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Subject Cannabis Harms: Here's the science that proves it
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Original Message Cannabis Harms: Here’s the science that proves it:

People need to be aware that when the cannabinoid, THC (Tetrahydrocannabinol) the psychoactive ingredient giving the ‘high’ in cannabis enters the brain, it sets in motion a chain of reactions that are inevitable, unpredictable, random and uncontrollable.

The chemicals taking messages from neuron (brain cell) to neuron are called neurotransmitters. There are dozens of them each performing their own specific functions. The gap between neurons is called the synapse, neurotransmitters cross this gap and fit into receptor sites by shape on the next cell.

THC mimics one of our most abundant neurotransmitters called anandamide. It is an endo-cannabinoid (produced in the body). Both occupy the same cannabinoid receptor sites, but THC will be present in much greater quantities.

Anandamide regulates how active neurons are, and how much neurotransmitter they release. This acts as a sort of ‘dimmer’ switch, slowing down communication between cells and keeping all the circulating chemicals on an even keel and in balance (homeostasis). Levels of the neurotransmitters, dopamine, serotonin, endorphins etc for pleasure, mood, appetite, motivation, body movement, cognition, concentration. memory, brain development etc are all kept in balance by anandamide.

But THC is much stronger and persistent. Being foreign to the body it has no enzymes to break it down, it is fat-soluble so remains in the fatty brain cells, around 50% for a week, 10% for a month, with traces for weeks afterwards, all the time giving out signals and interfering with total brain functioning.

Even one joint/month will ensure a permanent presence of THC, and as Professor Sir Robin Murray says, ‘users will be in a state of low grade intoxication most of the time’.


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