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Subject NEW: Massive study of 96,000 COVID-19 patients showed no benefit and increased mortality from hydroxychloroquine treatment

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To summarise the results:

- 1 in 11 patients in the control group died

- 1 in 6 patients treated with chloroquine or hydroxychloroquine alone died

- 1 in 5 treated with chloroquine and an antibiotic died

- 1 in 4 treated with hydroxychloroquine and an antibiotic died

Who wants those odds?
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If it's actually this bad for patients that have been given the all clear by their doctor to take it, why does the FDA say it's just fine then?

HMMMMMMM?

The study is flawed in how it judged the effectivness of HCQ in that it did not include zinc along with it.

Face it, you simply think over and over again in your head, orange man bad, HCQ bad, death and economic dispire good....
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The FDA says it's just fine? You can recycle your "orange man bad" slogan or follow the medical advice of your guru  all you want, but this is what FDA states:

[b]FDA cautions against use of hydroxychloroquine or chloroquine for COVID-19 outside of the hospital setting or a clinical trial due to risk of heart rhythm problems[/b]

The FDA is aware of reports of serious heart rhythm problems in patients with COVID-19 treated with hydroxychloroquine or chloroquine, often in combination with azithromycin and other QT prolonging medicines.  We are also aware of increased use of these medicines through outpatient prescriptions.  Therefore, we would like to remind health care professionals and patients of the known risks associated with both hydroxychloroquine and chloroquine.

Hydroxychloroquine and chloroquine have not been shown to be safe and effective for treating or preventing COVID-19.  They are being studied in clinical trials for COVID-19, and we have only authorized their temporary use during the COVID-19 pandemic for treatment of the virus in hospitalized patients when clinical trials are not available, or participation is not feasible, through an Emergency Use Authorization (EUA).

Hydroxychloroquine and chloroquine can cause abnormal heart rhythms such as QT interval prolongation and a dangerously rapid heart rate called ventricular tachycardia.  These risks may increase when these medicines are combined with other medicines known to prolong the QT interval, including the antibiotic azithromycin, which is also being used in some COVID-19 patients without FDA approval for this condition.  Patients who also have other health issues such as heart and kidney disease are likely to be at increased risk of these heart problems when receiving these medicines.

https://www.fda.gov/drugs/drug-safety-and-availability/fda-cautions-against-use-hydroxychloroquine-or-chloroquine-covid-19-outside-hospital-setting-or

This new study of 96,000 patients confirms FDA's caution.
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Putting aside the aforementioned (and manifold) concerns about the methodology of the study and the (rather obvious) conflicts of interest of parties mentioned -- the recommendations of "public agencies" like CDC & FDA are for government surveillance. They produce guidelines -- not standards of care. Standards of care are established through patient choice in concert with clinical experts that are licensed and ideally board-certified. Moreover, there can be multiple standards of care -- whether they are backed by hundreds of studies or not.
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Original Message New research published in The Lancet on Friday found that hydroxychloroquine and chloroquine has ‘no benefit’ for coronavirus patients, and could even increase the risk of heart arrhythmias and mortality.

“This is the first large scale study to find statistically robust evidence that treatment with chloroquine or hydroxychloroquine does not benefit patients with COVID-19,” said lead author of the study and Executive Director of the Brigham and Women’s Hospital Center in Boston Mandeep R. Mehra. “Instead, our findings suggest it may be associated with an increased risk of serious heart problems and increased risk of death.”

Treatment with hydroxychloroquine, chloroquine, or either drug in combination with azithromycin was also associated with higher odds of death, even after accounting for age, race, body mass index, and preexisting conditions.

The Lancet article is the largest study to date on the hyped drugs, analyzing data from nearly 15,000 COVID-19 patients who received hydroxychloroquine, chloroquine, or a combination of either drug with a macrolide antibiotic such as azithromycin, and 81,000 COVID-19 patients who did not receive any of those treatments. The data came from 671 hospitals across 6 continents.

The Lancet results support previous findings from a widely disseminated Brazilian study that found an increased risk of heart arrhythmias in COVID-19 patients receiving high doses of the drug. The study was discontinued shortly after, as subjecting patients to increased risk of death in the trial was deemed unethical by study coordinators.

China, Spain, Brazil, and the United States have also issued recommendations for use of hydroxychloroquine in limited populations, largely restricting them to use in clinical trial settings in light of the new reports of serious cardiac side effects.

But the authors of The Lancet study still warn that the overall likelihood that these drugs improve clinical outcomes in COVID-19 patients is quite low, and underline that the medicines should not be recommended by countries for widespread treatment of COVID-19.

“Several countries have advocated use of chloroquine and hydroxychloroquine, either alone or in combination, as potential treatments for COVID-19. Justification for repurposing these medicines in this way is based on a small number of anecdotal experiences that suggest they may have beneficial effects for people infected with the SARS-CoV-2 virus,” said Director of the Heart Center at University Hospital Zurich Frank Ruschitzka, who also co-authored The Lancet study.

[link to healthpolicy-watch.org (secure)]

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