Godlike Productions - Discussion Forum
Users Online Now: 1,597 (Who's On?)Visitors Today: 128,382
Pageviews Today: 221,851Threads Today: 70Posts Today: 1,390
02:56 AM


Rate this Thread

Absolute BS Crap Reasonable Nice Amazing
 

Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects

 
SN7
Offer Upgrade

User ID: 51691602
United States
12/09/2016 12:32 AM
Report Abusive Post
Report Copyright Violation
Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Study: [link to peerj.com (secure)]

"The hallucinogenic drink ayahuasca stimulates the brain, helping it fight Alzheimer’s and Down syndrome, according to a new study.

Ayahuasca has been studied before for its ability to fight depression, but in the latest research, published in PeerJ, one of the main substances present in the drink, harmine, was exposed to human neural cells.

The results found that the protein encoding gene DYRK1A, which is over-activated in patients suffering from Alzheimer’s and Down syndrome, was prevented from working when exposed to the substance.

Harmine also produced the same effect as antidepressant drugs but without the side-effects."
 Quoting: [link to www.rt.com (secure)]


(Taking Harmine or full spectrum Harmala alkaloids by themselves IS NOT considered Ayahuasca)

Peganum Harmala(Syrian Rue) seeds contain the highest % of Harmala alkaloids & can be easily extracted then separated from each other if you just want the Harmine. It can also be brewed as a tea, but extracting it is the better route though as you can more accurately measure the dosage...

Here's 2 detailed guides on how to extract Harmala from Syrian Rue seeds:

Harmalas Extraction & Separation Guide:
[link to wiki.dmt-nexus.me (secure)]

The Tao Of Rue Extraction:
[link to wiki.dmt-nexus.me (secure)]


(Harmala alkaloids are legal in most country's including the US)

(If you are taking any pharmaceutical drugs or illegal drugs lookup the "drug name" with "Harmine" or "Syrian Rue" included in the search. You shouldn't consume Harmala alkaloids if you are currently taking certain drugs as it can possibly cause dangerous interactions)

Harmine: is a reversible inhibitor of MAO-A (RIMA) at doses of 200mg.

Harmaline: is a reversible inhibitor of MAO-A (RIMA) at doses of 100mg.

Tetrahydroharmine: does not inhibit monoamine oxidase A. Instead, it weakly inhibits serotonin reuptake inhibition. At doses of 200mg, it has been reported to cause dream-like euphoria, pleasurable tingling sensations and an extensive array of psychedelic effects.

More Info(Including Drug Interactions) Here:

[link to psychonautwiki.org (secure)]

[link to www.erowid.org (secure)]

hf

Last Edited by COSMIC WARRIOR on 12/11/2016 03:51 AM
"The syntactical nature of reality, the real secret of magic, is that the world is made of words. And if you know the words that the world is made of, you can make of it whatever you wish."

~ Terence McKenna
SN7  (OP)

User ID: 51691602
United States
12/09/2016 12:35 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Harmala alkaloids are classed as MAOIs. This means that they inhibit the activity of monoamine oxidase metabolic enzymes of which two varieties exist: MOA-A and MOA-B. The alkaloids bind reversibly to the active site of the enzyme, inhibiting its endogenous function of destroying amine functions of neurotransmitters and externally administered centrally active drugs. This has the effect of potentiating and prolonging the central and peripheral activity of both neurotransmitters and a variety of drugs.

Harmala alkaloids are selective for MOA-A at reasonable doses and bind to the enzyme temporarily, so they are classed as a reversible inhibitor of monoamine-A (RIMA). At higher doses, they also begin to affect the MOA-B enzyme. Because of the reversible selectivity for MAO-A, harmala alkaloids are considered to be less dangerous in combination with food which contains tyramine and other substances with monoamine moieties which are reliant on monoamine oxidase for decomposition.

However, it is important to understand that this does not imply that harmala alkaloids will not cause neurotoxicity. Harmala alkaloids temporarily disable the brain's primary mechanism for breaking down neurotransmitters and drugs which can have negative consequences as material builds up in the synapses, leading to a huge range of downstream central and peripheral effects including sedation, stimulation, anxiety, cognitive dysphoria, euphoria, headaches, eye strain, and muscle convulsions.
 Quoting: [link to psychonautwiki.org (secure)]



Several alkaloids that function as monoamine oxidase inhibitors (MAOIs) are found in the seeds of Peganum harmala (also known as Harmal or Syrian Rue), as well as tobacco leaves including harmine, harmaline, and harmalol, which are members of a group of substances with a similar chemical structure collectively known as harmala alkaloids. These alkaloids are of interest for their use in Amazonian shamanism, where they are derived from other plants. The harmala alkaloid harmine, once known as telepathine and banisterine, is a naturally occurring beta-carboline alkaloid that is structurally related to harmaline, and also found in the vine Banisteriopsis caapi. Tetrahydroharmine is also found in B. caapi and P. harmala. Dr. Alexander Shulgin has suggested that harmine may be a breakdown product of harmaline. Harmine and harmaline are reversible MAOIs of the MAO-A isoform of the enzyme, and can stimulate the central nervous system by inhibiting the metabolism of monoamine compounds such as serotonin and norepinephrine.

The harmala alkaloids occur in Peganum harmala in concentrations of roughly 3%, though tests have documented anywhere from 2-7% or even higher, as natural sources tend to vary widely in chemical makeup. Harmala alkaloids are also found in the Banisteriopsis caapi vine, the key plant ingredient in the sacramental beverage Ayahuasca, in concentrations that range between 0.31-8.43% for harmine, 0.03-0.83% for harmaline and 0.05-2.94% for tetrahydroharmine.

Harmala alkaloids are also found in many other plants, such as passion flower. The leaves of P. incarnata have been reported variously to give 0.005%, 0.12 mg%, and nil, of harman alkaloids.
 Quoting: [link to en.m.wikipedia.org (secure)]


Last Edited by COSMIC WARRIOR on 12/11/2016 02:40 AM
"The syntactical nature of reality, the real secret of magic, is that the world is made of words. And if you know the words that the world is made of, you can make of it whatever you wish."

~ Terence McKenna
Anonymous Coward
User ID: 73540571
United States
12/09/2016 12:41 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
And passion flower is pretty widespread, pick regularly.
Anonymous Coward
User ID: 73566235
United States
12/09/2016 12:49 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
bump
Anonymous Coward
User ID: 71061882
United States
12/09/2016 01:28 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Telepathine?
hiding
SN7  (OP)

User ID: 51691602
United States
12/09/2016 01:39 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Telepathine?
hiding
 Quoting: Anonymous Coward 71061882


ohyeah

"Telepathine was originally thought to be the active chemical constituent of Banisteriopsis caapi, a key plant ingredient in the preparation of ayahuasca; a sacramental beverage from the Amazon. This isolated chemical was so named because of the reported effects of Ayahuasca among the indigenous users, including: collective contact with and/or visions of jaguars, snakes, and jeweled birds, and ancestral spirits; the ability to see future events; and as the name suggests, telepathic communication among tribal members. It was assumed to be a newly discovered chemical at the time, however, it was soon realized that Telepathine was already more widely known as "harmine" from its previous discovery in Peganum harmala (Syrian Rue)."

- [link to en.wikipedia.org (secure)]
"The syntactical nature of reality, the real secret of magic, is that the world is made of words. And if you know the words that the world is made of, you can make of it whatever you wish."

~ Terence McKenna
SN7  (OP)

User ID: 51691602
United States
12/09/2016 02:37 PM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
bump4
"The syntactical nature of reality, the real secret of magic, is that the world is made of words. And if you know the words that the world is made of, you can make of it whatever you wish."

~ Terence McKenna
Anonymous Coward
User ID: 72097633
United States
12/09/2016 02:46 PM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Pretty awesome stuff, hopefully more research into the therapeutic benefits for this and others will open up.
Anonymous Coward
User ID: 72097633
United States
12/09/2016 02:48 PM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Trump has picked a libertarian for his FDA pick, perhaps him and others can convince people to expand upon current research

see this for similar studies and info...

[link to www.maps.org]
Anonymous Coward
User ID: 73578408
United States
12/09/2016 07:04 PM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
where can you get the seeds?
SN7  (OP)

User ID: 51691602
United States
12/09/2016 07:42 PM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
where can you get the seeds?
 Quoting: Anonymous Coward 73578408


Locally you may be able to find them at middle eastern groceries/markets. But your best bet is ordering them in bulk from online vendors. You can also order the extract online but it's cheaper to just buy the seeds & extract it yourself...
"The syntactical nature of reality, the real secret of magic, is that the world is made of words. And if you know the words that the world is made of, you can make of it whatever you wish."

~ Terence McKenna
Anonymous Coward
User ID: 56226124
United States
12/09/2016 07:59 PM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
I went to my first Ayahuasca ceremony a month ago. I've quit smoking, got off almost all of the prescription medication I was on, I'm sleeping 8 hours a night (I haven't been able to get more than 6 hours a night in YEARS ) and I'm remembering my dreams.
SN7  (OP)

User ID: 51691602
United States
12/11/2016 12:07 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Here's another article with more details including info about Aya itself: [link to www.dailymail.co.uk]

Sadly there's only been 3 articles published about this so far...

Last Edited by COSMIC WARRIOR on 12/11/2016 12:09 AM
"The syntactical nature of reality, the real secret of magic, is that the world is made of words. And if you know the words that the world is made of, you can make of it whatever you wish."

~ Terence McKenna
Anonymous Coward
User ID: 61511463
United States
12/11/2016 12:43 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Why does everyone I see doin it seem more rooted in their bullshit when they all claim the opposite?
SN7  (OP)

User ID: 51691602
United States
12/11/2016 01:09 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Why does everyone I see doin it seem more rooted in their bullshit when they all claim the opposite?
 Quoting: Anonymous Coward 61511463


If you're talking about DMT do you know if they were overdoing it? That could be a reason why if you don't respect the spirit molecule it won't respect you... This thread however is about Harmala alkaloids not DMT, Harmine doesn't really have that much of a psychedelic effect...
"The syntactical nature of reality, the real secret of magic, is that the world is made of words. And if you know the words that the world is made of, you can make of it whatever you wish."

~ Terence McKenna
Deplorable Grove Street

User ID: 72801883
United States
12/11/2016 02:04 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
bump thanks for reminding me about harmaline.
Grove

And this is why we can't have nice things.
Anonymous Coward
User ID: 58307328
United States
12/11/2016 02:24 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
ever seen a retard on acid?
Anonymous Coward
User ID: 72258389
United States
12/11/2016 02:30 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
make sure to research maoi interactions

mixing with certain drugs and plants can be very dangerous
SN7  (OP)

User ID: 51691602
United States
12/11/2016 02:56 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
make sure to research maoi interactions

mixing with certain drugs and plants can be very dangerous
 Quoting: Anonymous Coward 72258389


hesright

I added a warning in the OP...
"The syntactical nature of reality, the real secret of magic, is that the world is made of words. And if you know the words that the world is made of, you can make of it whatever you wish."

~ Terence McKenna
Anonymous Coward
User ID: 72529963
United States
12/11/2016 03:35 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
sooooo..you dont consider vomiting a side effect?
Anonymous Coward
User ID: 72143248
Australia
12/11/2016 03:38 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
im just about to blaze some changa heh :D
SN7  (OP)

User ID: 51691602
United States
12/11/2016 03:43 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
sooooo..you dont consider vomiting a side effect?
 Quoting: Anonymous Coward 72529963


This thread isn't about DMT containing plant material/Ayahuasca. To properly consume oral DMT/Ayahuasca you have to combine it with another plant/drug or else it will have no effect.

This thread is about the other plant which contains Harmala & has practically no side effects besides possible interactions when taken in low to moderate doses.

Last Edited by COSMIC WARRIOR on 12/11/2016 03:45 AM
"The syntactical nature of reality, the real secret of magic, is that the world is made of words. And if you know the words that the world is made of, you can make of it whatever you wish."

~ Terence McKenna
Anonymous Coward
User ID: 73580176
United Kingdom
12/11/2016 03:45 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
The same can be achieved with a daily low liberty cap dosage, there is a whole fabric emotional sublayer through society most people miss out on, which makes life much easier to navigate, as you are aware of the causal cascades your words and actions cause, in everyday awareness we are oblivious to it much like the buffallo to the delicate fauna beneath its feet
Anonymous Coward
User ID: 73586290
Germany
12/11/2016 05:01 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
SN7 have you ever done salvia divinorum?
Anonymous Coward
User ID: 73579108
Philippines
12/11/2016 05:29 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
new age dmt heads are not conservatives

they are all libs and they all cannot help exposing themselves

but they have "the power" for now and just long enough to destroy themselves
Anonymous Coward
User ID: 72289315
Netherlands
12/11/2016 06:11 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
where can you get the seeds?
 Quoting: Anonymous Coward 73578408


Locally you may be able to find them at middle eastern groceries/markets. But your best bet is ordering them in bulk from online vendors. You can also order the extract online but it's cheaper to just buy the seeds & extract it yourself...
 Quoting: SN7


Available to everyone! Woohoo. And why is this not news? Oh, wait, it's a secret only GLP users know, health professionals boycot it and big pharma ignores it! Remember the secret vitamins? They cured my uncle's cancer. It must've been the pits he was eating. Quick, to GLP with uncle intel.

Stop the BS! Doctors are there to help you and much, much, much more educated on the subjects than you'll ever be. Pseudoscience is best avoided.
Christian Fighter

User ID: 73578236
Brazil
12/11/2016 06:17 AM

Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Bullshit!!
Bad drugs are bad drugs. Exactly the same about Cannabis. These shits kill! Stay away from them. Keep yourself clean and safe.
Anonymous Coward
User ID: 71433356
United States
12/11/2016 06:19 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Great news hf
Anonymous Coward
User ID: 73584786
Canada
12/11/2016 06:20 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
don't turn into a jitterbug

I knew someone who got heavy into dmt, they were unpredictable
Anonymous Coward
User ID: 73584786
Canada
12/11/2016 06:21 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
Pretty sure he moved to Tibet, it's been 6 years now. no word
Anonymous Coward
User ID: 73358163
United States
12/11/2016 07:12 AM
Report Abusive Post
Report Copyright Violation
Re: Substance Found In Hallucinogenic Brew Ayahuasca Fights Alzheimer’s & Down Syndrome, Also Has Same Effect As Antidepressants Without Side Effects
I'm not a scientist but I'm pretty sure Down syndrome can't be fixed.





GLP