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HCQ must be re-evaluated! IMPORTANT INFO! Works BEST vs. Omicron! FLCCC re-included HCQ
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[quote:S-man:MV81MDAwNzg1XzlDNjY2N0U3] I think am on to something with the Glasgow Preprint. https://www.gla.ac.uk/media/Media_829360_smxx.pdf The lack of cell fusion as an entry mechanism by Omicron is documented in the preprint..Page 17: [i]Omicron spike has switched entry route preference[/i] See Figure 6A. The other known mechanism of entry (endocytosis) is shown to be used much better by Omicron. (aside: This explains the lower involvement of the lungs in Omicron infections..). BUT most importantly, the endocytosis route has blockers that can be considered for use.. "Cathepsin blockers". This paper is older; from when Sars-COV-2 was using the TMPRSS2+Furin Cleavage Site, as well as endocytosis. https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1008461 [b]Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection[/b] Drugs targeting Cathepsin B/L are under development. [b][color=red]Hydroxychloroquine is thought to act against SARS-CoV-2 via several mechanisms, including blocking the endocytic pathway.[/b][/color]; it suppresses clathrin-mediated virus uptake and also prevents endosomal acidification, the latter required for Cathepsin B/L activity. https://www.researchgate.net/publication/351334815_Article_title_After_one_year_of_COVID-19_Pandemic_and_Hundreds_of_Suggested_Drugs_Will_Cathepsin_L_Inhibitors_be_the_Solution [b]After one year of COVID-19 Pandemic and Hundreds of Suggested Drugs, Will Cathepsin L Inhibitors be the Solution?[/b] Stock up on HCQ?? How crazy would it be to find that HCQ really is a solution to this part of the puzzle? [/quote]
Original Message
I think am on to something with the Glasgow Preprint.
[
link to www.gla.ac.uk (secure)
]
The lack of cell fusion as an entry mechanism by Omicron is documented in the preprint..Page 17:
Omicron spike has switched entry route preference
See Figure 6A.
The other known mechanism of entry (endocytosis) is shown to be used much better by Omicron. (aside: This explains the lower involvement of the lungs in Omicron infections..).
BUT most importantly, the endocytosis route has blockers that can be considered for use.. "Cathepsin blockers".
This paper is older; from when Sars-COV-2 was using the TMPRSS2+Furin Cleavage Site, as well as endocytosis.
[
link to journals.plos.org (secure)
]
Targeting TMPRSS2 and Cathepsin B/L together may be synergistic against SARS-CoV-2 infection
Drugs targeting Cathepsin B/L are under development.
Hydroxychloroquine is thought to act against SARS-CoV-2 via several mechanisms, including blocking the endocytic pathway.
; it suppresses clathrin-mediated virus uptake and also prevents endosomal acidification, the latter required for Cathepsin B/L activity.
[
link to www.researchgate.net (secure)
]
After one year of COVID-19 Pandemic and Hundreds of Suggested Drugs, Will Cathepsin L Inhibitors be the Solution?
Stock up on HCQ??
How crazy would it be to find that HCQ really is a solution to this part of the puzzle?
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