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09:32 PM

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Subject Microbiologist friends, I need some help.

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[quote:SloGenPhys:MV80MDE3Njc5XzcyNzQxNzcyX0RENjUwNERG]
For what it's worth...

The population of bacteria within your gut will carry myriad mutations among the same strain.  In other words, the seeds for resisting medications, antibacterials, etc.  already exist in the bacterial populations targeted for destruction.

You carry enterococci in your gut.  These enterococci are not genetically identical.   Some are already resistant.  When you take an antibiotic, it targets those lineages that are not resistant.  The result is that you have selected for the resistant lineages by killing off the non-resistant competition.  You have promoted the proliferation of the already-resistant enterococci.

Treatments may attempt to get around this by including multiple antibacterial strategies simultaneously, creating a broader scope of attack to include more lineages of enterococci.   But in the end, there likely  still exists some lineages that carry mutations conferring resistance to each of the strategies used.  And these unique strains will survive.

Health is a matter of repressing the proliferation of pathogenic gut flora by making the environment particularly suitable for healthy bacteria.  The healthy gut flora then out competes the unhealthy flora.

For perspective, btw... you have more total cells of other species on your body right now than you have human cells.  This can be so because bacterial cells are much smaller than "human" cells.  And this population of cells usually function in a mutually-agreeable synergistic complimentary fashion.  Imbalances in human health change conditions in the body that tend to promote unhealthy flora over healthy flora.  And antibacterials nuke everything indiscriminately, killing both beneficial and pathogenic species.  Which is why eating fermented foods, yogurt, and taking healthy probiotics is essential, especially when taking antibacterials.  You have to repopulate healthy flora.
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Original Message This is a very specific question. How does one prevent enterococci from becoming resistant while treating it with a quinolone antibiotic.

Does it help to keep the ph at a certain level? Does it help to cut off carbs? Take saccromyces? take NAC? Take a few days of a second antibiotic? Take metronidazole with it/after it? Take oil of oregano with it? How does one prevent this possibility?

I've attached a reference article so if anyone can explain how this works to me, I have too much going on right now and I don't have the time to research it. I figure if anyone would know it would be a genius over yonder.

If anyone has this specific answer and can explain how it happens and how to prevent it that would be so appreciated.

Also no lectures about rupturing tendons, I'm aware.

Asking for a friend... of course... lol.

[link to www.ncbi.nlm.nih.gov (secure)]

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