VACCINES.....What a shit !




p53 Damage and carcinogenicity

SV40 is believed to suppress the transcriptional properties of the tumor-suppressing p53 in humans through the SV40 Large T-antigen and SV40 Small T-antigen. p53 is responsible for initiating regulated cell death ("apoptosis"), or cell cycle arrest when a cell is damaged. A mutated p53 gene may contribute to uncontrolled cellular proliferation, leading to a tumor.

SV40 may act as a co-carcinogen with crocidolite to cause mesothelioma [12] (review [13]).

When SV40 infects nonpermissive cells such as 3T3 mouse cells the dsDNA of SV40 becomes covalently integrated. In nonpermissive cells only the early gene expression occurs and this leads to transformation, or oncogenesis. The nonpermissive host needs the Large T-antigen and the Small t-antigen in order to function. The Small T-antigen interacts with and integrates with the cellular phosphatase pp2A. This causes the cell to lose the ability to initiate transcription.
[edit] Polio vaccine contamination

Soon after its discovery, SV40 was identified in the injected form of the polio vaccine produced between 1955 and 1961. This is believed to be due to kidney cells from infected monkeys being used to amplify the vaccine virus during production. Both the Sabin vaccine (oral, live virus) and the Salk vaccine (injectable, killed virus) were affected; the technique used to inactivate the polio virus in the Salk vaccine, by means of formaldehyde, did not reliably kill SV40.

It was difficult to detect small quantities of virus until the advent of PCR; since then, stored samples of vaccine made after 1962 have tested negative for SV40, but no samples prior to 1962 could be found. Thus, although over 10 million people received the potentially contaminated batches of vaccine, there is no way to know whether they were exposed to the virus, and if so, whether it was in a quantity and by a route that would cause infection. It is also unknown how widespread the virus was among humans before the 1950s, though one study found that 12% of a sample of German medical students in 1952 had SV40 antibodies. Although horizontal transmission between people has been proposed, is not clear if this actually happens and if it does, how frequently it occurs.[14]

An analysis presented at the Vaccine Cell Substrate Conference in 2004[15] suggested that vaccines used in the former Soviet bloc countries, China, Japan, and Africa, could have been contaminated up to 1980, meaning that hundreds of millions more could have been exposed to the virus unknowingly.

[link to en.wikipedia.org]