Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects

Harmala alkaloids are classed as MAOIs. This means that they inhibit the activity of monoamine oxidase metabolic enzymes of which two varieties exist: MOA-A and MOA-B. The alkaloids bind reversibly to the active site of the enzyme, inhibiting its endogenous function of destroying amine functions of neurotransmitters and externally administered centrally active drugs. This has the effect of potentiating and prolonging the central and peripheral activity of both neurotransmitters and a variety of drugs.

Harmala alkaloids are selective for MOA-A at reasonable doses and bind to the enzyme temporarily, so they are classed as a reversible inhibitor of monoamine-A (RIMA). At higher doses, they also begin to affect the MOA-B enzyme. Because of the reversible selectivity for MAO-A, harmala alkaloids are considered to be less dangerous in combination with food which contains tyramine and other substances with monoamine moieties which are reliant on monoamine oxidase for decomposition.

However, it is important to understand that this does not imply that harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and drugs which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including sedation, stimulation, anxiety, cognitive dysphoria, euphoria, headaches, eye strain, and muscle convulsions.

Several alkaloids that function as monoamine oxidase inhibitors (MAOIs) are found in the seeds of Peganum harmala (also known as Harmal or Syrian Rue), as well as tobacco leaves including harmine, harmaline, and harmalol, which are members of a group of substances with a similar chemical structure collectively known as harmala alkaloids. These alkaloids are of interest for their use in Amazonian shamanism, where they are derived from other plants. The harmala alkaloid harmine, once known as telepathine and banisterine, is a naturally occurring beta-carboline alkaloid that is structurally related to harmaline, and also found in the vine Banisteriopsis caapi. Tetrahydroharmine is also found in B. caapi and P. harmala. Dr. Alexander Shulgin has suggested that harmine may be a breakdown product of harmaline. Harmine and harmaline are reversible MAOIs of the MAO-A isoform of the enzyme, and can stimulate the central nervous system by inhibiting the metabolism of monoamine compounds such as serotonin and norepinephrine.

The harmala alkaloids occur in Peganum harmala in concentrations of roughly 3%, though tests have documented anywhere from 2-7% or even higher, as natural sources tend to vary widely in chemical makeup. Harmala alkaloids are also found in the Banisteriopsis caapi vine, the key plant ingredient in the sacramental beverage Ayahuasca, in concentrations that range between 0.31-8.43% for harmine, 0.03-0.83% for harmaline and 0.05-2.94% for tetrahydroharmine.

Harmala alkaloids are also found in many other plants, such as passion flower. The leaves of P. incarnata have been reported variously to give 0.005%, 0.12 mg%, and nil, of harman alkaloids.

Telepathine?

where can you get the seeds?

Why does everyone I see doin it seem more rooted in their bullshit when they all claim the opposite?

make sure to research maoi interactions

mixing with certain drugs and plants can be very dangerous

sooooo..you dont consider vomiting a side effect?

Locally you may be able to find them at middle eastern groceries/markets. But your best bet is ordering them in bulk from online vendors. You can also order the extract online but it's cheaper to just buy the seeds & extract it yourself...