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Defeating H1N1: how do we supress the cytokin storm?

 
Anonymous Coward
User ID: 805064
Canada
10/28/2009 03:05 PM
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Defeating H1N1: how do we supress the cytokin storm?
Surprisingly, young healthy people with strong immune systems seem to be dying of the H5N1 avian flu virus- even more than children and the elderly, who die most frequently in normal influenza epidemics.

Health care experts say many of these patients appear to be suffering from a lethal "cytokine storm"?
What Is A Cytokine Storm?

A cytokine storm is an extreme immune system over-reaction in which cytokines, which are molecules that destroy viruses in the lungs, bring on a ferocious attack by various immune system cells on the lung tissue itself. The result is massive tissue death, making it very difficult to get enough oxygen into the blood steam. Patients usually die from heart failure as the heart becomes exhausted (from trying to pump enough blood to weakened lungs), from respiratory failure, or from massive hemorrhaging, in which the patient drowns in their own blood.

The problem is that the H5N1 virus appears to cause these “cytokine storms” in the young and the healthy. Very young children and older patients usually have weakened immune systems; they rarely get this extreme immune reaction.

This is the same lethal pattern that marked the 1918 Spanish Flu pandemic, which killed 40 to 100 million people, and seen more recently with SARS.
The Cytokine Controversy

Some researchers think that patients who contract bird flu may need drugs that suppress the immune response in addition to anti-viral drugs like Tamiflu. Doctors sometimes give corticosteroids in these situations to suppress the immune system.

Many health professionals are dubious about the idea of trying to suppress cytokines production with drugs, as the researchers have suggested. First of all, the idea of suppressing the immune system when faced with a dangerous infection, seems counter-intuitive. Secondly, using corticosteroids to suppress the immune system is pretty much the same as using stress hormones like cortisol that have damages the immune systems of large portions of the population. The idea of stressing out your capacity for immune response is hardly appealing.

Clearly more research is needed. My personal opinion is that that issue is at the crux of how well we manage to survive the pandemic when it happens. I will follow developments on this blog and at the Beat-Bird-Flu.com main pages. In the meantime, I have some tentative personal (and non-professional) recommendations:

[link to www.beat-bird-flu.com]
Anonymous Coward
User ID: 788813
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10/28/2009 03:07 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
Heard this before but good post for people that haven't read about this.
Anonymous Coward
User ID: 805008
Thailand
10/28/2009 03:14 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
Nicotine. Search for the GLP threads...covered extensively.

/
GoldenEye
User ID: 805079
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10/28/2009 03:15 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
What often kills people who catch Swine Flu is not the virus itself but the body’s immune system reaction which is called a cytokine storm. Ironically this often occurs in young, healthy people with good immune systems which is why the Swine Flu seems to be more dangerous to people between 20-50.

“If a cytokine storm occurs in the lungs, for example, fluids and immune cells such as macrophages may accumulate and eventually block off the airways, potentially resulting in death”

***** While this may sound completely insane, there have been studies showing that nicotine can reduce a cytokine storm and the ensuing inflammation. One such article detailing this information was “Body Blazes” by Lisa Melton published in Scientific American in June 2006. *****

For a full text of the 2006 article, go to this link:

[link to www.coloyan.com]

You can also read more about nicotine being an anti-inflammatory at:

[link to diseases-viruses.suite101.com]
Anonymous Coward (OP)
User ID: 805064
Canada
10/28/2009 03:16 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
is there a more natural cure?
czygyny

User ID: 804907
United States
10/28/2009 03:17 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
Well, there were lots of posts dealing with the cytokine storms a few months back.

Tobacco, Benadryl, among other things are supposed to mitigate cytokine storms.
Kletos, Eklektos & Pistos
Anonymous Coward
User ID: 548848
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10/28/2009 03:18 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
I wonder how over the counter allergy meds work for suppressing cytokine storms
snark

User ID: 790439
United States
10/28/2009 03:19 PM

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Re: Defeating H1N1: how do we supress the cytokin storm?
Smoke 'em if you've got 'em.
T For Texas, T For Tennessee!


The virtue of courage is a prerequisite for the practice of all other virtues, because otherwise one is virtuous only when virtue has no cost. There are times when something needs to be done, and yet we know that if we step up and do this needful thing, we will pay a heavy personal price. -C.S. Lewis
Anonymous Coward
User ID: 710552
United States
10/28/2009 03:37 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
Here's a claim that Vitamin A works on the cytokine storm problem

[link to www.scienceguardian.com]

Snippet:
Robert Houston Says:
April 5th, 2006 at 12:45 pm
You’re right, Truthseeker. The NY Times for all its verbiage has missed the main discoveries regarding avian flu. Its website allows one to search at once all 207 articles they’ve ever published on the subject. None of these articles mentions “cytokine”, “TNF”, or “vitamin.”

Yet the major finding from the foremost avian flu research center in the world is that the H5N1 virus is distinguished from milder flu viruses by its ability to hyperinduce the production of tumor necrosis factor (TNF) and other proinflammatory cytokines in the cells of the immune system, particularly the macrophages. This discovery, from the University of Hong Kong Dept. of Microbiology, was extended last August to specify the main mechanisms (1). Meanwhile, in nearby Taiwan, government scientists reported at about the same time that the main metabolite of vitamin A “could reduce…TNF-a production” and that “vitamin A may protect…patients from proinflammatory cytokine-mediated damage” (2). These findings were reported exclusively by Truthseeker last November (click HERE for his world scoop).

The ability of vitamin A to inhibit TNF in macrophages had long been known. Researchers at M.D. Anderson Cancer Center reported in 1994 that the major vitamin A metabolite “almost completely inhibited the production of TNF by macrophages” (3).

The Harvard review of Vitamin A mentioned above does not cite any of these studies but does review a number of other studies showing that vitamin A inhibits TNF (see section on Monocytes and Macrophages). It also references a clinical trial from Norway, which found that vitamin A supplementation at 6500 units a day (slightly above the daily requirement) resulted in “a significant decrease in TNF-a levels” - actually cutting them in half (4). Significant inhibition of TNF was also found in clinical trials of vitamin A (and other antioxidant vitamins) conducted in Italy (5) and Greece (6).

1. D. Lee et al. Hyperinduction of tumor necrosis factor alpha expression in response to avian influenza virus H5N1. J. Virol. 79:10147-54, Aug. 2005.

2. L. Ho et al. Retinoic acid blocks pro-inflammatory cytokine-induced matrix metalloproteinase production… Biochem. Pharmac. 70:200-8, 2005.

3. K. Mehta et al. Inhibition by all-trans-retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages. J. Leukoc. Biol. 44:336-42, 1994.

4. P. Aukrust et al. Decreased vitamin A levels in common variable immunodeficiency. Eur. J. Clin. Inv. 30:252-259, 2000.

5. G. Mantovani et al. Reactive oxygen species, antioxidant mechanisms and serum cytokine levels in cancer patients: impact of an antioxidant treatment. J. Cell. Mol. Med. 6:507-82, 2002.

6. T. Vassilakopoulos et al. Antioxidants attenuate the plasma cytokine response to exercise in humans. J. Appl. Physiol. 94:1025-32, 2003.
Anonymous Coward
User ID: 805008
Thailand
10/28/2009 03:42 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
is there a more natural cure?
 Quoting: Anonymous Coward 805064


More natural than nicotine????

Surely you did not just post that. Surely I did not just read that.

/
Anonymous Coward
User ID: 638079
United States
10/28/2009 03:44 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
Don't drink milk or eat red meat.

It will clog your whole system up.
Anonymous Coward
User ID: 800564
United States
10/28/2009 03:45 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
it worrying about it... and have a cigar:

Anonymous Coward
User ID: 800564
United States
10/28/2009 03:46 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
Quit worrying about it... and have a cigar:
 Quoting: Anonymous Coward 800564


Fixed.
Anonymous Coward
User ID: 780977
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10/28/2009 03:57 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
Cannabinoids

"Cannabinoids can modulate both the function and secretion of cytokines from immune cells. Therefore, cannabinoids may be considered for treatment of inflammatory disease. This review article will highlight recent research on cannabinoids and how they interact with the immune system and also their potential use as therapeutic agents for a number of inflammatory disorders."

[link to linkinghub.elsevier.com]
Anonymous Coward
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United Kingdom
10/28/2009 03:59 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
The article was about H5N1 but the title of the thread says H1N1.
Luftwaffle
User ID: 721267
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10/28/2009 04:01 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
The article was about H5N1 but the title of the thread says H1N1.
 Quoting: Anonymous Coward 599165



Perhaps a glimpse of things to come?

spock
Anonymous Coward
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10/28/2009 04:01 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
WHO memos 1972 explains how to turn vaccines into a means of killing

From Quayle's website:

[link to www.fightbackh1n1.com]


Excerpt:
WHO memos 1972 explains how to turn vaccines into a means of killing
H1N1 Swine Flu Is an Artificial Bioweapon
European Union Drugs Agency Recommends Baxter's H1N1 Flu Vaccine
Patented H1N1 Swine Flu Virus Back in 2008
Czech Republic Refuses Baxter Swine Flu Vaccine

Two key memorandums from WHO, discovered by Patrick Jordan, prove WHO has
intentionally created the three-shot killer vaccine that people in the USA and
other countries could soon be forced to take.

1972 WHO Bulletin 47, No 2 Memordanda #1 and #2 Virus-associated
immunopathology:

Animal models and implications for human disease * technically outline the
ability to create biological weapons in the form of vaccines that:

1) First totally disable the Immune System.

2) Load every cell of the Victims body up with Infection.

3) Switch the Immune System on causing the host to kill themselves in a Cytokine
Storm.

One, Two, Three, Dead.

These WHO Memorandas describe the three-stage impact of the three "shots" many
people will be forced to take this fall to allegedly treat a virus that WHO also
helped create and release.

This is a crucial piece of evidence of WHO's long-term genocidal intentions that
could stand in any court of law because these memorandums give the best and
fullest explanation WHO's and affiliated labs (such as the CDC) current
activities, such as their patenting of the most lethal bird flu viruses, their
sending that virus to Baxter's subsidiary in Austria, which weaponised it and
sent out 72 kilos to 16 labs in four countries almost triggering a global
pandemic.

For every crime, there needs to be motive, an indication that it was deliberate,
planned. The WHO memorandums provide the evidence of just that deliberate,
long-term planning to kill people by weakening their immune system by use of the
first vaccine, injecting a live virus into their body by a second, and creating
a cytokine storm using squalene in a third.
Anonymous Coward
User ID: 791278
United States
10/28/2009 04:19 PM
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Re: Defeating H1N1: how do we supress the cytokin storm?
Lots of info here [link to netidentity.us]