I see part of the collective consciousness is diving into this maxim lately; I am wrapping up the campaign of AC IV
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Based on my compiled wisdom and experience, the interpretation I can give is that the universe we reside in is governed by mental forces (ALL is mind comes from hermetic ideology) and when an individual comes to the realization that the hologram they experience is constructed for them (and not in it's true form), they no longer are subjected to the tiny lense of perception they were domesticated to perceive throughout their entire life.

Since we do not see reality in it's true form, we must accept that nothing in this reality is true or derived from truth; by utilizing the principle of cause and effect, one can now generate experiences without basing their motives off of fear alone, but simply universal wisdom and principles that can finally work with us, not against us.