Well, yes. And no. It depends on your frame of reference, I suppose.

What seems increasingly clear to me, I guess, is that the universe is pushing us towards this singular point of distress from a thousand different angles all at once. Such a coordination cannot be coincidental IMO, and so must be purposeful. This coordination might even be viewed by some as proof of God's existence.

So while one might not be able to defend the hypothesis that "the universe is against us", per se, it does seem that the universe is against us staying the way we are now. It is pushing for a change.