I found this also to be interesting from Prof. Potter:


[link to www.cancercompass.com]
1) Is there anything which interferes with the anticancer activity of salvestrols? I know about laetrile and also about fruit & veg sprayed with pesticide - I'm thinking of other environmental chemicals such as shampoos, hairspray, soap, perfume etc.

2) Returning to an earlier post in which you stated that cancer cells can't become resistant to salvestrols, what is to stop the cancer cell developing the same mechanism to repel salvestrols that they can develop to repel chemo - i.e. the formation of an intracellular "pump" which would push the salvestrols back out before they'd had chance to react with the CYP1B1?

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Dear Slarti, I've had 10 PhD students write their thesis on salvestrols so one more would be good.

Inhibitors of the CYP1B1 enzyme are carbon monoxide (smoking, effects lungs only), cyanide (laetrile, apricot kernels), and fungicides (agricultural sprays).

One point that needs clearing up here is that only fungicides and not pesticides inhibit the CYP1B1 enzyme. Furthermore it is only fungicides that deplete salvestrol levels in the fruit, and there is no evidence at all that pesticides are harmful to salvestrol production in plants.

All the cosmetics you mention are safe and harmless products. There a lot of scare mongering about cancer causing agents in this that and the other and its all usually rubbish. Most cosmetics are simply made out of natural oil derived molecules that are compatible with the body.

Resistance of cancer to salvestrols was something that concerned me initially. There is a P glycoprotein pump that pumps toxic molecules out of the cells and I was concerned that maybe the salvestrols could be pumped out by this same pump. It turned out that they cannot pump out the salvestrols because of the unique configuration of its structure it is recognised as friend and not foe. The salvestrols is recognised as food. The tumour cells likes salvestrols because it can eat them and feed off them when they are in low levels. So along comes a salvestrol into the tumour cell appearing as some food. It does not want to pump it out of the cell, it wants to hold on to it for as long as possible so that it can eat it. So the tumour cell keeps filling up with salvestrols until it reaches a level that switches the CYP1B1 enzyme on. Once CYP1B1 is switched on it digests the salvestrol and burns it up as fuel. This is a mini combustion reaction where the hydrocarbon (i.e. the salvestrol) gets oxidised and releases energy and ATP for the cells metabolic requirements. This combustion process changes the structure of the salvestrol so that it now fits the death switch and the cells are instructed to undergo apoptosis and die. So their is no resistance to this natural mechanism. Its on a dead mans trip switch that cannot fail. It has never failed in the evolution of humanity. Mammalian life would not exist without this organisational death switch intact. We would all just be a bundle of tumours if this did not work. Its when it does not work that actually gives rise to tumours. Its when there are insufficient salvestrols in the diet that it fails completely, and the low levels are just food for the tumours. So I let people make their own minds up about taking them. Do they want to be a bundle of tumours or a healthy human being that is the question ?