productions - Discussion Forum
Users Online Now: 1,989 (Who's On?)Visitors Today: 1,607,616
Pageviews Today: 2,345,582Threads Today: 633Posts Today: 13,189
07:06 PM


Rate this Thread

Absolute BS Crap Reasonable Nice Amazing
 

It's time to burn the GMO fields to ground. Light the blaze now!

 
To the Torch
User ID: 73757680
United States
07/10/2017 10:57 PM
Report Abusive Post
Report Copyright Violation
It's time to burn the GMO fields to ground. Light the blaze now!
The GMO Agenda Takes a Menacing Leap Forward with EPA’s Silent Approval of Monsanto/Dow’s RNAi Corn


One of the most important discoveries of our time is that all plants, including those we use for food and animal feed, contain a wide range of RNA molecules capable of inhibiting gene expression or translation. These non-coding RNA molecules neutralize targeted messenger RNA molecules (mRNAs), which prevents their translation into a protein, i.e. they "silence genes."

Compelling research has surfaced suggesting that not only do these genome-regulating small RNA molecules exist in our foods, but that they are capable of surviving digestion, and being absorbed into our bodies fully intact where they alter, suppress or silence genes, post-transcriptionally. Moreover, some of these small RNAs - primarily microRNAs (miRNAs) and small interfering RNAs (siRNAs) - are believed to be cross-kingdom mediators of genetic information, making it possible for RNAs in one species impacting many others through both their active and passive exposure to them.


While this discovery will have profound implications for the field of nutrition and medicine, it has also created enormous interest among biotech and agricultural firms, namely, Monsanto and Dow, looking to capitalize on the design of proprietary products using interference (RNAi) technology. In mid June, last month Monsanto received EPA approval for a type of corn genetically altered to produce an RNA-based pesticidal agent (aka, a plant-incorporated protectant (PIP)) which lethally targets a metabolic pathway within the corn rootworm, known within the industry as the "billion dollar bug." Branded as Smartstax PRO, the newly minted GMO plant produces a small, double-stranded RNA known as DvSnf7 dsRNA which disrupts a critical gene within the rootworm, causing its death. This was added on top of four other "stacked" GMO traits, such as the ability to produce two other pesticidal proteins (Cry1A.105 and Cry2Ab2), as well as survive exposure to both glyphosate (aka Monsanto's Roundup 2) and Glufosinate (aka Dow's Libertylink), highly toxic herbicides. Roundup, for instance, has demonstrated carcinogenicity in the parts per trillion range. Yet, the EPA considers it perfectly safe for consumers to ingest many orders of magnitude higher concentrations than that, proving its function as a cheerleader and not a regulator of the industry that controls our food supply.


[link to www.greenmedinfo.com]
Anonymous Coward (OP)
User ID: 73757680
United States
07/10/2017 11:01 PM
Report Abusive Post
Report Copyright Violation
Re: It's time to burn the GMO fields to ground. Light the blaze now!
One would imagine that such revolutionary technology would require short and long-term (decades) of safety testing before licensure. Instead, as is often the case with big-ticket market agendas, the product is being rushed to market. There are already significant biases in place within the EPA and USDA in regard to nucleic acids - assumptions that exempt them from cautionary considerations. RNA is considered Generally Accepted As Safe (GRAS), but this is because it is defined and perceived only as a physical substance rather than as the powerful signaling/informational molecule it is. The EPA's approval of RNAi food crops ignores the fact that it takes a multi-generational timescale to understand the influence of epigenetic modifiers on the genome of a species, much less the human species, whose timescale is orders of magnitude beyond animal models used to establish much of the risk/benefit data used in pre-approval evaluations. RNAi interference technology promises specificity -- one RNAi molecule change equals one gene suppressed -- but ignores the virtually infinite possibility of unintended, adverse effects in what are incomprehensibly complex biological systems. Indeed, researchers have warned that RNAi can not only profoundly affect gene expression, but that the changes it induces can permanently alter a species through inherited traits 1:
"Once a silencing effect is initiated, the effect may be inherited. The biochemistry of this process varies depending on the organism and remains an area of active research with many unknown aspects. Nevertheless, it is known for example that human cells can maintain the modifications necessary for TGS, creating actual or potential epigenetic inheritance within tissues and organisms (Hawkins et al., 2009). In some cases the dsRNA pathways induce RNA-dependent DNA methylation and chromatin changes (TGS) that persist through reproduction or cell division, and in other cases the cytoplasmic pathways remain active in descendents (Cogoni and Macino, 2000)."
Anonymous Coward
User ID: 17319534
United States
07/10/2017 11:04 PM
Report Abusive Post
Report Copyright Violation
Re: It's time to burn the GMO fields to ground. Light the blaze now!
Burn that GMO shit poison down!
Anonymous Coward (OP)
User ID: 73757680
United States
07/10/2017 11:09 PM
Report Abusive Post
Report Copyright Violation
Re: It's time to burn the GMO fields to ground. Light the blaze now!
Indeed, critics of RNA interference technology make the point that RNAi technology aims to target the production of a specific protein by identifying the sequence in question. But two or more genes can have sequence homologies. This means, as applies to the use of RNA interference in medicine, a gene that is targeted to turn off a "disease-causing gene" could have a number of off-target effects, one of which would be turning off a gene that is essential to health and vitality.

This is, in fact, what happened October of last year, when Alnylam Pharmaceuticals, a leading developer of RNAi drugs, announced it had decided to discontinue revusiran, its lead drug candidate, after an excess of deaths occurred in the experimental drug group versus placebo. This sent shockwaves throughout the overly exuberant RNAi drug industry, reducing their stock 6% on average.

Criticisms of RNAi in the agricultural sector are long-standing among the highly informed. For instance, Jonathan Latham, Ph.D. and Allison Wilson, Ph.D., wrote a seminal paper on the topic over a decade ago titled "Off-target effects of plant transgenic RNAi: three mechanisms lead to distinct toxicological and environmental hazards," wherein 3 of the primary safety concerns are addressed: 1) Off target effects leading to non-specific down-regulation of plant RNAs 2) Off target effects affecting non-target invertebrates feeding on plant material 3) potential effects on mammals. In mammals, long (>30 bp) perfectly duplexed RNAs (such as are typically produced by plant RNAi transgenes) are Pathogen Associated Molecular Patterns (PAMPS) and are consequently highly potent triggers of innate anti-viral defences. The effects of long dsRNAs on mammalian cellular functions are typically profound and extend to complete inhibition of protein translation and cell death. Nevertheless, the implications of such molecules in the mammalian diet have hardly been tested.

That's quite a serious list of concerns. As you can see, concern #3 includes the possibility that these dsRNAs may lead to protein translation and cell death. Clearly if the EPA has declared Monsanto and Dow's new RNAi corn safe for human consumption, they would need to prove this a non-issue.





GLP