New Drug Cures Multiple Viruses in Human Cells
Single treatment can kill 15 virus types in 11 mammals, study shows.:ebolavirus:
A colorized transmission electron micrograph picture of the Ebola virusThere's no cure for the common cold—yet.
A new drug can scout out and kill numerous types of viruses infecting human and animal cells, researchers have announced. It's the first time a single drug has been shown to work against a range of viruses, from those that cause seasonal sniffles to more fatal diseases.
"Several decades ago the discovery and production of antibiotics revolutionized the way bacterial infections were treated," said study co-author Todd Rider, a senior staff scientist at the Massachusetts Institute of Technology's Lincoln Laboratory and Division of Comparative Medicine.
"We hope that this will similarly revolutionize the way viral infections are treated. That covers everything from cold and flu viruses to more serious clinical pathogens like HIV and hepatitis viruses and ultimately even more deadly viruses like Ebola and smallpox."
video: "How Flu Viruses Attack"
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Alien-Like Viruses Tough to BeatThough there are plenty of drugs to treat bacterial infections, there are few that can battle viruses. The antiviral drugs that have been developed are highly specific, with each drug targeting just one strain of a virus, which can easily mutate and become resistant to the medication.
So Rider and colleagues took a different approach—tailoring their new drug to work with the body's built-in defense mechanism.
Viruses operate "sort of like the aliens in the Alien movies," Rider said. "They'll enter a cell, replicate inside the cell, and ultimately burst out of the cell," killing it.
(Take a quiz on infectious diseases.)
While taking over cells, viruses produce what's called long double-stranded RNA, a complex acid that controls the virus's chemical activities and is not produced in healthy human cells, according to the study, published July 27 in the journal PLoS ONE.
Human bodies do have natural defenses against viruses: They produce proteins that latch onto double-stranded RNA and prevent the virus from replicating itself. But many viruses have evolved ways to shut down these proteins.
New Drug Packs Double Whammy
Rider and his team developed a drug that combines the natural-defense protein with another protein that triggers a cell's suicide switch. All human cells have these suicide switches, which are usually activated when cells start to become cancerous, Rider said.
The result is like the mythological centaur, said Marie Pizzorno, a molecular virologist at Pennsylvania's Bucknell University.
"The horse is one piece of a protein that normally we make and that can recognize the [long double-stranded DNA] made by the virus, and the man is something that triggers the cell-death pathway," she said.
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