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FLU Treatment and Prevention tablets or syrup

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Anonymous Coward
User ID: 294436
11/5/2009 7:03 AM
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FLU Treatment and Prevention tablets or syrup

Quote

[link to www.influenzareport.com]

Summary

Amantadine is available as 100 mg tablets or capsules and as a syrup containing 50 mg/5ml.

Drug class: M2-inhibitor.

Indications: Treatment and Prevention of Influenza A.

Dosage: 200 mg qd both for treatment and prophylaxis. For prophylaxis, amantadine should be started as soon as possible after exposure and continued for at least 10 days.

Special Dosage: persons with reduced kidney function and elderly persons may need lower doses (or less frequent doses).

Pharmacokinetics: good absorption with peak concentration after 3 hours and a half-life of 17 hours. Excreted unchanged in the urine by glomerular filtration and tubular secretion. Reduced clearance in individuals > 60 years and in patients with renal insufficiency: half-life is increased when creatinine clearance is less than 40 ml/min. Amantadine is not removed by haemodialysis.

Contraindications: psychosis. Patients with insufficiently treated epileptic episodes.

Interactions: central nervous system stimulants; quinine and quinidine; thioridazine.

Side effects: gastrointestinal and CNS symptoms.

Comments/Warnings: no well-controlled studies have been done in pregnant women to evaluate the safety of amantadine. Amantadine should not be prescribed to pregnant women.

Amantadine is excreted in breast milk in low concentrations. Although no information is available on the effects in infants, the manufacturer recommends that amantadine be used cautiously in nursing mothers.

Patients receiving amantadine who note central nervous system effects or blurring of vision should be cautioned against driving or working in situations where alertness and adequate motor co-ordination are important.

Store amantadine at room temperature between 15 and 30°C (59 and 86°F).

Internet sources:

USA: [link to influenzareport.com]

Anonymous Coward
User ID: 294436 (OP)
11/5/2009 7:45 AM

Re: FLU Treatment and Prevention tablets or syrup	Quote
what no comments whatsoever ? Oh Well.....................

SHR

Forum Administrator
11/5/2009 7:57 AM

Re: FLU Treatment and Prevention tablets or syrup

Quote

I don't think M-2 inhibitors work any longer...used to....

While these antiviral drugs have been used successfully in combination with annual flu vaccinations to combat influenza infections, experience in recent years has shown the influenza A virus to be a moving target.

On February 22, 2006, the Journal of the American Medical Association published a report from the CDC indicating that influenza A viruses of the H3N2 subtype had become highly resistant to M2 inhibitors.2 A single amino acid substitution in the viral M2 protein rendered the inhibitors useless against infection, and as a result, neuraminidase inhibitors became the only antiviral drugs recommended for the prevention and treatment of influenza A (H3N2) infections.1

Three years later, preliminary data for the 2008-2009 flu season indicate that influenza A viruses of the H1N1 subtype have become resistant to the neuraminidase inhibitor Tamiflu (oseltamivir). According to a recent report in the Journal of the American Medical Association, "As of February 19, 2009, resistance to oseltamivir had been identified among 264 of 268 US influenza A (H1N1) viruses (98.5%) tested."3

[link to www.cas.org]

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