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Risk Assessment: Airborne HIV Outbreak Among Sputnik V Recipients - Binary Biocatastrophe
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Original Message
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The second shot of Sputnik V contains Ad5 Adenovirus. So does the second dose of the Johnson & Johnson and the Chinese single dose vaccine Convidecia, with some differences in manufacturing and choice of gene deletions.
Ad5 is known to sensitize immune cells to HIV Infection.
Preferential infection of human Ad5-specific CD4 T cells by HIV in Ad5 naturally exposed and recombinant Ad5-HIV vaccinated individuals | PNAS
[link to www.pnas.org (secure)]
To prevent a full blown Ad5 infection, the process of rendering the vector replication deficient is carried out under the strictest of quality control. However, recent news has shown that there can be problems of live replication competent Ad5 making it in the vaccine like what the Brazilians encountered with their Sputnik V batches.
Brazil Rejects the Gamaleya Vaccine | In the Pipeline
[link to blogs.sciencemag.org (secure)]
Canada has a highly evolved strain of HIV going around that targets a particular human leukocyte antigen called B-51:01. While the indigenous populations have the highest rates of this "HLA", it is not at all uncommon worldwide. Furthermore, this strain has little latency period -- it goes from HIV to AIDS fast.
Perspectives of Saskatchewan researchers and community members on HIV-1 strains circulating in Saskatchewan
[link to www.ncbi.nlm.nih.gov (secure)]
Extensive host immune adaptation in a concentrated North American HIV epidemic
[link to www.ncbi.nlm.nih.gov (secure)]
Based on what information we can draw from the Brazilian Sputnik V vaccine fiasco, when Sputnik V vaccine recipients travel to Canada, a proportion of those travellers will have a latent infection with the replication competent Ad5 virus used in the second Sputnik shot. And, depending on their HLA type, they could potentially catch the Saskatchewan HIV virus through saliva droplets in the air alone and bring that virus to their home country where havok would ensue.
The following ethnic groups/nations have the highest frequency of the B-51:01 human leukocyte antigen -- Cree Canadian, Northern Italians, Bulgarians, Saudi Arabians, Japanese Hokkaido Ainu, Chinese Uyghurs, Oman, Armenians, Greeks, Tibetans, etcetera.
Take for example the Northern Italians, the highest B-51:01 allele frequency next to Cree Amerindians.
San Marino finally gets vaccines, but goes with Sputnik V
[link to abcnews.go.com (secure)]
From San Marino, the Sputnik Ad5 vector could spread to others in the region who may end up travelling to Canada and being exposed to the Saskatchewan HIV and bringing it back home.
Inside Torontos HIV-positive pop-up restaurant Junes Eatery - NOW Magazine
[link to nowtoronto.com (secure)]
Casey House opens worlds first HIV+ spa in Toronto - NOW Magazine
[link to nowtoronto.com (secure)]
I don't believe Italy has deployed Sputnik V yet and neither has France, but they seem to intend to do so.
Mexico has already deployed the first shot of the Sputnik V vaccine in high numbers and if the second shots are supplied, will do the job of spreading the Ad5 vector to the USA, making them vulnerable once the airborne HIV gets rolling.
Mexico: Russia's Sputnik V shortages mean limited 2nd doses - ABC News
[link to abcnews.go.com (secure)]
I get the feeling the Sputnik V Brazil affair has given the manufacturer cold feet about whether or not new batches of the second dose that they produce will be scrutinized for live virus after this embarrassment.
It's also worth noting that the clinical trials of Sputnik V and Convidecia required negative HIV diagnosis for inclusion while the Johnson & Johnson explicitly included ART stabilized HIV positive subjects in their trials.
Questions section:
Question: Is the discovery of live Ad5 vector in Sputnuk V vaccine exclusive to this brand of vaccine or is it implicit in the various Ad5 vector COVID shots manufacturing process?
Question: Is the presence of latent Ad5 virus vector or Ad5 vector wild hybrid a strong enough softening agent to predispose chronic Ad5 infected to airborne saliva HIV infection?
Question: How does the short latency period Saskatchewan HIV strain effect the risk of a global airborne HIV catastrophe among Ad5 vaccine recipients?
Question: How virulent are the live Ad5 virus vector strains found by Brazil to be in the Sputnik V vaccine and how does this effect the risk of global HIV transmission in general and specifically the risk of an emergent airborne HIV strain? How do spike protein plasmid presences in adenoviruses effect adenovirus and HIV transmission rates and transmission routes?
Question: Assuming Ad5/HLA:5101 salivary droplet inhalation vulnerability to various HIV strains, what is the risk of HIV strains gaining mutations further facilitating airborne transmission?
Question: Do these risks warrant HIV testing and adenovirus testing/monitoring be performed alongside COVID testing?
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