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Subject The Herpes Virus Might Be Linked To Some Psychiatric Disorders Like Bipolar Disorder, Schizophrenia, and Major Depressive Disorders

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[quote:Sacred Geometry:MV8zODg4Njk3XzcwMDcyNjkyXzZBNDJCMkZC]
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(I wonder about WIFI and ElectroSmog,
perhaps also causing inflammatory reactions)

Suicide attempters have lower levels of neuroprotective substances in the cerebrospinal fluid

Published 2012-11-21. 
Updated 2014-09-22

https://ki.se/en/news/suicide-attempters-have-lower-levels-of-neuroprotective-substances-in-the-cerebrospinal-fluid

In a novel study, researchers at Karolinska Institutet (Stockholm, Sweden) report that patients with suicidal behavior had lower levels in the cerebrospinal fluid of the signaling molecule interleukin-8 and growth factor VEGF, which both effect the growth and protection of neurons.

The most depressed of the patients had also the lowest levels of VEGF.

According to the researchers this discovery, wich is presented in the journal Translational Psychiatry, may lead to a better understanding of underlying neurobiology of suicidal behavior and improved treatment of suicide attempters.

(( Treatment: ANTI INFLAMMATORY, and / or IMMUNO THERAPY?? Plus, lowering exposure to what cause the imflammation ))

Interleukin-8 (IL-8) - important in neuroprotection and innate immunity.

VEGF (vascular endothelial growth factor) - a vital angiogenic factor and plays a role in regulating the growth of neurons in the hippocampus, a brain area of importance in depression.

VEGF is also important in neurogenesis and synaptogenesis, and there are several animal studies suggesting that VEGF mediates the biological effect of electroconvulsive seizures and common antidepressants (SSRI).

[b]Earlier studies have also shown that suicidal patients had higher levels of the inflammatory marker interleukin-6 (IL-6) in the cerebrospinal fluid, which has been interpreted as a support of the theory that [u]inflammation of the brain can be a contributing cause in severe depression.[/u]

In their study in Translational Psychiatry, the research team shows that low cerebrospinal fluid VEGF and IL-8 is associated with an increased risk of suicide attempt. [/b]

43 suicide attempters and 20 healthy volunteers participated in the study. Depression severity was measured with the rating scale MADRS.

Lower levels of VEGF and IL-8

The results showed that suicide attempters had lower levels of VEGF and IL-8 in the cerebrospinal fluid, compared to healthy volunteers.

The suicide attempters with highest depression scores had the lowest VEGF levels. //

"It is important to study growth factors and inflammatory markers in patients with different psychiatric diagnoses to assess if these changes cross diagnostic boundaries", says Dr. Jussi Jokinen, researcher at the Department of Clinical Neuroscience.

"One possible interpretation of the role of low VEGF levels in suicidal behavior may be related to treatment resistance of depression. Time spent as depressed heightens risk for suicidal behavior."

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Original Message The Herpes Virus Might Be Linked To Some Psychiatric Disorders Like Bipolar Disorder, Schizophrenia, and Major Depressive Disorders

"For the first time, researchers at the University of Würzburg have identified that active infection of Purkinje neurons in the cerebellum with a human herpesvirus (HHV-6) is associated with some psychiatric disorders. Their paper, “Active HHV-6 Infection of Cerebellar Purkinje Cells in Mood Disorders,” was recently accepted for publication in the journal Frontiers in Microbiology."

"Until now, the association between virus-related inflammation in the brain and mood disorders has been hard for neuroscientists to pin down. Prusty and his Germany-based group had a hunch that the human herpesviruses HHV-6A and HHV-6B might play a vital role in the genesis of certain psychiatric disorders such as bipolar disorder, schizophrenia, and major depressive disorders. To investigate this possible link, they partnered with two of the largest human brain biopsy cohorts from SMRI, which is affiliated with the Stanley Division of Developmental Neurovirology at Johns Hopkins University.

"Inherited factors have long been known to increase the risk of developing several types of psychiatric disorders including bipolar disorder, major depressive disorder, and schizophrenia," Bhupesh Prusty said in a statement. “But there is also strong evidence that environmental factors, particularly those that lead to neuroinflammation early in life, might play an important etiologic role in the pathogenesis of these disorders as well. Viruses are such an environmental factor. Pathogens may disrupt neurodevelopment and cross-talk with the immune system at key developmental stages."

[link to www.psychologytoday.com (secure)]

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