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COVID Clotting mechanism discovered by Swedish Scientists
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In patients with serious and long-term COVID-19, disturbed blood coagulation has often been observed. Now, researchers at Linköping University (LiU), Sweden, have discovered that the body's immune system can affect the spike protein on the surface of the SARS-CoV-2 virus, leading to the production of a misfolded spike protein called amyloid. The discovery of a possible connection between harmful amyloid production and symptoms of COVID-19 has been published in the Journal of American Chemical Society.
[link to medicalxpress.com (secure)]
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My synopsis:
-First of all, the American Chemical Society is a huge MAINSTREAM professional organization. The JACS is a peer reviewed journal. These are not conspiracists, they are normal scientists
-Linköping University is one of the biggest universities in Sweden with an emphasis on PhDs.
-When a protein folds into a shape that isn't normal it is called an amyloid. As a result it doesn't act in a normal fashion.
-COVID spike proteins will react to the body's immune system and fold into amyloids
-In another unnatural action the spike protein amyloids join into long chains
-There are 30 other proteins in our body (non COVID related) that can fold this way, and they all lead to unique diseases
--One of these diseases is Alzheimer's, but there are other scary diseases too
-Using computer simulation, the researchers discovered that the coronavirus' spike protein contained seven different sequences which potentially could produce amyloid.
-Three of the seven sequences met the researchers' criteria for being counted as amyloid-producing sequences when experimentally tested. (magic, just like they were designed to do?)
-They produced, among other things, so-called fibrils, which look like long threads when examined under an electron microscope.
-They were able to produce the fibrils in the laboratory environment, but would this happen spontaneously in the body?
-In Alzheimer's the immune system slices and dices large proteins into smaller segments, and then some of the pieces turn into amyloids.
-The researchers were able to show that white blood cells do the same thing to the spike protein.
-A white blood cell type called neutrophils are produced very early after COVID infection, and this is the one that creates the amyloids.
-""We have never seen such perfect, but scary, fibrils as these ones from the amyloid-producing SARS-CoV-2 spike protein and pieces thereof. The fibrils starting from the full-sized spike protein branched out like limbs on a body. Amyloids don't usually branch out like that. We believe that it is due to the characteristics of the spike protein," says Per Hammarström, professor at the Department of Physics, Chemistry and Biology (IFM) at Linköping University." (amazing coincidence)
-Previous research, including a study by South African researchers, has indicated that the spike protein may be involved in the production of small blood clots.
-The blood contains the fibrin protein, which helps the blood to coagulate when a vessel is damaged, so that the hole seals again and stops bleeding. When the injury has begun to heal, the coagulate is supposed to be broken up by plasmin, which is also found in blood.
-The researchers at LiU mixed amyloid-producing protein pieces from the spike protein together with these bodily substances in test tubes, and saw that the fibrin coagulate which was then produced could not be broken down in the usual way by plasmin.
-Disturbed blood coagulation is also seen in many amyloid-related illnesses.
-"We can see that the spike protein, when affected by our own immune system, can produce amyloid structures, and that this can potentially affect our blood coagulation."
-These researchers restrict themselves to talking about micro blood clots, but anyone can see how this could result in huge clots and myocarditis, etc.
(Disclaimer: I was a trauma surgeon, not a research biologist so I am not an expert in this field. And I have been retired for more than 25 years...)
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