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Message Subject
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Mad World
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Poster Handle
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cerebrose |
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it seems to me that vitamin d may well play a part. but it may not be the lack of vitamin d but the bodies inability to properly absorb excessive amounts. this would be lead to a toxicity state, Hypervitaminosis D. one of Hypervitaminosis D symptoms is metastatic calcification of the soft tissues, this seems to me a possible degenerative precursor of one's nerve sheathing.
causcasians due to there low melanoma output may be at particular risk.
it was interesting to note that young children moving to areas of low ms concentration were likely to adopt a lower risk of ms. of course the areas of low risk were not defined! lol
Quoting: Anonymous Coward 71616872 Low risk=closer to Equator=more Sunlight=vitamin D So here is a thought. ALD is the accumulation of long chain fatty acids that build up, and destroy the myelin. Long chain fatty acids come from foods like cheese. Which most often comes from cows. Vitamin D is rather quickly available in milk, that many Caucasian children over the decades in America drink on the regular, unless an allergy is detected, starting quite young. At the preschool I worked at all the toddlers were served Whole Milk until the were 3.5 y/o. As children grow, the milk may substitute the lack of sunlight being farther from the Equator. And as kids reach closer and closer to puberty, milk drinking becomes less and less common, leading to deficiency in vitamin D, being location is same(low sunlight), an no longer being made up for, with milk. It would explain why those who change locations suddenly take on the low risk aspect. Quoting: Seer777 I had read somewhere that IFN-gamma was deficient in ALD, indicating weakened immune response; can't find it. But here're these: [IFN-gamma] ameliorates autoimmune encephalomyelitis by limiting myelin lipid peroxidation. [ link to www.ncbi.nlm.nih.gov] Dietary omega-3 polyunsaturated fatty acids from fish oil reduce interleukin-12 and interferon-gamma production in mice. [ link to www.ncbi.nlm.nih.gov] The fatty acid composition of the spleen lymphocytes was influenced by that of the diet fed. Thymidine incorporation into concanavalin A-stimulated spleen lymphocytes and interleukin (IL)-2 production were highest after feeding the coconut oil diet. Interferon (IFN)-gamma production was decreased by safflower oil or fish oil feeding. IL-4 production was not significantly affected by diet, although production was lowest by lymphocytes from fish oil-fed mice. The ratio of production of Th1- to Th2-type cytokines (determined as the IFN-gamma/IL-4 ratio) was lower for lymphocytes from mice fed the safflower oil or fish oil diets. After 4 h of culture, IL-2 mRNA levels were higher in cells from mice fed coconut oil, and IFN-gamma mRNA levels were higher in cells from mice fed coconut oil or safflower oil. After 8 h of culture, IL-2, IFN-gamma, and IL-4 mRNA levels were lowest in cells from mice fed fish oil. The ratio of the relative levels of IFN-gamma mRNA to IL-4 mRNA was highest in cells from mice fed coconut oil and was lowest in cells of mice fed fish oil.
Quoting: [link to www.ncbi.nlm.nih.gov]
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