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Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.

 
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10/26/2017 02:55 AM
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Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
Fusing an RNA-editing enzyme to an RNA-targeting Cas protein has enabled researchers to edit specific nucleotides within RNA molecules in human cells. The approach, called RNA Editing for Programmable A-to-I replacement (REPAIR), is described today (October 25) in Science, and has the potential to serve not only as a research tool, but as a temporary correctional therapy for disease-causing mutations, the researchers propose.

“This work is an impressive study from a highly productive research group that suggests the possibility of editing RNA transcripts to alter their coding potential in a programmable manner,” David Liu, a chemical biologist at Harvard University who was not involved in the project, writes in an email to The Scientist. “For applications that are best addressed through a transient change in a target RNA's sequence, this approach has strong potential,” he adds. Liu himself has a report out today in Nature describing specific nucleotide editing of DNA by a similar method.

The CRISPR-Cas9 system—a bacterial antiviral immune mechanism first discovered in Streptococcus thermophilus—is now widely used as a DNA editing technique, wherein the DNA nuclease Cas9 is directed to cut any DNA sequence of choice. By searching for similar immune systems in other microorganisms, researchers went on to discover a Cas9-related enzyme called Cas13 (originally termed C2c2), which, in 2016, the Broad Institute’s Feng Zhang and colleagues revealed targeted RNA not DNA.

Further developments with Cas13 led to a Nature paper earlier this month in which Zhang’s team showed that one family member, Cas13a, could be used in mammalian cells to knockdown particular messenger RNAs with similar efficiency to RNA interference. The team also engineered a catalytically inactive version of Cas13a that, when fused to a fluorescent protein, could be used to track RNAs of interest.

[link to www.the-scientist.com]
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Anonymous Coward
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10/26/2017 03:43 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
And now the bad news: can they think of any way it be used against people?
hankie

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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
They have already got an animal in a fake womb, this would be for more cloning.
Sorry I got a headache

These are the times that tries men's and
women's souls!

May we come though it victorious!
Coppercoal

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10/26/2017 04:23 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
Mark of the beast will probably be a "human upgrade". Want to upgrade to version 2.0? Inject this re-sequencer...

If that's the case, there will be unfortunate consequences post launch.
The big shots tried to hold it back; Fools tried to wish it away
The hopeful depend on a world without end; Whatever the hopeless may say
Sungaze_At_Dawn

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10/26/2017 08:44 AM

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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
A true genetic repair and upgrade under real people's government not controlling elites, would not be the mark of the beast.

Its what all progressing species does.
Ryan Goble

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10/26/2017 09:55 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
They extended something again did they?
Anonymous Coward
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10/26/2017 10:06 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
precise manipulations of RNA sequences in human cells.

they did that before...

obviously , some morons can not understand that humans are not robots ....
and for that , they will pay the ultimate price...
Anonymous Coward
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10/26/2017 10:58 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
viruses operate as I understand it by inserting RNA into cells

I wonder if this would be able to attack action of a virus
hollyavila

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10/26/2017 11:02 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
And now the bad news: can they think of any way it be used against people?
 Quoting: Anonymous Coward 51084153


of course. It's called transhumanism.
hollyavila

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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
Mark of the beast will probably be a "human upgrade". Want to upgrade to version 2.0? Inject this re-sequencer...

If that's the case, there will be unfortunate consequences post launch.
 Quoting: Coppercoal


You have the right idea, imho. Something about the mark will actually change us so we cannot hear or relate to God, so it will have to somehow alter DMT function in the brain. I wonder how that is playing into the research.
Or, it will interface AI into our consciousness.
Anthony Patch says that the goal of AI d wave computer and of CERN is to incarnate the fallen angel Lucifer into our realm.
Anonymous Coward
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10/26/2017 11:19 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
could this be used to start a zombie apocalypse ?
Anonymous Coward
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10/26/2017 11:20 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.


what could go wrong?
The Comedian :D

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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
And now the bad news: can they think of any way it be used against people?
 Quoting: Anonymous Coward 51084153


LOL, that happens by default.

Someone is going to accidentally "cure cancer" with this technology.


Saint Comedian, Patron Saint of Bringing the Butthurt to Dipshits

‘There are some assholes in the world that just need to be shot.’ - General Mattis, USMC, Secretary of Defense

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Lily o' the Valley

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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
And now the bad news: can they think of any way it be used against people?
 Quoting: Anonymous Coward 51084153


of course. It's called transhumanism.
 Quoting: hollyavila


Indeed it is.
"I have not yet begun to fight!" - Captain John Paul Jones

"Damn the torpedos - full speed ahead" - Admiral David Farragut

"Nuts!" - General Anthony McAuliffe

*** Good deeds bring rewards, bad actions bring troubles. That is a law of the universe. ***
The Comedian :D

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10/26/2017 11:28 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
could this be used to start a zombie apocalypse ?
 Quoting: Anonymous Coward 66333235


It's going to be hard not to.
The upside is, we already have 8 years of TWD footage on how to survive the ZA, plus 2 more of Fear.
1) Get a guy with a crossbow to join your team
2) Guns. Lots of guns.
3) Don't be afraid to eat dog food.

hillzombie
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‘There are some assholes in the world that just need to be shot.’ - General Mattis, USMC, Secretary of Defense

[link to www.godlikeproductions.com]

"Subterfuge and social pressure are the wheel and fire of the 21st century" - Some asshole

Legal Disclaimer: All comments are intended as humor and/or fiction and not advice, and not to be confused with any event or person, living or dead.
Lily o' the Valley

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10/26/2017 11:29 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
And now the bad news: can they think of any way it be used against people?
 Quoting: Anonymous Coward 51084153


LOL, that happens by default.

Someone is going to accidentally "cure cancer" with this technology.


 Quoting: The Comedian :D


Ewwww....

bitinglip
"I have not yet begun to fight!" - Captain John Paul Jones

"Damn the torpedos - full speed ahead" - Admiral David Farragut

"Nuts!" - General Anthony McAuliffe

*** Good deeds bring rewards, bad actions bring troubles. That is a law of the universe. ***
The Comedian :D

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10/26/2017 11:30 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
I am the farthest thing from a luddite you can imagine, but this motherfucking bullshit needs to stop, right now, before someone accidentally creates a synthetic ELE.
Saint Comedian, Patron Saint of Bringing the Butthurt to Dipshits

‘There are some assholes in the world that just need to be shot.’ - General Mattis, USMC, Secretary of Defense

[link to www.godlikeproductions.com]

"Subterfuge and social pressure are the wheel and fire of the 21st century" - Some asshole

Legal Disclaimer: All comments are intended as humor and/or fiction and not advice, and not to be confused with any event or person, living or dead.
The Comedian :D

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10/26/2017 11:31 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
And now the bad news: can they think of any way it be used against people?
 Quoting: Anonymous Coward 51084153


LOL, that happens by default.

Someone is going to accidentally "cure cancer" with this technology.


 Quoting: The Comedian :D


Ewwww....

bitinglip
 Quoting: Lily o' the Valley


jay
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‘There are some assholes in the world that just need to be shot.’ - General Mattis, USMC, Secretary of Defense

[link to www.godlikeproductions.com]

"Subterfuge and social pressure are the wheel and fire of the 21st century" - Some asshole

Legal Disclaimer: All comments are intended as humor and/or fiction and not advice, and not to be confused with any event or person, living or dead.
The Comedian :D

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10/26/2017 11:32 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.


what could go wrong?
 Quoting: Anonymous Coward 66333235


Bingo.
David was a fucking CRISPR technician.

Nukes are NOTHING compared to synthetic RNA and DNA recombinant tech.

Last Edited by The Comedian :D on 10/26/2017 12:16 PM
Saint Comedian, Patron Saint of Bringing the Butthurt to Dipshits

‘There are some assholes in the world that just need to be shot.’ - General Mattis, USMC, Secretary of Defense

[link to www.godlikeproductions.com]

"Subterfuge and social pressure are the wheel and fire of the 21st century" - Some asshole

Legal Disclaimer: All comments are intended as humor and/or fiction and not advice, and not to be confused with any event or person, living or dead.
Anonymous Coward
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10/26/2017 11:57 AM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.


what could go wrong?
 Quoting: Anonymous Coward 66333235


Bingo.
David was a fucking CRISPR technician.

Nukes are NOTHING compared to synthetic RNA and DAN recominant tech.
 Quoting: The Comedian :D


usually , in all movies first to die are "scientists" ....
Anonymous Coward
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10/26/2017 12:07 PM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
Putin was right..

Thread: YOU'RE TERMINATED: Vladimir Putin warns of future sci-fi super-human soldiers more ‘destructive than nuclear bombs’ who feel no fear or pain
Anonymous Coward
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10/26/2017 03:01 PM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
The answer is yes.

It can be used for nefarious purposes.

It already probably is.

China has the tech and no laws.

Also, if you change one thing you really don't know and won't know for a while what else changes when you manipulate gene a.

Until it shows up 3 generations later.
]
There are tons of problems with this.

I suggest you watch Jennifer Doudna on TED as she asks for a moratorium on such until we figure out exactly what the caveats should be.

It's all great.

Until we growl.
The Comedian :D

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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
The answer is yes.

It can be used for nefarious purposes.

It already probably is.

China has the tech and no laws.

Also, if you change one thing you really don't know and won't know for a while what else changes when you manipulate gene a.

Until it shows up 3 generations later.
]
There are tons of problems with this.

I suggest you watch Jennifer Doudna on TED as she asks for a moratorium on such until we figure out exactly what the caveats should be.

It's all great.

Until we growl.
 Quoting: Anonymous Coward 40647029


^this
Saint Comedian, Patron Saint of Bringing the Butthurt to Dipshits

‘There are some assholes in the world that just need to be shot.’ - General Mattis, USMC, Secretary of Defense

[link to www.godlikeproductions.com]

"Subterfuge and social pressure are the wheel and fire of the 21st century" - Some asshole

Legal Disclaimer: All comments are intended as humor and/or fiction and not advice, and not to be confused with any event or person, living or dead.
darkwolf007

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10/26/2017 03:22 PM

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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.


what could go wrong?
 Quoting: Anonymous Coward 66333235


"I'm sorry, dearie, but mommy died during child birth."
The number one and two participants in the Oppression Olympics? The SJWs and Feminists.

"Today, America would be outraged if U.N. troops entered Los Angeles to restore order [referring to the 1991 LA Riot]. Tomorrow they will be grateful! This is especially true if they were told that there were an outside threat from beyond [i.e., an "extraterrestrial" invasion], whether real or promulgated, that threatened our very existence. It is then that all peoples of the world will plead to deliver them from this evil. The one thing every man fears is the unknown. When presented with this scenario, individual rights will be willingly relinquished for the guarantee of their well-being granted to them by the World Government.”

- Dr. Henry Kissinger, Bilderberger Conference, Evians, France, 1991

"Some even believe we are part of a secret cabal working against the best interests of the United States, characterizing my family and me as internationalists and of conspiring with others around the world to build a more integrated global political and economic structure; one world, if you will. If that's the charge, I stand guilty, and I am proud of it." - David Rockefeller

"The supranational sovereignty of an intellectual elite and world bankers is surely preferable to the national auto-determination practiced in past centuries... We are on the verge of a global transformation. All we need is the right major crisis, and the nations will accept the New World Order." - David Rockefeller

Pepperspray: The new Liberal cologne.

Least PC Native American name? Struggles Through Life
darkwolf007

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10/26/2017 03:24 PM

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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
The answer is yes.

It can be used for nefarious purposes.

It already probably is.

China has the tech and no laws.

Also, if you change one thing you really don't know and won't know for a while what else changes when you manipulate gene a.

Until it shows up 3 generations later.
]
There are tons of problems with this.

I suggest you watch Jennifer Doudna on TED as she asks for a moratorium on such until we figure out exactly what the caveats should be.

It's all great.

Until we growl.
 Quoting: Anonymous Coward 40647029


^this
 Quoting: The Comedian :D


Soon... soon... there will be two camps of people. The "werewolves" versus the "vampires". Halloween will no longer be an October event, but year-round. yeahsure
The number one and two participants in the Oppression Olympics? The SJWs and Feminists.

"Today, America would be outraged if U.N. troops entered Los Angeles to restore order [referring to the 1991 LA Riot]. Tomorrow they will be grateful! This is especially true if they were told that there were an outside threat from beyond [i.e., an "extraterrestrial" invasion], whether real or promulgated, that threatened our very existence. It is then that all peoples of the world will plead to deliver them from this evil. The one thing every man fears is the unknown. When presented with this scenario, individual rights will be willingly relinquished for the guarantee of their well-being granted to them by the World Government.”

- Dr. Henry Kissinger, Bilderberger Conference, Evians, France, 1991

"Some even believe we are part of a secret cabal working against the best interests of the United States, characterizing my family and me as internationalists and of conspiring with others around the world to build a more integrated global political and economic structure; one world, if you will. If that's the charge, I stand guilty, and I am proud of it." - David Rockefeller

"The supranational sovereignty of an intellectual elite and world bankers is surely preferable to the national auto-determination practiced in past centuries... We are on the verge of a global transformation. All we need is the right major crisis, and the nations will accept the New World Order." - David Rockefeller

Pepperspray: The new Liberal cologne.

Least PC Native American name? Struggles Through Life
Anonymous Coward
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10/26/2017 03:28 PM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
Enzymes will do the same thing.or close.if they are so gung ho,they create enzymed plants that can be fed to animals.or extract enzymes from longevity animals and feed them to humans etc.

Say a galapogos tortoise fertile egg raw.enough of these will make you look turtlish but you will live a very long time.i suspect this is why the rich fund zoos.
Eating certain squid polyps may mean immortality.take these polyps and use as vegetable food then eat the vegetables.
You may have a clone of yourself growing out of your dick though.
darkwolf007

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10/26/2017 03:40 PM

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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
Enzymes will do the same thing.or close.if they are so gung ho,they create enzymed plants that can be fed to animals.or extract enzymes from longevity animals and feed them to humans etc.

Say a galapogos tortoise fertile egg raw.enough of these will make you look turtlish but you will live a very long time.i suspect this is why the rich fund zoos.
Eating certain squid polyps may mean immortality.take these polyps and use as vegetable food then eat the vegetables.
You may have a clone of yourself growing out of your dick though.
 Quoting: Anonymous Coward 72571647


That's one way to punish yourself in more ways than one, AC.
The number one and two participants in the Oppression Olympics? The SJWs and Feminists.

"Today, America would be outraged if U.N. troops entered Los Angeles to restore order [referring to the 1991 LA Riot]. Tomorrow they will be grateful! This is especially true if they were told that there were an outside threat from beyond [i.e., an "extraterrestrial" invasion], whether real or promulgated, that threatened our very existence. It is then that all peoples of the world will plead to deliver them from this evil. The one thing every man fears is the unknown. When presented with this scenario, individual rights will be willingly relinquished for the guarantee of their well-being granted to them by the World Government.”

- Dr. Henry Kissinger, Bilderberger Conference, Evians, France, 1991

"Some even believe we are part of a secret cabal working against the best interests of the United States, characterizing my family and me as internationalists and of conspiring with others around the world to build a more integrated global political and economic structure; one world, if you will. If that's the charge, I stand guilty, and I am proud of it." - David Rockefeller

"The supranational sovereignty of an intellectual elite and world bankers is surely preferable to the national auto-determination practiced in past centuries... We are on the verge of a global transformation. All we need is the right major crisis, and the nations will accept the New World Order." - David Rockefeller

Pepperspray: The new Liberal cologne.

Least PC Native American name? Struggles Through Life
The Comedian :D

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10/26/2017 03:46 PM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
Soon... soon... there will be two camps of people. The "werewolves" versus the "vampires". Halloween will no longer be an October event, but year-round. yeahsure
 Quoting: darkwolf007


Underworld: The Godlike Production
Saint Comedian, Patron Saint of Bringing the Butthurt to Dipshits

‘There are some assholes in the world that just need to be shot.’ - General Mattis, USMC, Secretary of Defense

[link to www.godlikeproductions.com]

"Subterfuge and social pressure are the wheel and fire of the 21st century" - Some asshole

Legal Disclaimer: All comments are intended as humor and/or fiction and not advice, and not to be confused with any event or person, living or dead.
darkwolf007

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10/26/2017 03:47 PM

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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
Soon... soon... there will be two camps of people. The "werewolves" versus the "vampires". Halloween will no longer be an October event, but year-round. yeahsure
 Quoting: darkwolf007


Underworld: The Godlike Production
 Quoting: The Comedian :D


That would make for an interesting new level of chaos around these parts.
The number one and two participants in the Oppression Olympics? The SJWs and Feminists.

"Today, America would be outraged if U.N. troops entered Los Angeles to restore order [referring to the 1991 LA Riot]. Tomorrow they will be grateful! This is especially true if they were told that there were an outside threat from beyond [i.e., an "extraterrestrial" invasion], whether real or promulgated, that threatened our very existence. It is then that all peoples of the world will plead to deliver them from this evil. The one thing every man fears is the unknown. When presented with this scenario, individual rights will be willingly relinquished for the guarantee of their well-being granted to them by the World Government.”

- Dr. Henry Kissinger, Bilderberger Conference, Evians, France, 1991

"Some even believe we are part of a secret cabal working against the best interests of the United States, characterizing my family and me as internationalists and of conspiring with others around the world to build a more integrated global political and economic structure; one world, if you will. If that's the charge, I stand guilty, and I am proud of it." - David Rockefeller

"The supranational sovereignty of an intellectual elite and world bankers is surely preferable to the national auto-determination practiced in past centuries... We are on the verge of a global transformation. All we need is the right major crisis, and the nations will accept the New World Order." - David Rockefeller

Pepperspray: The new Liberal cologne.

Least PC Native American name? Struggles Through Life
Anonymous Coward
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10/26/2017 03:51 PM
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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
Soon... soon... there will be two camps of and people. The "werewolves" versus the "vampires". Halloween will no longer be an October event, but year-round. yeahsure
 Quoting: darkwolf007


Underworld: The Godlike Production
 Quoting: The Comedian :D


humans against robots against vampires against werewolves...
darkwolf007

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10/26/2017 04:15 PM

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Re: Scientists extend the capabilities of the CRISPR-Cas system to include precise manipulations of RNA sequences in human cells.
Soon... soon... there will be two camps of and people. The "werewolves" versus the "vampires". Halloween will no longer be an October event, but year-round. yeahsure
 Quoting: darkwolf007


Underworld: The Godlike Production
 Quoting: The Comedian :D


humans against robots against vampires against werewolves...
 Quoting: 7.X.


New mini-series brought to you by Stephen King! lol
The number one and two participants in the Oppression Olympics? The SJWs and Feminists.

"Today, America would be outraged if U.N. troops entered Los Angeles to restore order [referring to the 1991 LA Riot]. Tomorrow they will be grateful! This is especially true if they were told that there were an outside threat from beyond [i.e., an "extraterrestrial" invasion], whether real or promulgated, that threatened our very existence. It is then that all peoples of the world will plead to deliver them from this evil. The one thing every man fears is the unknown. When presented with this scenario, individual rights will be willingly relinquished for the guarantee of their well-being granted to them by the World Government.”

- Dr. Henry Kissinger, Bilderberger Conference, Evians, France, 1991

"Some even believe we are part of a secret cabal working against the best interests of the United States, characterizing my family and me as internationalists and of conspiring with others around the world to build a more integrated global political and economic structure; one world, if you will. If that's the charge, I stand guilty, and I am proud of it." - David Rockefeller

"The supranational sovereignty of an intellectual elite and world bankers is surely preferable to the national auto-determination practiced in past centuries... We are on the verge of a global transformation. All we need is the right major crisis, and the nations will accept the New World Order." - David Rockefeller

Pepperspray: The new Liberal cologne.

Least PC Native American name? Struggles Through Life





GLP