CRISPR gene-editing tested in a person for the first time | |
Sammie User ID: 70867609 United States 11/16/2016 04:04 AM Report Abusive Post Report Copyright Violation | I'm not familiar either but I would imagine, as with most things, it has equal potential for both malice and benefit "Beware lest you lose the substance by grasping at the shadow". ~Aesop "Once in a dream I saw a snake swallowing its own tail, it swallowed and swallowed until it got halfway round, and there it stopped and there it stayed, it was stuffed with its own self. Some fix, that. We only have ourselves to go on, and it’s enough…" -Charles Bukowski "Grasping at things can only yield one of two results: Either the thing you are grasping at disappears, or you yourself disappear. It is only a matter of which occurs first." -Goenka |
TheKeyling User ID: 72766769 New Zealand 11/16/2016 04:08 AM Report Abusive Post Report Copyright Violation | |
DeplorableEgo User ID: 73426339 Germany 11/16/2016 04:22 AM Report Abusive Post Report Copyright Violation | Injecting MAN-MADE gene-editing immune cells which "attacks" certain proteins - What possibly could go wrong? "DNA-cutting enzyme with a molecular guide that can be programmed to tell the enzyme precisely where to cut. The disabled gene codes for the protein PD-1, which normally puts the brakes on a cell’s immune response: cancers take advantage of that function to proliferate." And auto immune disease wasn´t bad enough? Is this going to be auto-immune on steroids? "It is well known that CRISPR can result in gene edits at the wrong place in the genome, with potentially harmful effects." But they don´t list anywhere what those could be. "Because the technique targets T cells, which are involved in various kinds of immune responses, in a non-specific way, Chan worries that the approach might induce an excessive autoimmune response in which the cells would start attacking the gut, or adrenaline glands or other normal tissue. “All the T cells — everything will be active. That will be a concern,” says Chan." [link to www.nature.com] What are they really trying to change in the genome under the guise of "saving lives"? Actually, I´m worried that they could actually use this as a biological weapon and make it somehow communicable. Last Edited by PiggyGalore on 11/16/2016 04:29 AM |
DeplorableEgo User ID: 73426339 Germany 11/16/2016 04:32 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 69993567 Netherlands 11/16/2016 04:41 AM Report Abusive Post Report Copyright Violation | Fucking retards here, unless you want to be killed by everything nature will be throwing at us (like the resistant bacteria) this research is very important. Yes, there is a potential for evil doing, but that goes for nearly every scientific discovery, it's because humans are not perfect and biased and the scientific method is imperfect but selfcorrecting. Don't blame those who do nothing but sacrifice their time and energy for the betterment of our species. If you wanna talk malignant, let's talk religion.. Like banning the use of contraception in places infested with HIV/AIDS,despite there being proof that condoms help prevent the spread that's malignant. Also I blame the church for your stupidity. You could have been an educated rational person but they clouded your mind with make belief, that's malignant. |
Sungaze_At_Dawn User ID: 73221749 Canada 11/16/2016 04:47 AM Report Abusive Post Report Copyright Violation | |
DeplorableEgo User ID: 73426339 Germany 11/16/2016 11:00 AM Report Abusive Post Report Copyright Violation | Oh noes science! Quick get your epipen! Quoting: Anonymous Coward 69993567 Fucking retards here, unless you want to be killed by everything nature will be throwing at us (like the resistant bacteria) this research is very important. Yes, there is a potential for evil doing, but that goes for nearly every scientific discovery, it's because humans are not perfect and biased and the scientific method is imperfect but selfcorrecting. Don't blame those who do nothing but sacrifice their time and energy for the betterment of our species. If you wanna talk malignant, let's talk religion.. Like banning the use of contraception in places infested with HIV/AIDS,despite there being proof that condoms help prevent the spread that's malignant. Also I blame the church for your stupidity. You could have been an educated rational person but they clouded your mind with make belief, that's malignant. Go for it bud, inject away and believe what you want. I will continue to contend that the human body is the superior "advanced" technology and doesn´t need help from tinkering idiots in a lab. As for your "resistant bacteria" and HIV/AIDS both are a result of man´s intervention. You have "science" to thank for both. *clap-clap* [link to www.originofaids.com] |
DeplorableEgo User ID: 73452799 Germany 11/20/2016 03:58 AM Report Abusive Post Report Copyright Violation | |
Proud Deplorable Cybored User ID: 73441906 United Kingdom 11/20/2016 04:01 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 73450584 United States 11/20/2016 04:03 AM Report Abusive Post Report Copyright Violation | |
SeoKungFu User ID: 66943469 Bulgaria 11/20/2016 04:06 AM Report Abusive Post Report Copyright Violation | I am not anti-science, but am anti ignorant homosapienses stating that 90% of the DNA is junk, just because their little narrow-minded homosapientic minds cannot fully grasp what is going on, and next they will be editing genes. I am anti-ignorance, and earthian science had proved to be very much in the dark for ages ! "Have a vision of life that inspires you, then try every day to grow closer to the fulfillment of that vision." Deepak Chopra Cetrified Moran on a Divine Mission ! |
Anonymous Coward User ID: 72228894 United States 11/20/2016 04:42 AM Report Abusive Post Report Copyright Violation | It's a good thing. They have recently made advances in gene therapy that will allow them to treat diseases that were previously incurable. Now, of course, it will be interesting to see if the results they got in the lab will work in humans. Hopefully so. If this works, in the future, gene therapy could revolutionize the future of medicine. In the future, we could treat illnesses with gene therapy instead of toxic drugs. Chemotherapy is very toxic --- sometimes the chemo kills people. Thanks for posting! |
Anonymous Coward User ID: 62987524 Germany 11/20/2016 04:55 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 73452476 Belgium 11/20/2016 05:01 AM Report Abusive Post Report Copyright Violation | |
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serkok User ID: 73205275 Czechia 11/20/2016 05:04 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 73237334 Panama 11/20/2016 05:06 AM Report Abusive Post Report Copyright Violation | Injecting MAN-MADE gene-editing immune cells which "attacks" certain proteins - Quoting: DeplorableEgo What possibly could go wrong? "DNA-cutting enzyme with a molecular guide that can be programmed to tell the enzyme precisely where to cut. The disabled gene codes for the protein PD-1, which normally puts the brakes on a cell’s immune response: cancers take advantage of that function to proliferate." And auto immune disease wasn´t bad enough? Is this going to be auto-immune on steroids? "It is well known that CRISPR can result in gene edits at the wrong place in the genome, with potentially harmful effects." But they don´t list anywhere what those could be. "Because the technique targets T cells, which are involved in various kinds of immune responses, in a non-specific way, Chan worries that the approach might induce an excessive autoimmune response in which the cells would start attacking the gut, or adrenaline glands or other normal tissue. “All the T cells — everything will be active. That will be a concern,” says Chan." [link to www.nature.com] What are they really trying to change in the genome under the guise of "saving lives"? :tsopfu: Actually, I´m worried that they could actually use this as a biological weapon and make it somehow communicable. The first 2 sentences of your post really hit home with me. I had a horrifically bad reaction to a fluoroquinolone antibiotic, because it attacked the wrong cells in my body. The drug infiltrates and kills the bacteria causing the infection by attacking its ability to replicate. The problem is that tendon cells and mitochondrial DNA are similar enough to bacteria cells for the antibiotic to attack them in the same way, which can leave a person seriously crippled and in a world of hurt for years. We already have drugs that can infiltrate and rewrite human DNA with devastating results. It seems to me that this new technology would be like that on steroids. I cannot even begin to fathom how terrible the effects could be if something went wrong. |
CarimboHanky User ID: 73453350 United States 11/20/2016 05:11 AM Report Abusive Post Report Copyright Violation | funny thing... just today i was watching "inside man" a morgan spurlock show, episode name is "futurist" on netflix and the guy interviewed some "bio hacker" group that had a way of screening dna for imperfections that could result in health issues later in life and edit it to make it "perfect", the guy said they could get the new dna into a person via virus that may endanger your immune system, but havent tested the thing as they havent found a way to make it safe. he also said, once the techology is perfected it would be an arms race between wealthy families that forsure would try to create the fasted and smartest children... we are living in a really really interesting time. |
CD-8 T-Cell User ID: 71687374 United States 11/20/2016 05:12 AM Report Abusive Post Report Copyright Violation | Rather than doing a genetic gene splice directly into the human genome which can lead to unintended medical and physical consequences for the patient... A better approach is to use monoclonal antibodies that block the PD-1 cancer receptors directly on the cancer cell itself, the Chinese article did not mention PD-L1 receptors either only the PD-1, once you block the PD-1 and PDL-1 receptors of the cancer cell, the cancer cell will be unable to defend itself from the CD-8 killer T-Cells that the body will produce once the PD-1 and PD-L1 receptors are blocked. There is an American company already working on this and is also the first company to have the Zika vaccine in phase one clinical trials using what is called Sync-On technology that ultimately activates the CD-8 killer T-cells in your body to recognize various pathogens including cancer and many other diseases. |
CarimboHanky User ID: 73453350 United States 11/20/2016 05:16 AM Report Abusive Post Report Copyright Violation | |
Proud Deplorable Cybored User ID: 73441906 United Kingdom 11/20/2016 05:18 AM Report Abusive Post Report Copyright Violation | Thanks Cybored. I thought it was important, surprised it got ignored. The way we're going we'll bring about our own extinction. The only people left will he any undiscovered, unpolluted tribes. Maybe we've done this before. What concerns me most Tess, Is this is mainstream science now. Wonder what has been happening behind all those closed doors for the last 50 years that we don't know about? Last Edited by Cybored on 11/20/2016 05:19 AM Information is the most dangerous weapon of all ... "A computer is like air conditioning – it becomes useless when you open Windows" - Linus Torvalds |
Anonymous Coward User ID: 62987524 Germany 11/20/2016 05:18 AM Report Abusive Post Report Copyright Violation | [link to phys.org] Second layer of information in DNA confirmed This is why you don't tamper with stuff you don't understand... DNA has multiple layers like fractals they are harmonic with the environment because they act like antennas. |
Anonymous Coward User ID: 71687374 United States 11/20/2016 05:33 AM Report Abusive Post Report Copyright Violation | Rather than doing a genetic gene splice directly into the human genome which can lead to unintended medical and physical consequences for the patient... Quoting: CD-8 T-Cell 71687374 A better approach is to use monoclonal antibodies that block the PD-1 cancer receptors directly on the cancer cell itself, the Chinese article did not mention PD-L1 receptors either only the PD-1, once you block the PD-1 and PDL-1 receptors of the cancer cell, the cancer cell will be unable to defend itself from the CD-8 killer T-Cells that the body will produce once the PD-1 and PD-L1 receptors are blocked. There is an American company already working on this and is also the first company to have the Zika vaccine in phase one clinical trials using what is called Sync-On technology that ultimately activates the CD-8 killer T-cells in your body to recognize various pathogens including cancer and many other diseases. To continue the rest of the story... The article said the best way to kill cancer is with antigens and that is correct... .... what does that mean? That means the immune system needs the target data that instructs the immune system to create an army of CD-8 killer T-Cells.... like an Army of Navy Seals and Special Ops soldiers that now have orders to go after the the bad guys (cancer Viruses). The way to create the antigens is to use a DNA Marker that is made out of a material that is non toxic to the bodies immune system itself but yet contains a replica of the cancers DNA but without the PD-1 and PD-L1 receptors, so now we have two ways that can be used to activate the human body's own immune system to create an Army of CD-8 killer T-Cells to search and destroy cancer without killing the patient or screwing up the human geneome. This is the best Technology out there that the news media is reluctant to talk about because it is being with held and DARPA is providing huge $$$ for the trials. No surgery, no kemo no radiation... |
superflyscot User ID: 52965052 United Kingdom 11/20/2016 05:34 AM Report Abusive Post Report Copyright Violation | Cutting edge technology, and for many here, highly unethical. But wait until your kid or mother can be cured of a terminal illness with this technology and you may well change your mind. My friend is studying genetics at Cambridge and dismisses any ideas that any research could possibly be going on 'behind closed doors.' I'm far more cynical. China will advance further, quicker, because they are less concerned with ethics than the West. But, like anything, I'm willing to try it after all tests have been done. Good find, Tess. "Don't hate the black, don't hate the white, if you get bitten, just hate the bite" Sly Stone 'We’re the middle children of history. We have no Great War. No Great Depression. Our Great War’s a spiritual war. Our Great Depression is our lives.' 'The world is a drama, staged in a dream' |
MyNameIsRickMoranis Senior Forum Moderator User ID: 71504938 United States 11/20/2016 05:36 AM Report Abusive Post Report Copyright Violation | |
Anonymous Coward User ID: 71679163 United Kingdom 11/20/2016 05:37 AM Report Abusive Post Report Copyright Violation | Oh noes science! Quick get your epipen! Quoting: Anonymous Coward 69993567 Fucking retards here, unless you want to be killed by everything nature will be throwing at us (like the resistant bacteria) this research is very important. Yes, there is a potential for evil doing, but that goes for nearly every scientific discovery, it's because humans are not perfect and biased and the scientific method is imperfect but selfcorrecting. Don't blame those who do nothing but sacrifice their time and energy for the betterment of our species. If you wanna talk malignant, let's talk religion.. Like banning the use of contraception in places infested with HIV/AIDS,despite there being proof that condoms help prevent the spread that's malignant. Also I blame the church for your stupidity. You could have been an educated rational person but they clouded your mind with make belief, that's malignant. Alright smart guy. I think this is mental and I'm an atheist. Who will own the genes? The same types of company that owns the copyright to various modified crops? |
Anonymous Coward User ID: 62987524 Germany 11/20/2016 05:41 AM Report Abusive Post Report Copyright Violation | Oh noes science! Quick get your epipen! Quoting: Anonymous Coward 69993567 Fucking retards here, unless you want to be killed by everything nature will be throwing at us (like the resistant bacteria) this research is very important. Yes, there is a potential for evil doing, but that goes for nearly every scientific discovery, it's because humans are not perfect and biased and the scientific method is imperfect but selfcorrecting. Don't blame those who do nothing but sacrifice their time and energy for the betterment of our species. If you wanna talk malignant, let's talk religion.. Like banning the use of contraception in places infested with HIV/AIDS,despite there being proof that condoms help prevent the spread that's malignant. Also I blame the church for your stupidity. You could have been an educated rational person but they clouded your mind with make belief, that's malignant. Alright smart guy. I think this is mental and I'm an atheist. Who will own the genes? The same types of company that owns the copyright to various modified crops? He himself is a fucking retard.. these guys will the the first in the line for a chip inside their brain. |
superflyscot User ID: 52965052 United Kingdom 11/20/2016 05:52 AM Report Abusive Post Report Copyright Violation | My friend just told me that she wants to see the results of the trial first...she says she thinks it is incredible if it actually works BUT crispr/cas has been proven to also have unspecific activity (no idea what that means but it sounds bad) so it could also be a bit dangerous. I know a crazy Russian guy who applies a magnetic/electrical small charge to his and others' brains to research neuroscience. It's unethical and there are risks, but, as he says, scientific advances throughout history weren't tied down by ethics and thank God, otherwise we may still be using VHS videos. "Don't hate the black, don't hate the white, if you get bitten, just hate the bite" Sly Stone 'We’re the middle children of history. We have no Great War. No Great Depression. Our Great War’s a spiritual war. Our Great Depression is our lives.' 'The world is a drama, staged in a dream' |
Anonymous Coward User ID: 71687374 United States 11/20/2016 05:57 AM Report Abusive Post Report Copyright Violation | Oh noes science! Quick get your epipen! Quoting: Anonymous Coward 69993567 Fucking retards here, unless you want to be killed by everything nature will be throwing at us (like the resistant bacteria) this research is very important. Yes, there is a potential for evil doing, but that goes for nearly every scientific discovery, it's because humans are not perfect and biased and the scientific method is imperfect but selfcorrecting. Don't blame those who do nothing but sacrifice their time and energy for the betterment of our species. If you wanna talk malignant, let's talk religion.. Like banning the use of contraception in places infested with HIV/AIDS,despite there being proof that condoms help prevent the spread that's malignant. Also I blame the church for your stupidity. You could have been an educated rational person but they clouded your mind with make belief, that's malignant. Alright smart guy. I think this is mental and I'm an atheist. Who will own the genes? The same types of company that owns the copyright to various modified crops? It's the law, no one can own or patent the human Genome.... what is patentable however are the DNA sequences for the antigen markers, the markers only look like a cancer virus but will not harm the body because it is made from inert synthetic material that is gets eliminated and filtered out of the body... the ability to identify the many cancer viruses using the Synthetic DNA Monoclonal Antibodies are patentable because it is not a human DNA material that does not replicate the human genome just the virus DNA material...it generates a huge immune response that activates killer T-Cells of the immune system... |
Anonymous Coward User ID: 71687374 United States 11/20/2016 06:06 AM Report Abusive Post Report Copyright Violation | Oh noes science! Quick get your epipen! Quoting: Anonymous Coward 69993567 Fucking retards here, unless you want to be killed by everything nature will be throwing at us (like the resistant bacteria) this research is very important. Yes, there is a potential for evil doing, but that goes for nearly every scientific discovery, it's because humans are not perfect and biased and the scientific method is imperfect but selfcorrecting. Don't blame those who do nothing but sacrifice their time and energy for the betterment of our species. If you wanna talk malignant, let's talk religion.. Like banning the use of contraception in places infested with HIV/AIDS,despite there being proof that condoms help prevent the spread that's malignant. Also I blame the church for your stupidity. You could have been an educated rational person but they clouded your mind with make belief, that's malignant. Alright smart guy. I think this is mental and I'm an atheist. Who will own the genes? The same types of company that owns the copyright to various modified crops? It's the law, no one can own or patent the human Genome.... what is patentable however are the DNA sequences for the antigen markers, the markers only look like a cancer virus but will not harm the body because it is made from inert synthetic material that is gets eliminated and filtered out of the body... the ability to identify the many cancer viruses using the Synthetic DNA Monoclonal Antibodies are patentable because it is not a human DNA material that does not replicate the human genome just the virus DNA material...it generates a huge immune response that activates killer T-Cells of the immune system... What I am trying to do is educate you all on a better Technology other than CRISPR... Researchers should not modify the human Genome itself that god created... just unblind the human immune system so that it can recognize the cancers, viruses and bacteria that plague the humans and animals of planet earth. And that is what Sync-On tech can do... |